Incidental Mutation 'R3873:Morc3'
ID 276694
Institutional Source Beutler Lab
Gene Symbol Morc3
Ensembl Gene ENSMUSG00000039456
Gene Name microrchidia 3
Synonyms Zcwcc3, D16Jhu32e, 1110051N18Rik, 1110051N18Rik
MMRRC Submission 040791-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R3873 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 93629009-93672961 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 93659324 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 411 (V411I)
Ref Sequence ENSEMBL: ENSMUSP00000144369 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044068] [ENSMUST00000201097] [ENSMUST00000201754] [ENSMUST00000202261]
AlphaFold F7BJB9
Predicted Effect probably damaging
Transcript: ENSMUST00000044068
AA Change: V411I

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000040152
Gene: ENSMUSG00000039456
AA Change: V411I

DomainStartEndE-ValueType
Pfam:HATPase_c 25 130 8e-8 PFAM
Pfam:HATPase_c_3 26 164 1.1e-18 PFAM
Pfam:zf-CW 409 452 2.7e-19 PFAM
low complexity region 461 472 N/A INTRINSIC
low complexity region 630 639 N/A INTRINSIC
coiled coil region 765 871 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000201097
AA Change: V340I

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000144058
Gene: ENSMUSG00000039456
AA Change: V340I

DomainStartEndE-ValueType
Blast:HATPase_c 1 70 4e-39 BLAST
Pfam:zf-CW 340 383 1.2e-16 PFAM
low complexity region 392 403 N/A INTRINSIC
low complexity region 557 566 N/A INTRINSIC
coiled coil region 692 798 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000201754
SMART Domains Protein: ENSMUSP00000144357
Gene: ENSMUSG00000039456

DomainStartEndE-ValueType
Pfam:HATPase_c 25 91 1.3e-6 PFAM
Pfam:HATPase_c_3 26 92 1.2e-8 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000202261
AA Change: V411I

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000144369
Gene: ENSMUSG00000039456
AA Change: V411I

