Incidental Mutation 'R3766:Psg26'
ID 274706
Institutional Source Beutler Lab
Gene Symbol Psg26
Ensembl Gene ENSMUSG00000070799
Gene Name pregnancy-specific beta-1-glycoprotein 26
Synonyms EG574429, cea14
MMRRC Submission 040743-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.048) question?
Stock # R3766 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 18208507-18218102 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 18208996 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 471 (T471A)
Ref Sequence ENSEMBL: ENSMUSP00000092392 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094798]
AlphaFold Q4KL65
Predicted Effect probably benign
Transcript: ENSMUST00000094798
AA Change: T471A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000092392
Gene: ENSMUSG00000070799
AA Change: T471A

DomainStartEndE-ValueType
IG 40 141 4.93e-3 SMART
IG 160 261 2.39e-1 SMART
IG 280 379 6.07e-3 SMART
IGc2 397 461 5.48e-10 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency 98% (41/42)
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aacs C T 5: 125,583,326 (GRCm39) T294M probably damaging Het
Brf2 G T 8: 27,614,496 (GRCm39) T230N possibly damaging Het
Ccne2 A G 4: 11,199,293 (GRCm39) probably benign Het
Crbn T C 6: 106,771,987 (GRCm39) K106E possibly damaging Het
Cttnbp2nl G A 3: 104,912,117 (GRCm39) T589I probably benign Het
Dock10 A G 1: 80,514,643 (GRCm39) S1091P probably damaging Het
Fh1 A G 1: 175,442,316 (GRCm39) V178A probably damaging Het
Fndc1 A G 17: 8,003,253 (GRCm39) S111P probably damaging Het
Frk A G 10: 34,360,001 (GRCm39) M1V probably null Het
Gm29394 C T 15: 57,912,024 (GRCm39) probably benign Het
Herc2 A G 7: 55,813,572 (GRCm39) D2601G probably damaging Het
Hspa13 T C 16: 75,561,974 (GRCm39) D75G probably benign Het
Itgav T C 2: 83,632,229 (GRCm39) probably null Het
Kif6 A T 17: 50,065,671 (GRCm39) probably benign Het
Lypla1 G A 1: 4,911,201 (GRCm39) R104Q probably benign Het
Map1b T C 13: 99,570,595 (GRCm39) K709E unknown Het
Or52l1 A T 7: 104,830,088 (GRCm39) I159K probably damaging Het
Or56b1b G A 7: 108,164,402 (GRCm39) P200L probably benign Het
Pcdhb16 A T 18: 37,611,249 (GRCm39) K70* probably null Het
Pex5l T G 3: 33,061,327 (GRCm39) D174A probably benign Het
Plac8l1 A T 18: 42,313,460 (GRCm39) M94K probably benign Het
Plxna1 T C 6: 89,311,757 (GRCm39) probably benign Het
Pus3 C A 9: 35,477,968 (GRCm39) T400K probably benign Het
Pxk T C 14: 8,136,863 (GRCm38) probably benign Het
Rapgef2 T C 3: 78,996,057 (GRCm39) T569A probably benign Het
Sall4 T C 2: 168,597,964 (GRCm39) Q292R possibly damaging Het
Slc18b1 A G 10: 23,674,647 (GRCm39) D34G probably damaging Het
Slc45a1 T C 4: 150,722,517 (GRCm39) R456G probably damaging Het
Sox13 T C 1: 133,318,536 (GRCm39) R81G possibly damaging Het
Spag9 A G 11: 93,951,109 (GRCm39) probably benign Het
Ston1 C T 17: 88,942,788 (GRCm39) P65S probably damaging Het
Tada2b A T 5: 36,633,761 (GRCm39) D197E probably benign Het
Tcim T A 8: 24,928,765 (GRCm39) R50W probably damaging Het
Tnpo3 T C 6: 29,579,688 (GRCm39) D235G probably benign Het
Trim59 A G 3: 68,944,137 (GRCm39) V401A probably benign Het
Trpm3 A C 19: 22,425,741 (GRCm39) Q32P probably benign Het
Tubgcp5 T A 7: 55,480,614 (GRCm39) M1018K probably damaging Het
