Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00985:Tas2r124'

27723

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r124

Ensembl Gene

ENSMUSG00000060412

Gene Name

taste receptor, type 2, member 124

Synonyms

mt2r50, mGR24, Tas2r24, T2R24

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

IGL00985

Quality Score

Status

Chromosome

Chromosomal Location

132731693-132732622 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 132732492 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 267 (T267I)

Ref Sequence

ENSEMBL: ENSMUSP00000075509 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000076150]

AlphaFold

Q7M718

Predicted Effect

probably benign
Transcript: ENSMUST00000076150
AA Change: T267I

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000075509
Gene: ENSMUSG00000060412
AA Change: T267I

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	298	2.3e-92	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A630091E08Rik	G	T	7: 98,193,125 (GRCm39)		noncoding transcript	Het
Abca15	G	A	7: 119,996,241 (GRCm39)	G1389E	probably damaging	Het
Adcy3	T	C	12: 4,184,600 (GRCm39)	V92A	probably damaging	Het
Aoc1l1	A	G	6: 48,954,481 (GRCm39)	S540G	probably benign	Het
Aplnr	A	T	2: 84,968,007 (GRCm39)	Y344F	probably benign	Het
Atm	A	T	9: 53,371,116 (GRCm39)	V2241E	probably damaging	Het
Cep290	T	C	10: 100,403,023 (GRCm39)		probably benign	Het
Cnpy1	A	T	5: 28,414,152 (GRCm39)	Y91*	probably null	Het
Cobl	C	A	11: 12,204,843 (GRCm39)	G613W	probably damaging	Het
Csn1s2a	T	C	5: 87,932,439 (GRCm39)	S121P	possibly damaging	Het
Flg2	A	T	3: 93,110,585 (GRCm39)	Y871F	unknown	Het
Gapvd1	T	A	2: 34,585,575 (GRCm39)	D1008V	probably damaging	Het
Gask1a	T	C	9: 121,807,401 (GRCm39)	L515P	probably damaging	Het
Igfl3	T	C	7: 17,914,000 (GRCm39)		probably null	Het
Kmt2b	A	T	7: 30,279,352 (GRCm39)	V1470E	probably damaging	Het
Mcc	A	T	18: 44,624,306 (GRCm39)	L413Q	probably damaging	Het
Mia2	G	A	12: 59,235,146 (GRCm39)	G610D	probably damaging	Het
Mlst8	A	T	17: 24,696,287 (GRCm39)	D147E	probably damaging	Het
Muc19	G	T	15: 91,770,943 (GRCm39)		noncoding transcript	Het
Mybpc3	A	G	2: 90,965,704 (GRCm39)	E1172G	probably benign	Het
Niban3	T	C	8: 72,057,507 (GRCm39)		probably benign	Het
Nop14	A	T	5: 34,802,133 (GRCm39)	L557Q	probably damaging	Het
P3h3	T	C	6: 124,822,552 (GRCm39)	T540A	probably benign	Het
Phc3	T	A	3: 30,968,346 (GRCm39)	I897F	probably benign	Het
Plekhh2	G	A	17: 84,871,356 (GRCm39)	V205I	probably benign	Het
Poc5	A	G	13: 96,547,254 (GRCm39)	K506E	probably damaging	Het
Pum1	C	A	4: 130,471,100 (GRCm39)	T450K	probably damaging	Het
Retnlg	G	A	16: 48,694,688 (GRCm39)	R112H	possibly damaging	Het
Rgl2	T	C	17: 34,151,075 (GRCm39)	V101A	probably damaging	Het
Serinc5	A	G	13: 92,842,779 (GRCm39)	T410A	probably damaging	Het
Shroom1	T	C	11: 53,356,796 (GRCm39)	V553A	probably benign	Het
Slco4c1	A	T	1: 96,768,912 (GRCm39)	W317R	probably damaging	Het
Snap91	T	C	9: 86,703,790 (GRCm39)	T268A	probably benign	Het
Supt16	T	C	14: 52,399,148 (GRCm39)	K1044E	possibly damaging	Het
Tarbp1	A	T	8: 127,185,900 (GRCm39)	L431I	probably damaging	Het
Tm7sf3	C	T	6: 146,507,692 (GRCm39)	V457I	possibly damaging	Het
Tmem132c	A	T	5: 127,581,930 (GRCm39)	S382C	probably damaging	Het
Tmprss7	C	A	16: 45,482,685 (GRCm39)	C582F	probably damaging	Het
Tsc2	T	C	17: 24,816,105 (GRCm39)	E1694G	probably damaging	Het
Txndc2	G	T	17: 65,945,544 (GRCm39)	S211Y	possibly damaging	Het
Ubr3	A	C	2: 69,833,775 (GRCm39)	T205P	probably damaging	Het
Vmn2r116	G	A	17: 23,620,489 (GRCm39)	G741D	probably damaging	Het
Vps8	G	A	16: 21,296,334 (GRCm39)		probably benign	Het
Wdr19	G	A	5: 65,409,642 (GRCm39)	D1127N	probably benign	Het
Zim1	T	A	7: 6,685,759 (GRCm39)	Y83F	possibly damaging	Het

