Incidental Mutation 'R3878:Tm9sf3'
ID |
276969 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Tm9sf3
|
Ensembl Gene |
ENSMUSG00000025016 |
Gene Name |
transmembrane 9 superfamily member 3 |
Synonyms |
2810031D16Rik, 1810073M23Rik, Smbp |
Accession Numbers |
|
Essential gene? |
Essential
(E-score: 1.000)
|
Stock # |
R3878 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
19 |
Chromosomal Location |
41199283-41252436 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 41235152 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Valine to Alanine
at position 169
(V169A)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000025989
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000025989]
|
AlphaFold |
Q9ET30 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000025989
AA Change: V169A
PolyPhen 2
Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000025989 Gene: ENSMUSG00000025016 AA Change: V169A
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
Pfam:EMP70
|
55 |
544 |
6.2e-164 |
PFAM |
transmembrane domain
|
549 |
571 |
N/A |
INTRINSIC |
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.3%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 41 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1700020A23Rik |
C |
T |
2: 130,247,560 (GRCm39) |
T32M |
probably benign |
Het |
A2ml1 |
T |
C |
6: 128,531,324 (GRCm39) |
S915G |
probably benign |
Het |
Ablim1 |
T |
C |
19: 57,025,642 (GRCm39) |
|
probably null |
Het |
Atosb |
T |
G |
4: 43,035,867 (GRCm39) |
H288P |
probably damaging |
Het |
Cadm2 |
C |
T |
16: 66,612,329 (GRCm39) |
E78K |
probably damaging |
Het |
Ceacam5 |
C |
T |
7: 17,484,506 (GRCm39) |
P416L |
probably damaging |
Het |
Chsy3 |
T |
C |
18: 59,542,845 (GRCm39) |
F661S |
probably damaging |
Het |
Clstn3 |
G |
A |
6: 124,434,901 (GRCm39) |
T338I |
probably damaging |
Het |
Ctif |
A |
G |
18: 75,653,048 (GRCm39) |
I403T |
probably damaging |
Het |
Dnaaf9 |
T |
C |
2: 130,620,423 (GRCm39) |
R237G |
possibly damaging |
Het |
Eprs1 |
T |
A |
1: 185,148,150 (GRCm39) |
|
probably null |
Het |
Frs2 |
A |
C |
10: 116,914,815 (GRCm39) |
S35A |
probably benign |
Het |
Gpr155 |
C |
T |
2: 73,198,736 (GRCm39) |
W394* |
probably null |
Het |
Ift140 |
G |
A |
17: 25,247,918 (GRCm39) |
V259M |
probably benign |
Het |
Igkv9-124 |
A |
T |
6: 67,919,191 (GRCm39) |
S74T |
probably benign |
Het |
Krt14 |
C |
T |
11: 100,097,915 (GRCm39) |
V123M |
possibly damaging |
Het |
Mcm2 |
G |
A |
6: 88,869,990 (GRCm39) |
R60C |
probably damaging |
Het |
Nebl |
T |
C |
2: 17,398,063 (GRCm39) |
T457A |
possibly damaging |
Het |
Nlrp4g |
A |
G |
9: 124,349,362 (GRCm38) |
|
noncoding transcript |
Het |
Nsa2 |
C |
G |
13: 97,268,542 (GRCm39) |
G175A |
probably benign |
Het |
Or8k40 |
T |
C |
2: 86,584,972 (GRCm39) |
T37A |
probably benign |
Het |
Pax1 |
A |
T |
2: 147,204,228 (GRCm39) |
|
probably benign |
Het |
Pdzd2 |
T |
C |
15: 12,376,262 (GRCm39) |
E1291G |
probably benign |
Het |
Relb |
G |
A |
7: 19,351,769 (GRCm39) |
H115Y |
probably damaging |
Het |
Rnase10 |
A |
G |
14: 51,246,889 (GRCm39) |
E52G |
probably damaging |
Het |
Sla2 |
G |
A |
2: 156,717,862 (GRCm39) |
R137C |
probably damaging |
Het |
Slc14a2 |
C |
T |
18: 78,202,289 (GRCm39) |
V614I |
probably benign |
Het |
Slc20a2 |
T |
C |
8: 23,058,399 (GRCm39) |
L645P |
possibly damaging |
Het |
Smoc2 |
A |
G |
17: 14,545,879 (GRCm39) |
D56G |
probably damaging |
Het |
Szt2 |
A |
G |
4: 118,247,782 (GRCm39) |
S789P |
probably damaging |
Het |
Tenm2 |
A |
G |
11: 36,030,401 (GRCm39) |
|
probably null |
Het |
Trbv13-1 |
C |
T |
6: 41,093,322 (GRCm39) |
T86I |
probably benign |
Het |
Trim24 |
A |
G |
6: 37,941,708 (GRCm39) |
D886G |
probably benign |
Het |
Trim33 |
A |
G |
