Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00901:Cfap69'

27381

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cfap69

Ensembl Gene

ENSMUSG00000040473

Gene Name

cilia and flagella associated protein 69

Synonyms

A330021E22Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00901

Quality Score

Status

Chromosome

Chromosomal Location

5629284-5714232 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 5669162 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000143393 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000054865] [ENSMUST00000061008] [ENSMUST00000132510] [ENSMUST00000135252] [ENSMUST00000148347] [ENSMUST00000196165]

AlphaFold

Q8BH53

Predicted Effect

probably benign
Transcript: ENSMUST00000054865

SMART Domains

Protein: ENSMUSP00000053206
Gene: ENSMUSG00000040473

Domain	Start	End	E-Value	Type
low complexity region	2	16	N/A	INTRINSIC
low complexity region	847	860	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000061008

SMART Domains

Protein: ENSMUSP00000051741
Gene: ENSMUSG00000040473

Domain	Start	End	E-Value	Type
low complexity region	2	16	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000132510

SMART Domains

Protein: ENSMUSP00000122569
Gene: ENSMUSG00000040473

Domain	Start	End	E-Value	Type
low complexity region	2	16	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000135252

SMART Domains

Protein: ENSMUSP00000117518
Gene: ENSMUSG00000040473

Domain	Start	End	E-Value	Type
low complexity region	2	16	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000148347

SMART Domains

Protein: ENSMUSP00000119944
Gene: ENSMUSG00000040473

Domain	Start	End	E-Value	Type
low complexity region	383	396	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000196165

SMART Domains

Protein: ENSMUSP00000143393
Gene: ENSMUSG00000040473

Domain	Start	End	E-Value	Type
low complexity region	2	16	N/A	INTRINSIC
low complexity region	676	689	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000199314

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit faster response kinetics and stimuli integration to olfactory stimulation and impaired olfaction a buried food pellet test with a background of the same odor. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acot6	A	G	12: 84,153,250 (GRCm39)	Y164C	probably benign	Het
Anpep	A	G	7: 79,489,171 (GRCm39)	S334P	probably benign	Het
Arhgef1	A	G	7: 24,612,118 (GRCm39)	E129G	probably damaging	Het
Bmt2	G	T	6: 13,628,748 (GRCm39)	H312N	probably damaging	Het
Brme1	A	G	8: 84,893,400 (GRCm39)	D189G	probably damaging	Het
Ces2g	A	G	8: 105,691,761 (GRCm39)	Y272C	probably benign	Het
Cftr	T	C	6: 18,268,429 (GRCm39)		probably null	Het
Clec2g	A	G	6: 128,925,655 (GRCm39)		probably benign	Het
Cyp2b9	A	T	7: 25,897,930 (GRCm39)	I245F	probably damaging	Het
Fbxo6	T	A	4: 148,230,600 (GRCm39)	I221F	probably damaging	Het
Fbxw21	A	C	9: 108,985,467 (GRCm39)	C104G	probably benign	Het
Flna	A	G	X: 73,273,534 (GRCm39)	S101P	probably damaging	Het
Hnrnpm	C	A	17: 33,868,876 (GRCm39)	R517L	probably damaging	Het
Ift88	T	A	14: 57,681,902 (GRCm39)	F229I	probably damaging	Het
Map2k3	T	C	11: 60,832,747 (GRCm39)	S31P	probably benign	Het
Mia2	A	G	12: 59,154,815 (GRCm39)	D176G	probably damaging	Het
Or12d2	T	G	17: 37,624,598 (GRCm39)	K226Q	possibly damaging	Het
Or12e10	A	G	2: 87,640,992 (GRCm39)	Y276C	probably damaging	Het
Or14j6	T	A	17: 38,215,148 (GRCm39)	V237D	probably damaging	Het
Pde7b	C	T	10: 20,494,875 (GRCm39)		probably null	Het
Polr3b	T	C	10: 84,467,660 (GRCm39)	I80T	possibly damaging	Het
Prpf4b	T	A	13: 35,078,465 (GRCm39)	Y692N	probably damaging	Het
Rabl2	T	C	15: 89,474,473 (GRCm39)		probably benign	Het
Rasgrp1	T	C	2: 117,115,611 (GRCm39)	K659R	probably damaging	Het
Ryr3	A	T	2: 112,716,934 (GRCm39)	S774T	probably damaging	Het
Sema5b	C	T	16: 35,471,685 (GRCm39)	T426M	probably damaging	Het
Serpinb10	A	G	1: 107,468,726 (GRCm39)	K123R	probably benign	Het
Slc33a1	T	C	3: 63,871,433 (GRCm39)	D60G	probably benign	Het
Tnks	A	T	8: 35,305,549 (GRCm39)	Y92*	probably null	Het
Tvp23b	T	A	11: 62,774,606 (GRCm39)		probably benign	Het
Wnk1	T	A	6: 119,937,669 (GRCm39)	Q1218L	probably damaging	Het