DomainStartEndE-ValueType
Pfam:HATPase_c 25 130 8e-8 PFAM
Pfam:HATPase_c_3 26 164 1.1e-18 PFAM
Pfam:zf-CW 409 452 2.7e-19 PFAM
low complexity region 461 472 N/A INTRINSIC
low complexity region 630 639 N/A INTRINSIC
coiled coil region 765 871 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232425
Predicted Effect unknown
Transcript: ENSMUST00000232639
AA Change: V36I
Meta Mutation Damage Score 0.2932 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 95.9%
Validation Efficiency 100% (50/50)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]
PHENOTYPE: Mice homozygous for a null allele die at or within a day of birth. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca5 T A 11: 110,201,059 (GRCm39) Y447F probably damaging Het
Acaca A G 11: 84,203,547 (GRCm39) probably benign Het
Adam5 T C 8: 25,305,125 (GRCm39) T110A probably benign Het
Agtpbp1 T C 13: 59,608,410 (GRCm39) M175V possibly damaging Het
Akt1 T C 12: 112,622,967 (GRCm39) N367S probably benign Het
Ankrd61 T A 5: 143,828,646 (GRCm39) T67S probably damaging Het
Arl8a T C 1: 135,080,610 (GRCm39) probably null Het
Arvcf G A 16: 18,221,783 (GRCm39) R736Q probably damaging Het
Baz2a T A 10: 127,959,979 (GRCm39) M1419K probably damaging Het
Cep295 A T 9: 15,244,661 (GRCm39) V1265E probably damaging Het
Cfap299 A T 5: 98,885,482 (GRCm39) I130F probably damaging Het
Cyp2c29 A G 19: 39,317,588 (GRCm39) D397G probably damaging Het
Dlgap4 T C 2: 156,591,267 (GRCm39) S818P probably benign Het
Dnah2 A G 11: 69,320,174 (GRCm39) I3965T probably damaging Het
Dst A G 1: 34,328,701 (GRCm39) T4590A probably damaging Het
Eif1ad10 T C 12: 88,216,476 (GRCm39) D132G unknown Het
Fscb G T 12: 64,519,906 (GRCm39) P520Q unknown Het
Gli1 T A 10: 127,167,225 (GRCm39) N676I probably damaging Het
Hspg2 T C 4: 137,266,660 (GRCm39) I1916T probably damaging Het
Igfals G A 17: 25,100,579 (GRCm39) V557I possibly damaging Het
Il7 A T 3: 7,669,224 (GRCm39) V4D probably damaging Het
Itgae T A 11: 73,004,442 (GRCm39) I243N probably damaging Het
Itpa T G 2: 130,522,930 (GRCm39) S176A probably damaging Het
Klhl13 T C X: 23,151,415 (GRCm39) D21G probably benign Het
Krt26 T C 11: 99,225,570 (GRCm39) K304E probably damaging Het
Ly6g6e T C 17: 35,296,159 (GRCm39) V10A probably benign Het
Mrpl32 G T 13: 14,787,630 (GRCm39) probably benign Het
Ncald G A 15: 37,397,497 (GRCm39) A61V probably damaging Het
Nek2 T C 1: 191,559,320 (GRCm39) V275A probably benign Het
Or12d12 T A 17: 37,610,870 (GRCm39) T148S probably benign Het
Or4f6 T C 2: 111,838,668 (GRCm39) T288A possibly damaging Het
Or5l13 T A 2: 87,779,874 (GRCm39) R234S probably damaging Het
Or5m10b T A 2: 85,699,306 (GRCm39) Y123* probably null Het
Pgam5 T C 5: 110,413,465 (GRCm39) Y210C probably damaging Het
Phf5a T C 15: 81,754,628 (GRCm39) N50D probably benign Het
Prl7d1 A G 13: 27,900,651 (GRCm39) M1T probably null Het
Sacs A G 14: 61,429,735 (GRCm39) K595R possibly damaging Het
Scyl3 A G 1: 163,778,206 (GRCm39) N448S probably benign Het
Serpinb9g A T 13: 33,670,518 (GRCm39) D2V probably benign Het
Sgsh A G 11: 119,241,773 (GRCm39) L111P probably damaging Het
Smg1 T C 7: 117,753,885 (GRCm39) probably benign Het
Taar1 T C 10: 23,796,482 (GRCm39) L60P probably damaging Het
Tmem51 T C 4: 141,759,059 (GRCm39) T230A probably damaging Het
Ubr4 T C 4: 139,151,301 (GRCm39) V623A probably damaging Het
Usp34 C T 11: 23,439,033 (GRCm39) P3532S possibly damaging Het
Vipr2 T C 12: 116,099,724 (GRCm39) probably benign Het
Vmn2r16 T C 5: 109,488,177 (GRCm39) M350T probably benign Het
Vmn2r22 T C 6: 123,614,339 (GRCm39) E417G possibly damaging Het
Vmn2r9 C A 5: 108,995,701 (GRCm39) V316F probably benign Het
Zfp53 C T 17: 21,728,893 (GRCm39) P309S probably damaging Het
Other mutations in Morc3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00561:Morc3 APN 16 93,670,283 (GRCm39) critical splice donor site probably null
IGL01015:Morc3 APN 16 93,659,534 (GRCm39) missense probably damaging 1.00
IGL01374:Morc3 APN 16 93,641,101 (GRCm39) missense probably damaging 1.00
IGL01634:Morc3 APN 16 93,670,125 (GRCm39) missense probably benign 0.02
IGL01845:Morc3 APN 16 93,657,455 (GRCm39) missense probably damaging 0.96
IGL02202:Morc3 APN 16 93,667,749 (GRCm39) missense probably benign 0.01
IGL02478:Morc3 APN 16 93,661,844 (GRCm39) splice site probably benign
IGL03026:Morc3 APN 16 93,659,612 (GRCm39) splice site probably benign
IGL03115:Morc3 APN 16 93,667,971 (GRCm39) missense probably damaging 0.99
Ballista UTSW 16 93,638,271 (GRCm39) missense probably damaging 1.00
mindy UTSW 16 93,663,421 (GRCm39) missense probably benign 0.03
Pfaff UTSW 16 93,659,572 (GRCm39) missense probably damaging 0.96
shield UTSW 16 93,671,700 (GRCm39) missense probably damaging 0.98
