Incidental Mutation 'R3783:Gpr174'
ID 272150
Institutional Source Beutler Lab
Gene Symbol Gpr174
Ensembl Gene ENSMUSG00000073008
Gene Name G protein-coupled receptor 174
Synonyms LOC213439
MMRRC Submission 040875-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.015) question?
Stock # R3783 (G1)
Quality Score 222
Status Validated
Chromosome X
Chromosomal Location 106299484-106340375 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 106336670 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 161 (T161A)
Ref Sequence ENSEMBL: ENSMUSP00000137372 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000101294] [ENSMUST00000117310] [ENSMUST00000118820] [ENSMUST00000120971] [ENSMUST00000178838]
AlphaFold Q3U507
Predicted Effect probably benign
Transcript: ENSMUST00000101294
AA Change: T161A

PolyPhen 2 Score 0.076 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000098852
Gene: ENSMUSG00000073008
AA Change: T161A

DomainStartEndE-ValueType
Pfam:7tm_1 36 292 2.5e-45 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000117310
AA Change: T161A

PolyPhen 2 Score 0.076 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000112808
Gene: ENSMUSG00000073008
AA Change: T161A

DomainStartEndE-ValueType
Pfam:7tm_1 36 292 2.5e-45 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000118820
AA Change: T161A

PolyPhen 2 Score 0.076 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000113032
Gene: ENSMUSG00000073008
AA Change: T161A

DomainStartEndE-ValueType
Pfam:7tm_1 36 292 2.6e-40 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000120971
AA Change: T161A

PolyPhen 2 Score 0.076 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000112974
Gene: ENSMUSG00000073008
AA Change: T161A

DomainStartEndE-ValueType
Pfam:7tm_1 36 292 2.5e-45 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138031
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156709
Predicted Effect probably benign
Transcript: ENSMUST00000178838
AA Change: T161A

PolyPhen 2 Score 0.076 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000137372
Gene: ENSMUSG00000073008
AA Change: T161A

