Incidental Mutation 'R3820:Micall2'
ID 274853
Institutional Source Beutler Lab
Gene Symbol Micall2
Ensembl Gene ENSMUSG00000036718
Gene Name MICAL-like 2
Synonyms MICAL-L2, Jrab, A930021H16Rik
MMRRC Submission 040882-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.352) question?
Stock # R3820 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 139692451-139722091 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 139701611 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Aspartic acid at position 461 (G461D)
Ref Sequence ENSEMBL: ENSMUSP00000127937 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044642] [ENSMUST00000170773]
AlphaFold Q3TN34
Predicted Effect unknown
Transcript: ENSMUST00000044642
AA Change: G544D
SMART Domains Protein: ENSMUSP00000039707
Gene: ENSMUSG00000036718
AA Change: G544D

DomainStartEndE-ValueType
CH 3 102 4.34e-20 SMART
LIM 187 241 1.62e-5 SMART
low complexity region 242 253 N/A INTRINSIC
low complexity region 326 344 N/A INTRINSIC
low complexity region 428 489 N/A INTRINSIC
low complexity region 502 518 N/A INTRINSIC
low complexity region 728 746 N/A INTRINSIC
low complexity region 755 770 N/A INTRINSIC
DUF3585 840 980 3.1e-63 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000165645
Predicted Effect possibly damaging
Transcript: ENSMUST00000170773
AA Change: G461D

PolyPhen 2 Score 0.921 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000127937
Gene: ENSMUSG00000036718
AA Change: G461D

