Incidental Mutation 'R3801:Fndc7'
ID 272966
Institutional Source Beutler Lab
Gene Symbol Fndc7
Ensembl Gene ENSMUSG00000045326
Gene Name fibronectin type III domain containing 7
Synonyms E230011A21Rik
MMRRC Submission 040760-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3801 (G1)
Quality Score 177
Status Not validated
Chromosome 3
Chromosomal Location 108760994-108797324 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 108776464 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 526 (T526A)
Ref Sequence ENSEMBL: ENSMUSP00000099680 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053065] [ENSMUST00000102620] [ENSMUST00000180063]
AlphaFold A2AED3
Predicted Effect possibly damaging
Transcript: ENSMUST00000053065
AA Change: T440A

PolyPhen 2 Score 0.939 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000051172
Gene: ENSMUSG00000045326
AA Change: T440A

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
FN3 29 102 2.62e-5 SMART
FN3 113 189 1.31e-5 SMART
Blast:FN3 201 274 9e-44 BLAST
FN3 283 360 1.07e-1 SMART
FN3 457 530 5.1e1 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000102620
AA Change: T526A

PolyPhen 2 Score 0.954 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000099680
Gene: ENSMUSG00000045326
AA Change: T526A

DomainStartEndE-ValueType
FN3 29 102 2.62e-5 SMART
FN3 113 189 1.31e-5 SMART
FN3 201 275 2.44e-5 SMART
Blast:FN3 287 360 1e-43 BLAST
FN3 369 446 1.07e-1 SMART
FN3 543 616 5.1e1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139137
SMART Domains Protein: ENSMUSP00000117562
Gene: ENSMUSG00000045326

DomainStartEndE-ValueType
Blast:FN3 1 123 3e-27 BLAST
SCOP:d1f6fb2 3 64 3e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147002
Predicted Effect possibly damaging
Transcript: ENSMUST00000180063
AA Change: T526A

PolyPhen 2 Score 0.482 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000136215
Gene: ENSMUSG00000045326
AA Change: T526A

