Incidental Mutation 'R3783:Thoc5'
ID 272126
Institutional Source Beutler Lab
Gene Symbol Thoc5
Ensembl Gene ENSMUSG00000034274
Gene Name THO complex 5
Synonyms Fmip, PK1.3, 1700060C24Rik, A430085L24Rik
MMRRC Submission 040875-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R3783 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 4845339-4878867 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to G at 4870372 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000118940 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038237] [ENSMUST00000101615] [ENSMUST00000142543]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000038237
SMART Domains Protein: ENSMUSP00000045580
Gene: ENSMUSG00000034274

DomainStartEndE-ValueType
Pfam:FimP 97 452 1.1e-133 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000101615
SMART Domains Protein: ENSMUSP00000099137
Gene: ENSMUSG00000034274

DomainStartEndE-ValueType
low complexity region 34 41 N/A INTRINSIC
Pfam:FimP 48 405 7.5e-142 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000121125
Predicted Effect probably benign
Transcript: ENSMUST00000142543
SMART Domains Protein: ENSMUSP00000118940
Gene: ENSMUSG00000034274

DomainStartEndE-ValueType
Pfam:FimP 1 301 1.3e-97 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155872
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency 98% (45/46)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality prior to E5.5. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700012B07Rik G T 11: 109,684,980 (GRCm39) C172* probably null Het
Akap6 A G 12: 52,927,552 (GRCm39) H154R probably damaging Het
Aoc1 T C 6: 48,882,589 (GRCm39) L177P probably damaging Het
Ascc3 A G 10: 50,604,350 (GRCm39) T1357A probably damaging Het
Atp13a3 A T 16: 30,173,067 (GRCm39) V270D probably damaging Het
Carmil3 T C 14: 55,734,433 (GRCm39) F418S probably damaging Het
Ccdc93 A G 1: 121,365,598 (GRCm39) N77S probably damaging Het
Cpt1b T C 15: 89,309,392 (GRCm39) K47R probably damaging Het
Cyp4f14 A G 17: 33,135,736 (GRCm39) Y42H probably benign Het
Dmxl1 G A 18: 49,998,189 (GRCm39) S763N probably damaging Het
Fancd2 T G 6: 113,542,165 (GRCm39) S770A probably damaging Het
Firrm A T 1: 163,815,252 (GRCm39) C90S probably benign Het
Flnb T G 14: 7,889,236 (GRCm38) W529G probably benign Het
Fryl T C 5: 73,258,819 (GRCm39) Y655C probably benign Het
Gml C T 15: 74,685,521 (GRCm39) V155M probably damaging Het
Gpr174 A G X: 106,336,670 (GRCm39) T161A probably benign Het
Heatr1 G T 13: 12,449,341 (GRCm39) L1946F probably damaging Het
Inpp5k T C 11: 75,538,512 (GRCm39) L461P probably damaging Het
Isy1 T C 6: 87,798,527 (GRCm39) E209G possibly damaging Het
Kdm5b A G 1: 134,558,280 (GRCm39) H1429R probably benign Het
Magi2 C T 5: 20,670,907 (GRCm39) T580M probably damaging Het
Map3k1 C T 13: 111,892,754 (GRCm39) V834I probably benign Het
Mdn1 A T 4: 32,720,818 (GRCm39) E2310D probably benign Het
Myo15a A T 11: 60,368,398 (GRCm39) Y386F probably damaging Het
Neurod1 T A 2: 79,284,939 (GRCm39) N148I probably damaging Het
Niban1 C T 1: 151,565,399 (GRCm39) S243L possibly damaging Het
Nsa2 G T 13: 97,272,042 (GRCm39) Q60K possibly damaging Het
Pcdha1 T A 18: 37,063,855 (GRCm39) L173Q probably damaging Het
Pdpk1 T C 17: 24,329,824 (GRCm39) T71A possibly damaging Het
Plxna2 T A 1: 194,489,829 (GRCm39) V1692E probably damaging Het
Pmepa1 G A 2: 173,069,926 (GRCm39) R210W probably damaging Het
Psg27 T A 7: 18,294,279 (GRCm39) Q376L probably damaging Het
Psmd4 T C 3: 94,942,562 (GRCm39) D6G possibly damaging Het
Ptch1 T G 13: 63,672,773 (GRCm39) E944A probably benign Het
Rala T A 13: 18,057,031 (GRCm39) E185V probably benign Het
Sall4 A G 2: 168,598,043 (GRCm39) S266P probably damaging Het
