Incidental Mutation 'R3788:Or51a25'
ID 272380
Institutional Source Beutler Lab
Gene Symbol Or51a25
Ensembl Gene ENSMUSG00000066272
Gene Name olfactory receptor family 51 subfamily A member 25
Synonyms MOR11-1, Olfr559, GA_x6K02T2PBJ9-5441154-5440198
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R3788 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 102372739-102373695 bp(-) (GRCm39)
Type of Mutation splice site (2 bp from exon)
DNA Base Change (assembly) A to G at 102372694 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000095820 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084816] [ENSMUST00000215657] [ENSMUST00000216312]
AlphaFold Q8VH14
Predicted Effect probably null
Transcript: ENSMUST00000084816
SMART Domains Protein: ENSMUSP00000095820
Gene: ENSMUSG00000066272

DomainStartEndE-ValueType
Pfam:7tm_4 37 317 1.1e-117 PFAM
Pfam:7TM_GPCR_Srsx 41 215 1e-10 PFAM
Pfam:7tm_1 47 299 3e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215657
Predicted Effect probably benign
Transcript: ENSMUST00000216312
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency 100% (61/61)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 T A 3: 121,846,561 (GRCm39) V26E possibly damaging Het
Abhd16a A G 17: 35,320,563 (GRCm39) N411S probably damaging Het
Akap13 G A 7: 75,351,901 (GRCm39) probably null Het
Aph1b T C 9: 66,701,348 (GRCm39) probably benign Het
Aspm C T 1: 139,390,941 (GRCm39) T742I probably damaging Het
Bclaf3 A G X: 158,349,492 (GRCm39) H619R probably benign Het
Bltp2 T A 11: 78,179,123 (GRCm39) probably null Het
Cemip A T 7: 83,593,106 (GRCm39) L1199H probably damaging Het
Chd2 G A 7: 73,096,878 (GRCm39) probably benign Het
Clnk A G 5: 38,872,341 (GRCm39) Y310H probably damaging Het
Crmp1 A G 5: 37,441,484 (GRCm39) D522G probably damaging Het
Cyth3 A G 5: 143,622,298 (GRCm39) probably benign Het
Dcbld1 T A 10: 52,195,754 (GRCm39) Y392N probably damaging Het
Flnc T C 6: 29,454,056 (GRCm39) F1820L probably damaging Het
Galnt18 G A 7: 111,119,322 (GRCm39) R385* probably null Het
Gpatch3 C A 4: 133,302,479 (GRCm39) R137S possibly damaging Het
Gpc6 C T 14: 117,861,878 (GRCm39) P265S probably damaging Het
Harbi1 T A 2: 91,550,952 (GRCm39) D308E probably benign Het
Hdhd2 G A 18: 77,042,883 (GRCm39) probably null Het
Hk1 T C 10: 62,111,467 (GRCm39) K737E possibly damaging Het
Hnrnpr G A 4: 136,063,624 (GRCm39) V345M probably damaging Het
Ift56 T A 6: 38,380,459 (GRCm39) probably null Het
Kalrn T C 16: 34,040,610 (GRCm39) H944R probably damaging Het
Kdm2a A T 19: 4,401,833 (GRCm39) C207S probably damaging Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Krt75 C T 15: 101,481,956 (GRCm39) G104D possibly damaging Het
Lnpk A T 2: 74,352,607 (GRCm39) S358R probably benign Het
Map2 A G 1: 66,456,022 (GRCm39) T1512A probably damaging Het
Marchf10 T A 11: 105,287,905 (GRCm39) L132F probably damaging Het
Mfrp G A 9: 44,016,754 (GRCm39) W65* probably null Het
Mgat5 A G 1: 127,294,180 (GRCm39) D174G probably benign Het
Miga2 T A 2: 30,261,237 (GRCm39) Y177* probably null Het
Mroh3 T C 1: 136,113,213 (GRCm39) D747G probably damaging Het
Muc5b A G 7: 141,417,571 (GRCm39) T3506A possibly damaging Het
Myo7b G T 18: 32,107,165 (GRCm39) P1277T possibly damaging Het
Naaa C T 5: 92,420,413 (GRCm39) probably null Het
Ndufs2 T C 1: 171,062,889 (GRCm39) D410G possibly damaging Het
Or5p78 T A 7: 108,212,280 (GRCm39) Y255* probably null Het
Or7e177 A G 9: 20,211,666 (GRCm39) I58V probably benign Het