sparkle UTSW 16 93,667,362 (GRCm39) missense probably damaging 1.00
Stooges UTSW 16 93,638,275 (GRCm39) missense probably damaging 1.00
Sword UTSW 16 93,671,645 (GRCm39) critical splice acceptor site probably null
R0173:Morc3 UTSW 16 93,629,094 (GRCm39) splice site probably null
R0413:Morc3 UTSW 16 93,667,362 (GRCm39) missense probably damaging 1.00
R0639:Morc3 UTSW 16 93,650,738 (GRCm39) missense probably damaging 1.00
R0842:Morc3 UTSW 16 93,670,284 (GRCm39) critical splice donor site probably null
R1134:Morc3 UTSW 16 93,667,557 (GRCm39) missense probably benign
R1162:Morc3 UTSW 16 93,649,996 (GRCm39) missense probably damaging 1.00
R1498:Morc3 UTSW 16 93,650,743 (GRCm39) missense probably damaging 1.00
R1520:Morc3 UTSW 16 93,641,129 (GRCm39) missense probably damaging 0.96
R1603:Morc3 UTSW 16 93,663,391 (GRCm39) missense probably benign
R1622:Morc3 UTSW 16 93,671,694 (GRCm39) missense probably benign 0.28
R1630:Morc3 UTSW 16 93,663,421 (GRCm39) missense probably benign 0.03
R1818:Morc3 UTSW 16 93,652,398 (GRCm39) missense probably damaging 1.00
R1902:Morc3 UTSW 16 93,667,385 (GRCm39) missense probably damaging 1.00
R2090:Morc3 UTSW 16 93,663,341 (GRCm39) missense probably benign 0.23
R2261:Morc3 UTSW 16 93,650,109 (GRCm39) splice site probably benign
R2360:Morc3 UTSW 16 93,638,275 (GRCm39) missense probably damaging 1.00
R2407:Morc3 UTSW 16 93,641,215 (GRCm39) critical splice donor site probably null
R2519:Morc3 UTSW 16 93,659,427 (GRCm39) splice site probably null
R3736:Morc3 UTSW 16 93,671,700 (GRCm39) missense probably damaging 0.98
R4114:Morc3 UTSW 16 93,670,227 (GRCm39) missense probably benign 0.01
R4115:Morc3 UTSW 16 93,670,227 (GRCm39) missense probably benign 0.01
R4116:Morc3 UTSW 16 93,670,227 (GRCm39) missense probably benign 0.01
R4472:Morc3 UTSW 16 93,671,645 (GRCm39) critical splice acceptor site probably null
R4609:Morc3 UTSW 16 93,661,856 (GRCm39) missense probably benign 0.01
R4708:Morc3 UTSW 16 93,670,126 (GRCm39) missense probably benign 0.19
R4883:Morc3 UTSW 16 93,667,250 (GRCm39) critical splice acceptor site probably null
R4945:Morc3 UTSW 16 93,668,082 (GRCm39) missense probably damaging 1.00
R4965:Morc3 UTSW 16 93,657,475 (GRCm39) nonsense probably null
R5399:Morc3 UTSW 16 93,659,427 (GRCm39) splice site probably null
R5481:Morc3 UTSW 16 93,659,543 (GRCm39) missense probably damaging 0.99
R5540:Morc3 UTSW 16 93,644,268 (GRCm39) missense probably benign
R5970:Morc3 UTSW 16 93,663,341 (GRCm39) missense possibly damaging 0.65
R6006:Morc3 UTSW 16 93,663,381 (GRCm39) missense possibly damaging 0.67
R6044:Morc3 UTSW 16 93,663,330 (GRCm39) missense probably benign 0.02
R6045:Morc3 UTSW 16 93,671,733 (GRCm39) missense probably damaging 1.00
R6155:Morc3 UTSW 16 93,659,313 (GRCm39) missense possibly damaging 0.94
R6165:Morc3 UTSW 16 93,638,271 (GRCm39) missense probably damaging 1.00
R6225:Morc3 UTSW 16 93,642,082 (GRCm39) nonsense probably null
R6240:Morc3 UTSW 16 93,659,572 (GRCm39) missense probably damaging 0.96
R6835:Morc3 UTSW 16 93,644,309 (GRCm39) missense probably damaging 1.00
R6918:Morc3 UTSW 16 93,650,023 (GRCm39) missense probably benign 0.36
R6944:Morc3 UTSW 16 93,667,460 (GRCm39) missense probably benign
R7311:Morc3 UTSW 16 93,646,061 (GRCm39) missense probably damaging 1.00
R7398:Morc3 UTSW 16 93,671,748 (GRCm39) missense probably damaging 1.00
R7553:Morc3 UTSW 16 93,667,824 (GRCm39) missense probably damaging 0.98
R8056:Morc3 UTSW 16 93,642,064 (GRCm39) missense probably benign 0.07
R8299:Morc3 UTSW 16 93,650,088 (GRCm39) missense probably damaging 1.00
R8317:Morc3 UTSW 16 93,659,417 (GRCm39) missense probably benign 0.25
R8542:Morc3 UTSW 16 93,644,319 (GRCm39) critical splice donor site probably null
R8697:Morc3 UTSW 16 93,667,908 (GRCm39) missense probably benign 0.00
R8739:Morc3 UTSW 16 93,657,398 (GRCm39) missense probably damaging 1.00
R9072:Morc3 UTSW 16 93,667,482 (GRCm39) missense probably benign 0.00
R9235:Morc3 UTSW 16 93,659,321 (GRCm39) missense probably damaging 1.00
R9305:Morc3 UTSW 16 93,667,302 (GRCm39) missense probably benign 0.00
R9405:Morc3 UTSW 16 93,642,036 (GRCm39) missense probably damaging 1.00
R9431:Morc3 UTSW 16 93,667,771 (GRCm39) nonsense probably null
R9440:Morc3 UTSW 16 93,649,975 (GRCm39) critical splice acceptor site probably null
R9524:Morc3 UTSW 16 93,667,401 (GRCm39) missense probably benign 0.09
R9571:Morc3 UTSW 16 93,641,107 (GRCm39) missense possibly damaging 0.89
X0023:Morc3 UTSW 16 93,644,287 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTGACTTAACTCCTGAAAGTTACC -3'
(R):5'- TCTAGGCAGGAAAATCACATGG -3'

Sequencing Primer
(F):5'- TCAGGATTGGAAATAAGCAG -3'
(R):5'- GGAATAACACATCACAAGCACTGTTC -3'
Posted On 2015-04-06