3: 103,259,321 (GRCm39) |
I1003M |
probably damaging |
Het |
Trim37 |
T |
C |
11: 87,096,828 (GRCm39) |
V777A |
probably benign |
Het |
Ttc7 |
A |
C |
17: 87,678,166 (GRCm39) |
|
probably benign |
Het |
Ttn |
T |
C |
2: 76,596,364 (GRCm39) |
D11856G |
possibly damaging |
Het |
Vmn1r226 |
A |
T |
17: 20,908,260 (GRCm39) |
D164V |
possibly damaging |
Het |
Vmn1r34 |
G |
A |
6: 66,614,552 (GRCm39) |
T62I |
possibly damaging |
Het |
Wapl |
T |
C |
14: 34,414,104 (GRCm39) |
L322P |
probably damaging |
Het |
Zfp62 |
A |
G |
11: 49,105,960 (GRCm39) |
D17G |
probably damaging |
Het |
|
Other mutations in Tm9sf3 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01395:Tm9sf3
|
APN |
19 |
41,244,715 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02176:Tm9sf3
|
APN |
19 |
41,235,076 (GRCm39) |
splice site |
probably benign |
|
PIT4687001:Tm9sf3
|
UTSW |
19 |
41,206,630 (GRCm39) |
missense |
probably damaging |
1.00 |
R0504:Tm9sf3
|
UTSW |
19 |
41,236,331 (GRCm39) |
splice site |
probably benign |
|
R0564:Tm9sf3
|
UTSW |
19 |
41,233,964 (GRCm39) |
splice site |
probably benign |
|
R0586:Tm9sf3
|
UTSW |
19 |
41,244,582 (GRCm39) |
critical splice donor site |
probably null |
|
R1224:Tm9sf3
|
UTSW |
19 |
41,211,634 (GRCm39) |
missense |
probably damaging |
1.00 |
R1533:Tm9sf3
|
UTSW |
19 |
41,227,223 (GRCm39) |
missense |
probably benign |
0.00 |
R1646:Tm9sf3
|
UTSW |
19 |
41,211,618 (GRCm39) |
missense |
possibly damaging |
0.79 |
R1748:Tm9sf3
|
UTSW |
19 |
41,244,668 (GRCm39) |
missense |
probably benign |
0.01 |
R2022:Tm9sf3
|
UTSW |
19 |
41,227,231 (GRCm39) |
missense |
probably damaging |
1.00 |
R2172:Tm9sf3
|
UTSW |
19 |
41,205,859 (GRCm39) |
missense |
probably damaging |
1.00 |
R3844:Tm9sf3
|
UTSW |
19 |
41,205,555 (GRCm39) |
missense |
possibly damaging |
0.95 |
R4384:Tm9sf3
|
UTSW |
19 |
41,236,372 (GRCm39) |
missense |
probably damaging |
1.00 |
R4385:Tm9sf3
|
UTSW |
19 |
41,236,372 (GRCm39) |
missense |
probably damaging |
1.00 |
R4582:Tm9sf3
|
UTSW |
19 |
41,244,605 (GRCm39) |
missense |
probably damaging |
1.00 |
R5497:Tm9sf3
|
UTSW |
19 |
41,203,555 (GRCm39) |
missense |
probably benign |
0.03 |
R5876:Tm9sf3
|
UTSW |
19 |
41,229,023 (GRCm39) |
missense |
probably damaging |
1.00 |
R6305:Tm9sf3
|
UTSW |
19 |
41,233,881 (GRCm39) |
critical splice donor site |
probably null |
|
R6924:Tm9sf3
|
UTSW |
19 |
41,206,717 (GRCm39) |
missense |
probably damaging |
1.00 |
R6936:Tm9sf3
|
UTSW |
19 |
41,211,638 (GRCm39) |
missense |
probably benign |
0.44 |
R7121:Tm9sf3
|
UTSW |
19 |
41,233,944 (GRCm39) |
nonsense |
probably null |
|
R7287:Tm9sf3
|
UTSW |
19 |
41,205,818 (GRCm39) |
missense |
probably damaging |
1.00 |
R7303:Tm9sf3
|
UTSW |
19 |
41,227,198 (GRCm39) |
missense |
probably damaging |
0.97 |
R7677:Tm9sf3
|
UTSW |
19 |
41,209,743 (GRCm39) |
missense |
probably damaging |
1.00 |
R8212:Tm9sf3
|
UTSW |
19 |
41,229,074 (GRCm39) |
missense |
probably damaging |
0.99 |
R8220:Tm9sf3
|
UTSW |
19 |
41,203,526 (GRCm39) |
missense |
possibly damaging |
0.80 |
R8715:Tm9sf3
|
UTSW |
19 |
41,244,724 (GRCm39) |
missense |
probably damaging |
1.00 |
X0026:Tm9sf3
|
UTSW |
19 |
41,235,202 (GRCm39) |
nonsense |
probably null |
|
X0026:Tm9sf3
|
UTSW |
19 |
41,235,201 (GRCm39) |
missense |
possibly damaging |
0.91 |
Z1088:Tm9sf3
|
UTSW |
19 |
41,220,817 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1176:Tm9sf3
|
UTSW |
19 |
41,227,248 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1177:Tm9sf3
|
UTSW |
19 |
41,233,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- CACACTGAGGAATTTTGTTGCATC -3'
(R):5'- TGCTTGCTAAGAAGGCCAG -3'
Sequencing Primer
(F):5'- AACACAACCATTTCTTCCTCTA -3'
(R):5'- CATGAAGATAATGGTAGAGTTGCCTC -3'
|
Posted On |
2015-04-06 |