Or8g35 A G 9: 39,381,365 (GRCm39) I219T probably benign Het
Osbp A T 19: 11,956,285 (GRCm39) Y409F probably benign Het
Plxnb1 T A 9: 108,938,355 (GRCm39) V1303D possibly damaging Het
Prkcg G A 7: 3,362,263 (GRCm39) D246N probably damaging Het
Ranbp17 GCCTGGATACTGACC GCC 11: 33,169,203 (GRCm39) probably benign Het
Sbf1 G A 15: 89,183,731 (GRCm39) R1261* probably null Het
Scn4a T C 11: 106,235,100 (GRCm39) N341S probably damaging Het
Sec61a2 C A 2: 5,884,436 (GRCm39) probably null Het
Sgcd T A 11: 47,246,032 (GRCm39) K57* probably null Het
Sinhcaf A G 6: 148,827,617 (GRCm39) S134P possibly damaging Het
Slc12a5 T C 2: 164,835,695 (GRCm39) L861P probably damaging Het
Slc6a16 A G 7: 44,909,386 (GRCm39) D184G probably benign Het
Snx7 A G 3: 117,632,639 (GRCm39) probably benign Het
Sptbn2 A G 19: 4,795,950 (GRCm39) I1710V probably damaging Het
Sytl2 A T 7: 90,025,289 (GRCm39) I426F probably benign Het
Tdp1 A G 12: 99,858,011 (GRCm39) probably benign Het
Tmem232 C A 17: 65,689,628 (GRCm39) D496Y possibly damaging Het
Tomm20l C T 12: 71,158,516 (GRCm39) A58V possibly damaging Het
Ttn T C 2: 76,775,618 (GRCm39) E1854G unknown Het
Ttn A G 2: 76,804,552 (GRCm39) V240A probably benign Het
Vmn2r98 A T 17: 19,300,887 (GRCm39) T630S probably benign Het
Xrcc1 G C 7: 24,266,333 (GRCm39) A220P probably benign Het
Other mutations in Or51a25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02832:Or51a25 APN 7 102,372,858 (GRCm39) missense probably benign 0.01
R0505:Or51a25 UTSW 7 102,373,236 (GRCm39) missense probably damaging 0.97
R1131:Or51a25 UTSW 7 102,372,887 (GRCm39) missense probably damaging 0.99
R1449:Or51a25 UTSW 7 102,373,397 (GRCm39) missense probably damaging 1.00
R3915:Or51a25 UTSW 7 102,373,409 (GRCm39) missense possibly damaging 0.95
R3980:Or51a25 UTSW 7 102,372,959 (GRCm39) missense probably damaging 0.98
R4647:Or51a25 UTSW 7 102,373,299 (GRCm39) missense probably damaging 1.00
R5242:Or51a25 UTSW 7 102,373,483 (GRCm39) missense probably benign 0.41
R5404:Or51a25 UTSW 7 102,372,807 (GRCm39) missense possibly damaging 0.95
R5464:Or51a25 UTSW 7 102,373,124 (GRCm39) missense possibly damaging 0.85
R5807:Or51a25 UTSW 7 102,373,409 (GRCm39) missense possibly damaging 0.95
R5965:Or51a25 UTSW 7 102,373,467 (GRCm39) missense probably benign 0.00
R6008:Or51a25 UTSW 7 102,373,574 (GRCm39) missense probably damaging 1.00
R6036:Or51a25 UTSW 7 102,373,692 (GRCm39) missense probably benign
R6036:Or51a25 UTSW 7 102,373,692 (GRCm39) missense probably benign
R6493:Or51a25 UTSW 7 102,373,287 (GRCm39) missense possibly damaging 0.85
R6756:Or51a25 UTSW 7 102,373,295 (GRCm39) missense probably benign 0.03
R7201:Or51a25 UTSW 7 102,373,692 (GRCm39) missense probably benign
R7460:Or51a25 UTSW 7 102,373,028 (GRCm39) missense probably benign 0.09
R7695:Or51a25 UTSW 7 102,372,866 (GRCm39) missense probably benign 0.37
R8145:Or51a25 UTSW 7 102,372,937 (GRCm39) missense probably damaging 0.98
R8371:Or51a25 UTSW 7 102,372,790 (GRCm39) missense probably damaging 1.00
R8499:Or51a25 UTSW 7 102,372,932 (GRCm39) missense probably damaging 1.00
R9185:Or51a25 UTSW 7 102,373,409 (GRCm39) missense possibly damaging 0.95
R9230:Or51a25 UTSW 7 102,372,795 (GRCm39) missense possibly damaging 0.95
X0025:Or51a25 UTSW 7 102,373,022 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCCAGGAAACATTGGCTTTAAG -3'
(R):5'- AAAGCACCTGCCTCACATTG -3'

Sequencing Primer
(F):5'- TTCAGGTCAGAGAATGTAGCTC -3'
(R):5'- ACATTGTTCATGCCCTGGTTG -3'
Posted On 2015-03-25