Incidental Mutation 'R3773:Or7a41'
ID 273444
Institutional Source Beutler Lab
Gene Symbol Or7a41
Ensembl Gene ENSMUSG00000060205
Gene Name olfactory receptor family 7 subfamily A member 41
Synonyms MOR139-3, Olfr57, GA_x6K02T2QGN0-2777431-2776472, IF12
MMRRC Submission 040749-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R3773 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 78870557-78871636 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 78871014 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 128 (C128Y)
Ref Sequence ENSEMBL: ENSMUSP00000144814 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000082244] [ENSMUST00000203906]
AlphaFold Q8VGU7
Predicted Effect possibly damaging
Transcript: ENSMUST00000082244
AA Change: C128Y

PolyPhen 2 Score 0.946 (Sensitivity: 0.80; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000080872
Gene: ENSMUSG00000060205
AA Change: C128Y

DomainStartEndE-ValueType
Pfam:7tm_4 32 308 2.2e-49 PFAM
Pfam:7tm_1 42 291 6e-28 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000203906
AA Change: C128Y

PolyPhen 2 Score 0.946 (Sensitivity: 0.80; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000144814
Gene: ENSMUSG00000060205
AA Change: C128Y

DomainStartEndE-ValueType
low complexity region 9 19 N/A INTRINSIC
Pfam:7tm_4 32 308 2e-49 PFAM
Pfam:7tm_1 42 291 1.9e-23 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 T A 6: 128,532,046 (GRCm39) K899N probably benign Het
Acsbg3 T C 17: 57,183,262 (GRCm39) M1T probably null Het
Adgrv1 G A 13: 81,647,162 (GRCm39) S3126L probably damaging Het
Apba3 C A 10: 81,108,443 (GRCm39) probably null Het
Apobec4 G T 1: 152,632,556 (GRCm39) A195S probably benign Het
Asap3 C T 4: 135,954,886 (GRCm39) T72I probably benign Het
Cand2 T A 6: 115,762,178 (GRCm39) H201Q probably damaging Het
Cd109 CATTTATTTATTTATTTATTTATTTATTTATTTAT CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT 9: 78,619,782 (GRCm39) probably benign Het
Chd1 A G 17: 17,594,913 (GRCm39) D16G probably damaging Het
Csgalnact2 T C 6: 118,103,180 (GRCm39) K19E probably benign Het
Cspg4b A G 13: 113,454,743 (GRCm39) E263G probably benign Het
Cyp17a1 T G 19: 46,658,162 (GRCm39) K250T probably damaging Het
Ddx41 G A 13: 55,682,293 (GRCm39) R205W possibly damaging Het
Dgcr8 T C 16: 18,074,639 (GRCm39) D712G probably damaging Het
Dsg2 T C 18: 20,724,919 (GRCm39) W442R probably damaging Het
Elavl2 C T 4: 91,152,325 (GRCm39) G131R probably damaging Het
Elf1 T C 14: 79,804,650 (GRCm39) V105A possibly damaging Het
Ercc6l2 A G 13: 63,989,264 (GRCm39) D270G probably damaging Het
Fmn1 T G 2: 113,412,463 (GRCm39) S996A probably damaging Het
Frmd4a A T 2: 4,595,433 (GRCm39) E109D probably damaging Het
Fry A T 5: 150,321,663 (GRCm39) R999S probably damaging Het
Gak G A 5: 108,730,538 (GRCm39) T956I probably benign Het
Gps2 T C 11: 69,806,927 (GRCm39) F21L probably damaging Het
Grhl3 C T 4: 135,283,158 (GRCm39) W303* probably null Het
Hmcn2 C T 2: 31,250,908 (GRCm39) T790M probably damaging Het
Lrp5 G A 19: 3,662,330 (GRCm39) R173C probably damaging Het
Matk T A 10: 81,094,131 (GRCm39) L21Q probably benign Het
Mthfr T C 4: 148,128,907 (GRCm39) V160A probably benign Het
Nhlrc4 T A 17: 26,162,367 (GRCm39) K127* probably null Het
Nsd1 G A 13: 55,394,486 (GRCm39) V696I probably benign Het
Nup210l T G 3: 90,027,201 (GRCm39) Y194* probably null Het
Or1j16 A T 2: 36,530,333 (GRCm39) Y94F probably benign Het
Or2h2 G T 17: 37,396,957 (GRCm39) Y33* probably null Het
Or9q2 T A 19: 13,772,568 (GRCm39) M136L probably benign Het
Pcdhb15 T A 18: 37,608,943 (GRCm39) V725D probably benign Het
Pes1 A G 11: 3,925,548 (GRCm39) Y221C probably damaging Het
Prkd3 T C 17: 79,266,535 (GRCm39) I603V possibly damaging Het
Ptpn13 A G 5: 103,624,987 (GRCm39) E97G probably damaging Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Ptprs T C 17: 56,735,978 (GRCm39) T152A possibly damaging Het
