Mutagenetix > Incidental Mutation

Incidental Mutation 'R3813:Prss41'

274172

Institutional Source

Beutler Lab

Gene Symbol

Prss41

Ensembl Gene

ENSMUSG00000024114

Gene Name

serine protease 41

Synonyms

Tessp1, 4931440B09Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

R3813 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

24055759-24063146 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 24056596 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Stop codon at position 160 (R160*)

Ref Sequence

ENSEMBL: ENSMUSP00000120141 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000024926] [ENSMUST00000059906] [ENSMUST00000115444] [ENSMUST00000122936] [ENSMUST00000151797]

AlphaFold

Q920S2

Predicted Effect

probably null
Transcript: ENSMUST00000024926
AA Change: R200*

SMART Domains

Protein: ENSMUSP00000024926
Gene: ENSMUSG00000024114
AA Change: R200*

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Tryp_SPc	52	289	2.48e-79	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000059906

SMART Domains

Protein: ENSMUSP00000059491
Gene: ENSMUSG00000049620

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Tryp_SPc	33	271	9.03e-91	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000115444

SMART Domains

Protein: ENSMUSP00000111104
Gene: ENSMUSG00000049620

Domain	Start	End	E-Value	Type
Tryp_SPc	15	253	4.5e-93	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000122936
AA Change: R160*

SMART Domains

Protein: ENSMUSP00000120141
Gene: ENSMUSG00000024114
AA Change: R160*

Domain	Start	End	E-Value	Type
Tryp_SPc	12	249	2.48e-79	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141788

Predicted Effect

probably benign
Transcript: ENSMUST00000151797

SMART Domains

Protein: ENSMUSP00000122453
Gene: ENSMUSG00000024114

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Tryp_SPc	52	204	2.91e-12	SMART
low complexity region	228	244	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000164140

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.2%
3x: 98.7%
10x: 97.5%
20x: 95.8%

Validation Efficiency

100% (50/50)

