Incidental Mutation 'R3779:Acot10'
ID 271980
Institutional Source Beutler Lab
Gene Symbol Acot10
Ensembl Gene ENSMUSG00000047565
Gene Name acyl-CoA thioesterase 10
Synonyms p48, MT-ACT48, Acate3
Accession Numbers
Essential gene? Probably non essential (E-score: 0.147) question?
Stock # R3779 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 20665300-20666836 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 20665628 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 371 (V371A)
Ref Sequence ENSEMBL: ENSMUSP00000051333 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052910]
AlphaFold Q32MW3
Predicted Effect probably damaging
Transcript: ENSMUST00000052910
AA Change: V371A

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000051333
Gene: ENSMUSG00000047565
AA Change: V371A

DomainStartEndE-ValueType
SCOP:d1lo7a_ 108 222 1e-4 SMART
PDB:4IEN|D 277 400 3e-6 PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226407
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227439
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228652
Meta Mutation Damage Score 0.3664 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.7%
Validation Efficiency 98% (47/48)
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310079G19Rik A G 16: 88,424,273 (GRCm39) C73R probably damaging Het
Ambn C A 5: 88,613,201 (GRCm39) probably benign Het
Ankrd34a T C 3: 96,506,247 (GRCm39) F484L possibly damaging Het
Bcl11a A G 11: 24,114,568 (GRCm39) K637R probably damaging Het
Cenpe T C 3: 134,962,337 (GRCm39) S1968P possibly damaging Het
Cfap61 T C 2: 145,792,714 (GRCm39) I52T probably damaging Het
Cit A T 5: 115,997,400 (GRCm39) M128L probably benign Het
Cnga1 G T 5: 72,762,126 (GRCm39) L463I probably damaging Het
Dnah11 C T 12: 118,094,448 (GRCm39) probably benign Het
Elovl4 ACT A 9: 83,667,201 (GRCm39) probably null Het
Ep400 A G 5: 110,839,515 (GRCm39) I1853T unknown Het
Flg2 C T 3: 93,109,730 (GRCm39) S586L unknown Het
Gm10608 CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA 9: 118,989,784 (GRCm39) probably benign Het
Gm21886 G T 18: 80,132,649 (GRCm39) Q170K possibly damaging Het
Gm5819 A G 18: 8,694,429 (GRCm39) E118G probably damaging Het
Gm9376 T C 14: 118,504,727 (GRCm39) V53A probably benign Het
H2-T3 T C 17: 36,500,574 (GRCm39) T90A probably damaging Het
Hif1an A G 19: 44,557,847 (GRCm39) D243G probably damaging Het
Hmgcs2 C T 3: 98,206,428 (GRCm39) probably benign Het
Ighv1-72 A T 12: 115,721,636 (GRCm39) S107T probably damaging Het
Jak1 G A 4: 101,013,687 (GRCm39) H1014Y probably benign Het
Klrb1c T C 6: 128,757,306 (GRCm39) D253G probably damaging Het
Lpin1 G A 12: 16,614,569 (GRCm39) T404M probably damaging Het
Map3k9 A T 12: 81,790,565 (GRCm39) probably benign Het
Mtrex A T 13: 113,039,926 (GRCm39) probably benign Het
Myl12a G T 17: 71,301,631 (GRCm39) H165Q possibly damaging Het
Or6c38 A G 10: 128,929,165 (GRCm39) F226S possibly damaging Het
Pdgfrb T A 18: 61,205,738 (GRCm39) S575T probably damaging Het
Phldb2 T C 16: 45,569,118 (GRCm39) Y1247C probably damaging Het
