Incidental Mutation 'R3845:Vmn2r91'
| ID |
277351 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r91
|
| Ensembl Gene |
ENSMUSG00000091206 |
| Gene Name |
vomeronasal 2, receptor 91 |
| Synonyms |
EG665210 |
| MMRRC Submission |
040893-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.065)
|
| Stock # |
R3845 (G1)
|
| Quality Score |
137 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
18305319-18356905 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 18327860 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Isoleucine
at position 485
(V485I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000127465
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000172359]
|
| AlphaFold |
E9Q2U5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000172359
AA Change: V485I
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000127465
Gene: ENSMUSG00000091206
AA Change: V485I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
462 |
2.2e-38 |
PFAM |
|
Pfam:NCD3G
|
510 |
564 |
6.7e-20 |
PFAM |
|
Pfam:7tm_3
|
597 |
832 |
2.1e-53 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.6%
- 20x: 95.8%
|
| Validation Efficiency |
98% (45/46) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 47 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam34l |
T |
C |
8: 44,079,669 (GRCm39) |
N185S |
probably benign |
Het |
| Apool |
A |
T |
X: 111,274,155 (GRCm39) |
|
probably benign |
Het |
| Atp4a |
A |
G |
7: 30,416,540 (GRCm39) |
N439S |
probably null |
Het |
| AU041133 |
T |
A |
10: 81,987,152 (GRCm39) |
H268Q |
probably damaging |
Het |
| Ccdc136 |
C |
T |
6: 29,417,176 (GRCm39) |
R666W |
probably benign |
Het |
| Ccdc97 |
T |
C |
7: 25,414,453 (GRCm39) |
|
probably benign |
Het |
| Celf1 |
T |
C |
2: 90,839,583 (GRCm39) |
V336A |
possibly damaging |
Het |
| Chd3 |
T |
C |
11: 69,237,585 (GRCm39) |
N1870D |
possibly damaging |
Het |
| Col5a3 |
C |
T |
9: 20,719,673 (GRCm39) |
D229N |
unknown |
Het |
| Cpn1 |
G |
T |
19: 43,962,523 (GRCm39) |
P142Q |
possibly damaging |
Het |
| Cubn |
T |
C |
2: 13,287,819 (GRCm39) |
D3420G |
probably damaging |
Het |
| Cyp2u1 |
A |
G |
3: 131,087,135 (GRCm39) |
F482S |
possibly damaging |
Het |
| Foxo1 |
T |
A |
3: 52,253,701 (GRCm39) |
D621E |
probably benign |
Het |
| Grid2 |
A |
G |
6: 64,322,826 (GRCm39) |
M609V |
possibly damaging |
Het |
| Hsd17b3 |
A |
T |
13: 64,236,876 (GRCm39) |
F23I |
possibly damaging |
Het |
| Kcnk10 |
A |
G |
12: 98,407,003 (GRCm39) |
I217T |
probably benign |
Het |
| Mis18bp1 |
G |
A |
12: 65,195,916 (GRCm39) |
S616L |
possibly damaging |
Het |
| Mtch1 |
A |
T |
17: 29,561,806 (GRCm39) |
F133I |
probably damaging |
Het |
| Myh4 |
T |
A |
11: 67,149,931 (GRCm39) |
V1830E |
possibly damaging |
Het |
| Nav3 |
T |
C |
10: 109,689,237 (GRCm39) |
M347V |
possibly damaging |
Het |
| Nbea |
A |
G |
3: 55,993,713 (GRCm39) |
|
probably benign |
Het |
| Nhej1 |
A |
T |
1: 75,008,042 (GRCm39) |
D76E |
probably benign |
Het |
| Nsf |
C |
T |
11: 103,821,578 (GRCm39) |
E26K |
possibly damaging |
Het |
| Or5m12 |
A |
C |
2: 85,735,081 (GRCm39) |
C106G |
probably damaging |
Het |
| Pias3 |
T |
C |
3: 96,609,526 (GRCm39) |
V307A |
probably benign |
Het |
| Pltp |
T |
A |
2: 164,696,208 (GRCm39) |
M135L |
probably benign |
Het |
| Plxna2 |
A |
G |
1: 194,476,098 (GRCm39) |
Y1106C |
probably damaging |
Het |
| Pramel26 |
T |
C |
4: 143,538,545 (GRCm39) |
E142G |
probably damaging |
Het |
| Ptgir |
G |
A |
7: 16,641,311 (GRCm39) |
R201H |
probably damaging |
Het |
| Ptk7 |
A |
T |
17: 46,897,344 (GRCm39) |
D329E |
probably benign |
Het |
| Pygl |
T |
C |
12: 70,245,217 (GRCm39) |
D411G |
probably benign |
Het |
| Rev1 |
A |
T |
1: 38,138,069 (GRCm39) |
