Incidental Mutation 'R3498:Mindy4'
ID 273651
Institutional Source Beutler Lab
Gene Symbol Mindy4
Ensembl Gene ENSMUSG00000038022
Gene Name MINDY lysine 48 deubiquitinase 4
Synonyms Fam188b, C330043M08Rik, LOC384387
MMRRC Submission 040661-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R3498 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 55180368-55297207 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 55193510 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 68 (R68G)
Ref Sequence ENSEMBL: ENSMUSP00000145151 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053094] [ENSMUST00000204842]
AlphaFold Q3UQI9
Predicted Effect probably benign
Transcript: ENSMUST00000053094
AA Change: R68G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000061221
Gene: ENSMUSG00000038022
AA Change: R68G

DomainStartEndE-ValueType
low complexity region 154 166 N/A INTRINSIC
low complexity region 224 240 N/A INTRINSIC
low complexity region 265 277 N/A INTRINSIC
DUF4205 403 739 1.47e-187 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000204842
AA Change: R68G

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000145151
Gene: ENSMUSG00000038022
AA Change: R68G

DomainStartEndE-ValueType
low complexity region 154 166 N/A INTRINSIC
low complexity region 224 240 N/A INTRINSIC
low complexity region 265 277 N/A INTRINSIC
DUF4205 403 591 6.19e-10 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 96.0%
Validation Efficiency 100% (43/43)
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A3galt2 T C 4: 128,649,350 (GRCm39) F6L probably benign Het
Aurkc A G 7: 7,003,029 (GRCm39) I175V probably damaging Het
Azi2 A G 9: 117,878,475 (GRCm39) D105G probably damaging Het
Bcat1 A G 6: 144,965,068 (GRCm39) V45A probably damaging Het
Cass4 C T 2: 172,274,478 (GRCm39) P753L probably damaging Het
Cimip3 AC A 17: 47,744,348 (GRCm39) probably benign Het
Ddx42 A G 11: 106,122,019 (GRCm39) E178G possibly damaging Het
Dmpk T C 7: 18,820,306 (GRCm39) I101T probably damaging Het
Dnah17 C T 11: 117,971,675 (GRCm39) probably benign Het
Fosb C T 7: 19,040,557 (GRCm39) R161H probably damaging Het
Gm6729 T C 10: 86,376,582 (GRCm39) noncoding transcript Het
Gnb1 T A 4: 155,639,483 (GRCm39) N237K possibly damaging Het
Gpr35 A G 1: 92,911,113 (GRCm39) Y275C probably damaging Het
Hmcn1 A T 1: 150,480,853 (GRCm39) I4441N probably damaging Het
Ighe G A 12: 113,234,994 (GRCm39) Q389* probably null Het
Kcnj11 T C 7: 45,749,026 (GRCm39) D23G probably damaging Het
Lats2 G T 14: 57,959,923 (GRCm39) A191E possibly damaging Het
Lyplal1 A G 1: 185,820,857 (GRCm39) S197P possibly damaging Het
Map4 G T 9: 109,864,280 (GRCm39) V502L probably benign Het
Mgat5 A G 1: 127,312,571 (GRCm39) M237V possibly damaging Het
Nell1 T A 7: 49,907,927 (GRCm39) V362E possibly damaging Het
Or5m8 T A 2: 85,822,774 (GRCm39) F204L probably benign Het
Or6c66b T A 10: 129,376,778 (GRCm39) I124N probably damaging Het
P4ha2 T C 11: 54,010,079 (GRCm39) Y279H probably benign Het
Pcid2 A G 8: 13,150,413 (GRCm39) V13A possibly damaging Het
Polr2j T C 5: 136,151,624 (GRCm39) I116T probably benign Het
Prdm9 A G 17: 15,783,207 (GRCm39) probably benign Het
Prr5 T A 15: 84,587,345 (GRCm39) V365E probably benign Het
Ptprf A T 4: 118,082,127 (GRCm39) I1037N probably damaging Het
Ranbp17 GCCTGGATACTGACC GCC 11: 33,169,203 (GRCm39) probably benign Het
Sde2 T A 1: 180,685,750 (GRCm39) C101S probably damaging Het
Sec1 T C 7: 45,328,663 (GRCm39) H128R probably damaging Het
Serpinb6a A T 13: 34,102,764 (GRCm39) M253K probably damaging Het
Slc1a4 A T 11: 20,263,973 (GRCm39) I248N probably damaging Het
Slc22a4 T G 11: 53,882,879 (GRCm39) K328N probably benign Het
Slc24a4 A T 12: 102,200,951 (GRCm39) K278N probably benign Het
Slc6a21 T A 7: 44,930,266 (GRCm39) W222R probably damaging Het
Slc7a2 A G 8: 41,365,567 (GRCm39) E466G probably benign Het
Sspo A G 6: 48,444,914 (GRCm39) T2133A possibly damaging Het
Taco1 A G 11: 105,963,364 (GRCm39) M172V probably benign Het
Tmem127 T A 2: 127,098,040 (GRCm39) H36Q probably benign Het
Tmem229b-ps C T 10: 53,351,223 (GRCm39) noncoding transcript Het
