Incidental Mutation 'IGL00905:Pramel25'
ID 27210
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pramel25
Ensembl Gene ENSMUSG00000066031
Gene Name PRAME like 25
Synonyms MGC:91194, Gm13023
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # IGL00905
Quality Score
Status
Chromosome 4
Chromosomal Location 143515922-143522145 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 143521844 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 487 (T487A)
Ref Sequence ENSEMBL: ENSMUSP00000082232 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085144] [ENSMUST00000105770] [ENSMUST00000149739]
AlphaFold A2A8N2
Predicted Effect probably benign
Transcript: ENSMUST00000085144
AA Change: T487A

PolyPhen 2 Score 0.432 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000082232
Gene: ENSMUSG00000066031
AA Change: T487A

DomainStartEndE-ValueType
SCOP:d1a4ya_ 222 420 3e-9 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000105770
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139978
Predicted Effect probably benign
Transcript: ENSMUST00000149739
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atg16l2 T C 7: 100,949,373 (GRCm39) E58G probably damaging Het
D130040H23Rik A T 8: 69,753,422 (GRCm39) K16I possibly damaging Het
D630003M21Rik T C 2: 158,055,332 (GRCm39) T602A possibly damaging Het
Fam161b C T 12: 84,404,459 (GRCm39) V74I probably benign Het
Grk1 A G 8: 13,466,068 (GRCm39) E504G probably benign Het
Hnrnpm C A 17: 33,868,876 (GRCm39) R517L probably damaging Het
L3mbtl3 C T 10: 26,189,744 (GRCm39) probably null Het
Map1s A G 8: 71,358,673 (GRCm39) probably benign Het
Mprip T C 11: 59,662,994 (GRCm39) V982A possibly damaging Het
Or5aq1b A G 2: 86,901,563 (GRCm39) I305T probably benign Het
Or8g19 T G 9: 39,056,326 (GRCm39) F310C probably damaging Het
Phf1 A T 17: 27,155,568 (GRCm39) R378W possibly damaging Het
Ptpn3 A T 4: 57,270,050 (GRCm39) D37E possibly damaging Het
Rcbtb1 A G 14: 59,465,754 (GRCm39) S366G probably benign Het
Scn5a C A 9: 119,365,567 (GRCm39) W360L probably damaging Het
Scrib A G 15: 75,936,839 (GRCm39) F398S probably damaging Het
Slc25a47 C A 12: 108,821,314 (GRCm39) T141K probably benign Het
Slc9a1 T A 4: 133,097,859 (GRCm39) M2K probably benign Het
Tango6 G T 8: 107,469,104 (GRCm39) probably null Het
Tmem231 A T 8: 112,645,072 (GRCm39) probably benign Het
Tnr G A 1: 159,679,752 (GRCm39) R242Q probably benign Het
Usp5 G A 6: 124,792,576 (GRCm39) P821S probably damaging Het
Utp11 G T 4: 124,577,586 (GRCm39) P63Q probably damaging Het
Vmn1r6 T A 6: 56,979,789 (GRCm39) N128K probably damaging Het
Other mutations in Pramel25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01621:Pramel25 APN 4 143,520,502 (GRCm39) missense probably benign
IGL01777:Pramel25 APN 4 143,521,688 (GRCm39) missense possibly damaging 0.87
IGL02075:Pramel25 APN 4 143,521,602 (GRCm39) missense probably benign 0.05
IGL02098:Pramel25 APN 4 143,520,248 (GRCm39) critical splice donor site probably null
IGL02148:Pramel25 APN 4 143,519,304 (GRCm39) missense probably benign 0.25
IGL02355:Pramel25 APN 4 143,519,580 (GRCm39) missense probably damaging 1.00
IGL02362:Pramel25 APN 4 143,519,580 (GRCm39) missense probably damaging 1.00
IGL02828:Pramel25 APN 4 143,521,695 (GRCm39) missense possibly damaging 0.95
IGL03102:Pramel25 APN 4 143,520,116 (GRCm39) missense possibly damaging 0.84
IGL03234:Pramel25 APN 4 143,521,506 (GRCm39) missense probably benign 0.33
BB004:Pramel25 UTSW 4 143,519,536 (GRCm39) missense probably benign 0.29
BB014:Pramel25 UTSW 4 143,519,536 (GRCm39) missense probably benign 0.29
K3955:Pramel25 UTSW 4 143,521,710 (GRCm39) missense possibly damaging 0.79
R0054:Pramel25 UTSW 4 143,521,572 (GRCm39) missense probably damaging 1.00
R0637:Pramel25 UTSW 4 143,520,479 (GRCm39) missense probably benign 0.35
R1227:Pramel25 UTSW 4 143,520,134 (GRCm39) missense probably benign 0.00
R1370:Pramel25 UTSW 4 143,521,874 (GRCm39) missense possibly damaging 0.94
R1709:Pramel25 UTSW 4 143,520,116 (GRCm39) missense possibly damaging 0.84
R1982:Pramel25 UTSW 4 143,521,720 (GRCm39) missense probably benign 0.02
R2292:Pramel25 UTSW 4 143,520,446 (GRCm39) missense probably benign 0.08
R3087:Pramel25 UTSW 4 143,520,416 (GRCm39) missense probably benign 0.25
R4235:Pramel25 UTSW 4 143,521,344 (GRCm39) missense probably damaging 0.97
R4454:Pramel25 UTSW 4 143,519,394 (GRCm39) missense probably benign 0.00
R4504:Pramel25 UTSW 4 143,520,553 (GRCm39) missense probably benign 0.08
R4937:Pramel25 UTSW 4 143,520,407 (GRCm39) missense possibly damaging 0.46
R5041:Pramel25 UTSW 4 143,520,260 (GRCm39) missense probably benign 0.01
R5379:Pramel25 UTSW 4 143,521,493 (GRCm39) missense probably benign 0.00
R5399:Pramel25 UTSW 4 143,521,602 (GRCm39) missense probably benign 0.00
R5445:Pramel25 UTSW 4 143,521,707 (GRCm39) missense possibly damaging 0.50
R6059:Pramel25 UTSW 4 143,520,550 (GRCm39) missense possibly damaging 0.80
R6885:Pramel25 UTSW 4 143,520,103 (GRCm39) missense probably damaging 1.00
R7846:Pramel25 UTSW 4 143,520,563 (GRCm39) missense probably benign 0.02
R7927:Pramel25 UTSW 4 143,519,536 (GRCm39) missense probably benign 0.29
R8285:Pramel25 UTSW 4 143,520,636 (GRCm39) missense probably benign 0.02
R8840:Pramel25 UTSW 4 143,521,638 (GRCm39) missense probably damaging 1.00
R8849:Pramel25 UTSW 4 143,521,596 (GRCm39) missense probably damaging 0.99
R8921:Pramel25 UTSW 4 143,519,322 (GRCm39) nonsense probably null
R9128:Pramel25 UTSW 4 143,520,178 (GRCm39) missense probably benign 0.00
R9232:Pramel25 UTSW 4 143,520,263 (GRCm39) missense probably benign 0.01
R9643:Pramel25 UTSW 4 143,521,855 (GRCm39) nonsense probably null
R9674:Pramel25 UTSW 4 143,520,162 (GRCm39) missense probably benign 0.02
Z1177:Pramel25 UTSW 4 143,521,551 (GRCm39) missense probably damaging 1.00
Posted On 2013-04-17