Incidental Mutation 'R3498:Or6c66b'
ID 273669
Institutional Source Beutler Lab
Gene Symbol Or6c66b
Ensembl Gene ENSMUSG00000094496
Gene Name olfactory receptor family 6 subfamily C member 66B
Synonyms Olfr792, MOR108-2, GA_x6K02T2PULF-11219415-11220350
MMRRC Submission 040661-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R3498 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 129376408-129377343 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 129376778 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 124 (I124N)
Ref Sequence ENSEMBL: ENSMUSP00000149872 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076575] [ENSMUST00000215436]
AlphaFold Q7TRH9
Predicted Effect probably damaging
Transcript: ENSMUST00000076575
AA Change: I124N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000096707
Gene: ENSMUSG00000094496
AA Change: I124N

DomainStartEndE-ValueType
Pfam:7tm_4 28 306 1.9e-53 PFAM
Pfam:7tm_1 39 288 4.7e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215436
AA Change: I124N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 96.0%
Validation Efficiency 100% (43/43)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A3galt2 T C 4: 128,649,350 (GRCm39) F6L probably benign Het
Aurkc A G 7: 7,003,029 (GRCm39) I175V probably damaging Het
Azi2 A G 9: 117,878,475 (GRCm39) D105G probably damaging Het
Bcat1 A G 6: 144,965,068 (GRCm39) V45A probably damaging Het
Cass4 C T 2: 172,274,478 (GRCm39) P753L probably damaging Het
Cimip3 AC A 17: 47,744,348 (GRCm39) probably benign Het
Ddx42 A G 11: 106,122,019 (GRCm39) E178G possibly damaging Het
Dmpk T C 7: 18,820,306 (GRCm39) I101T probably damaging Het
Dnah17 C T 11: 117,971,675 (GRCm39) probably benign Het
Fosb C T 7: 19,040,557 (GRCm39) R161H probably damaging Het
Gm6729 T C 10: 86,376,582 (GRCm39) noncoding transcript Het
Gnb1 T A 4: 155,639,483 (GRCm39) N237K possibly damaging Het
Gpr35 A G 1: 92,911,113 (GRCm39) Y275C probably damaging Het
Hmcn1 A T 1: 150,480,853 (GRCm39) I4441N probably damaging Het
Ighe G A 12: 113,234,994 (GRCm39) Q389* probably null Het
Kcnj11 T C 7: 45,749,026 (GRCm39) D23G probably damaging Het
Lats2 G T 14: 57,959,923 (GRCm39) A191E possibly damaging Het
Lyplal1 A G 1: 185,820,857 (GRCm39) S197P possibly damaging Het
Map4 G T 9: 109,864,280 (GRCm39) V502L probably benign Het
Mgat5 A G 1: 127,312,571 (GRCm39) M237V possibly damaging Het
Mindy4 A G 6: 55,193,510 (GRCm39) R68G probably benign Het
Nell1 T A 7: 49,907,927 (GRCm39) V362E possibly damaging Het
Or5m8 T A 2: 85,822,774 (GRCm39) F204L probably benign Het
P4ha2 T C 11: 54,010,079 (GRCm39) Y279H probably benign Het
Pcid2 A G 8: 13,150,413 (GRCm39) V13A possibly damaging Het
Polr2j T C 5: 136,151,624 (GRCm39) I116T probably benign Het
Prdm9 A G 17: 15,783,207 (GRCm39) probably benign Het
Prr5 T A 15: 84,587,345 (GRCm39) V365E probably benign Het
Ptprf A T 4: 118,082,127 (GRCm39) I1037N probably damaging Het
Ranbp17 GCCTGGATACTGACC GCC 11: 33,169,203 (GRCm39) probably benign Het
Sde2 T A 1: 180,685,750 (GRCm39) C101S probably damaging Het
Sec1 T C 7: 45,328,663 (GRCm39) H128R probably damaging Het
Serpinb6a A T 13: 34,102,764 (GRCm39) M253K probably damaging Het
Slc1a4 A T 11: 20,263,973 (GRCm39) I248N probably damaging Het
Slc22a4 T G 11: 53,882,879 (GRCm39) K328N probably benign Het
Slc24a4 A T 12: 102,200,951 (GRCm39) K278N probably benign Het
Slc6a21 T A 7: 44,930,266 (GRCm39) W222R probably damaging Het
Slc7a2 A G 8: 41,365,567 (GRCm39) E466G probably benign Het
Sspo A G 6: 48,444,914 (GRCm39) T2133A possibly damaging Het
Taco1 A G 11: 105,963,364 (GRCm39) M172V probably benign Het
Tmem127 T A 2: 127,098,040 (GRCm39) H36Q probably benign Het
Tmem229b-ps C T 10: 53,351,223 (GRCm39) noncoding transcript Het
Vac14 A G 8: 111,397,722 (GRCm39) D479G probably benign Het
Vmn1r176 T A 7: 23,534,667 (GRCm39) K162I probably benign Het
Other mutations in Or6c66b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01285:Or6c66b APN 10 129,376,711 (GRCm39) missense probably benign 0.07
IGL01459:Or6c66b APN 10 129,376,410 (GRCm39) start codon destroyed probably null 1.00
IGL02090:Or6c66b APN 10 129,377,176 (GRCm39) missense probably damaging 1.00
IGL03338:Or6c66b APN 10 129,376,925 (GRCm39) missense probably damaging 0.99
R0382:Or6c66b UTSW 10 129,376,883 (GRCm39) missense probably benign 0.01
R1672:Or6c66b UTSW 10 129,376,561 (GRCm39) missense probably benign 0.00
R2285:Or6c66b UTSW 10 129,376,537 (GRCm39) missense probably benign 0.22
R2938:Or6c66b UTSW 10 129,376,484 (GRCm39) missense probably damaging 1.00
R5309:Or6c66b UTSW 10 129,377,134 (GRCm39) missense probably benign 0.01
R5312:Or6c66b UTSW 10 129,377,134 (GRCm39) missense probably benign 0.01
R6004:Or6c66b UTSW 10 129,376,759 (GRCm39) missense probably benign 0.31
R6800:Or6c66b UTSW 10 129,377,132 (GRCm39) missense probably damaging 1.00
R7127:Or6c66b UTSW 10 129,376,936 (GRCm39) missense probably damaging 1.00
R7167:Or6c66b UTSW 10 129,376,607 (GRCm39) missense possibly damaging 0.88
R7763:Or6c66b UTSW 10 129,377,324 (GRCm39) missense probably benign
R7819:Or6c66b UTSW 10 129,376,562 (GRCm39) missense probably benign 0.01
R8104:Or6c66b UTSW 10 129,376,826 (GRCm39) missense probably benign
R8189:Or6c66b UTSW 10 129,377,122 (GRCm39) missense probably damaging 0.99
R8672:Or6c66b UTSW 10 129,376,596 (GRCm39) missense probably damaging 0.99
Z1189:Or6c66b UTSW 10 129,377,246 (GRCm39) missense probably benign 0.44
Predicted Primers PCR Primer
(F):5'- TCACTCTGATAGATTCACACCTCAAG -3'
(R):5'- CTGTGCAAGAGATGAGCAGC -3'

Sequencing Primer
(F):5'- TGATAGATTCACACCTCAAGACACC -3'
(R):5'- CAGCAAGGGGGAGGAGTCAC -3'
Posted On 2015-04-02