Incidental Mutation 'R3813:Or5d35'
ID 274130
Institutional Source Beutler Lab
Gene Symbol Or5d35
Ensembl Gene ENSMUSG00000045150
Gene Name olfactory receptor family 5 subfamily D member 35
Synonyms MOR174-2, GA_x6K02T2Q125-49516664-49517629, Olfr1161
Accession Numbers
Essential gene? Probably non essential (E-score: 0.111) question?
Stock # R3813 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 87855046-87856057 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87855105 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 13 (F13S)
Ref Sequence ENSEMBL: ENSMUSP00000150220 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054845] [ENSMUST00000214438] [ENSMUST00000217006]
AlphaFold Q7TR29
Predicted Effect probably damaging
Transcript: ENSMUST00000054845
AA Change: F13S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000060977
Gene: ENSMUSG00000045150
AA Change: F13S

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 8.8e-52 PFAM
Pfam:7tm_1 42 291 9e-16 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214438
AA Change: F13S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000217006
AA Change: F13S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.5956 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 100% (50/50)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts3 T C 5: 89,825,785 (GRCm39) D1018G possibly damaging Het
Adgrg1 T A 8: 95,738,193 (GRCm39) L562Q probably benign Het
Ankrd11 T C 8: 123,618,117 (GRCm39) T1891A probably benign Het
Arid2 A G 15: 96,267,831 (GRCm39) N648S probably benign Het
B4galt3 C A 1: 171,101,613 (GRCm39) H196N probably damaging Het
Cacna1s A T 1: 136,013,085 (GRCm39) I312F probably damaging Het
Cenpj A G 14: 56,790,679 (GRCm39) S457P probably benign Het
Cep120 G A 18: 53,873,284 (GRCm39) probably benign Het
Cfap70 T A 14: 20,471,190 (GRCm39) I493L possibly damaging Het
Cfap97d1 A T 11: 101,882,314 (GRCm39) R106S probably benign Het
Csmd3 T C 15: 48,655,209 (GRCm39) D31G possibly damaging Het
Cstf3 T C 2: 104,439,466 (GRCm39) Y54H probably damaging Het
Cubn T A 2: 13,299,136 (GRCm39) Y3179F probably damaging Het
Cyp2s1 C T 7: 25,505,291 (GRCm39) probably null Het
Dll4 C A 2: 119,161,510 (GRCm39) T364N possibly damaging Het
Doc2g C T 19: 4,054,466 (GRCm39) probably null Het
Etl4 A G 2: 20,793,246 (GRCm39) E657G probably damaging Het
Fhdc1 A G 3: 84,371,577 (GRCm39) probably null Het
Fndc1 T C 17: 7,992,154 (GRCm39) H514R unknown Het
Gpat3 A G 5: 101,039,505 (GRCm39) probably benign Het
H2-Q4 A G 17: 35,602,071 (GRCm39) H311R possibly damaging Het
Hipk4 T C 7: 27,223,372 (GRCm39) L144S probably damaging Het
Hspa4 G A 11: 53,161,806 (GRCm39) P449S probably benign Het
Kif7 A G 7: 79,363,638 (GRCm39) V90A probably damaging Het
Klhl38 T C 15: 58,185,953 (GRCm39) I259V probably benign Het
Krt9 T A 11: 100,080,503 (GRCm39) E414D probably damaging Het
Lmo2 T C 2: 103,811,407 (GRCm39) Y147H probably damaging Het
Lrp2 G A 2: 69,294,923 (GRCm39) P3465L probably damaging Het
Lrriq1 T C 10: 103,051,972 (GRCm39) E260G probably damaging Het
Macf1 A G 4: 123,268,560 (GRCm39) S4689P probably damaging Het
Manba G A 3: 135,269,023 (GRCm39) E643K possibly damaging Het
Mc3r T A 2: 172,090,799 (GRCm39) L7Q probably benign Het
Mdga1 G A 17: 30,057,453 (GRCm39) P788S probably damaging Het
Or6c70 T A 10: 129,709,855 (GRCm39) Y257F probably damaging Het
Pcdh12 G A 18: 38,416,667 (GRCm39) R153* probably null Het
Plk3 T C 4: 116,990,647 (GRCm39) Y89C probably damaging Het
Prss41 G A 17: 24,056,596 (GRCm39) R160* probably null Het
Rae1 T A 2: 172,848,666 (GRCm39) probably benign Het
Rbm17 T A 2: 11,600,246 (GRCm39) probably benign Het
Recql4 A T 15: 76,588,694 (GRCm39) M1039K possibly damaging Het
Setx GTGGCT GT 2: 29,044,073 (GRCm39) 1814 probably null Het
Slit3 A G 11: 35,566,806 (GRCm39) Y1026C probably damaging Het
Tbl2 T A 5: 135,185,375 (GRCm39) probably null Het
Tex2 G A 11: 106,402,770 (GRCm39) T1034I unknown Het
Tmem241 A T 18: 12,200,167 (GRCm39) probably benign Het
Tmtc1 T C 6: 148,256,389 (GRCm39) probably benign Het
Trappc9 A T 15: 72,930,242 (GRCm39) I38N probably damaging Het
Trmt1 T A 8: 85,421,846 (GRCm39) probably benign Het
Vps37d G A 5: 135,103,304 (GRCm39) Q113* probably null Het
Zup1 T C 10: 33,816,218 (GRCm39) E242G possibly damaging Het
Other mutations in Or5d35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01084:Or5d35 APN 2 87,855,347 (GRCm39) missense probably benign 0.23
IGL01564:Or5d35 APN 2 87,855,648 (GRCm39) missense probably benign 0.00
IGL01588:Or5d35 APN 2 87,855,417 (GRCm39) missense probably benign
R0268:Or5d35 UTSW 2 87,855,812 (GRCm39) missense probably damaging 0.99
R1587:Or5d35 UTSW 2 87,855,477 (GRCm39) missense probably damaging 1.00
R1995:Or5d35 UTSW 2 87,856,016 (GRCm39) missense probably benign 0.06
R2249:Or5d35 UTSW 2 87,855,707 (GRCm39) missense probably damaging 0.98
R4473:Or5d35 UTSW 2 87,855,464 (GRCm39) missense probably damaging 1.00
R4772:Or5d35 UTSW 2 87,855,207 (GRCm39) missense probably damaging 0.99
R4787:Or5d35 UTSW 2 87,855,204 (GRCm39) missense possibly damaging 0.79
R4870:Or5d35 UTSW 2 87,855,804 (GRCm39) missense probably damaging 1.00
R5260:Or5d35 UTSW 2 87,855,818 (GRCm39) missense probably benign 0.02
R5896:Or5d35 UTSW 2 87,855,465 (GRCm39) missense probably damaging 0.98
R6262:Or5d35 UTSW 2 87,855,738 (GRCm39) missense probably benign 0.00
R7330:Or5d35 UTSW 2 87,855,265 (GRCm39) missense possibly damaging 0.59
R8702:Or5d35 UTSW 2 87,855,839 (GRCm39) missense possibly damaging 0.69
R9100:Or5d35 UTSW 2 87,855,330 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AATGTGTGATCTTCGTTTCTCTGACAC -3'
(R):5'- GCATCTTGGGAGCAATGACAG -3'

Sequencing Primer
(F):5'- TCGTTTCTCTGACACACCAAAATC -3'
(R):5'- TGACAGAGGAATAGCAGAAATCCAC -3'
Posted On 2015-04-02