Incidental Mutation 'R3829:Vmn2r91'
ID 273917
Institutional Source Beutler Lab
Gene Symbol Vmn2r91
Ensembl Gene ENSMUSG00000091206
Gene Name vomeronasal 2, receptor 91
Synonyms EG665210
MMRRC Submission 040776-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R3829 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 18305319-18356905 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 18325759 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Glycine at position 126 (W126G)
Ref Sequence ENSEMBL: ENSMUSP00000127465 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000172359]
AlphaFold E9Q2U5
Predicted Effect probably damaging
Transcript: ENSMUST00000172359
AA Change: W126G

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000127465
Gene: ENSMUSG00000091206
AA Change: W126G

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:ANF_receptor 83 462 2.2e-38 PFAM
Pfam:NCD3G 510 564 6.7e-20 PFAM
Pfam:7tm_3 597 832 2.1e-53 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.7%
  • 20x: 96.1%
Validation Efficiency 100% (54/54)
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931414P19Rik G T 14: 54,821,966 (GRCm39) H466Q probably damaging Het
4933411K16Rik A T 19: 42,041,322 (GRCm39) H151L probably damaging Het
A330008L17Rik A G 8: 100,148,389 (GRCm39) noncoding transcript Het
Abcc5 C A 16: 20,184,615 (GRCm39) V1015L probably benign Het
Bach2 T A 4: 32,563,150 (GRCm39) L539H probably damaging Het
Birc6 A G 17: 74,962,173 (GRCm39) K3929R probably damaging Het
C1qtnf2 A G 11: 43,382,148 (GRCm39) D320G probably benign Het
Cbr2 A T 11: 120,621,278 (GRCm39) H140Q probably benign Het
Cbs T C 17: 31,836,355 (GRCm39) probably benign Het
Cdc42bpg T C 19: 6,367,675 (GRCm39) V1015A probably damaging Het
Cep104 T G 4: 154,069,400 (GRCm39) M207R probably damaging Het
Chil6 A T 3: 106,313,274 (GRCm39) M25K probably benign Het
Cln5 A G 14: 103,310,795 (GRCm39) D154G probably damaging Het
Col4a1 C A 8: 11,259,650 (GRCm39) G1341V probably damaging Het
Commd9 C A 2: 101,727,486 (GRCm39) N93K probably benign Het
Cplane2 C T 4: 140,945,900 (GRCm39) R148C probably damaging Het
Cx3cl1 A T 8: 95,503,934 (GRCm39) probably benign Het
Cyct T C 2: 76,184,512 (GRCm39) K80E probably damaging Het
Dhx37 T C 5: 125,508,677 (GRCm39) K86R probably benign Het
Dnah17 G A 11: 117,931,984 (GRCm39) probably benign Het
Etl4 T C 2: 20,790,232 (GRCm39) V628A probably benign Het
Fam234a T C 17: 26,437,163 (GRCm39) E172G probably benign Het
Foxp2 C T 6: 15,379,830 (GRCm39) probably benign Het
Frem1 A T 4: 82,917,167 (GRCm39) F592Y probably damaging Het
Gm10259 T G 3: 25,266,693 (GRCm39) noncoding transcript Het
Gm17521 C A X: 121,938,922 (GRCm39) G149C unknown Het
Gpat4 G A 8: 23,670,171 (GRCm39) P286L probably damaging Het
Grpel1 T A 5: 36,626,827 (GRCm39) N36K probably benign Het
Hap1 G T 11: 100,246,847 (GRCm39) D19E probably damaging Het
Lpcat1 T C 13: 73,637,212 (GRCm39) I114T possibly damaging Het
Mast4 G T 13: 102,875,319 (GRCm39) H1350N probably damaging Het
Mrpl50 T C 4: 49,514,539 (GRCm39) E44G probably damaging Het
Myg1 G C 15: 102,246,171 (GRCm39) G349R probably damaging Het
