Incidental Mutation 'R3835:Vmn2r24'
ID 275584
Institutional Source Beutler Lab
Gene Symbol Vmn2r24
Ensembl Gene ENSMUSG00000072780
Gene Name vomeronasal 2, receptor 24
Synonyms EG243628
MMRRC Submission 040890-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R3835 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 123755930-123793239 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 123764412 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Tyrosine at position 430 (D430Y)
Ref Sequence ENSEMBL: ENSMUSP00000074602 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075095]
AlphaFold D3YUI0
Predicted Effect probably benign
Transcript: ENSMUST00000075095
AA Change: D430Y

PolyPhen 2 Score 0.329 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000074602
Gene: ENSMUSG00000072780
AA Change: D430Y

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 82 469 1.6e-32 PFAM
Pfam:NCD3G 518 571 1.1e-22 PFAM
Pfam:7tm_3 602 839 1.1e-54 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency 98% (43/44)
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrl4 T C 3: 151,216,254 (GRCm39) I479T probably damaging Het
Adh6a G A 3: 138,033,275 (GRCm39) probably null Het
Anapc7 A G 5: 122,581,940 (GRCm39) T528A possibly damaging Het
Ap5b1 A G 19: 5,618,918 (GRCm39) T113A possibly damaging Het
Apaf1 G A 10: 90,895,449 (GRCm39) R439C probably benign Het
Apoa5 A T 9: 46,181,878 (GRCm39) H318L probably damaging Het
Bltp2 A G 11: 78,169,911 (GRCm39) R1545G probably benign Het
Btnl9 T G 11: 49,071,512 (GRCm39) T104P probably damaging Het
Cimip3 AC A 17: 47,744,348 (GRCm39) probably benign Het
Dennd5a T C 7: 109,533,449 (GRCm39) K107R probably benign Het
Dthd1 A T 5: 63,007,128 (GRCm39) R610W probably damaging Het
Eno1 T C 4: 150,331,119 (GRCm39) S186P probably benign Het
Gipc2 C A 3: 151,833,823 (GRCm39) V153F probably damaging Het
Gpt A G 15: 76,582,783 (GRCm39) Y295C probably damaging Het
Kcnh5 T A 12: 74,945,044 (GRCm39) Q735L probably benign Het
Lrrc10 A G 10: 116,881,691 (GRCm39) N122D possibly damaging Het
Lrrc37 C A 11: 103,510,836 (GRCm39) L377F unknown Het
Meis2 T C 2: 115,752,228 (GRCm39) H301R probably damaging Het
Muc5b A T 7: 141,412,918 (GRCm39) I1955F unknown Het
Nalcn A T 14: 123,530,834 (GRCm39) probably benign Het
Nmt2 T C 2: 3,315,723 (GRCm39) probably benign Het
Nnt C T 13: 119,509,031 (GRCm39) G403R probably damaging Het
Or4a79 T G 2: 89,551,799 (GRCm39) I219L possibly damaging Het
Or4d6 T A 19: 12,086,764 (GRCm39) I49F possibly damaging Het
Or5b109 A T 19: 13,212,103 (GRCm39) D163V probably benign Het
Ovgp1 A G 3: 105,893,631 (GRCm39) E468G probably benign Het
Pax6 G A 2: 105,526,795 (GRCm39) E234K probably benign Het
Prkdc A G 16: 15,609,810 (GRCm39) E3138G probably damaging Het
Prmt6 T C 3: 110,158,121 (GRCm39) D56G possibly damaging Het
Ptprt A G 2: 161,389,307 (GRCm39) V1261A probably damaging Het
Qtrt2 A G 16: 43,701,435 (GRCm39) S42P probably damaging Het
Rab9b C T X: 135,762,259 (GRCm39) R47Q possibly damaging Het