M72K |
probably damaging |
Het |
| Sfrp1 |
T |
C |
8: 23,902,264 (GRCm39) |
L155P |
probably damaging |
Het |
| Slc5a4a |
A |
G |
10: 76,024,983 (GRCm39) |
E620G |
probably damaging |
Het |
| Smarca2 |
A |
G |
19: 26,698,273 (GRCm39) |
I1314V |
probably benign |
Het |
| Tas2r109 |
G |
A |
6: 132,957,766 (GRCm39) |
L55F |
probably damaging |
Het |
| Tek |
T |
A |
4: 94,693,109 (GRCm39) |
C274S |
probably damaging |
Het |
| Tektl1 |
T |
C |
10: 78,584,532 (GRCm39) |
N330S |
probably benign |
Het |
| Tent4b |
A |
T |
8: 88,977,292 (GRCm39) |
I322F |
possibly damaging |
Het |
| Tmem38b |
T |
A |
4: 53,859,905 (GRCm39) |
D228E |
probably benign |
Het |
| Topbp1 |
T |
C |
9: 103,187,122 (GRCm39) |
V109A |
possibly damaging |
Het |
| Trbv5 |
A |
G |
6: 41,039,682 (GRCm39) |
I96V |
probably benign |
Het |
| Trim16 |
T |
G |
11: 62,727,498 (GRCm39) |
|
probably benign |
Het |
| Upf3a |
A |
T |
8: 13,848,238 (GRCm39) |
T345S |
probably benign |
Het |
| Usp15 |
A |
G |
10: 122,955,040 (GRCm39) |
S913P |
probably damaging |
Het |
| Vmn2r124 |
T |
A |
17: 18,293,953 (GRCm39) |
V680D |
possibly damaging |
Het |
| Zdbf2 |
A |
T |
1: 63,347,483 (GRCm39) |
H1954L |
possibly damaging |
Het |
|
| Other mutations in Vmn2r91 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00983:Vmn2r91
|
APN |
17 |
18,325,820 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01121:Vmn2r91
|
APN |
17 |
18,356,766 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01464:Vmn2r91
|
APN |
17 |
18,327,864 (GRCm39) |
missense |
probably null |
0.00 |
|
IGL02003:Vmn2r91
|
APN |
17 |
18,327,921 (GRCm39) |
missense |
probably benign |
|
|
IGL02709:Vmn2r91
|
APN |
17 |
18,325,711 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
IGL02795:Vmn2r91
|
APN |
17 |
18,305,539 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02813:Vmn2r91
|
APN |
17 |
18,356,348 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02830:Vmn2r91
|
APN |
17 |
18,356,884 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03130:Vmn2r91
|
APN |
17 |
18,330,373 (GRCm39) |
splice site |
probably benign |
|
|
BB006:Vmn2r91
|
UTSW |
17 |
18,327,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB016:Vmn2r91
|
UTSW |
17 |
18,327,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0164:Vmn2r91
|
UTSW |
17 |
18,326,399 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0164:Vmn2r91
|
UTSW |
17 |
18,326,399 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0393:Vmn2r91
|
UTSW |
17 |
18,325,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1142:Vmn2r91
|
UTSW |
17 |
18,356,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1603:Vmn2r91
|
UTSW |
17 |
18,326,405 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1992:Vmn2r91
|
UTSW |
17 |
18,356,142 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2182:Vmn2r91
|
UTSW |
17 |
18,325,691 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2424:Vmn2r91
|
UTSW |
17 |
18,356,431 (GRCm39) |
nonsense |
probably null |
|
|
R2512:Vmn2r91
|
UTSW |
17 |
18,356,048 (GRCm39) |
missense |
probably benign |
|
|
R2885:Vmn2r91
|
UTSW |
17 |
18,325,628 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2909:Vmn2r91
|
UTSW |
17 |
18,356,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3009:Vmn2r91
|
UTSW |
17 |
18,325,717 (GRCm39) |
missense |
probably benign |
0.11 |
|
R3079:Vmn2r91
|
UTSW |
17 |
18,355,973 (GRCm39) |
splice site |
probably null |
|
|
R3080:Vmn2r91
|
UTSW |
17 |
18,355,973 (GRCm39) |
splice site |
probably null |
|
|
R3434:Vmn2r91
|
UTSW |
17 |
18,330,370 (GRCm39) |
splice site |
probably benign |
|
|
R3723:Vmn2r91
|
UTSW |
17 |
18,305,540 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3829:Vmn2r91