Myh1 A G 11: 67,096,423 (GRCm39) I301V probably benign Het
Ncapg2 A T 12: 116,370,938 (GRCm39) probably benign Het
Ncor2 T C 5: 125,195,756 (GRCm39) probably benign Het
Neo1 A G 9: 58,820,452 (GRCm39) Y824H possibly damaging Het
Or1o4 T A 17: 37,591,140 (GRCm39) Y57F probably damaging Het
Orc1 T A 4: 108,462,828 (GRCm39) M635K probably damaging Het
Phip A G 9: 82,753,698 (GRCm39) I1682T probably benign Het
Ppp2r1b A G 9: 50,773,794 (GRCm39) N223S probably benign Het
Ralb A T 1: 119,399,447 (GRCm39) C204S probably benign Het
Rgs12 G A 5: 35,123,359 (GRCm39) V381M possibly damaging Het
Rtkn2 A T 10: 67,833,456 (GRCm39) probably null Het
Srrm3 A G 5: 135,886,068 (GRCm39) D336G probably damaging Het
Stk11 T C 10: 79,963,782 (GRCm39) probably null Het
Svep1 A G 4: 58,096,177 (GRCm39) L1481P probably damaging Het
Tiam2 C G 17: 3,557,976 (GRCm39) probably benign Het
Tmem59l A G 8: 70,939,951 (GRCm39) L6S unknown Het
Tmprss11b T C 5: 86,809,449 (GRCm39) T348A probably damaging Het
Ube3b C A 5: 114,538,012 (GRCm39) Q368K probably damaging Het
Veph1 T A 3: 66,066,748 (GRCm39) E413D possibly damaging Het
Yrdc T A 4: 124,745,554 (GRCm39) M1K probably null Het
Zfp445 T C 9: 122,682,142 (GRCm39) M600V probably benign Het
Other mutations in Vmn2r91
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00983:Vmn2r91 APN 17 18,325,820 (GRCm39) missense probably benign 0.00
IGL01121:Vmn2r91 APN 17 18,356,766 (GRCm39) missense possibly damaging 0.94
IGL01464:Vmn2r91 APN 17 18,327,864 (GRCm39) missense probably null 0.00
IGL02003:Vmn2r91 APN 17 18,327,921 (GRCm39) missense probably benign
IGL02709:Vmn2r91 APN 17 18,325,711 (GRCm39) missense possibly damaging 0.74
IGL02795:Vmn2r91 APN 17 18,305,539 (GRCm39) missense probably benign 0.01
IGL02813:Vmn2r91 APN 17 18,356,348 (GRCm39) missense possibly damaging 0.91
IGL02830:Vmn2r91 APN 17 18,356,884 (GRCm39) missense probably benign 0.01
IGL03130:Vmn2r91 APN 17 18,330,373 (GRCm39) splice site probably benign
BB006:Vmn2r91 UTSW 17 18,327,906 (GRCm39) missense probably damaging 1.00
BB016:Vmn2r91 UTSW 17 18,327,906 (GRCm39) missense probably damaging 1.00
R0164:Vmn2r91 UTSW 17 18,326,399 (GRCm39) missense probably benign 0.00
R0164:Vmn2r91 UTSW 17 18,326,399 (GRCm39) missense probably benign 0.00
R0393:Vmn2r91 UTSW 17 18,325,712 (GRCm39) missense probably damaging 1.00
R1142:Vmn2r91 UTSW 17 18,356,705 (GRCm39) missense probably damaging 1.00
R1603:Vmn2r91 UTSW 17 18,326,405 (GRCm39) missense probably benign 0.04
R1992:Vmn2r91 UTSW 17 18,356,142 (GRCm39) missense probably damaging 1.00
R2182:Vmn2r91 UTSW 17 18,325,691 (GRCm39) missense possibly damaging 0.94
R2424:Vmn2r91 UTSW 17 18,356,431 (GRCm39) nonsense probably null
R2512:Vmn2r91 UTSW 17 18,356,048 (GRCm39) missense probably benign
R2885:Vmn2r91 UTSW 17 18,325,628 (GRCm39) missense probably benign 0.00
R2909:Vmn2r91 UTSW 17 18,356,661 (GRCm39) missense probably damaging 1.00
R3009:Vmn2r91 UTSW 17 18,325,717 (GRCm39) missense probably benign 0.11
R3079:Vmn2r91 UTSW 17 18,355,973 (GRCm39) splice site probably null
R3080:Vmn2r91 UTSW 17 18,355,973 (GRCm39) splice site probably null
R3434:Vmn2r91 UTSW 17 18,330,370 (GRCm39) splice site probably benign
