Incidental Mutation 'IGL00911:Tas1r2'
ID 27222
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas1r2
Ensembl Gene ENSMUSG00000028738
Gene Name taste receptor, type 1, member 2
Synonyms TR2, Gpr71, T1r2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # IGL00911
Quality Score
Status
Chromosome 4
Chromosomal Location 139380849-139397591 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 139387602 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Threonine at position 354 (P354T)
Ref Sequence ENSEMBL: ENSMUSP00000030510 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030510] [ENSMUST00000166773] [ENSMUST00000178644]
AlphaFold Q925I4
Predicted Effect probably benign
Transcript: ENSMUST00000030510
AA Change: P354T

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000030510
Gene: ENSMUSG00000028738
AA Change: P354T

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 73 459 2e-90 PFAM
Pfam:NCD3G 495 548 2.4e-17 PFAM
Pfam:7tm_3 581 818 2.8e-33 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000166773
AA Change: P325T

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000127737
Gene: ENSMUSG00000028738
AA Change: P325T

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 73 213 5.3e-38 PFAM
Pfam:ANF_receptor 217 429 8.4e-31 PFAM
Pfam:NCD3G 466 519 7.4e-19 PFAM
Pfam:7tm_3 550 790 3e-47 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000178644
SMART Domains Protein: ENSMUSP00000136776
Gene: ENSMUSG00000094439