Rpgrip1 A G 14: 52,384,710 (GRCm39) E606G probably damaging Het
Setx C T 2: 29,035,072 (GRCm39) S519L possibly damaging Het
Slc15a2 A T 16: 36,592,490 (GRCm39) C191* probably null Het
Snrk T C 9: 121,966,069 (GRCm39) probably benign Het
St6galnac1 T C 11: 116,657,109 (GRCm39) D422G probably damaging Het
Stag1 C T 9: 100,620,035 (GRCm39) T46I probably damaging Het
Tagln T C 9: 45,843,008 (GRCm39) I18V probably benign Het
Tasor2 T C 13: 3,625,292 (GRCm39) T1553A probably benign Het
Tbx18 C A 9: 87,611,689 (GRCm39) A114S probably benign Het
Ttc16 T C 2: 32,659,322 (GRCm39) D259G probably damaging Het
Vldlr A G 19: 27,212,214 (GRCm39) D76G probably damaging Het
Xlr3a T C X: 72,138,644 (GRCm39) E5G probably damaging Het
Other mutations in Vmn2r24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00954:Vmn2r24 APN 6 123,792,596 (GRCm39) missense probably damaging 1.00
IGL01382:Vmn2r24 APN 6 123,763,938 (GRCm39) missense possibly damaging 0.62
IGL01592:Vmn2r24 APN 6 123,764,445 (GRCm39) missense probably benign 0.30
IGL01754:Vmn2r24 APN 6 123,781,120 (GRCm39) missense probably damaging 1.00
IGL01939:Vmn2r24 APN 6 123,764,404 (GRCm39) missense probably benign
IGL02140:Vmn2r24 APN 6 123,757,631 (GRCm39) missense probably damaging 0.98
IGL02272:Vmn2r24 APN 6 123,763,843 (GRCm39) missense possibly damaging 0.94
IGL02568:Vmn2r24 APN 6 123,792,812 (GRCm39) missense probably benign 0.36
IGL02748:Vmn2r24 APN 6 123,793,057 (GRCm39) missense possibly damaging 0.90
IGL03022:Vmn2r24 APN 6 123,755,967 (GRCm39) missense probably damaging 0.99
IGL03343:Vmn2r24 APN 6 123,793,070 (GRCm39) missense probably damaging 1.00
R0357:Vmn2r24 UTSW 6 123,792,369 (GRCm39) frame shift probably null
R0453:Vmn2r24 UTSW 6 123,757,350 (GRCm39) critical splice acceptor site probably null
R0538:Vmn2r24 UTSW 6 123,793,012 (GRCm39) missense probably benign 0.32
R0607:Vmn2r24 UTSW 6 123,763,893 (GRCm39) missense probably benign
R1381:Vmn2r24 UTSW 6 123,763,692 (GRCm39) missense probably damaging 1.00
R1589:Vmn2r24 UTSW 6 123,783,479 (GRCm39) splice site probably benign
R1848:Vmn2r24 UTSW 6 123,793,183 (GRCm39) missense probably damaging 1.00
R2035:Vmn2r24 UTSW 6 123,793,019 (GRCm39) missense probably damaging 1.00
R2077:Vmn2r24 UTSW 6 123,792,358 (GRCm39) missense probably damaging 1.00
R2122:Vmn2r24 UTSW 6 123,792,353 (GRCm39) missense possibly damaging 0.81
R2145:Vmn2r24 UTSW 6 123,755,972 (GRCm39) missense probably benign
R2483:Vmn2r24 UTSW 6 123,792,997 (GRCm39) missense probably damaging 1.00
R2512:Vmn2r24 UTSW 6 123,763,985 (GRCm39) missense probably benign 0.01
R3001:Vmn2r24 UTSW 6 123,781,231 (GRCm39) missense probably benign 0.00
R3002:Vmn2r24 UTSW 6 123,781,231 (GRCm39) missense probably benign 0.00
R3236:Vmn2r24 UTSW 6 123,755,984 (GRCm39) nonsense probably null
R3623:Vmn2r24 UTSW 6 123,792,997 (GRCm39) missense probably damaging 1.00
R3624:Vmn2r24 UTSW 6 123,792,997 (GRCm39) missense probably damaging 1.00
R4074:Vmn2r24 UTSW 6 123,764,374 (GRCm39) missense possibly damaging 0.92
