Incidental Mutation 'R3813:Gpat3'
ID 274143
Institutional Source Beutler Lab
Gene Symbol Gpat3
Ensembl Gene ENSMUSG00000029314
Gene Name glycerol-3-phosphate acyltransferase 3
Synonyms 4933407I02Rik, Agpat9, A230097K15Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.140) question?
Stock # R3813 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 100994095-101046968 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 101039505 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000108508 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031255] [ENSMUST00000092990] [ENSMUST00000112887]
AlphaFold Q8C0N2
Predicted Effect probably benign
Transcript: ENSMUST00000031255
SMART Domains Protein: ENSMUSP00000031255
Gene: ENSMUSG00000029314

DomainStartEndE-ValueType
transmembrane domain 10 32 N/A INTRINSIC
Blast:PlsC 99 160 7e-6 BLAST
low complexity region 166 177 N/A INTRINSIC
PlsC 223 334 5.96e-22 SMART
Blast:PlsC 348 396 2e-22 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000092990
SMART Domains Protein: ENSMUSP00000090667
Gene: ENSMUSG00000029314

DomainStartEndE-ValueType
transmembrane domain 10 32 N/A INTRINSIC
Blast:PlsC 99 160 7e-6 BLAST
low complexity region 166 177 N/A INTRINSIC
PlsC 223 334 5.96e-22 SMART
Blast:PlsC 348 396 2e-22 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000112887
SMART Domains Protein: ENSMUSP00000108508
Gene: ENSMUSG00000029314