Pinlyp T A 7: 24,241,260 (GRCm39) T181S probably benign Het
Pkn2 A G 3: 142,499,741 (GRCm39) V928A possibly damaging Het
Skint5 C T 4: 113,636,237 (GRCm39) probably benign Het
Slc24a1 A G 9: 64,855,579 (GRCm39) Y443H unknown Het
Sp8 G T 12: 118,812,750 (GRCm39) V202L possibly damaging Het
Svil A G 18: 5,090,855 (GRCm39) N915S probably damaging Het
Syncrip A C 9: 88,358,992 (GRCm39) D172E probably damaging Het
Tex26 T C 5: 149,369,316 (GRCm39) I48T probably damaging Het
Trpm6 A C 19: 18,853,403 (GRCm39) I1808L possibly damaging Het
Uba2 T C 7: 33,854,071 (GRCm39) probably null Het
Vwa8 T A 14: 79,339,762 (GRCm39) probably benign Het
Wfs1 C A 5: 37,125,968 (GRCm39) V308L probably benign Het
Wrn T A 8: 33,731,048 (GRCm39) R1095W probably damaging Het
Zfp808 T A 13: 62,319,717 (GRCm39) N315K probably damaging Het
Other mutations in Acot10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01306:Acot10 APN 15 20,666,051 (GRCm39) missense probably benign 0.11
IGL01610:Acot10 APN 15 20,665,781 (GRCm39) missense probably damaging 1.00
IGL02457:Acot10 APN 15 20,666,229 (GRCm39) missense possibly damaging 0.88
IGL02587:Acot10 APN 15 20,665,883 (GRCm39) missense possibly damaging 0.93
IGL02951:Acot10 APN 15 20,665,868 (GRCm39) missense probably benign 0.36
ANU23:Acot10 UTSW 15 20,666,051 (GRCm39) missense probably benign 0.11
PIT4151001:Acot10 UTSW 15 20,666,684 (GRCm39) missense probably damaging 0.98
R0026:Acot10 UTSW 15 20,666,322 (GRCm39) missense probably benign 0.10
R0026:Acot10 UTSW 15 20,666,322 (GRCm39) missense probably benign 0.10
R0462:Acot10 UTSW 15 20,666,712 (GRCm39) missense possibly damaging 0.85
R1312:Acot10 UTSW 15 20,666,585 (GRCm39) missense probably benign 0.00
R1495:Acot10 UTSW 15 20,665,593 (GRCm39) missense probably damaging 0.99
R2128:Acot10 UTSW 15 20,666,712 (GRCm39) missense probably benign 0.00
R4110:Acot10 UTSW 15 20,666,612 (GRCm39) missense probably damaging 1.00
R4111:Acot10 UTSW 15 20,666,612 (GRCm39) missense probably damaging 1.00
R4464:Acot10 UTSW 15 20,665,830 (GRCm39) nonsense probably null
R4668:Acot10 UTSW 15 20,666,028 (GRCm39) missense probably benign
R4933:Acot10 UTSW 15 20,666,416 (GRCm39) missense possibly damaging 0.88
R5255:Acot10 UTSW 15 20,666,018 (GRCm39) missense probably benign 0.01
R5885:Acot10 UTSW 15 20,666,190 (GRCm39) missense probably benign 0.01
R6190:Acot10 UTSW 15 20,665,871 (GRCm39) missense possibly damaging 0.80
R6301:Acot10 UTSW 15 20,666,348 (GRCm39) missense probably benign 0.05
R6805:Acot10 UTSW 15 20,665,452 (GRCm39) missense probably benign 0.42
R7334:Acot10 UTSW 15 20,665,629 (GRCm39) missense possibly damaging 0.86
R7601:Acot10 UTSW 15 20,665,715 (GRCm39) missense probably damaging 1.00
R8400:Acot10 UTSW 15 20,666,258 (GRCm39) missense possibly damaging 0.56
R9195:Acot10 UTSW 15 20,665,517 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAGGTTACTGGGGTACTCATAGAC -3'
(R):5'- ATATTTGTCACCCTCAGGAACG -3'

Sequencing Primer
(F):5'- AGACTTGAAATGTCGCTGTCC -3'
(R):5'- TTTGTCACCCTCAGGAACGAAATG -3'
Posted On 2015-03-25