DomainStartEndE-ValueType
Pfam:7tm_1 36 292 2.5e-45 PFAM
Meta Mutation Damage Score 0.0702 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency 98% (45/46)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein belonging to the G protein-coupled receptor superfamily. These proteins are characterized by the presence of seven alpha-helical transmembrane domains, and they activate or interact with various endogenous or exogenous ligands, including neurotransmitters, hormones, and odorant and taste substances. This family member is classified as an orphan receptor because the cognate ligand has not been identified. [provided by RefSeq, Sep 2011]
PHENOTYPE: Male mice hemizygous for a knock-out allele exhibit abnormal T cell proliferation, abnormal regulatory T cell physiology and decreased susceptibility to EAE. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700012B07Rik G T 11: 109,684,980 (GRCm39) C172* probably null Het
Akap6 A G 12: 52,927,552 (GRCm39) H154R probably damaging Het
Aoc1 T C 6: 48,882,589 (GRCm39) L177P probably damaging Het
Ascc3 A G 10: 50,604,350 (GRCm39) T1357A probably damaging Het
Atp13a3 A T 16: 30,173,067 (GRCm39) V270D probably damaging Het
Carmil3 T C 14: 55,734,433 (GRCm39) F418S probably damaging Het
Ccdc93 A G 1: 121,365,598 (GRCm39) N77S probably damaging Het
Cpt1b T C 15: 89,309,392 (GRCm39) K47R probably damaging Het
Cyp4f14 A G 17: 33,135,736 (GRCm39) Y42H probably benign Het
Dmxl1 G A 18: 49,998,189 (GRCm39) S763N probably damaging Het
Fancd2 T G 6: 113,542,165 (GRCm39) S770A probably damaging Het
Firrm A T 1: 163,815,252 (GRCm39) C90S probably benign Het
Flnb T G 14: 7,889,236 (GRCm38) W529G probably benign Het
Fryl T C 5: 73,258,819 (GRCm39) Y655C probably benign Het
Gml C T 15: 74,685,521 (GRCm39) V155M probably damaging Het
Heatr1 G T 13: 12,449,341 (GRCm39) L1946F probably damaging Het
Inpp5k T C 11: 75,538,512 (GRCm39) L461P probably damaging Het
Isy1 T C 6: 87,798,527 (GRCm39) E209G possibly damaging Het
Kdm5b A G 1: 134,558,280 (GRCm39) H1429R probably benign Het
Magi2 C T 5: 20,670,907 (GRCm39) T580M probably damaging Het
Map3k1 C T 13: 111,892,754 (GRCm39) V834I probably benign Het
Mdn1 A T 4: 32,720,818 (GRCm39) E2310D probably benign Het
Myo15a A T 11: 60,368,398 (GRCm39) Y386F probably damaging Het
Neurod1 T A 2: 79,284,939 (GRCm39) N148I probably damaging Het
Niban1 C T 1: 151,565,399 (GRCm39) S243L possibly damaging Het
Nsa2 G T 13: 97,272,042 (GRCm39) Q60K possibly damaging Het
Pcdha1 T A 18: 37,063,855 (GRCm39) L173Q probably damaging Het
Pdpk1 T C 17: 24,329,824 (GRCm39) T71A possibly damaging Het
Plxna2 T A 1: 194,489,829 (GRCm39) V1692E probably damaging Het
Pmepa1 G A 2: 173,069,926 (GRCm39) R210W probably damaging Het
Psg27 T A 7: 18,294,279 (GRCm39) Q376L probably damaging Het
Psmd4 T C 3: 94,942,562 (GRCm39) D6G possibly damaging Het
Ptch1 T G 13: 63,672,773 (GRCm39) E944A probably benign Het
Rala T A 13: 18,057,031 (GRCm39) E185V probably benign Het
Sall4 A G 2: 168,598,043 (GRCm39) S266P probably damaging Het
Scn10a T C 9: 119,520,628 (GRCm39) T91A probably damaging Het
Synrg T C 11: 83,892,746 (GRCm39) F613S probably damaging Het
Tekt1 A G 11: 72,235,720 (GRCm39) I376T probably damaging Het
Tet2 T C 3: 133,185,124 (GRCm39) K1182R possibly damaging Het
Thbs4 T C 13: 92,909,672 (GRCm39) N375S probably benign Het
Thoc5 A G 11: 4,870,372 (GRCm39) probably benign Het
Tmprss9 G T 10: 80,723,301 (GRCm39) V254F probably damaging Het
Tro G A X: 149,438,048 (GRCm39) T203I possibly damaging Het
Ttbk2 A T 2: 120,604,296 (GRCm39) probably benign Het
Usf2 A G 7: 30,655,256 (GRCm39) V133A probably benign Het
Wap G A 11: 6,588,550 (GRCm39) Q25* probably null Het
Xdh C T 17: 74,200,590 (GRCm39) probably benign Het
Xrn1 G T 9: 95,851,338 (GRCm39) M153I probably benign Het
Other mutations in Gpr174
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02379:Gpr174 APN X 106,337,084 (GRCm39) missense probably damaging 1.00
IGL02512:Gpr174 APN X 106,336,577 (GRCm39) nonsense probably null
IGL02563:Gpr174 APN X 106,336,854 (GRCm39) missense probably benign 0.25
Z1177:Gpr174 UTSW X 106,336,799 (GRCm39) missense possibly damaging 0.88
Predicted Primers PCR Primer
(F):5'- TGTATGCCAGCATCTACTTCTTGG -3'
(R):5'- ACAGGTCAGAATCATCTTCAGGG -3'

Sequencing Primer
(F):5'- GTCTGCATCAGTGTGCGAAG -3'
(R):5'- TCTCTCCAAGATGTTGAGAAATGGG -3'
Posted On 2015-03-25