Incidental Mutation 'R3876:Or4k39'
ID 276831
Institutional Source Beutler Lab
Gene Symbol Or4k39
Ensembl Gene ENSMUSG00000062280
Gene Name olfactory receptor family 4 subfamily K member 39, pseudogene 1
Synonyms GA_x6K02T2Q125-72459956-72460837, MOR248-25_p, MOR248-17P, Olfr1285
MMRRC Submission 041606-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # R3876 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 111238802-111239643 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 111238967 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 69 (V69A)
Gene Model predicted gene model for transcript(s): [ENSMUST00000184954]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000150164
AA Change: V69A

PolyPhen 2 Score 0.572 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000121467
Gene: ENSMUSG00000062280
AA Change: V69A

DomainStartEndE-ValueType
Pfam:7tm_4 24 293 2.9e-40 PFAM
Pfam:7tm_1 34 280 1.8e-15 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184954
AA Change: *83Q
SMART Domains Protein: ENSMUSP00000144852
Gene: ENSMUSG00000096703
AA Change: *83Q

DomainStartEndE-ValueType
Pfam:7tm_4 1 264 7.6e-38 PFAM
Pfam:7tm_1 5 251 7.2e-15 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208523
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220153
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency 100% (53/53)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931414P19Rik G A 14: 54,828,857 (GRCm39) R215* probably null Het
Brinp2 C A 1: 158,074,416 (GRCm39) L568F probably damaging Het
Brip1 T C 11: 86,043,616 (GRCm39) Y316C probably damaging Het
Cdk5rap2 ATGTG ATG 4: 70,208,214 (GRCm39) probably null Het
Cfap69 G T 5: 5,634,645 (GRCm39) probably benign Het
Chrnb4 T C 9: 54,951,182 (GRCm39) E27G probably damaging Het
Clec14a A G 12: 58,315,430 (GRCm39) V64A possibly damaging Het
Crygs A G 16: 22,625,262 (GRCm39) Y60H probably damaging Het
Dpp10 T A 1: 123,281,216 (GRCm39) Q611L probably damaging Het
Entpd1 T C 19: 40,725,264 (GRCm39) L450P probably damaging Het
Eogt G A 6: 97,097,151 (GRCm39) S317L probably damaging Het
Exosc10 T A 4: 148,657,376 (GRCm39) S584T probably benign Het
Fam184a C T 10: 53,575,157 (GRCm39) V151I probably damaging Het
Fbxo43 A G 15: 36,152,258 (GRCm39) V517A probably damaging Het
Flii T C 11: 60,610,698 (GRCm39) T533A possibly damaging Het
Frmpd1 T G 4: 45,284,093 (GRCm39) H971Q probably benign Het
Gata3 A T 2: 9,867,954 (GRCm39) N333K probably damaging Het
Hectd1 A G 12: 51,815,513 (GRCm39) S1525P probably damaging Het
Ibtk A G 9: 85,600,479 (GRCm39) I816T probably benign Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Krt34 T C 11: 99,931,791 (GRCm39) T143A probably benign Het
Lipn G T 19: 34,046,828 (GRCm39) M43I probably benign Het
Lrp1b A G 2: 41,335,206 (GRCm39) C779R probably damaging Het
Mios G A 6: 8,233,189 (GRCm39) R779Q probably damaging Het
Mme A T 3: 63,269,480 (GRCm39) probably benign Het
Ncstn A G 1: 171,897,640 (GRCm39) S418P probably benign Het
Oprk1 T A 1: 5,672,884 (GRCm39) C340* probably null Het
Or10d1c T A 9: 38,894,166 (GRCm39) Y58F probably damaging Het
Or4c29 T C 2: 88,739,952 (GRCm39) T262A possibly damaging Het
Or6c210 C T 10: 129,496,143 (GRCm39) P156L probably benign Het
Or6z7 G A 7: 6,484,131 (GRCm39) A8V probably benign Het
Pald1 T A 10: 61,183,266 (GRCm39) N323Y probably damaging Het
Pcdhac1 C A 18: 37,224,945 (GRCm39) A586E probably damaging Het
Pcnx2 C T 8: 126,614,897 (GRCm39) A185T probably benign Het
Pik3r1 G A 13: 101,821,465 (GRCm39) H430Y probably benign Het
Polr3b G A 10: 84,556,382 (GRCm39) probably null Het
Prl8a6 A T 13: 27,617,015 (GRCm39) L225* probably null Het
Psme4 T C 11: 30,806,068 (GRCm39) S89P probably damaging Het
Pygl G A 12: 70,248,113 (GRCm39) T250I probably damaging Het
Rgs13 T A 1: 144,016,528 (GRCm39) K72* probably null Het
Ryr2 T A 13: 11,603,045 (GRCm39) I4514F probably damaging Het
Septin3 A T 15: 82,170,002 (GRCm39) D32V probably damaging Het
Sfrp2 C T 3: 83,674,335 (GRCm39) P163S possibly damaging Het
Spata31 A G 13: 65,068,745 (GRCm39) T298A probably benign Het
Stxbp2 T C 8: 3,683,369 (GRCm39) probably null Het
Syne1 A T 10: 5,002,345 (GRCm39) M282K possibly damaging Het
Timd2 T C 11: 46,561,847 (GRCm39) probably null Het
Tlr11 G A 14: 50,600,611 (GRCm39) V866I probably benign Het
Trappc10 T C 10: 78,056,020 (GRCm39) probably null Het
Zfp512b AG AGG 2: 181,230,556 (GRCm39) probably null Het
Other mutations in Or4k39
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01328:Or4k39 APN 2 111,239,564 (GRCm39) missense probably damaging 1.00
IGL01819:Or4k39 APN 2 111,239,078 (GRCm39) missense probably damaging 0.99
IGL02109:Or4k39 APN 2 111,238,838 (GRCm39) exon noncoding transcript
IGL02407:Or4k39 APN 2 111,238,923 (GRCm39) exon noncoding transcript
R0054:Or4k39 UTSW 2 111,239,140 (GRCm39) missense probably benign 0.00
R1665:Or4k39 UTSW 2 111,239,098 (GRCm39) missense probably damaging 1.00
R2339:Or4k39 UTSW 2 111,239,534 (GRCm39) missense probably benign 0.36
R4260:Or4k39 UTSW 2 111,238,850 (GRCm39) exon noncoding transcript
R4439:Or4k39 UTSW 2 111,239,653 (GRCm39) exon noncoding transcript
R4762:Or4k39 UTSW 2 111,239,225 (GRCm39) exon noncoding transcript
R4821:Or4k39 UTSW 2 111,239,570 (GRCm39) exon noncoding transcript
R5120:Or4k39 UTSW 2 111,239,585 (GRCm39) exon noncoding transcript
R5215:Or4k39 UTSW 2 111,239,631 (GRCm39) exon noncoding transcript
R5244:Or4k39 UTSW 2 111,238,899 (GRCm39) exon noncoding transcript
R5667:Or4k39 UTSW 2 111,238,818 (GRCm39) exon noncoding transcript
R5671:Or4k39 UTSW 2 111,238,818 (GRCm39) exon noncoding transcript
R5687:Or4k39 UTSW 2 111,239,033 (GRCm39) exon noncoding transcript
Predicted Primers PCR Primer
(F):5'- AATCAAACTGTGGTTTCTGCG -3'
(R):5'- GATGCACTTCTGTCTGTCCATG -3'

Sequencing Primer
(F):5'- GGACTGTGTACCTCAAGGCAAC -3'
(R):5'- TGTCCATGCTGCCGCTG -3'
Posted On 2015-04-06