Vac14 A G 8: 111,397,722 (GRCm39) D479G probably benign Het
Vmn1r176 T A 7: 23,534,667 (GRCm39) K162I probably benign Het
Other mutations in Mindy4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01098:Mindy4 APN 6 55,261,727 (GRCm39) splice site probably benign
IGL01483:Mindy4 APN 6 55,193,670 (GRCm39) missense probably damaging 1.00
IGL01721:Mindy4 APN 6 55,200,984 (GRCm39) missense probably damaging 1.00
IGL01965:Mindy4 APN 6 55,237,517 (GRCm39) splice site probably benign
IGL02214:Mindy4 APN 6 55,193,636 (GRCm39) missense possibly damaging 0.88
IGL03058:Mindy4 APN 6 55,285,183 (GRCm39) missense probably damaging 1.00
IGL03077:Mindy4 APN 6 55,286,315 (GRCm39) missense probably damaging 1.00
IGL03296:Mindy4 APN 6 55,274,738 (GRCm39) critical splice donor site probably null
R0383:Mindy4 UTSW 6 55,253,619 (GRCm39) missense probably benign 0.00
R0384:Mindy4 UTSW 6 55,193,669 (GRCm39) missense probably damaging 1.00
R0636:Mindy4 UTSW 6 55,253,570 (GRCm39) missense possibly damaging 0.73
R0848:Mindy4 UTSW 6 55,295,271 (GRCm39) nonsense probably null
R1171:Mindy4 UTSW 6 55,232,601 (GRCm39) missense possibly damaging 0.75
R1210:Mindy4 UTSW 6 55,261,798 (GRCm39) missense possibly damaging 0.92
R1341:Mindy4 UTSW 6 55,232,601 (GRCm39) missense probably benign 0.00
R2030:Mindy4 UTSW 6 55,188,247 (GRCm39) missense probably damaging 1.00
R2127:Mindy4 UTSW 6 55,195,250 (GRCm39) missense probably benign 0.05
R2237:Mindy4 UTSW 6 55,278,055 (GRCm39) missense probably damaging 1.00
R2238:Mindy4 UTSW 6 55,278,055 (GRCm39) missense probably damaging 1.00
R2250:Mindy4 UTSW 6 55,277,934 (GRCm39) missense probably damaging 0.99
R2571:Mindy4 UTSW 6 55,261,770 (GRCm39) missense probably damaging 1.00
R2846:Mindy4 UTSW 6 55,255,085 (GRCm39) missense probably damaging 1.00
R3001:Mindy4 UTSW 6 55,195,349 (GRCm39) missense probably benign 0.21
R3002:Mindy4 UTSW 6 55,195,349 (GRCm39) missense probably benign 0.21
R4167:Mindy4 UTSW 6 55,201,331 (GRCm39) missense possibly damaging 0.93
R4767:Mindy4 UTSW 6 55,237,550 (GRCm39) missense probably damaging 0.98
R4812:Mindy4 UTSW 6 55,256,088 (GRCm39) missense possibly damaging 0.64
R5109:Mindy4 UTSW 6 55,193,730 (GRCm39) splice site probably null
R5203:Mindy4 UTSW 6 55,232,646 (GRCm39) missense probably benign 0.00
R5221:Mindy4 UTSW 6 55,201,092 (GRCm39) missense probably benign
R5628:Mindy4 UTSW 6 55,237,579 (GRCm39) missense probably damaging 0.98
R6265:Mindy4 UTSW 6 55,278,049 (GRCm39) missense probably damaging 0.99
R6596:Mindy4 UTSW 6 55,201,001 (GRCm39) missense probably damaging 0.99
R7084:Mindy4 UTSW 6 55,255,220 (GRCm39) missense probably benign
R7350:Mindy4 UTSW 6 55,278,010 (GRCm39) missense probably damaging 0.97
R7535:Mindy4 UTSW 6 55,274,738 (GRCm39) critical splice donor site probably null
R7625:Mindy4 UTSW 6 55,253,598 (GRCm39) missense possibly damaging 0.95
R8052:Mindy4 UTSW 6 55,277,977 (GRCm39) missense probably damaging 0.99
R8727:Mindy4 UTSW 6 55,256,055 (GRCm39) unclassified probably benign
R8884:Mindy4 UTSW 6 55,255,223 (GRCm39) missense probably benign 0.00
R8886:Mindy4 UTSW 6 55,255,223 (GRCm39) missense probably benign 0.00
R8890:Mindy4 UTSW 6 55,255,223 (GRCm39) missense probably benign 0.00
R8892:Mindy4 UTSW 6 55,255,223 (GRCm39) missense probably benign 0.00
R8893:Mindy4 UTSW 6 55,255,223 (GRCm39) missense probably benign 0.00
R8894:Mindy4 UTSW 6 55,255,223 (GRCm39) missense probably benign 0.00
R8896:Mindy4 UTSW 6 55,255,223 (GRCm39) missense probably benign 0.00
R8932:Mindy4 UTSW 6 55,201,115 (GRCm39) missense probably benign
R9018:Mindy4 UTSW 6 55,278,072 (GRCm39) missense possibly damaging 0.91
R9045:Mindy4 UTSW 6 55,295,283 (GRCm39) missense probably benign 0.16
R9185:Mindy4 UTSW 6 55,295,261 (GRCm39) missense possibly damaging 0.88
X0065:Mindy4 UTSW 6 55,239,801 (GRCm39) missense probably damaging 0.99
Z1177:Mindy4 UTSW 6 55,201,326 (GRCm39) missense probably benign 0.10
Predicted Primers PCR Primer
(F):5'- AGGAGATTAACTTGGACAGTCCTC -3'
(R):5'- GCTTCTGACCATGATGTCCG -3'

Sequencing Primer
(F):5'- CTCACAGTGCACAAGATAGTGGTTC -3'
(R):5'- CCCGTATCTTCATCTGAAAGGTCG -3'
Posted On 2015-04-02