DomainStartEndE-ValueType
SCOP:d1lbva_ 1 60 5e-3 SMART
Pfam:Filament 165 253 7.3e-13 PFAM
low complexity region 255 268 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous mutant mice show diminished behavioral and nervous responses to sweet tastants. Response to umami tastants is unimpaired. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afm T C 5: 90,673,450 (GRCm39) V234A probably benign Het
Alas1 T A 9: 106,113,671 (GRCm39) I525F probably benign Het
Ambra1 T A 2: 91,598,027 (GRCm39) probably benign Het
Apbb2 G A 5: 66,608,855 (GRCm39) T264M probably damaging Het
Arb2a T A 13: 78,100,094 (GRCm39) probably benign Het
Arhgap40 A G 2: 158,376,636 (GRCm39) probably benign Het
Chd9 C T 8: 91,778,320 (GRCm39) P2793L probably damaging Het
Clstn1 T G 4: 149,727,648 (GRCm39) probably benign Het
Cyp2f2 T C 7: 26,821,354 (GRCm39) V13A probably damaging Het
Dnah1 C T 14: 31,026,391 (GRCm39) probably null Het
Eogt A T 6: 97,096,961 (GRCm39) V349E probably damaging Het
Epb41 T C 4: 131,717,095 (GRCm39) D353G possibly damaging Het
Fbxo38 T A 18: 62,663,871 (GRCm39) I207F possibly damaging Het
Frem2 T C 3: 53,479,883 (GRCm39) S1937G probably damaging Het
Hnrnpm C A 17: 33,868,876 (GRCm39) R517L probably damaging Het
Kcnh3 G T 15: 99,130,882 (GRCm39) G500* probably null Het
Khdc1b A T 1: 21,454,578 (GRCm39) K94* probably null Het
Lpcat2 T C 8: 93,617,338 (GRCm39) Y367H probably damaging Het
Lrrd1 A C 5: 3,915,689 (GRCm39) N762T probably benign Het
Mbl2 T A 19: 30,215,794 (GRCm39) D100E possibly damaging Het
Mthfr T G 4: 148,125,759 (GRCm39) S31A probably benign Het
Nrp1 T A 8: 129,202,688 (GRCm39) S558T probably benign Het
Nrxn3 T C 12: 90,171,366 (GRCm39) L1254P probably damaging Het
Or2ag12 A T 7: 106,277,040 (GRCm39) Y218N probably damaging Het
Pabpc1l C A 2: 163,884,343 (GRCm39) T360K probably damaging Het
Pcgf1 G A 6: 83,057,606 (GRCm39) G92S probably damaging Het
Penk T C 4: 4,134,347 (GRCm39) Y100C probably damaging Het
Pik3r1 T C 13: 101,894,169 (GRCm39) probably benign Het
Pkhd1 T A 1: 20,187,971 (GRCm39) T3446S probably benign Het
Plcg2 G A 8: 118,313,254 (GRCm39) D473N probably benign Het
Poll G T 19: 45,542,040 (GRCm39) T422K probably damaging Het
Skint3 T A 4: 112,113,106 (GRCm39) probably benign Het
Stab2 C A 10: 86,805,617 (GRCm39) C243F probably damaging Het
Supt6 T C 11: 78,122,007 (GRCm39) E215G possibly damaging Het
Tenm2 G A 11: 35,899,560 (GRCm39) Q2533* probably null Het
Tmem121 C T 12: 113,151,851 (GRCm39) A23V probably damaging Het
Other mutations in Tas1r2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00952:Tas1r2 APN 4 139,382,563 (GRCm39) missense probably benign 0.00
IGL00972:Tas1r2 APN 4 139,387,347 (GRCm39) missense probably damaging 0.99
IGL01939:Tas1r2 APN 4 139,396,488 (GRCm39) missense probably damaging 1.00
IGL02247:Tas1r2 APN 4 139,396,827 (GRCm39) missense probably damaging 1.00
IGL02663:Tas1r2 APN 4 139,387,593 (GRCm39) missense probably benign
IGL03155:Tas1r2 APN 4 139,396,467 (GRCm39) missense possibly damaging 0.95
R0395:Tas1r2 UTSW 4 139,382,665 (GRCm39) missense possibly damaging 0.86
R0798:Tas1r2 UTSW 4 139,397,024 (GRCm39) missense probably damaging 1.00
R1221:Tas1r2 UTSW 4 139,396,436 (GRCm39) missense probably benign 0.00
R1223:Tas1r2 UTSW 4 139,387,515 (GRCm39) missense probably damaging 1.00
R1261:Tas1r2 UTSW 4 139,382,599 (GRCm39) missense probably damaging 0.99
R1262:Tas1r2 UTSW 4 139,382,599 (GRCm39) missense probably damaging 0.99
R1330:Tas1r2 UTSW 4 139,396,640 (GRCm39) missense probably benign 0.05
R1466:Tas1r2 UTSW 4 139,396,722 (GRCm39) missense probably damaging 1.00
R1466:Tas1r2 UTSW 4 139,396,722 (GRCm39) missense probably damaging 1.00
R1879:Tas1r2 UTSW 4 139,397,006 (GRCm39) missense probably damaging 1.00
R2112:Tas1r2 UTSW 4 139,382,666 (GRCm39) missense probably benign 0.00
R2156:Tas1r2 UTSW 4 139,396,352 (GRCm39) missense possibly damaging 0.79
R2509:Tas1r2 UTSW 4 139,387,162 (GRCm39) missense probably damaging 1.00
R2510:Tas1r2 UTSW 4 139,387,162 (GRCm39) missense probably damaging 1.00
R2511:Tas1r2 UTSW 4 139,387,162 (GRCm39) missense probably damaging 1.00
R3429:Tas1r2 UTSW 4 139,396,886 (GRCm39) missense probably damaging 1.00
R3430:Tas1r2 UTSW 4 139,396,886 (GRCm39) missense probably damaging 1.00
R3703:Tas1r2 UTSW 4 139,394,729 (GRCm39) missense probably damaging 1.00
R4105:Tas1r2 UTSW 4 139,387,363 (GRCm39) missense probably benign 0.06
R4106:Tas1r2 UTSW 4 139,387,363 (GRCm39) missense probably benign 0.06
R4107:Tas1r2 UTSW 4 139,387,363 (GRCm39) missense probably benign 0.06
R4614:Tas1r2 UTSW 4 139,387,098 (GRCm39) missense probably damaging 1.00
R4811:Tas1r2 UTSW 4 139,396,311 (GRCm39) missense probably damaging 1.00
R5314:Tas1r2 UTSW 4 139,382,672 (GRCm39) missense probably damaging 1.00
R5461:Tas1r2 UTSW 4 139,387,320 (GRCm39) missense probably benign 0.01
R5639:Tas1r2 UTSW 4 139,387,107 (GRCm39) missense probably damaging 1.00
R5703:Tas1r2 UTSW 4 139,394,647 (GRCm39) missense probably damaging 1.00
R6176:Tas1r2 UTSW 4 139,396,199 (GRCm39) missense probably damaging 1.00
R6297:Tas1r2 UTSW 4 139,389,361 (GRCm39) missense possibly damaging 0.47
R6441:Tas1r2 UTSW 4 139,396,467 (GRCm39) missense probably damaging 0.99
R6748:Tas1r2 UTSW 4 139,396,922 (GRCm39) missense probably damaging 0.98
R6863:Tas1r2 UTSW 4 139,397,030 (GRCm39) missense probably damaging 1.00
R6975:Tas1r2 UTSW 4 139,397,031 (GRCm39) missense probably damaging 1.00
R7106:Tas1r2 UTSW 4 139,389,360 (GRCm39) missense probably benign
R7265:Tas1r2 UTSW 4 139,396,963 (GRCm39) missense probably benign 0.01
R7580:Tas1r2 UTSW 4 139,387,056 (GRCm39) missense probably benign 0.05
R7651:Tas1r2 UTSW 4 139,396,938 (GRCm39) missense probably benign 0.14
R8041:Tas1r2 UTSW 4 139,387,290 (GRCm39) missense possibly damaging 0.65
R8530:Tas1r2 UTSW 4 139,389,460 (GRCm39) missense probably benign
R8747:Tas1r2 UTSW 4 139,387,318 (GRCm39) missense probably benign
R8824:Tas1r2 UTSW 4 139,381,074 (GRCm39) splice site probably benign
R8904:Tas1r2 UTSW 4 139,394,714 (GRCm39) missense probably damaging 1.00
R8906:Tas1r2 UTSW 4 139,397,046 (GRCm39) missense probably damaging 1.00
R9315:Tas1r2 UTSW 4 139,381,046 (GRCm39) missense possibly damaging 0.91
R9336:Tas1r2 UTSW 4 139,389,316 (GRCm39) missense probably damaging 1.00
R9419:Tas1r2 UTSW 4 139,387,036 (GRCm39) missense possibly damaging 0.65
R9776:Tas1r2 UTSW 4 139,396,208 (GRCm39) missense possibly damaging 0.68
Z1088:Tas1r2 UTSW 4 139,387,735 (GRCm39) missense possibly damaging 0.90
Posted On 2013-04-17