R3723:Vmn2r91 UTSW 17 18,305,540 (GRCm39) critical splice donor site probably null
R3845:Vmn2r91 UTSW 17 18,327,860 (GRCm39) missense probably benign 0.00
R3846:Vmn2r91 UTSW 17 18,327,860 (GRCm39) missense probably benign 0.00
R4118:Vmn2r91 UTSW 17 18,330,358 (GRCm39) missense probably damaging 1.00
R4285:Vmn2r91 UTSW 17 18,356,030 (GRCm39) missense probably benign 0.00
R4729:Vmn2r91 UTSW 17 18,327,906 (GRCm39) missense probably damaging 1.00
R4793:Vmn2r91 UTSW 17 18,325,658 (GRCm39) missense probably damaging 1.00
R4932:Vmn2r91 UTSW 17 18,356,751 (GRCm39) missense possibly damaging 0.84
R5016:Vmn2r91 UTSW 17 18,330,322 (GRCm39) nonsense probably null
R5018:Vmn2r91 UTSW 17 18,356,700 (GRCm39) missense probably damaging 1.00
R5605:Vmn2r91 UTSW 17 18,356,763 (GRCm39) missense probably damaging 1.00
R5815:Vmn2r91 UTSW 17 18,326,464 (GRCm39) missense probably benign 0.01
R6146:Vmn2r91 UTSW 17 18,356,518 (GRCm39) missense probably benign 0.07
R6187:Vmn2r91 UTSW 17 18,326,888 (GRCm39) missense probably benign 0.05
R6426:Vmn2r91 UTSW 17 18,355,865 (GRCm39) splice site probably null
R6450:Vmn2r91 UTSW 17 18,305,527 (GRCm39) missense probably damaging 0.98
R6767:Vmn2r91 UTSW 17 18,327,807 (GRCm39) missense probably damaging 0.98
R6986:Vmn2r91 UTSW 17 18,356,271 (GRCm39) missense probably benign 0.10
R7112:Vmn2r91 UTSW 17 18,325,880 (GRCm39) missense possibly damaging 0.83
R7178:Vmn2r91 UTSW 17 18,356,424 (GRCm39) missense probably damaging 1.00
R7330:Vmn2r91 UTSW 17 18,326,429 (GRCm39) missense probably damaging 1.00
R7368:Vmn2r91 UTSW 17 18,356,540 (GRCm39) missense possibly damaging 0.75
R7380:Vmn2r91 UTSW 17 18,356,838 (GRCm39) nonsense probably null
R7397:Vmn2r91 UTSW 17 18,356,060 (GRCm39) missense probably benign 0.02
R7625:Vmn2r91 UTSW 17 18,325,693 (GRCm39) missense probably damaging 1.00
R7739:Vmn2r91 UTSW 17 18,356,080 (GRCm39) missense probably benign 0.00
R7749:Vmn2r91 UTSW 17 18,356,540 (GRCm39) missense possibly damaging 0.75
R7755:Vmn2r91 UTSW 17 18,330,311 (GRCm39) missense possibly damaging 0.88
R7929:Vmn2r91 UTSW 17 18,327,906 (GRCm39) missense probably damaging 1.00
R7981:Vmn2r91 UTSW 17 18,327,887 (GRCm39) missense probably benign 0.02
R8211:Vmn2r91 UTSW 17 18,326,762 (GRCm39) missense probably damaging 1.00
R8325:Vmn2r91 UTSW 17 18,356,625 (GRCm39) missense probably damaging 1.00
R8781:Vmn2r91 UTSW 17 18,305,323 (GRCm39) missense possibly damaging 0.78
R8974:Vmn2r91 UTSW 17 18,325,636 (GRCm39) missense probably benign 0.27
R9047:Vmn2r91 UTSW 17 18,326,296 (GRCm39) missense probably benign 0.00
R9048:Vmn2r91 UTSW 17 18,356,122 (GRCm39) missense probably benign 0.00
R9109:Vmn2r91 UTSW 17 18,327,905 (GRCm39) missense probably damaging 1.00
R9211:Vmn2r91 UTSW 17 18,356,819 (GRCm39) nonsense probably null
R9555:Vmn2r91 UTSW 17 18,325,792 (GRCm39) missense possibly damaging 0.78
R9616:Vmn2r91 UTSW 17 18,356,305 (GRCm39) missense possibly damaging 0.81
Predicted Primers PCR Primer
(F):5'- TGTGGCATATTTGGTCATCCTC -3'
(R):5'- ACCTGGCTCATTGACAACAC -3'

Sequencing Primer
(F):5'- GGCATATTTGGTCATCCTCTTATG -3'
(R):5'- ATCACTCTTTCCATTTAAAGACACC -3'
Posted On 2015-04-02