Ube2o A G 11: 116,437,689 (GRCm39) probably benign Het
Ugcg C T 4: 59,207,798 (GRCm39) P46S probably benign Het
Uvrag G T 7: 98,537,350 (GRCm39) S615* probably null Het
Vmn2r6 T A 3: 64,463,929 (GRCm39) I302L probably benign Het
Vmn2r73 C T 7: 85,521,198 (GRCm39) V257I probably benign Het
Other mutations in Psg26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01010:Psg26 APN 7 18,212,255 (GRCm39) missense possibly damaging 0.83
IGL01383:Psg26 APN 7 18,214,179 (GRCm39) missense possibly damaging 0.90
IGL01453:Psg26 APN 7 18,213,999 (GRCm39) missense possibly damaging 0.91
IGL01603:Psg26 APN 7 18,209,028 (GRCm39) missense probably damaging 0.98
IGL02201:Psg26 APN 7 18,214,071 (GRCm39) missense probably benign 0.04
IGL02468:Psg26 APN 7 18,212,387 (GRCm39) missense probably damaging 0.96
IGL02648:Psg26 APN 7 18,216,691 (GRCm39) missense probably benign 0.05
IGL02812:Psg26 APN 7 18,209,080 (GRCm39) missense probably benign 0.00
R0226:Psg26 UTSW 7 18,217,883 (GRCm39) missense possibly damaging 0.81
R0352:Psg26 UTSW 7 18,209,181 (GRCm39) missense probably benign 0.00
R0369:Psg26 UTSW 7 18,216,481 (GRCm39) nonsense probably null
R0718:Psg26 UTSW 7 18,212,212 (GRCm39) missense probably benign 0.18
R0718:Psg26 UTSW 7 18,209,160 (GRCm39) missense probably benign 0.23
R1710:Psg26 UTSW 7 18,213,966 (GRCm39) missense probably damaging 0.99
R1899:Psg26 UTSW 7 18,212,350 (GRCm39) missense probably benign 0.01
R1958:Psg26 UTSW 7 18,212,264 (GRCm39) missense probably benign 0.04
R2102:Psg26 UTSW 7 18,209,067 (GRCm39) missense probably damaging 1.00
R4544:Psg26 UTSW 7 18,212,464 (GRCm39) missense probably damaging 1.00
R4977:Psg26 UTSW 7 18,209,235 (GRCm39) missense probably benign 0.11
R5000:Psg26 UTSW 7 18,214,057 (GRCm39) missense possibly damaging 0.95
R5376:Psg26 UTSW 7 18,214,030 (GRCm39) missense probably benign
R5416:Psg26 UTSW 7 18,216,525 (GRCm39) missense probably benign
R5435:Psg26 UTSW 7 18,212,398 (GRCm39) missense possibly damaging 0.60
R6000:Psg26 UTSW 7 18,216,617 (GRCm39) nonsense probably null
R6285:Psg26 UTSW 7 18,216,753 (GRCm39) missense probably benign
R7062:Psg26 UTSW 7 18,216,521 (GRCm39) missense probably damaging 1.00
R7083:Psg26 UTSW 7 18,213,934 (GRCm39) nonsense probably null
R7513:Psg26 UTSW 7 18,209,225 (GRCm39) missense probably benign 0.03
R7817:Psg26 UTSW 7 18,216,572 (GRCm39) missense not run
R7857:Psg26 UTSW 7 18,212,215 (GRCm39) missense possibly damaging 0.71
R7905:Psg26 UTSW 7 18,209,242 (GRCm39) missense probably benign 0.00
R8047:Psg26 UTSW 7 18,212,474 (GRCm39) missense possibly damaging 0.50
R8789:Psg26 UTSW 7 18,216,494 (GRCm39) missense probably damaging 1.00
R8877:Psg26 UTSW 7 18,217,865 (GRCm39) missense probably benign 0.01
R9012:Psg26 UTSW 7 18,216,596 (GRCm39) missense probably benign 0.19
R9203:Psg26 UTSW 7 18,212,382 (GRCm39) missense probably damaging 0.98
R9327:Psg26 UTSW 7 18,216,480 (GRCm39) missense probably damaging 1.00
R9547:Psg26 UTSW 7 18,214,087 (GRCm39) missense probably benign 0.00
Z1177:Psg26 UTSW 7 18,214,216 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- GGGCTGCATTGTCTACCAATAG -3'
(R):5'- CCGTTGGCTCTTCAACAATC -3'

Sequencing Primer
(F):5'- TGGTACCATGAGGACCATTGAATAC -3'
(R):5'- TCAGAGTTTGCAGCTCACAG -3'
Posted On 2015-04-02