Incidental Mutation 'R3499:Or10d1c'
ID 273707
Institutional Source Beutler Lab
Gene Symbol Or10d1c
Ensembl Gene ENSMUSG00000057424
Gene Name olfactory receptor family 10 subfamily D member 1C
Synonyms GA_x6K02T2PVTD-32678895-32677963, Olfr934, MOR224-6
MMRRC Submission 040662-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R3499 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 38893406-38894338 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 38893761 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 193 (L193P)
Ref Sequence ENSEMBL: ENSMUSP00000150864 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074211] [ENSMUST00000214324] [ENSMUST00000216238] [ENSMUST00000216823]
AlphaFold Q9EQ87
Predicted Effect probably damaging
Transcript: ENSMUST00000074211
AA Change: L193P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000073835
Gene: ENSMUSG00000057424
AA Change: L193P

DomainStartEndE-ValueType
Pfam:7tm_4 29 304 1.7e-48 PFAM
Pfam:7TM_GPCR_Srsx 33 222 7.2e-9 PFAM
Pfam:7tm_1 39 286 5.4e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214324
AA Change: L193P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably benign
Transcript: ENSMUST00000216238
Predicted Effect probably damaging
Transcript: ENSMUST00000216823
AA Change: L193P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.7%
  • 20x: 96.3%
Validation Efficiency 100% (46/46)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6430571L13Rik A T 9: 107,219,678 (GRCm39) T44S probably damaging Het
Cass4 C T 2: 172,274,478 (GRCm39) P753L probably damaging Het
Cimip3 AC A 17: 47,744,348 (GRCm39) probably benign Het
Ctif A T 18: 75,744,828 (GRCm39) L92Q possibly damaging Het
Dnah11 C A 12: 117,874,758 (GRCm39) D4036Y probably damaging Het
Dnah17 C T 11: 117,971,675 (GRCm39) probably benign Het
Dnah6 G C 6: 73,009,616 (GRCm39) A3725G probably benign Het
Ebag9 A G 15: 44,493,528 (GRCm39) N117D probably benign Het
Elf4 C T X: 47,507,942 (GRCm39) E158K probably benign Het
Ephb6 C T 6: 41,593,093 (GRCm39) R444* probably null Het
Fcgbpl1 T A 7: 27,853,980 (GRCm39) I1648K probably benign Het
Fndc1 C T 17: 7,972,416 (GRCm39) M1505I possibly damaging Het
Gpr35 A G 1: 92,911,113 (GRCm39) Y275C probably damaging Het
Hmcn1 A T 1: 150,480,853 (GRCm39) I4441N probably damaging Het
Kif13a T C 13: 46,978,815 (GRCm39) D195G probably damaging Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Ksr2 C A 5: 117,827,640 (GRCm39) T473K probably damaging Het
Kxd1 T C 8: 70,966,632 (GRCm39) probably null Het
Lyplal1 A G 1: 185,820,857 (GRCm39) S197P possibly damaging Het
Macf1 A T 4: 123,421,098 (GRCm39) L52* probably null Het
Mrgprb5 A G 7: 47,818,661 (GRCm39) S25P probably benign Het
Nucb1 T C 7: 45,148,300 (GRCm39) H171R probably benign Het
Or4a15 A T 2: 89,193,294 (GRCm39) F160I probably benign Het
Or56b35 G A 7: 104,963,607 (GRCm39) C132Y probably damaging Het
Or8h8 A G 2: 86,753,373 (GRCm39) F168L possibly damaging Het
Or8k18 A G 2: 86,085,185 (GRCm39) M284T possibly damaging Het
Prkdc A T 16: 15,585,889 (GRCm39) I2476F probably damaging Het
Ptprf A T 4: 118,082,127 (GRCm39) I1037N probably damaging Het
Ralgapa1 T G 12: 55,741,928 (GRCm39) probably benign Het
Ranbp17 GCCTGGATACTGACC GCC 11: 33,169,203 (GRCm39) probably benign Het
Sla2 G A 2: 156,717,862 (GRCm39) R137C probably damaging Het
Slc28a3 C T 13: 58,721,253 (GRCm39) probably benign Het
Slc44a4 A G 17: 35,140,656 (GRCm39) D283G probably benign Het
Slc6a9 A G 4: 117,714,000 (GRCm39) I105V probably benign Het
Smgc A G 15: 91,726,206 (GRCm39) T51A possibly damaging Het
Smyd5 T A 6: 85,415,172 (GRCm39) L60H probably damaging Het
Spred1 A T 2: 117,005,867 (GRCm39) M210L probably benign Het
Syne2 G A 12: 76,101,752 (GRCm39) probably null Het
Tab3 T C X: 84,658,727 (GRCm39) I418T probably benign Het
Tbc1d12 A T 19: 38,884,478 (GRCm39) E343V possibly damaging Het
Tktl2 T A 8: 66,965,897 (GRCm39) I485N probably damaging Het
Tmem181a T A 17: 6,330,894 (GRCm39) Y51* probably null Het
Tmem229b-ps C T 10: 53,351,223 (GRCm39) noncoding transcript Het
Trip11 A G 12: 101,859,953 (GRCm39) I307T possibly damaging Het
Ttf1 T C 2: 28,955,499 (GRCm39) S288P possibly damaging Het
Zfp395 G T 14: 65,628,742 (GRCm39) R198L possibly damaging Het
Other mutations in Or10d1c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02156:Or10d1c APN 9 38,893,842 (GRCm39) missense possibly damaging 0.71
R1061:Or10d1c UTSW 9 38,893,779 (GRCm39) missense probably damaging 1.00
R1604:Or10d1c UTSW 9 38,893,914 (GRCm39) missense probably benign 0.01
R1776:Or10d1c UTSW 9 38,894,190 (GRCm39) missense probably damaging 1.00
R3761:Or10d1c UTSW 9 38,893,662 (GRCm39) missense possibly damaging 0.94
R3876:Or10d1c UTSW 9 38,894,166 (GRCm39) missense probably damaging 1.00
R4191:Or10d1c UTSW 9 38,894,313 (GRCm39) missense probably benign 0.01
R4192:Or10d1c UTSW 9 38,894,313 (GRCm39) missense probably benign 0.01
R4333:Or10d1c UTSW 9 38,893,884 (GRCm39) missense possibly damaging 0.85
R4876:Or10d1c UTSW 9 38,893,922 (GRCm39) nonsense probably null
R5539:Or10d1c UTSW 9 38,893,573 (GRCm39) missense possibly damaging 0.85
R6916:Or10d1c UTSW 9 38,894,200 (GRCm39) missense probably benign 0.14
R7097:Or10d1c UTSW 9 38,893,914 (GRCm39) missense probably benign 0.01
R7338:Or10d1c UTSW 9 38,893,816 (GRCm39) missense probably damaging 0.99
R8116:Or10d1c UTSW 9 38,894,169 (GRCm39) missense probably damaging 1.00
R9350:Or10d1c UTSW 9 38,894,081 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- GAACTGCTGCATTAAGCCAGG -3'
(R):5'- CAAAGTGTGTGCCATCATGG -3'

Sequencing Primer
(F):5'- CTGCTGCATTAAGCCAGGGATTG -3'
(R):5'- CATCATGGCTGTGGGGACATC -3'
Posted On 2015-04-02