Incidental Mutation 'IGL00846:Vopp1'
ID27570
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vopp1
Ensembl Gene ENSMUSG00000037788
Gene Namevesicular, overexpressed in cancer, prosurvival protein 1
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.026) question?
Stock #IGL00846
Quality Score
Status
Chromosome6
Chromosomal Location57727807-57825159 bp(-) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) A to G at 57754480 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000144953 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114297] [ENSMUST00000127485] [ENSMUST00000145608] [ENSMUST00000204878]
Predicted Effect probably benign
Transcript: ENSMUST00000114297
SMART Domains Protein: ENSMUSP00000109936
Gene: ENSMUSG00000037788

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
transmembrane domain 59 81 N/A INTRINSIC
low complexity region 115 126 N/A INTRINSIC
low complexity region 149 165 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000127485
SMART Domains Protein: ENSMUSP00000115377
Gene: ENSMUSG00000037788

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:WBP-1 37 106 7e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000145608
SMART Domains Protein: ENSMUSP00000145084
Gene: ENSMUSG00000037788

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
transmembrane domain 59 81 N/A INTRINSIC
low complexity region 112 121 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000204878
SMART Domains Protein: ENSMUSP00000144953
Gene: ENSMUSG00000037788

DomainStartEndE-ValueType
low complexity region 48 59 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atxn2l T C 7: 126,499,178 T181A probably damaging Het
Caskin1 T C 17: 24,499,349 probably null Het
Cass4 A C 2: 172,429,723 probably benign Het
Cdh26 A T 2: 178,481,624 Y672F possibly damaging Het
Cep290 T A 10: 100,540,333 probably benign Het
Cntnap2 T C 6: 47,193,038 L1146P probably benign Het
Cntnap5b T G 1: 100,164,223 C230G probably damaging Het
Ctnnd1 C T 2: 84,622,010 probably null Het
Cux1 A G 5: 136,326,796 I324T probably damaging Het
Dnajb4 T C 3: 152,193,481 N36S probably damaging Het
Fancc T A 13: 63,340,456 T237S possibly damaging Het
Fip1l1 A G 5: 74,587,065 probably benign Het
Hemgn G T 4: 46,396,171 T355K possibly damaging Het
Hivep1 T A 13: 42,167,616 L42* probably null Het
Hps3 A G 3: 20,025,792 W234R probably benign Het
Kit A T 5: 75,640,811 N586I probably damaging Het
Mettl14 T A 3: 123,371,363 K109N probably damaging Het
Mmab A T 5: 114,433,317 M166K probably benign Het
Naprt T A 15: 75,891,788 Y395F probably benign Het
Nostrin C T 2: 69,185,555 probably benign Het
Pgap1 G T 1: 54,492,021 probably benign Het
Plpp5 A T 8: 25,720,558 I59F probably damaging Het
Prrc2b T C 2: 32,199,097 probably benign Het
Scn4a A T 11: 106,328,118 V958D probably benign Het
Serpinb3b T A 1: 107,155,849 N200I probably damaging Het
Slc22a15 T A 3: 101,860,820 Q512L probably benign Het
Tmf1 A T 6: 97,173,316 Y477N possibly damaging Het
Trim10 T A 17: 36,871,692 L150H probably damaging Het
Ttc41 A G 10: 86,736,933 E723G possibly damaging Het
Usp25 A G 16: 77,062,405 S264G probably damaging Het
Wapl G T 14: 34,692,744 probably benign Het
Wbp1 A G 6: 83,120,041 F93S probably damaging Het
Wt1 G T 2: 105,166,957 R413L probably damaging Het
Zfp345 C T 2: 150,472,618 G333D possibly damaging Het
Zmynd11 C A 13: 9,720,772 probably null Het
Other mutations in Vopp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03155:Vopp1 APN 6 57762507 missense possibly damaging 0.92
R1233:Vopp1 UTSW 6 57789995 missense probably damaging 0.98
R1708:Vopp1 UTSW 6 57762512 missense probably damaging 1.00
R1916:Vopp1 UTSW 6 57754587 missense probably benign 0.02
R4082:Vopp1 UTSW 6 57789979 nonsense probably null
R4392:Vopp1 UTSW 6 57762476 missense probably damaging 1.00
R4585:Vopp1 UTSW 6 57754548 missense probably damaging 1.00
R4586:Vopp1 UTSW 6 57754548 missense probably damaging 1.00
R4879:Vopp1 UTSW 6 57762370 intron probably benign
R6797:Vopp1 UTSW 6 57762507 missense possibly damaging 0.92
Posted On2013-04-17