R4075:Vmn2r24 UTSW 6 123,764,374 (GRCm39) missense possibly damaging 0.92
R4812:Vmn2r24 UTSW 6 123,756,144 (GRCm39) missense probably benign 0.00
R4825:Vmn2r24 UTSW 6 123,792,739 (GRCm39) missense probably benign 0.02
R5351:Vmn2r24 UTSW 6 123,793,223 (GRCm39) missense possibly damaging 0.80
R5665:Vmn2r24 UTSW 6 123,763,938 (GRCm39) missense possibly damaging 0.62
R5790:Vmn2r24 UTSW 6 123,792,499 (GRCm39) missense probably benign
R5808:Vmn2r24 UTSW 6 123,792,597 (GRCm39) nonsense probably null
R5879:Vmn2r24 UTSW 6 123,764,226 (GRCm39) missense possibly damaging 0.89
R5923:Vmn2r24 UTSW 6 123,792,751 (GRCm39) missense probably damaging 0.96
R5969:Vmn2r24 UTSW 6 123,755,981 (GRCm39) missense probably benign 0.00
R6050:Vmn2r24 UTSW 6 123,792,691 (GRCm39) missense probably damaging 1.00
R6171:Vmn2r24 UTSW 6 123,764,205 (GRCm39) missense probably damaging 0.98
R6174:Vmn2r24 UTSW 6 123,793,236 (GRCm39) missense probably benign 0.00
R6356:Vmn2r24 UTSW 6 123,783,368 (GRCm39) missense possibly damaging 0.93
R6562:Vmn2r24 UTSW 6 123,757,386 (GRCm39) missense probably benign 0.01
R6563:Vmn2r24 UTSW 6 123,781,137 (GRCm39) missense possibly damaging 0.86
R6584:Vmn2r24 UTSW 6 123,792,764 (GRCm39) missense possibly damaging 0.53
R6630:Vmn2r24 UTSW 6 123,763,981 (GRCm39) missense probably benign 0.00
R6803:Vmn2r24 UTSW 6 123,755,960 (GRCm39) missense possibly damaging 0.64
R6864:Vmn2r24 UTSW 6 123,756,117 (GRCm39) missense possibly damaging 0.89
R7252:Vmn2r24 UTSW 6 123,764,191 (GRCm39) missense possibly damaging 0.90
R7369:Vmn2r24 UTSW 6 123,792,638 (GRCm39) missense probably damaging 0.99
R7646:Vmn2r24 UTSW 6 123,793,169 (GRCm39) missense probably benign 0.20
R7799:Vmn2r24 UTSW 6 123,757,422 (GRCm39) missense probably benign 0.00
R7803:Vmn2r24 UTSW 6 123,757,438 (GRCm39) missense probably benign 0.00
R7959:Vmn2r24 UTSW 6 123,755,949 (GRCm39) missense possibly damaging 0.86
R8215:Vmn2r24 UTSW 6 123,756,077 (GRCm39) missense probably benign 0.10
R8796:Vmn2r24 UTSW 6 123,757,500 (GRCm39) missense probably benign
R9172:Vmn2r24 UTSW 6 123,783,432 (GRCm39) missense probably damaging 1.00
R9300:Vmn2r24 UTSW 6 123,793,030 (GRCm39) missense possibly damaging 0.46
R9369:Vmn2r24 UTSW 6 123,792,357 (GRCm39) missense probably damaging 1.00
R9375:Vmn2r24 UTSW 6 123,792,542 (GRCm39) missense probably damaging 1.00
R9523:Vmn2r24 UTSW 6 123,763,950 (GRCm39) missense possibly damaging 0.89
R9546:Vmn2r24 UTSW 6 123,764,266 (GRCm39) missense probably damaging 0.98
RF006:Vmn2r24 UTSW 6 123,783,378 (GRCm39) missense probably damaging 1.00
RF016:Vmn2r24 UTSW 6 123,781,174 (GRCm39) missense probably benign 0.04
X0023:Vmn2r24 UTSW 6 123,764,359 (GRCm39) missense probably damaging 0.99
Z1088:Vmn2r24 UTSW 6 123,781,155 (GRCm39) missense probably benign 0.00
Z1177:Vmn2r24 UTSW 6 123,763,719 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TTATCCAGGATGTGTGGTCCATC -3'
(R):5'- TACTTTGAGAAGGAGATAGTAGCAC -3'

Sequencing Primer
(F):5'- GCCCATATTTTGATAAGGATGGAGTC -3'
(R):5'- TGAGAAGGAGATAGTAGCACATATTC -3'
Posted On 2015-04-06