DomainStartEndE-ValueType
transmembrane domain 10 32 N/A INTRINSIC
Blast:PlsC 99 160 7e-6 BLAST
low complexity region 166 177 N/A INTRINSIC
PlsC 223 334 5.96e-22 SMART
Blast:PlsC 348 396 2e-22 BLAST
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 100% (50/50)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the lysophosphatidic acid acyltransferase protein family. The encoded protein is an enzyme which catalyzes the conversion of glycerol-3-phosphate to lysophosphatidic acid in the synthesis of triacylglycerol. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]
PHENOTYPE: Under high-fat feeding, mice homozygous for a knock-out allele exhibit increased energy expenditure, improved glucose homeostasis, enlarged livers, increased total serum cholesterol levels, altered liver cholesterol metabolism, and female-specific protection from diet-induced obesity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts3 T C 5: 89,825,785 (GRCm39) D1018G possibly damaging Het
Adgrg1 T A 8: 95,738,193 (GRCm39) L562Q probably benign Het
Ankrd11 T C 8: 123,618,117 (GRCm39) T1891A probably benign Het
Arid2 A G 15: 96,267,831 (GRCm39) N648S probably benign Het
B4galt3 C A 1: 171,101,613 (GRCm39) H196N probably damaging Het
Cacna1s A T 1: 136,013,085 (GRCm39) I312F probably damaging Het
Cenpj A G 14: 56,790,679 (GRCm39) S457P probably benign Het
Cep120 G A 18: 53,873,284 (GRCm39) probably benign Het
Cfap70 T A 14: 20,471,190 (GRCm39) I493L possibly damaging Het
Cfap97d1 A T 11: 101,882,314 (GRCm39) R106S probably benign Het
Csmd3 T C 15: 48,655,209 (GRCm39) D31G possibly damaging Het
Cstf3 T C 2: 104,439,466 (GRCm39) Y54H probably damaging Het
Cubn T A 2: 13,299,136 (GRCm39) Y3179F probably damaging Het
Cyp2s1 C T 7: 25,505,291 (GRCm39) probably null Het
Dll4 C A 2: 119,161,510 (GRCm39) T364N possibly damaging Het
Doc2g C T 19: 4,054,466 (GRCm39) probably null Het
Etl4 A G 2: 20,793,246 (GRCm39) E657G probably damaging Het
Fhdc1 A G 3: 84,371,577 (GRCm39) probably null Het
Fndc1 T C 17: 7,992,154 (GRCm39) H514R unknown Het
H2-Q4 A G 17: 35,602,071 (GRCm39) H311R possibly damaging Het
Hipk4 T C 7: 27,223,372 (GRCm39) L144S probably damaging Het
Hspa4 G A 11: 53,161,806 (GRCm39) P449S probably benign Het
Kif7 A G 7: 79,363,638 (GRCm39) V90A probably damaging Het
Klhl38 T C 15: 58,185,953 (GRCm39) I259V probably benign Het
Krt9 T A 11: 100,080,503 (GRCm39) E414D probably damaging Het
Lmo2 T C 2: 103,811,407 (GRCm39) Y147H probably damaging Het
Lrp2 G A 2: 69,294,923 (GRCm39) P3465L probably damaging Het
Lrriq1 T C 10: 103,051,972 (GRCm39) E260G probably damaging Het
Macf1 A G 4: 123,268,560 (GRCm39) S4689P probably damaging Het
Manba G A 3: 135,269,023 (GRCm39) E643K possibly damaging Het
Mc3r T A 2: 172,090,799 (GRCm39) L7Q probably benign Het
Mdga1 G A 17: 30,057,453 (GRCm39) P788S probably damaging Het
Or5d35 T C 2: 87,855,105 (GRCm39) F13S probably damaging Het
Or6c70 T A 10: 129,709,855 (GRCm39) Y257F probably damaging Het
Pcdh12 G A 18: 38,416,667 (GRCm39) R153* probably null Het
Plk3 T C 4: 116,990,647 (GRCm39) Y89C probably damaging Het
Prss41 G A 17: 24,056,596 (GRCm39) R160* probably null Het
Rae1 T A 2: 172,848,666 (GRCm39) probably benign Het
Rbm17 T A 2: 11,600,246 (GRCm39) probably benign Het
Recql4 A T 15: 76,588,694 (GRCm39) M1039K possibly damaging Het
Setx GTGGCT GT 2: 29,044,073 (GRCm39) 1814 probably null Het
Slit3 A G 11: 35,566,806 (GRCm39) Y1026C probably damaging Het
Tbl2 T A 5: 135,185,375 (GRCm39) probably null Het
Tex2 G A 11: 106,402,770 (GRCm39) T1034I unknown Het
Tmem241 A T 18: 12,200,167 (GRCm39) probably benign Het
Tmtc1 T C 6: 148,256,389 (GRCm39) probably benign Het
Trappc9 A T 15: 72,930,242 (GRCm39) I38N probably damaging Het
Trmt1 T A 8: 85,421,846 (GRCm39) probably benign Het
Vps37d G A 5: 135,103,304 (GRCm39) Q113* probably null Het
Zup1 T C 10: 33,816,218 (GRCm39) E242G possibly damaging Het
Other mutations in Gpat3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00848:Gpat3 APN 5 101,041,010 (GRCm39) missense probably benign 0.01
R1429:Gpat3 UTSW 5 101,040,953 (GRCm39) missense probably damaging 0.99
R1539:Gpat3 UTSW 5 101,031,254 (GRCm39) missense probably benign 0.00
R1830:Gpat3 UTSW 5 101,041,046 (GRCm39) missense probably benign
R2030:Gpat3 UTSW 5 101,045,687 (GRCm39) missense probably benign
R2440:Gpat3 UTSW 5 101,005,039 (GRCm39) missense probably benign
R2444:Gpat3 UTSW 5 101,005,039 (GRCm39) missense probably benign
R3039:Gpat3 UTSW 5 101,045,671 (GRCm39) missense possibly damaging 0.75
R3830:Gpat3 UTSW 5 101,032,252 (GRCm39) missense probably benign 0.02
R4636:Gpat3 UTSW 5 101,005,039 (GRCm39) missense probably benign
R4637:Gpat3 UTSW 5 101,005,039 (GRCm39) missense probably benign
R4679:Gpat3 UTSW 5 101,041,322 (GRCm39) missense probably damaging 1.00
R4792:Gpat3 UTSW 5 101,005,039 (GRCm39) missense probably benign
R5229:Gpat3 UTSW 5 101,031,290 (GRCm39) missense probably damaging 1.00
R5661:Gpat3 UTSW 5 101,033,808 (GRCm39) nonsense probably null
R6383:Gpat3 UTSW 5 101,041,010 (GRCm39) missense probably benign 0.01
R8064:Gpat3 UTSW 5 101,039,522 (GRCm39) missense probably benign 0.36
R8234:Gpat3 UTSW 5 101,005,076 (GRCm39) critical splice donor site probably null
R9047:Gpat3 UTSW 5 100,994,788 (GRCm39) missense probably benign 0.00
R9180:Gpat3 UTSW 5 101,032,230 (GRCm39) missense probably benign 0.00
X0023:Gpat3 UTSW 5 101,033,826 (GRCm39) missense possibly damaging 0.88
Predicted Primers PCR Primer
(F):5'- TATGAACACATGGCCGTCC -3'
(R):5'- GCTCTGTGACTCATCAGAAAGC -3'

Sequencing Primer
(F):5'- GCCTGAGCTAATGAGACCTTGTTAC -3'
(R):5'- CAGGAAATGAGAAGATAGCCCCTC -3'
Posted On 2015-04-02