Scn10a T C 9: 119,520,628 (GRCm39) T91A probably damaging Het
Synrg T C 11: 83,892,746 (GRCm39) F613S probably damaging Het
Tekt1 A G 11: 72,235,720 (GRCm39) I376T probably damaging Het
Tet2 T C 3: 133,185,124 (GRCm39) K1182R possibly damaging Het
Thbs4 T C 13: 92,909,672 (GRCm39) N375S probably benign Het
Tmprss9 G T 10: 80,723,301 (GRCm39) V254F probably damaging Het
Tro G A X: 149,438,048 (GRCm39) T203I possibly damaging Het
Ttbk2 A T 2: 120,604,296 (GRCm39) probably benign Het
Usf2 A G 7: 30,655,256 (GRCm39) V133A probably benign Het
Wap G A 11: 6,588,550 (GRCm39) Q25* probably null Het
Xdh C T 17: 74,200,590 (GRCm39) probably benign Het
Xrn1 G T 9: 95,851,338 (GRCm39) M153I probably benign Het
Other mutations in Thoc5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00790:Thoc5 APN 11 4,868,147 (GRCm39) missense probably damaging 0.96
IGL02039:Thoc5 APN 11 4,872,027 (GRCm39) critical splice donor site probably null
IGL02227:Thoc5 APN 11 4,876,217 (GRCm39) missense probably benign 0.02
IGL02970:Thoc5 APN 11 4,854,201 (GRCm39) missense probably damaging 0.99
R0398:Thoc5 UTSW 11 4,871,978 (GRCm39) missense possibly damaging 0.84
R0401:Thoc5 UTSW 11 4,852,213 (GRCm39) utr 5 prime probably benign
R0453:Thoc5 UTSW 11 4,868,217 (GRCm39) missense possibly damaging 0.60
R1223:Thoc5 UTSW 11 4,871,922 (GRCm39) missense probably benign 0.40
R1438:Thoc5 UTSW 11 4,861,427 (GRCm39) splice site probably benign
R1661:Thoc5 UTSW 11 4,869,792 (GRCm39) missense probably benign 0.04
R1665:Thoc5 UTSW 11 4,869,792 (GRCm39) missense probably benign 0.04
R1776:Thoc5 UTSW 11 4,864,517 (GRCm39) splice site probably benign
R1830:Thoc5 UTSW 11 4,864,608 (GRCm39) missense probably benign 0.02
R1912:Thoc5 UTSW 11 4,865,561 (GRCm39) missense probably benign 0.15
R3001:Thoc5 UTSW 11 4,878,688 (GRCm39) missense probably benign
R3002:Thoc5 UTSW 11 4,878,688 (GRCm39) missense probably benign
R4534:Thoc5 UTSW 11 4,874,807 (GRCm39) nonsense probably null
R4619:Thoc5 UTSW 11 4,876,218 (GRCm39) missense probably damaging 0.96
R4747:Thoc5 UTSW 11 4,854,187 (GRCm39) missense probably damaging 0.99
R5106:Thoc5 UTSW 11 4,860,630 (GRCm39) missense probably damaging 1.00
R5310:Thoc5 UTSW 11 4,860,648 (GRCm39) missense probably damaging 1.00
R5914:Thoc5 UTSW 11 4,870,416 (GRCm39) missense possibly damaging 0.58
R5936:Thoc5 UTSW 11 4,854,133 (GRCm39) missense probably damaging 1.00
R6167:Thoc5 UTSW 11 4,865,497 (GRCm39) missense probably benign 0.12
R6209:Thoc5 UTSW 11 4,855,697 (GRCm39) missense probably damaging 1.00
R6243:Thoc5 UTSW 11 4,869,753 (GRCm39) missense possibly damaging 0.59
R6504:Thoc5 UTSW 11 4,874,815 (GRCm39) nonsense probably null
R6833:Thoc5 UTSW 11 4,869,804 (GRCm39) missense probably damaging 1.00
R6874:Thoc5 UTSW 11 4,851,261 (GRCm39) missense probably damaging 1.00
R7048:Thoc5 UTSW 11 4,876,237 (GRCm39) critical splice donor site probably null
R7197:Thoc5 UTSW 11 4,865,563 (GRCm39) missense probably benign 0.01
R7753:Thoc5 UTSW 11 4,852,156 (GRCm39) missense probably damaging 0.99
R7828:Thoc5 UTSW 11 4,852,306 (GRCm39) start gained probably benign
R8416:Thoc5 UTSW 11 4,876,068 (GRCm39) missense probably benign 0.41
R8428:Thoc5 UTSW 11 4,876,115 (GRCm39) missense probably damaging 0.99
R8673:Thoc5 UTSW 11 4,876,061 (GRCm39) missense possibly damaging 0.52
R8964:Thoc5 UTSW 11 4,860,647 (GRCm39) missense possibly damaging 0.80
R9214:Thoc5 UTSW 11 4,864,303 (GRCm39) missense probably benign 0.13
R9651:Thoc5 UTSW 11 4,849,883 (GRCm39) missense possibly damaging 0.52
Predicted Primers PCR Primer
(F):5'- GCCTTTTCTTAGAAGCTGGCC -3'
(R):5'- ACAAGTTCTGAGGAAAAGGTTTCTG -3'

Sequencing Primer
(F):5'- TGGCCACAGATTCATGGGAAC -3'
(R):5'- CTGAGGAAAAGGTTTCTGTTTGTATG -3'
Posted On 2015-03-25