|Institutional Source||Beutler Lab|
|Gene Name||trace amine-associated receptor 1|
|Is this an essential gene?||Probably non essential (E-score: 0.144)|
|Stock #||R3873 (G1)|
|Chromosomal Location||23920356-23921469 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 23920584 bp|
|Amino Acid Change||Leucine to Proline at position 60 (L60P)|
|Ref Sequence||ENSEMBL: ENSMUSP00000049527 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000051532]|
|Predicted Effect||probably damaging
AA Change: L60P
PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
AA Change: L60P
|Meta Mutation Damage Score||0.594|
|Coding Region Coverage||
|Validation Efficiency||100% (50/50)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a G-protein coupled receptor activated by trace amines. The encoded protein responds little or not at all to dopamine, serotonin, epinephrine, or histamine, but responds well to beta-phenylethylamine, p-tyramine, octopamine, and tryptamine. While primarily functioning in neurologic systems, there is evidence that this gene is involved in blood cell and immunologic functions as well. This gene is thought to be intronless. [provided by RefSeq, Nov 2015]
PHENOTYPE: Mice homozygous for a null mutation display decreased prepulse inhibition and increased sensitivity to amphetamines. Mice homozygous for another knock-out allele exhibit increased sensitivity to MDMA-induced hyperthermia, brain dopamine and serotonin levels, and induced hyperactivity. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Taar1||
(F):5'- AAAGCCCAGCCTGTGTCTAG -3'
(R):5'- CAGCACAGTAGCGGTCAATG -3'
(F):5'- AGTTCTCTGCAGTGATGCATC -3'
(R):5'- CACAGTAGCGGTCAATGGAAATG -3'