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts3	T	C	5: 89,825,785 (GRCm39)	D1018G	possibly damaging	Het
Adgrg1	T	A	8: 95,738,193 (GRCm39)	L562Q	probably benign	Het
Ankrd11	T	C	8: 123,618,117 (GRCm39)	T1891A	probably benign	Het
Arid2	A	G	15: 96,267,831 (GRCm39)	N648S	probably benign	Het
B4galt3	C	A	1: 171,101,613 (GRCm39)	H196N	probably damaging	Het
Cacna1s	A	T	1: 136,013,085 (GRCm39)	I312F	probably damaging	Het
Cenpj	A	G	14: 56,790,679 (GRCm39)	S457P	probably benign	Het
Cep120	G	A	18: 53,873,284 (GRCm39)		probably benign	Het
Cfap70	T	A	14: 20,471,190 (GRCm39)	I493L	possibly damaging	Het
Cfap97d1	A	T	11: 101,882,314 (GRCm39)	R106S	probably benign	Het
Csmd3	T	C	15: 48,655,209 (GRCm39)	D31G	possibly damaging	Het
Cstf3	T	C	2: 104,439,466 (GRCm39)	Y54H	probably damaging	Het
Cubn	T	A	2: 13,299,136 (GRCm39)	Y3179F	probably damaging	Het
Cyp2s1	C	T	7: 25,505,291 (GRCm39)		probably null	Het
Dll4	C	A	2: 119,161,510 (GRCm39)	T364N	possibly damaging	Het
Doc2g	C	T	19: 4,054,466 (GRCm39)		probably null	Het
Etl4	A	G	2: 20,793,246 (GRCm39)	E657G	probably damaging	Het
Fhdc1	A	G	3: 84,371,577 (GRCm39)		probably null	Het
Fndc1	T	C	17: 7,992,154 (GRCm39)	H514R	unknown	Het
Gpat3	A	G	5: 101,039,505 (GRCm39)		probably benign	Het
H2-Q4	A	G	17: 35,602,071 (GRCm39)	H311R	possibly damaging	Het
Hipk4	T	C	7: 27,223,372 (GRCm39)	L144S	probably damaging	Het
Hspa4	G	A	11: 53,161,806 (GRCm39)	P449S	probably benign	Het
Kif7	A	G	7: 79,363,638 (GRCm39)	V90A	probably damaging	Het
Klhl38	T	C	15: 58,185,953 (GRCm39)	I259V	probably benign	Het
Krt9	T	A	11: 100,080,503 (GRCm39)	E414D	probably damaging	Het
Lmo2	T	C	2: 103,811,407 (GRCm39)	Y147H	probably damaging	Het
Lrp2	G	A	2: 69,294,923 (GRCm39)	P3465L	probably damaging	Het
Lrriq1	T	C	10: 103,051,972 (GRCm39)	E260G	probably damaging	Het
Macf1	A	G	4: 123,268,560 (GRCm39)	S4689P	probably damaging	Het
Manba	G	A	3: 135,269,023 (GRCm39)	E643K	possibly damaging	Het
Mc3r	T	A	2: 172,090,799 (GRCm39)	L7Q	probably benign	Het
Mdga1	G	A	17: 30,057,453 (GRCm39)	P788S	probably damaging	Het
Or5d35	T	C	2: 87,855,105 (GRCm39)	F13S	probably damaging	Het
Or6c70	T	A	10: 129,709,855 (GRCm39)	Y257F	probably damaging	Het
Pcdh12	G	A	18: 38,416,667 (GRCm39)	R153*	probably null	Het
Plk3	T	C	4: 116,990,647 (GRCm39)	Y89C	probably damaging	Het
Rae1	T	A	2: 172,848,666 (GRCm39)		probably benign	Het
Rbm17	T	A	2: 11,600,246 (GRCm39)		probably benign	Het
Recql4	A	T	15: 76,588,694 (GRCm39)	M1039K	possibly damaging	Het
Setx	GTGGCT	GT	2: 29,044,073 (GRCm39)	1814	probably null	Het
Slit3	A	G	11: 35,566,806 (GRCm39)	Y1026C	probably damaging	Het
Tbl2	T	A	5: 135,185,375 (GRCm39)		probably null	Het
Tex2	G	A	11: 106,402,770 (GRCm39)	T1034I	unknown	Het
Tmem241	A	T	18: 12,200,167 (GRCm39)		probably benign	Het
Tmtc1	T	C	6: 148,256,389 (GRCm39)		probably benign	Het
Trappc9	A	T	15: 72,930,242 (GRCm39)	I38N	probably damaging	Het
Trmt1	T	A	8: 85,421,846 (GRCm39)		probably benign	Het
Vps37d	G	A	5: 135,103,304 (GRCm39)	Q113*	probably null	Het
Zup1	T	C	10: 33,816,218 (GRCm39)	E242G	possibly damaging	Het

Other mutations in Prss41

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02215:Prss41	APN	17	24,062,830 (GRCm39)	missense	probably benign	0.01
IGL03031:Prss41	APN	17	24,061,396 (GRCm39)	missense	probably damaging	1.00
IGL03131:Prss41	APN	17	24,061,498 (GRCm39)	missense	probably benign	0.00
FR4737:Prss41	UTSW	17	24,063,071 (GRCm39)	small deletion	probably benign
R0491:Prss41	UTSW	17	24,061,477 (GRCm39)	missense	possibly damaging	0.91
R2014:Prss41	UTSW	17	24,056,464 (GRCm39)	critical splice donor site	probably null
R4888:Prss41	UTSW	17	24,055,977 (GRCm39)	missense	probably benign	0.08
R5707:Prss41	UTSW	17	24,061,390 (GRCm39)	missense	probably benign	0.00
R6904:Prss41	UTSW	17	24,056,622 (GRCm39)	missense	probably benign	0.15
R7486:Prss41	UTSW	17	24,063,072 (GRCm39)	small deletion	probably benign
R7782:Prss41	UTSW	17	24,056,087 (GRCm39)	missense	probably benign	0.40
R8087:Prss41	UTSW	17	24,056,076 (GRCm39)	missense	probably damaging	1.00
R8141:Prss41	UTSW	17	24,056,607 (GRCm39)	missense	probably damaging	1.00
R9189:Prss41	UTSW	17	24,061,361 (GRCm39)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- TCTCCAGCCTGAAGTGAAGGAG -3'
(R):5'- CTCTTGCCCTTAAGAGTAGAGG -3'

Sequencing Primer
(F):5'- CCTGAAGTGAAGGAGAGGGG -3'
(R):5'- CTTGCCCTTAAGAGTAGAGGAGGTC -3'

Posted On

2015-04-02