Incidental Mutation 'R3784:Vmn1r200'
ID |
272189 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn1r200
|
Ensembl Gene |
ENSMUSG00000101073 |
Gene Name |
vomeronasal 1 receptor 200 |
Synonyms |
V1rh3 |
MMRRC Submission |
040876-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.144)
|
Stock # |
R3784 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
13 |
Chromosomal Location |
22579199-22580137 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 22580025 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Tyrosine to Phenylalanine
at position 276
(Y276F)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000154179
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000074324]
[ENSMUST00000226157]
[ENSMUST00000227326]
[ENSMUST00000228726]
|
AlphaFold |
Q8R281 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000074324
AA Change: Y276F
PolyPhen 2
Score 0.820 (Sensitivity: 0.84; Specificity: 0.93)
|
SMART Domains |
Protein: ENSMUSP00000073934 Gene: ENSMUSG00000101073 AA Change: Y276F
Domain | Start | End | E-Value | Type |
Pfam:V1R
|
24 |
307 |
5.5e-36 |
PFAM |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000091731
AA Change: Y276F
PolyPhen 2
Score 0.820 (Sensitivity: 0.84; Specificity: 0.93)
|
SMART Domains |
Protein: ENSMUSP00000089325 Gene: ENSMUSG00000069291 AA Change: Y276F
Domain | Start | End | E-Value | Type |
Pfam:TAS2R
|
2 |
291 |
1.3e-8 |
PFAM |
Pfam:V1R
|
34 |
297 |
3.8e-37 |
PFAM |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000226157
AA Change: Y276F
PolyPhen 2
Score 0.820 (Sensitivity: 0.84; Specificity: 0.93)
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226901
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000227326
AA Change: Y267F
PolyPhen 2
Score 0.646 (Sensitivity: 0.87; Specificity: 0.91)
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000228726
AA Change: Y276F
PolyPhen 2
Score 0.820 (Sensitivity: 0.84; Specificity: 0.93)
|
Meta Mutation Damage Score |
0.1795 |
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 97.1%
- 20x: 94.6%
|
Validation Efficiency |
100% (44/44) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 41 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1700012B07Rik |
G |
T |
11: 109,684,980 (GRCm39) |
C172* |
probably null |
Het |
3110082I17Rik |
G |
T |
5: 139,441,197 (GRCm39) |
P35Q |
probably damaging |
Het |
Adam11 |
T |
C |
11: 102,665,193 (GRCm39) |
|
probably null |
Het |
Ank2 |
A |
G |
3: 126,746,842 (GRCm39) |
L581P |
probably damaging |
Het |
Armc2 |
T |
C |
10: 41,798,190 (GRCm39) |
I779V |
probably benign |
Het |
Atp8a2 |
A |
T |
14: 60,011,415 (GRCm39) |
Y965N |
probably damaging |
Het |
C3 |
A |
G |
17: 57,533,067 (GRCm39) |
V146A |
probably damaging |
Het |
Cfap206 |
A |
T |
4: 34,716,445 (GRCm39) |
I340N |
probably damaging |
Het |
Col3a1 |
A |
G |
1: 45,386,295 (GRCm39) |
D145G |
probably damaging |
Het |
Drosha |
A |
G |
15: 12,890,615 (GRCm39) |
D954G |
possibly damaging |
Het |
Fam161b |
A |
T |
12: 84,408,464 (GRCm39) |
|
probably null |
Het |
Fat2 |
C |
T |
11: 55,147,012 (GRCm39) |
A3995T |
probably benign |
Het |
Foxg1 |
A |
G |
12: 49,432,382 (GRCm39) |
T372A |
probably benign |
Het |
Heatr1 |
G |
T |
13: 12,449,341 (GRCm39) |
L1946F |
probably damaging |
Het |
Hook1 |
T |
C |
4: 95,877,888 (GRCm39) |
F55L |
probably damaging |
Het |
Iars2 |
T |
C |
1: 185,019,328 (GRCm39) |
K986R |
probably benign |
Het |
Inpp5k |
T |
C |
11: 75,538,512 (GRCm39) |
L461P |
probably damaging |
Het |
Klra8 |
T |
A |
6: 130,102,018 (GRCm39) |
D139V |
probably benign |
Het |
Mical3 |
T |
C |
6: 120,998,298 (GRCm39) |
Y20C |
probably benign |
Het |
Myo15a |
A |
T |
11: 60,368,398 (GRCm39) |
Y386F |
probably damaging |
Het |
Ncoa6 |
G |
A |
2: 155,249,677 (GRCm39) |
T1209I |
probably damaging |
Het |