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
FN3 29 102 2.62e-5 SMART
FN3 113 189 1.31e-5 SMART
FN3 201 275 2.44e-5 SMART
Blast:FN3 287 360 2e-43 BLAST
FN3 369 446 1.07e-1 SMART
FN3 543 616 5.1e1 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700011L22Rik C T 8: 79,974,922 (GRCm39) E54K probably benign Het
Als2 A C 1: 59,206,358 (GRCm39) M1634R probably damaging Het
Ankfy1 T C 11: 72,640,246 (GRCm39) S531P probably benign Het
Atp6v1e1 A G 6: 120,778,020 (GRCm39) Y172H probably benign Het
Brd1 C T 15: 88,601,243 (GRCm39) V464M probably damaging Het
Btaf1 A T 19: 36,963,948 (GRCm39) T840S probably benign Het
Btaf1 A T 19: 36,966,373 (GRCm39) H1047L probably benign Het
Cacnb2 A G 2: 14,829,074 (GRCm39) D3G possibly damaging Het
Capn13 G A 17: 73,646,396 (GRCm39) P339L probably benign Het
Cgrrf1 G T 14: 47,069,820 (GRCm39) G30C probably damaging Het
Crnkl1 T C 2: 145,761,715 (GRCm39) D614G probably benign Het
Cyp2c23 C T 19: 43,995,478 (GRCm39) V430I probably benign Het
Dazl G A 17: 50,588,309 (GRCm39) R289W probably benign Het
Dsg1b C T 18: 20,523,260 (GRCm39) P96S probably damaging Het
Dusp14 A G 11: 83,939,535 (GRCm39) S169P possibly damaging Het
Egfem1 A G 3: 29,206,075 (GRCm39) D91G probably benign Het
Eif1 A G 11: 100,211,650 (GRCm39) K95E probably damaging Het
Fap C T 2: 62,376,994 (GRCm39) V191I probably benign Het
Flnc T C 6: 29,447,403 (GRCm39) Y1069H probably damaging Het
Fras1 A T 5: 96,881,791 (GRCm39) T2508S probably benign Het
Gast T C 11: 100,227,636 (GRCm39) S73P probably damaging Het
Grap2 A G 15: 80,507,947 (GRCm39) T4A possibly damaging Het
Grm8 T G 6: 28,125,635 (GRCm39) N164H possibly damaging Het
Hyal5 A T 6: 24,876,523 (GRCm39) H132L probably benign Het
Iqcm C A 8: 76,396,021 (GRCm39) T188K possibly damaging Het
Kank4 A G 4: 98,668,370 (GRCm39) S26P probably damaging Het
Lipo3 C T 19: 33,762,257 (GRCm39) C80Y probably damaging Het
Lrrk2 A G 15: 91,621,314 (GRCm39) R963G probably benign Het
Lrtm2 G A 6: 119,294,444 (GRCm39) T229I probably damaging Het
Mb21d2 A T 16: 28,646,755 (GRCm39) D406E possibly damaging Het
Meikin T A 11: 54,290,697 (GRCm39) probably null Het
Mybl1 A T 1: 9,743,439 (GRCm39) F538I probably damaging Het
Nectin2 T C 7: 19,451,561 (GRCm39) D491G probably benign Het
Nf1 A G 11: 79,450,347 (GRCm39) D511G probably null Het
Nid2 T C 14: 19,860,065 (GRCm39) C1328R probably damaging Het
Nlrp1a T A 11: 71,013,529 (GRCm39) M574L probably benign Het
Nrap C T 19: 56,310,211 (GRCm39) D1595N probably damaging Het
Nrg3 G A 14: 38,098,391 (GRCm39) P496S probably damaging Het
Or4k41 A T 2: 111,279,910 (GRCm39) I142F probably benign Het
Pak3 G A X: 142,492,727 (GRCm39) V87I probably damaging Het
Phf8 T C X: 150,355,572 (GRCm39) S512P possibly damaging Het
Phkb G T 8: 86,648,858 (GRCm39) E225* probably null Het
Plaa T C 4: 94,458,125 (GRCm39) D615G probably damaging Het
Prdm12 A G 2: 31,541,959 (GRCm39) K223E probably damaging Het
Prkd1 C A 12: 50,430,205 (GRCm39) R634L possibly damaging Het
Rassf3 T A 10: 121,250,271 (GRCm39) I181F possibly damaging Het
Samd8 G A 14: 21,825,133 (GRCm39) V30M probably damaging Het
Sema4f A T 6: 82,895,608 (GRCm39) H308Q possibly damaging Het
Skint4 G T 4: 111,975,378 (GRCm39) V113L probably damaging Het
Slc16a10 G C 10: 39,932,620 (GRCm39) H314D possibly damaging Het
Slpi A G 2: 164,198,158 (GRCm39) L12P probably damaging Het
Smco1 A G 16: 32,092,716 (GRCm39) Y129C probably benign Het
Spag17 A G 3: 99,961,169 (GRCm39) K985R possibly damaging Het
Stc1 T C 14: 69,275,924 (GRCm39) I239T probably benign Het
Suclg2 A T 6: 95,474,649 (GRCm39) I372N probably damaging Het
Tmed4 C A 11: 6,224,233 (GRCm39) V80F probably damaging Het
Tnpo2 T A 8: 85,781,800 (GRCm39) probably null Het
Top1 A G 2: 160,544,688 (GRCm39) H268R probably damaging Het
Triobp A T 15: 78,857,900 (GRCm39) Q1167L probably benign Het
Txndc16 G A 14: 45,388,809 (GRCm39) P536L possibly damaging Het
Usp13 C T 3: 32,935,657 (GRCm39) A360V possibly damaging Het
Vhl G A 6: 113,606,423 (GRCm39) V147I probably benign Het