Rims1 T C 1: 22,492,034 (GRCm39) D842G probably damaging Het
Rin2 C T 2: 145,702,366 (GRCm39) T354I probably benign Het
Rnf26rt C T 6: 76,473,942 (GRCm39) V225I probably benign Het
Rngtt T C 4: 33,330,889 (GRCm39) I164T probably damaging Het
Scn9a T C 2: 66,313,992 (GRCm39) N1909D probably benign Het
Shisal1 A T 15: 84,290,886 (GRCm39) Y120* probably null Het
Ska3 C T 14: 58,047,534 (GRCm39) V334I probably benign Het
Slco1a8 T C 6: 141,918,061 (GRCm39) K605R probably benign Het
Srebf2 A G 15: 82,066,309 (GRCm39) K579R probably benign Het
Stxbp5 G A 10: 9,644,671 (GRCm39) T960I probably damaging Het
Suco A T 1: 161,671,565 (GRCm39) probably null Het
Tecta T C 9: 42,242,292 (GRCm39) T2094A probably damaging Het
Tenm4 A T 7: 96,344,087 (GRCm39) R227W probably damaging Het
Tmem131l A G 3: 83,805,893 (GRCm39) S1517P probably damaging Het
Trio A G 15: 27,748,177 (GRCm39) S2492P probably damaging Het
Tsg101 T C 7: 46,539,363 (GRCm39) *254W probably null Het
Ttn T C 2: 76,601,711 (GRCm39) T16872A probably benign Het
Ugt2b38 A G 5: 87,571,954 (GRCm39) V26A probably damaging Het
Upb1 T A 10: 75,275,672 (GRCm39) probably null Het
Vmn1r32 T A 6: 66,530,351 (GRCm39) I142F probably benign Het
Vmn1r60 C A 7: 5,547,710 (GRCm39) C130F possibly damaging Het
Vmn2r101 A G 17: 19,809,919 (GRCm39) D235G probably benign Het
Wnk1 C T 6: 119,979,241 (GRCm39) R282Q possibly damaging Het
Xrn2 T C 2: 146,903,207 (GRCm39) V765A probably benign Het
Zbed4 T C 15: 88,665,050 (GRCm39) S373P probably benign Het
Zfp251 A G 15: 76,737,836 (GRCm39) I414T possibly damaging Het
Zfp423 A T 8: 88,507,140 (GRCm39) L1047Q probably benign Het
Zfp426 A T 9: 20,384,413 (GRCm39) probably null Het
Zfp61 T C 7: 23,995,406 (GRCm39) M1V probably null Het
Other mutations in Or7a41
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01347:Or7a41 APN 10 78,871,445 (GRCm39) missense probably benign 0.05
IGL02230:Or7a41 APN 10 78,870,876 (GRCm39) missense probably damaging 0.99
IGL02283:Or7a41 APN 10 78,871,379 (GRCm39) missense probably damaging 1.00
IGL02878:Or7a41 APN 10 78,871,392 (GRCm39) missense probably benign 0.23
IGL02975:Or7a41 APN 10 78,870,867 (GRCm39) missense possibly damaging 0.83
IGL03259:Or7a41 APN 10 78,871,234 (GRCm39) nonsense probably null
R1366:Or7a41 UTSW 10 78,870,876 (GRCm39) missense probably damaging 1.00
R1438:Or7a41 UTSW 10 78,871,122 (GRCm39) missense possibly damaging 0.88
R1528:Or7a41 UTSW 10 78,871,398 (GRCm39) missense probably damaging 0.96
R1601:Or7a41 UTSW 10 78,871,338 (GRCm39) missense possibly damaging 0.56
R2032:Or7a41 UTSW 10 78,871,163 (GRCm39) missense possibly damaging 0.86
R2112:Or7a41 UTSW 10 78,871,248 (GRCm39) missense probably damaging 1.00
R2382:Or7a41 UTSW 10 78,870,968 (GRCm39) missense possibly damaging 0.52
R2967:Or7a41 UTSW 10 78,870,887 (GRCm39) missense probably damaging 1.00
R3940:Or7a41 UTSW 10 78,871,038 (GRCm39) missense probably damaging 1.00
R4405:Or7a41 UTSW 10 78,871,244 (GRCm39) missense probably benign
R5944:Or7a41 UTSW 10 78,871,223 (GRCm39) missense probably benign 0.00
R6563:Or7a41 UTSW 10 78,871,051 (GRCm39) missense possibly damaging 0.67
R6614:Or7a41 UTSW 10 78,870,925 (GRCm39) nonsense probably null
R7181:Or7a41 UTSW 10 78,871,287 (GRCm39) missense probably damaging 0.98
R7639:Or7a41 UTSW 10 78,871,206 (GRCm39) missense probably damaging 0.99
R9427:Or7a41 UTSW 10 78,871,395 (GRCm39) missense probably damaging 0.99
R9508:Or7a41 UTSW 10 78,870,933 (GRCm39) missense probably damaging 1.00
R9652:Or7a41 UTSW 10 78,871,230 (GRCm39) missense probably benign 0.05
R9681:Or7a41 UTSW 10 78,871,577 (GRCm39) missense probably benign
R9767:Or7a41 UTSW 10 78,870,765 (GRCm39) missense possibly damaging 0.78
Predicted Primers PCR Primer
(F):5'- GGCCATCATTGTTGACTCCC -3'
(R):5'- AGGCCTGGTGTACAACTTG -3'

Sequencing Primer
(F):5'- GTTGACTCCCACCTGCACAC -3'
(R):5'- AGGCCTGGTGTACAACTTGATTAAG -3'
Posted On 2015-03-25