Nsa2 |
G |
T |
13: 97,272,042 (GRCm39) |
Q60K |
possibly damaging |
Het |
Olfml2b |
A |
G |
1: 170,509,551 (GRCm39) |
D633G |
probably damaging |
Het |
Plekhg3 |
T |
C |
12: 76,607,294 (GRCm39) |
|
probably null |
Het |
Plxna2 |
T |
A |
1: 194,326,925 (GRCm39) |
D286E |
probably benign |
Het |
Pmepa1 |
G |
A |
2: 173,069,926 (GRCm39) |
R210W |
probably damaging |
Het |
Prmt7 |
C |
A |
8: 106,968,768 (GRCm39) |
Q361K |
probably benign |
Het |
Prrc2c |
T |
C |
1: 162,537,238 (GRCm39) |
|
probably benign |
Het |
Psg27 |
T |
A |
7: 18,294,279 (GRCm39) |
Q376L |
probably damaging |
Het |
Ptch1 |
T |
G |
13: 63,672,773 (GRCm39) |
E944A |
probably benign |
Het |
Rad51b |
C |
T |
12: 79,347,419 (GRCm39) |
Q28* |
probably null |
Het |
Rala |
T |
A |
13: 18,057,031 (GRCm39) |
E185V |
probably benign |
Het |
Sall4 |
A |
G |
2: 168,598,043 (GRCm39) |
S266P |
probably damaging |
Het |
Senp6 |
T |
G |
9: 79,999,568 (GRCm39) |
I74S |
probably benign |
Het |
Spats2l |
A |
G |
1: 57,924,938 (GRCm39) |
E112G |
probably damaging |
Het |
Synrg |
T |
C |
11: 83,892,746 (GRCm39) |
F613S |
probably damaging |
Het |
Taf15 |
G |
A |
11: 83,397,248 (GRCm39) |
D313N |
unknown |
Het |
Tekt1 |
A |
G |
11: 72,235,720 (GRCm39) |
I376T |
probably damaging |
Het |
Thbs4 |
T |
C |
13: 92,909,672 (GRCm39) |
N375S |
probably benign |
Het |
Tubb6 |
A |
G |
18: 67,526,063 (GRCm39) |
T72A |
possibly damaging |
Het |
Txndc16 |
A |
T |
14: 45,403,343 (GRCm39) |
V32E |
probably damaging |
Het |
|
Other mutations in Vmn1r200 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00970:Vmn1r200
|
APN |
13 |
22,579,893 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01123:Vmn1r200
|
APN |
13 |
22,579,571 (GRCm39) |
missense |
probably benign |
0.01 |
IGL01943:Vmn1r200
|
APN |
13 |
22,580,097 (GRCm39) |
missense |
possibly damaging |
0.77 |
IGL02691:Vmn1r200
|
APN |
13 |
22,579,428 (GRCm39) |
missense |
probably damaging |
1.00 |
R0491:Vmn1r200
|
UTSW |
13 |
22,579,361 (GRCm39) |
missense |
probably benign |
0.00 |
R0507:Vmn1r200
|
UTSW |
13 |
22,579,718 (GRCm39) |
missense |
probably benign |
0.00 |
R0530:Vmn1r200
|
UTSW |
13 |
22,579,667 (GRCm39) |
missense |
probably damaging |
1.00 |
R1033:Vmn1r200
|
UTSW |
13 |
22,580,060 (GRCm39) |
missense |
probably damaging |
1.00 |
R1054:Vmn1r200
|
UTSW |
13 |
22,579,624 (GRCm39) |
missense |
probably damaging |
1.00 |
R1714:Vmn1r200
|
UTSW |
13 |
22,579,640 (GRCm39) |
missense |
possibly damaging |
0.96 |
R1920:Vmn1r200
|
UTSW |
13 |
22,579,663 (GRCm39) |
missense |
probably damaging |
1.00 |
R2118:Vmn1r200
|
UTSW |
13 |
22,579,353 (GRCm39) |
missense |
probably damaging |
1.00 |
R4827:Vmn1r200
|
UTSW |
13 |
22,579,265 (GRCm39) |
missense |
probably benign |
0.00 |
R5285:Vmn1r200
|
UTSW |
13 |
22,579,457 (GRCm39) |
missense |
possibly damaging |
0.51 |
R5299:Vmn1r200
|
UTSW |
13 |
22,579,945 (GRCm39) |
nonsense |
probably null |
|
R6127:Vmn1r200
|
UTSW |
13 |
22,579,373 (GRCm39) |
missense |
probably benign |
0.07 |
R7167:Vmn1r200
|
UTSW |
13 |
22,579,487 (GRCm39) |
missense |
possibly damaging |
0.91 |
R7854:Vmn1r200
|
UTSW |
13 |
22,580,009 (GRCm39) |
missense |
probably benign |
0.08 |
R7977:Vmn1r200
|
UTSW |
13 |
22,580,025 (GRCm39) |
missense |
possibly damaging |
0.82 |
R7987:Vmn1r200
|
UTSW |
13 |
22,580,025 (GRCm39) |
missense |
possibly damaging |
0.82 |
R8061:Vmn1r200
|
UTSW |
13 |
22,579,453 (GRCm39) |
nonsense |
probably null |
|
R8208:Vmn1r200
|
UTSW |
13 |
22,579,470 (GRCm39) |
missense |
probably damaging |
0.99 |
R9481:Vmn1r200
|
UTSW |
13 |
22,579,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TCCAAGCTTCTCTACAGAACTC -3'
(R):5'- AGCTCAAGACTGTGAATAACCAAG -3'
Sequencing Primer
(F):5'- AGAACTCCCCCTGAGCTGAGAG -3'
(R):5'- CACATGCTTAAAGTACATTGTGGAAC -3'
|
Posted On |
2015-03-25 |