Other mutations in Cfap69

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Cfap69	APN	5	5,634,682 (GRCm39)	missense	probably damaging	1.00
IGL00234:Cfap69	APN	5	5,667,295 (GRCm39)	missense	probably benign	0.03
IGL00658:Cfap69	APN	5	5,675,857 (GRCm39)	missense	probably damaging	1.00
IGL01410:Cfap69	APN	5	5,696,979 (GRCm39)	missense	probably damaging	1.00
IGL01415:Cfap69	APN	5	5,696,979 (GRCm39)	missense	probably damaging	1.00
IGL01839:Cfap69	APN	5	5,676,027 (GRCm39)	nonsense	probably null
IGL01993:Cfap69	APN	5	5,631,284 (GRCm39)	missense	probably damaging	0.99
IGL02821:Cfap69	APN	5	5,714,017 (GRCm39)	missense	probably benign	0.01
IGL03212:Cfap69	APN	5	5,707,849 (GRCm39)	critical splice acceptor site	probably null
IGL03339:Cfap69	APN	5	5,636,436 (GRCm39)	splice site	probably benign
IGL03052:Cfap69	UTSW	5	5,639,206 (GRCm39)	missense	probably damaging	0.97
R0049:Cfap69	UTSW	5	5,663,734 (GRCm39)	missense	probably benign	0.45
R0049:Cfap69	UTSW	5	5,663,734 (GRCm39)	missense	probably benign	0.45
R0387:Cfap69	UTSW	5	5,639,303 (GRCm39)	missense	probably damaging	0.98
R0433:Cfap69	UTSW	5	5,699,853 (GRCm39)	missense	probably damaging	0.99
R0690:Cfap69	UTSW	5	5,713,951 (GRCm39)	missense	probably damaging	0.99
R0702:Cfap69	UTSW	5	5,694,465 (GRCm39)	missense	probably benign	0.27
R0718:Cfap69	UTSW	5	5,671,924 (GRCm39)	missense	probably damaging	1.00
R1525:Cfap69	UTSW	5	5,690,230 (GRCm39)	splice site	probably null
R1670:Cfap69	UTSW	5	5,636,409 (GRCm39)	missense	probably benign	0.27
R1677:Cfap69	UTSW	5	5,632,457 (GRCm39)	missense	probably damaging	1.00
R1857:Cfap69	UTSW	5	5,632,518 (GRCm39)	missense	possibly damaging	0.92
R1916:Cfap69	UTSW	5	5,713,970 (GRCm39)	missense	probably damaging	0.99
R1937:Cfap69	UTSW	5	5,643,818 (GRCm39)	missense	probably damaging	1.00
R2029:Cfap69	UTSW	5	5,654,306 (GRCm39)	missense	probably damaging	1.00
R2106:Cfap69	UTSW	5	5,645,979 (GRCm39)	missense	probably benign	0.05
R2177:Cfap69	UTSW	5	5,675,803 (GRCm39)	missense	probably damaging	1.00
R2261:Cfap69	UTSW	5	5,646,018 (GRCm39)	missense	probably damaging	0.99
R2939:Cfap69	UTSW	5	5,694,432 (GRCm39)	missense	probably damaging	0.99
R3706:Cfap69	UTSW	5	5,663,843 (GRCm39)	nonsense	probably null
R3876:Cfap69	UTSW	5	5,634,645 (GRCm39)	splice site	probably benign
R3893:Cfap69	UTSW	5	5,631,245 (GRCm39)	missense	probably damaging	1.00