Vldlr A T 19: 27,195,021 (GRCm39) T3S probably damaging Het
Vps54 T A 11: 21,218,832 (GRCm39) D130E probably benign Het
Zfp808 T A 13: 62,319,897 (GRCm39) H375Q probably damaging Het
Zfp87 A T 13: 67,669,334 (GRCm39) N37K probably damaging Het
Other mutations in Fndc7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02077:Fndc7 APN 3 108,790,784 (GRCm39) missense probably benign 0.17
IGL02823:Fndc7 APN 3 108,776,487 (GRCm39) missense probably damaging 1.00
IGL02896:Fndc7 APN 3 108,770,247 (GRCm39) missense probably benign 0.04
IGL03196:Fndc7 APN 3 108,790,760 (GRCm39) missense probably damaging 1.00
IGL03343:Fndc7 APN 3 108,774,624 (GRCm39) missense probably damaging 1.00
IGL03377:Fndc7 APN 3 108,783,848 (GRCm39) missense probably benign 0.12
R0240:Fndc7 UTSW 3 108,766,235 (GRCm39) splice site probably benign
R0324:Fndc7 UTSW 3 108,784,015 (GRCm39) splice site probably null
R0457:Fndc7 UTSW 3 108,783,861 (GRCm39) missense probably benign 0.02
R0630:Fndc7 UTSW 3 108,783,931 (GRCm39) missense probably damaging 1.00
R0891:Fndc7 UTSW 3 108,777,904 (GRCm39) missense possibly damaging 0.54
R1752:Fndc7 UTSW 3 108,776,646 (GRCm39) missense probably benign 0.14
R1772:Fndc7 UTSW 3 108,777,850 (GRCm39) missense probably damaging 1.00
R1923:Fndc7 UTSW 3 108,784,003 (GRCm39) missense probably benign 0.00
R1957:Fndc7 UTSW 3 108,790,825 (GRCm39) missense probably damaging 0.98
R4592:Fndc7 UTSW 3 108,766,218 (GRCm39) missense probably damaging 1.00
R4650:Fndc7 UTSW 3 108,770,135 (GRCm39) missense probably benign 0.15
R4652:Fndc7 UTSW 3 108,770,135 (GRCm39) missense probably benign 0.15
R4791:Fndc7 UTSW 3 108,783,975 (GRCm39) missense probably benign 0.00
R4933:Fndc7 UTSW 3 108,783,986 (GRCm39) missense probably benign 0.01
R5004:Fndc7 UTSW 3 108,790,789 (GRCm39) missense probably damaging 1.00
R5042:Fndc7 UTSW 3 108,770,102 (GRCm39) missense probably damaging 1.00
R5054:Fndc7 UTSW 3 108,788,663 (GRCm39) missense probably damaging 0.97
R5175:Fndc7 UTSW 3 108,776,482 (GRCm39) missense probably benign 0.04
R5325:Fndc7 UTSW 3 108,790,765 (GRCm39) missense probably damaging 1.00
R5571:Fndc7 UTSW 3 108,763,724 (GRCm39) missense possibly damaging 0.68
R5638:Fndc7 UTSW 3 108,770,208 (GRCm39) missense possibly damaging 0.69
R5846:Fndc7 UTSW 3 108,788,707 (GRCm39) missense probably damaging 1.00
R6488:Fndc7 UTSW 3 108,777,891 (GRCm39) missense probably damaging 0.99
R6737:Fndc7 UTSW 3 108,779,594 (GRCm39) missense probably damaging 1.00
R6993:Fndc7 UTSW 3 108,783,907 (GRCm39) missense probably benign 0.00
R6998:Fndc7 UTSW 3 108,783,964 (GRCm39) missense probably benign 0.02
R6999:Fndc7 UTSW 3 108,783,964 (GRCm39) missense probably benign 0.02
R7000:Fndc7 UTSW 3 108,783,964 (GRCm39) missense probably benign 0.02
R7001:Fndc7 UTSW 3 108,783,964 (GRCm39) missense probably benign 0.02
R7181:Fndc7 UTSW 3 108,788,640 (GRCm39) critical splice donor site probably null
R7324:Fndc7 UTSW 3 108,779,537 (GRCm39) missense probably benign 0.06
R7425:Fndc7 UTSW 3 108,783,975 (GRCm39) missense probably benign 0.00
R7631:Fndc7 UTSW 3 108,776,568 (GRCm39) missense probably damaging 1.00
R7702:Fndc7 UTSW 3 108,770,129 (GRCm39) missense probably damaging 0.98
R7713:Fndc7 UTSW 3 108,777,979 (GRCm39) missense possibly damaging 0.90
R7909:Fndc7 UTSW 3 108,770,232 (GRCm39) missense probably benign 0.04
R7946:Fndc7 UTSW 3 108,779,452 (GRCm39) missense possibly damaging 0.78
R8023:Fndc7 UTSW 3 108,774,461 (GRCm39) missense probably damaging 1.00
R8694:Fndc7 UTSW 3 108,779,622 (GRCm39) nonsense probably null
R8708:Fndc7 UTSW 3 108,774,528 (GRCm39) missense probably benign 0.00
R9325:Fndc7 UTSW 3 108,790,834 (GRCm39) missense possibly damaging 0.55
R9608:Fndc7 UTSW 3 108,774,597 (GRCm39) missense probably damaging 1.00
Z1088:Fndc7 UTSW 3 108,790,816 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGGGCAAGACAAGAGACTTC -3'
(R):5'- GCATTCTCCATGATCAATGTGC -3'

Sequencing Primer
(F):5'- TTTTCCCCTCGAAGAATGGGGC -3'
(R):5'- CATGATCAATGTGCACTGGC -3'
Posted On 2015-03-25