|
UTSW |
17 |
18,325,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3846:Vmn2r91
|
UTSW |
17 |
18,327,860 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4118:Vmn2r91
|
UTSW |
17 |
18,330,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4285:Vmn2r91
|
UTSW |
17 |
18,356,030 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4729:Vmn2r91
|
UTSW |
17 |
18,327,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4793:Vmn2r91
|
UTSW |
17 |
18,325,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4932:Vmn2r91
|
UTSW |
17 |
18,356,751 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5016:Vmn2r91
|
UTSW |
17 |
18,330,322 (GRCm39) |
nonsense |
probably null |
|
|
R5018:Vmn2r91
|
UTSW |
17 |
18,356,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5605:Vmn2r91
|
UTSW |
17 |
18,356,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5815:Vmn2r91
|
UTSW |
17 |
18,326,464 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6146:Vmn2r91
|
UTSW |
17 |
18,356,518 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6187:Vmn2r91
|
UTSW |
17 |
18,326,888 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6426:Vmn2r91
|
UTSW |
17 |
18,355,865 (GRCm39) |
splice site |
probably null |
|
|
R6450:Vmn2r91
|
UTSW |
17 |
18,305,527 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6767:Vmn2r91
|
UTSW |
17 |
18,327,807 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6986:Vmn2r91
|
UTSW |
17 |
18,356,271 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7112:Vmn2r91
|
UTSW |
17 |
18,325,880 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7178:Vmn2r91
|
UTSW |
17 |
18,356,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7330:Vmn2r91
|
UTSW |
17 |
18,326,429 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7368:Vmn2r91
|
UTSW |
17 |
18,356,540 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7380:Vmn2r91
|
UTSW |
17 |
18,356,838 (GRCm39) |
nonsense |
probably null |
|
|
R7397:Vmn2r91
|
UTSW |
17 |
18,356,060 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7625:Vmn2r91
|
UTSW |
17 |
18,325,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7739:Vmn2r91
|
UTSW |
17 |
18,356,080 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7749:Vmn2r91
|
UTSW |
17 |
18,356,540 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7755:Vmn2r91
|
UTSW |
17 |
18,330,311 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7929:Vmn2r91
|
UTSW |
17 |
18,327,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7981:Vmn2r91
|
UTSW |
17 |
18,327,887 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8211:Vmn2r91
|
UTSW |
17 |
18,326,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8325:Vmn2r91
|
UTSW |
17 |
18,356,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8781:Vmn2r91
|
UTSW |
17 |
18,305,323 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R8974:Vmn2r91
|
UTSW |
17 |
18,325,636 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9047:Vmn2r91
|
UTSW |
17 |
18,326,296 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9048:Vmn2r91
|
UTSW |
17 |
18,356,122 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9109:Vmn2r91
|
UTSW |
17 |
18,327,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9211:Vmn2r91
|
UTSW |
17 |
18,356,819 (GRCm39) |
nonsense |
probably null |
|
|
R9555:Vmn2r91
|
UTSW |
17 |
18,325,792 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9616:Vmn2r91
|
UTSW |
17 |
18,356,305 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCCTCATTTTCAACACTGGAGC -3'
(R):5'- TCCTCATATAAGTTAGCAATGAGGG -3'
Sequencing Primer
(F):5'- CTAAAAGCAAGTAAGTCTTCCTAGC -3'
(R):5'- CTGATACTCAAAGTGTAATGGAACTG -3'
|
| Posted On |
2015-04-06 |
Incidental Mutation