DomainStartEndE-ValueType
SCOP:d1bkra_ 1 25 9e-5 SMART
Blast:DUF3585 1 45 2e-7 BLAST
LIM 104 158 1.62e-5 SMART
low complexity region 159 170 N/A INTRINSIC
low complexity region 243 261 N/A INTRINSIC
low complexity region 345 406 N/A INTRINSIC
low complexity region 419 435 N/A INTRINSIC
low complexity region 645 663 N/A INTRINSIC
low complexity region 672 687 N/A INTRINSIC
DUF3585 757 897 3.1e-63 SMART
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.8%
  • 20x: 96.4%
Validation Efficiency 96% (47/49)
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921524L21Rik G T 18: 6,630,166 (GRCm39) probably null Het
Aarsd1 T A 11: 101,301,971 (GRCm39) I332F probably damaging Het
Abcd2 C T 15: 91,058,908 (GRCm39) G512D probably damaging Het
Adam6a T C 12: 113,507,798 (GRCm39) I57T probably benign Het
Adam6b C T 12: 113,453,984 (GRCm39) T267I probably benign Het
Ap1g2 G A 14: 55,338,030 (GRCm39) probably benign Het
Arhgap22 G A 14: 33,089,378 (GRCm39) E455K probably benign Het
Bltp1 G A 3: 37,094,583 (GRCm39) V917I probably damaging Het
Ccdc93 T C 1: 121,389,969 (GRCm39) I253T probably damaging Het
Cd44 T C 2: 102,731,738 (GRCm39) probably null Het
Cnot6 A T 11: 49,579,999 (GRCm39) S98T probably benign Het
Dnah9 C A 11: 65,741,829 (GRCm39) probably null Het
Edar T C 10: 58,457,185 (GRCm39) Y131C probably damaging Het
Eif5 A T 12: 111,506,618 (GRCm39) R43* probably null Het
Eml4 C A 17: 83,780,494 (GRCm39) T667K probably damaging Het
Fchsd1 A G 18: 38,102,510 (GRCm39) probably benign Het
Flt1 A G 5: 147,636,827 (GRCm39) probably benign Het
Frem2 T A 3: 53,424,270 (GRCm39) I3056F probably damaging Het
Hivep1 A T 13: 42,337,787 (GRCm39) H2622L possibly damaging Het
Ido2 T C 8: 25,023,771 (GRCm39) I356V probably benign Het
Insyn2b T C 11: 34,353,007 (GRCm39) S350P probably benign Het
Itgb3 C A 11: 104,524,438 (GRCm39) Y191* probably null Het
Kcnma1 T C 14: 23,350,006 (GRCm39) T1178A possibly damaging Het
Kcnt1 A G 2: 25,790,904 (GRCm39) H486R probably damaging Het
Kif21a T C 15: 90,852,277 (GRCm39) N950S probably benign Het
Lama1 C A 17: 68,086,041 (GRCm39) probably null Het
Lrrc4b T A 7: 44,111,982 (GRCm39) V618E probably damaging Het
Mrc2 G A 11: 105,239,257 (GRCm39) probably null Het
Ncoa6 T A 2: 155,248,858 (GRCm39) N1482I probably damaging Het
Pcdhga10 A G 18: 37,880,995 (GRCm39) N252S probably damaging Het
Pcdhgb7 C A 18: 37,885,286 (GRCm39) T152K possibly damaging Het
Pds5a A G 5: 65,811,419 (GRCm39) V338A possibly damaging Het
Pds5b T C 5: 150,659,802 (GRCm39) V255A possibly damaging Het
Prkar2a T G 9: 108,624,155 (GRCm39) F391V probably damaging Het
Prr14l A G 5: 32,986,328 (GRCm39) C1056R probably damaging Het
Ptpn23 A G 9: 110,218,862 (GRCm39) probably benign Het
Serpinb5 T A 1: 106,802,802 (GRCm39) Y112* probably null Het
Slc17a4 C T 13: 24,085,752 (GRCm39) R387H probably benign Het
Tdrd5 A G 1: 156,113,053 (GRCm39) V409A probably benign Het
Tenm2 A T 11: 35,915,147 (GRCm39) I2129N probably damaging Het
Tmem8b C A 4: 43,689,745 (GRCm39) H800N probably damaging Het
Trpm3 A T 19: 22,964,813 (GRCm39) N1436I probably benign Het
Unc13c A T 9: 73,838,240 (GRCm39) S870R probably benign Het
Vmn2r16 C T 5: 109,510,143 (GRCm39) P509S probably benign Het
Vmn2r60 A T 7: 41,785,125 (GRCm39) E112D probably damaging Het
Xpnpep1 G A 19: 52,992,250 (GRCm39) probably benign Het
Zfp729a A T 13: 67,769,438 (GRCm39) C264S probably damaging Het
Zmynd8 T A 2: 165,657,381 (GRCm39) K521* probably null Het
Other mutations in Micall2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00231:Micall2 APN 5 139,703,311 (GRCm39) critical splice acceptor site probably null
IGL00496:Micall2 APN 5 139,702,083 (GRCm39) missense probably benign 0.01
IGL02641:Micall2 APN 5 139,705,094 (GRCm39) missense probably damaging 1.00
IGL03245:Micall2 APN 5 139,705,014 (GRCm39) missense probably damaging 1.00
IGL03252:Micall2 APN 5 139,702,481 (GRCm39) missense probably benign 0.01
R1214:Micall2 UTSW 5 139,697,396 (GRCm39) missense probably damaging 0.97
R1468:Micall2 UTSW 5 139,705,097 (GRCm39) missense probably damaging 1.00
R1468:Micall2 UTSW 5 139,705,097 (GRCm39) missense probably damaging 1.00
R1831:Micall2 UTSW 5 139,702,508 (GRCm39) missense probably benign 0.09
R1833:Micall2 UTSW 5 139,702,508 (GRCm39) missense probably benign 0.09
R1969:Micall2 UTSW 5 139,721,885 (GRCm39) missense probably damaging 1.00
R2023:Micall2 UTSW 5 139,703,266 (GRCm39) missense possibly damaging 0.51
R2060:Micall2 UTSW 5 139,697,317 (GRCm39) missense probably damaging 0.98
R2330:Micall2 UTSW 5 139,703,270 (GRCm39) missense probably damaging 1.00
R4299:Micall2 UTSW 5 139,695,226 (GRCm39) intron probably benign
R4334:Micall2 UTSW 5 139,699,105 (GRCm39) missense probably damaging 1.00
R4451:Micall2 UTSW 5 139,692,852 (GRCm39) missense probably damaging 1.00
R4769:Micall2 UTSW 5 139,692,641 (GRCm39) missense probably damaging 0.97
R4911:Micall2 UTSW 5 139,702,580 (GRCm39) missense probably damaging 1.00
R4996:Micall2 UTSW 5 139,696,344 (GRCm39) missense probably benign 0.31
R5118:Micall2 UTSW 5 139,702,202 (GRCm39) missense probably damaging 1.00
R5155:Micall2 UTSW 5 139,695,986 (GRCm39) missense probably damaging 1.00
R5475:Micall2 UTSW 5 139,702,224 (GRCm39) missense probably damaging 1.00
R5750:Micall2 UTSW 5 139,701,456 (GRCm39) splice site probably null
R5998:Micall2 UTSW 5 139,692,666 (GRCm39) critical splice acceptor site probably null
R6181:Micall2 UTSW 5 139,702,506 (GRCm39) missense probably benign 0.41
R6852:Micall2 UTSW 5 139,701,548 (GRCm39) missense possibly damaging 0.90
R7046:Micall2 UTSW 5 139,694,699 (GRCm39) unclassified probably benign
R7395:Micall2 UTSW 5 139,702,124 (GRCm39) missense possibly damaging 0.78
R8514:Micall2 UTSW 5 139,701,977 (GRCm39) missense probably damaging 1.00
R8889:Micall2 UTSW 5 139,703,254 (GRCm39) missense probably damaging 0.98
R8892:Micall2 UTSW 5 139,703,254 (GRCm39) missense probably damaging 0.98
R8960:Micall2 UTSW 5 139,702,025 (GRCm39) missense probably benign 0.23
R9060:Micall2 UTSW 5 139,705,035 (GRCm39) missense probably damaging 1.00
R9209:Micall2 UTSW 5 139,696,170 (GRCm39) missense unknown
R9227:Micall2 UTSW 5 139,701,827 (GRCm39) missense unknown
R9230:Micall2 UTSW 5 139,701,827 (GRCm39) missense unknown
R9260:Micall2 UTSW 5 139,695,453 (GRCm39) missense unknown
R9452:Micall2 UTSW 5 139,703,311 (GRCm39) critical splice acceptor site probably null
Z1088:Micall2 UTSW 5 139,702,050 (GRCm39) missense probably benign 0.12
Z1088:Micall2 UTSW 5 139,692,649 (GRCm39) missense probably damaging 1.00
Z1177:Micall2 UTSW 5 139,696,057 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TCACAGAGAGACAGACCTGG -3'
(R):5'- ACTGTAGTGACTGTCCCCAC -3'

Sequencing Primer
(F):5'- GCAGGTCGCAGCTACATC -3'
(R):5'- AAGGTCCCCACTGTGGTGTC -3'
Posted On 2015-04-02