Incidental Mutation 'R3845:Apool'
ID 277356
Institutional Source Beutler Lab
Gene Symbol Apool
Ensembl Gene ENSMUSG00000025525
Gene Name apolipoprotein O-like
Synonyms 9430083G14Rik, Micos27, E130106L15Rik, 6720473G16Rik
MMRRC Submission 040893-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3845 (G1)
Quality Score 222
Status Validated
Chromosome X
Chromosomal Location 111221049-111282452 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 111274155 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000109042 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026599] [ENSMUST00000113415]
AlphaFold Q78IK4
Predicted Effect probably benign
Transcript: ENSMUST00000026599
SMART Domains Protein: ENSMUSP00000026599
Gene: ENSMUSG00000025525

DomainStartEndE-ValueType
Pfam:ApoO 37 179 5e-39 PFAM
low complexity region 186 201 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000113415
SMART Domains Protein: ENSMUSP00000109042
Gene: ENSMUSG00000025525

DomainStartEndE-ValueType
Pfam:ApoO 1 133 9.5e-40 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 95.8%
Validation Efficiency 98% (45/46)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein which contains an apolipoprotein O superfamily domain. This domain is found on proteins in circulating lipoprotein complexes. [provided by RefSeq, Sep 2011]
PHENOTYPE: Male chimeras hemizygous for a gene trapped allele appear normal at E9.5. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam34l T C 8: 44,079,669 (GRCm39) N185S probably benign Het
Atp4a A G 7: 30,416,540 (GRCm39) N439S probably null Het
AU041133 T A 10: 81,987,152 (GRCm39) H268Q probably damaging Het
Ccdc136 C T 6: 29,417,176 (GRCm39) R666W probably benign Het
Ccdc97 T C 7: 25,414,453 (GRCm39) probably benign Het
Celf1 T C 2: 90,839,583 (GRCm39) V336A possibly damaging Het
Chd3 T C 11: 69,237,585 (GRCm39) N1870D possibly damaging Het
Col5a3 C T 9: 20,719,673 (GRCm39) D229N unknown Het
Cpn1 G T 19: 43,962,523 (GRCm39) P142Q possibly damaging Het
Cubn T C 2: 13,287,819 (GRCm39) D3420G probably damaging Het
Cyp2u1 A G 3: 131,087,135 (GRCm39) F482S possibly damaging Het
Foxo1 T A 3: 52,253,701 (GRCm39) D621E probably benign Het
Grid2 A G 6: 64,322,826 (GRCm39) M609V possibly damaging Het
Hsd17b3 A T 13: 64,236,876 (GRCm39) F23I possibly damaging Het
Kcnk10 A G 12: 98,407,003 (GRCm39) I217T probably benign Het
Mis18bp1 G A 12: 65,195,916 (GRCm39) S616L possibly damaging Het
Mtch1 A T 17: 29,561,806 (GRCm39) F133I probably damaging Het
Myh4 T A 11: 67,149,931 (GRCm39) V1830E possibly damaging Het
Nav3 T C 10: 109,689,237 (GRCm39) M347V possibly damaging Het
Nbea A G 3: 55,993,713 (GRCm39) probably benign Het
Nhej1 A T 1: 75,008,042 (GRCm39) D76E probably benign Het
Nsf C T 11: 103,821,578 (GRCm39) E26K possibly damaging Het
Or5m12 A C 2: 85,735,081 (GRCm39) C106G probably damaging Het
Pias3 T C 3: 96,609,526 (GRCm39) V307A probably benign Het
Pltp T A 2: 164,696,208 (GRCm39) M135L probably benign Het
Plxna2 A G 1: 194,476,098 (GRCm39) Y1106C probably damaging Het
Pramel26 T C 4: 143,538,545 (GRCm39) E142G probably damaging Het
Ptgir G A 7: 16,641,311 (GRCm39) R201H probably damaging Het
Ptk7 A T 17: 46,897,344 (GRCm39) D329E probably benign Het
Pygl T C 12: 70,245,217 (GRCm39) D411G probably benign Het
Rev1 A T 1: 38,138,069 (GRCm39) M72K probably damaging Het
Sfrp1 T C 8: 23,902,264 (GRCm39) L155P probably damaging Het
Slc5a4a A G 10: 76,024,983 (GRCm39) E620G probably damaging Het
Smarca2 A G 19: 26,698,273 (GRCm39) I1314V probably benign Het
Tas2r109 G A 6: 132,957,766 (GRCm39) L55F probably damaging Het
Tek T A 4: 94,693,109 (GRCm39) C274S probably damaging Het
Tektl1 T C 10: 78,584,532 (GRCm39) N330S probably benign Het
Tent4b A T 8: 88,977,292 (GRCm39) I322F possibly damaging Het
Tmem38b T A 4: 53,859,905 (GRCm39) D228E probably benign Het
Topbp1 T C 9: 103,187,122 (GRCm39) V109A possibly damaging Het
Trbv5 A G 6: 41,039,682 (GRCm39) I96V probably benign Het
Trim16 T G 11: 62,727,498 (GRCm39) probably benign Het
Upf3a A T 8: 13,848,238 (GRCm39) T345S probably benign Het
Usp15 A G 10: 122,955,040 (GRCm39) S913P probably damaging Het
Vmn2r124 T A 17: 18,293,953 (GRCm39) V680D possibly damaging Het
Vmn2r91 G A 17: 18,327,860 (GRCm39) V485I probably benign Het
Zdbf2 A T 1: 63,347,483 (GRCm39) H1954L possibly damaging Het
Other mutations in Apool
AlleleSourceChrCoordTypePredicted EffectPPH Score
R2017:Apool UTSW X 111,274,258 (GRCm39) missense probably benign 0.04
R3846:Apool UTSW X 111,274,155 (GRCm39) splice site probably benign
R4732:Apool UTSW X 111,281,897 (GRCm39) missense probably damaging 0.98
R4733:Apool UTSW X 111,281,897 (GRCm39) missense probably damaging 0.98
R5072:Apool UTSW X 111,259,540 (GRCm39) nonsense probably null
R5073:Apool UTSW X 111,259,540 (GRCm39) nonsense probably null
R5074:Apool UTSW X 111,259,540 (GRCm39) nonsense probably null
X0022:Apool UTSW X 111,263,911 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- AAGAAGCGTGTCATTGAAGC -3'
(R):5'- TCAGGAATCTAGATCCCTCATAAGC -3'

Sequencing Primer
(F):5'- AGAAGCGTGTCATTGAAGCTTTGAG -3'
(R):5'- TGGGAAAACATAAGTTCAAAGCATC -3'
Posted On 2015-04-06