R4033:Cfap69	UTSW	5	5,654,389 (GRCm39)	missense	possibly damaging	0.87
R4760:Cfap69	UTSW	5	5,696,939 (GRCm39)	missense	probably damaging	1.00
R4787:Cfap69	UTSW	5	5,696,934 (GRCm39)	critical splice donor site	probably null
R4932:Cfap69	UTSW	5	5,675,820 (GRCm39)	missense	probably damaging	1.00
R5215:Cfap69	UTSW	5	5,639,133 (GRCm39)	missense	possibly damaging	0.82
R5258:Cfap69	UTSW	5	5,654,271 (GRCm39)	splice site	probably null
R5596:Cfap69	UTSW	5	5,676,020 (GRCm39)	missense	probably damaging	1.00
R5673:Cfap69	UTSW	5	5,646,027 (GRCm39)	missense	possibly damaging	0.66
R5752:Cfap69	UTSW	5	5,639,204 (GRCm39)	missense	probably damaging	1.00
R5933:Cfap69	UTSW	5	5,690,183 (GRCm39)	missense	probably damaging	1.00
R6148:Cfap69	UTSW	5	5,713,996 (GRCm39)	missense	probably benign	0.03
R6511:Cfap69	UTSW	5	5,667,220 (GRCm39)	missense	probably damaging	0.98
R6550:Cfap69	UTSW	5	5,631,220 (GRCm39)	missense	probably benign	0.03
R6870:Cfap69	UTSW	5	5,671,958 (GRCm39)	missense	probably benign	0.26
R7455:Cfap69	UTSW	5	5,675,873 (GRCm39)	missense	possibly damaging	0.92
R7544:Cfap69	UTSW	5	5,645,936 (GRCm39)	missense	not run
R7547:Cfap69	UTSW	5	5,654,290 (GRCm39)	missense	possibly damaging	0.88
R7787:Cfap69	UTSW	5	5,639,260 (GRCm39)	missense	probably damaging	1.00
R8049:Cfap69	UTSW	5	5,669,085 (GRCm39)	intron	probably benign
R8110:Cfap69	UTSW	5	5,632,515 (GRCm39)	missense	possibly damaging	0.79
R8128:Cfap69	UTSW	5	5,646,034 (GRCm39)	missense	probably benign
R8306:Cfap69	UTSW	5	5,654,287 (GRCm39)	missense	probably benign	0.01
R9028:Cfap69	UTSW	5	5,696,958 (GRCm39)	missense	probably benign	0.02
R9106:Cfap69	UTSW	5	5,690,190 (GRCm39)	missense	possibly damaging	0.92
R9179:Cfap69	UTSW	5	5,676,064 (GRCm39)	missense	probably benign	0.30
R9199:Cfap69	UTSW	5	5,668,952 (GRCm39)	missense	possibly damaging	0.87
R9422:Cfap69	UTSW	5	5,699,851 (GRCm39)	missense	probably benign	0.00
R9585:Cfap69	UTSW	5	5,631,269 (GRCm39)	missense	possibly damaging	0.52
R9617:Cfap69	UTSW	5	5,639,164 (GRCm39)	missense	probably damaging	1.00
R9674:Cfap69	UTSW	5	5,697,021 (GRCm39)	missense	possibly damaging	0.68
R9697:Cfap69	UTSW	5	5,676,041 (GRCm39)	missense	possibly damaging	0.60
X0010:Cfap69	UTSW	5	5,694,503 (GRCm39)	splice site	probably null
Z1177:Cfap69	UTSW	5	5,636,384 (GRCm39)	missense	possibly damaging	0.94

Posted On

2013-04-17