Other mutations in Tas2r124

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01343:Tas2r124	APN	6	132,732,378 (GRCm39)	missense	probably damaging	1.00
IGL01646:Tas2r124	APN	6	132,732,332 (GRCm39)	missense	probably damaging	0.98
IGL01743:Tas2r124	APN	6	132,731,798 (GRCm39)	missense	probably benign	0.01
IGL02251:Tas2r124	APN	6	132,732,524 (GRCm39)	missense	probably benign	0.02
IGL03081:Tas2r124	APN	6	132,732,497 (GRCm39)	missense	possibly damaging	0.61
IGL03309:Tas2r124	APN	6	132,731,898 (GRCm39)	missense	probably benign	0.01
IGL03374:Tas2r124	APN	6	132,732,081 (GRCm39)	missense	probably benign	0.00
P0012:Tas2r124	UTSW	6	132,732,503 (GRCm39)	missense	possibly damaging	0.70
R1450:Tas2r124	UTSW	6	132,732,019 (GRCm39)	missense	probably damaging	1.00
R1804:Tas2r124	UTSW	6	132,732,488 (GRCm39)	missense	probably benign	0.11
R2048:Tas2r124	UTSW	6	132,731,858 (GRCm39)	missense	possibly damaging	0.94
R2846:Tas2r124	UTSW	6	132,732,230 (GRCm39)	missense	possibly damaging	0.73
R3415:Tas2r124	UTSW	6	132,732,601 (GRCm39)	missense	probably benign	0.00
R3416:Tas2r124	UTSW	6	132,732,601 (GRCm39)	missense	probably benign	0.00
R3417:Tas2r124	UTSW	6	132,732,601 (GRCm39)	missense	probably benign	0.00
R4306:Tas2r124	UTSW	6	132,731,954 (GRCm39)	missense	probably benign	0.03
R4308:Tas2r124	UTSW	6	132,731,954 (GRCm39)	missense	probably benign	0.03
R4823:Tas2r124	UTSW	6	132,732,509 (GRCm39)	missense	probably damaging	0.98
R4867:Tas2r124	UTSW	6	132,732,156 (GRCm39)	missense	probably damaging	0.98
R4949:Tas2r124	UTSW	6	132,731,858 (GRCm39)	missense	possibly damaging	0.94
R5242:Tas2r124	UTSW	6	132,732,503 (GRCm39)	missense	possibly damaging	0.70
R6001:Tas2r124	UTSW	6	132,732,416 (GRCm39)	missense	probably damaging	0.99
R6263:Tas2r124	UTSW	6	132,731,867 (GRCm39)	missense	probably benign	0.45
R6313:Tas2r124	UTSW	6	132,732,410 (GRCm39)	missense	probably benign	0.00
R6394:Tas2r124	UTSW	6	132,732,039 (GRCm39)	missense	probably damaging	1.00
R7685:Tas2r124	UTSW	6	132,732,056 (GRCm39)	missense	probably damaging	0.97
R8354:Tas2r124	UTSW	6	132,732,410 (GRCm39)	missense	probably benign	0.10
R9045:Tas2r124	UTSW	6	132,732,034 (GRCm39)	missense	probably damaging	0.99
R9615:Tas2r124	UTSW	6	132,732,492 (GRCm39)	missense	probably benign	0.02

Posted On

2013-04-17