Incidental Mutation 'R3846:Or10ag56'
ID 277365
Institutional Source Beutler Lab
Gene Symbol Or10ag56
Ensembl Gene ENSMUSG00000083706
Gene Name olfactory receptor family 10 subfamily AG member 56
Synonyms Olfr1118, GA_x6K02T2Q125-48795705-48796673, Olfr1118-ps, MOR264-22
MMRRC Submission 040894-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.102) question?
Stock # R3846 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 87139108-87140103 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87139526 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 151 (V151A)
Ref Sequence ENSEMBL: ENSMUSP00000150394 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090717] [ENSMUST00000121296] [ENSMUST00000216396]
AlphaFold A0A1L1STN9
Predicted Effect probably benign
Transcript: ENSMUST00000090717
AA Change: V131A

PolyPhen 2 Score 0.079 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000132837
Gene: ENSMUSG00000070855
AA Change: V131A

DomainStartEndE-ValueType
Pfam:7tm_4 22 298 1.1e-53 PFAM
Pfam:7tm_1 32 281 1.1e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000120328
Predicted Effect probably benign
Transcript: ENSMUST00000121296
AA Change: V131A

PolyPhen 2 Score 0.079 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000144143
Gene: ENSMUSG00000083706
AA Change: V131A

DomainStartEndE-ValueType
Pfam:7tm_4 22 298 1.2e-51 PFAM
Pfam:7tm_1 32 281 7.2e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216396
AA Change: V151A

PolyPhen 2 Score 0.149 (Sensitivity: 0.92; Specificity: 0.87)
Meta Mutation Damage Score 0.2603 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency 97% (38/39)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930568D16Rik A G 2: 35,244,570 (GRCm39) Y261H probably damaging Het
Acad10 T A 5: 121,772,749 (GRCm39) I511F probably benign Het
Adgb G A 10: 10,258,465 (GRCm39) probably benign Het
Adgrg3 T C 8: 95,767,049 (GRCm39) V468A probably benign Het
Ano4 A T 10: 88,831,114 (GRCm39) I468N possibly damaging Het
Apool A T X: 111,274,155 (GRCm39) probably benign Het
Arhgap32 T C 9: 32,101,320 (GRCm39) V295A probably benign Het
Ccser2 A G 14: 36,662,245 (GRCm39) V313A probably benign Het
Ctnnd1 T C 2: 84,447,271 (GRCm39) I325V probably benign Het
Cubn T C 2: 13,287,819 (GRCm39) D3420G probably damaging Het
Dnah12 A G 14: 26,431,366 (GRCm39) T395A probably benign Het
Dock2 T G 11: 34,623,198 (GRCm39) H65P possibly damaging Het
Fsip2 A T 2: 82,816,759 (GRCm39) Q4164L possibly damaging Het
Gapvd1 A T 2: 34,619,084 (GRCm39) Y96* probably null Het
Gja3 T A 14: 57,273,161 (GRCm39) K404* probably null Het
Hdac1-ps A G 17: 78,800,401 (GRCm39) K464R possibly damaging Het
Hmcn2 A G 2: 31,320,362 (GRCm39) I3948V possibly damaging Het
Hr C T 14: 70,808,893 (GRCm39) R1090W probably damaging Het
Hrnr A G 3: 93,239,464 (GRCm39) H3234R unknown Het
Ifi207 T A 1: 173,562,869 (GRCm39) E92D probably benign Het
Iqgap2 G A 13: 95,810,186 (GRCm39) probably benign Het
Itgax G T 7: 127,732,939 (GRCm39) V273F probably damaging Het
Lamc3 A G 2: 31,814,604 (GRCm39) M1043V probably benign Het
Lgmn T C 12: 102,370,588 (GRCm39) N114S possibly damaging Het
Mov10l1 A G 15: 88,896,345 (GRCm39) N678D possibly damaging Het
Nlrp9c A G 7: 26,081,701 (GRCm39) probably null Het
Notch4 A G 17: 34,797,071 (GRCm39) T940A probably damaging Het
Nudt15 T A 14: 73,760,911 (GRCm39) Q60L probably benign Het
Or52e7 T C 7: 104,684,896 (GRCm39) C164R probably benign Het
Phip G A 9: 82,758,179 (GRCm39) R1505* probably null Het
Ptger2 T G 14: 45,226,784 (GRCm39) S121R probably damaging Het
Scyl2 A T 10: 89,476,403 (GRCm39) F907L probably damaging Het
Silc1 T A 12: 27,210,301 (GRCm39) noncoding transcript Het
Trpc4 C A 3: 54,225,433 (GRCm39) F843L probably benign Het
Tysnd1 C T 10: 61,531,867 (GRCm39) S173L possibly damaging Het
Vmn2r124 T A 17: 18,293,953 (GRCm39) V680D possibly damaging Het
Vmn2r91 G A 17: 18,327,860 (GRCm39) V485I probably benign Het
Other mutations in Or10ag56
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01328:Or10ag56 APN 2 87,139,925 (GRCm39) missense possibly damaging 0.95
IGL01458:Or10ag56 APN 2 87,139,826 (GRCm39) missense probably damaging 1.00
IGL02544:Or10ag56 APN 2 87,139,471 (GRCm39) missense possibly damaging 0.91
IGL02748:Or10ag56 APN 2 87,140,009 (GRCm39) missense probably damaging 1.00
IGL03077:Or10ag56 APN 2 87,140,056 (GRCm39) makesense probably null
R0411:Or10ag56 UTSW 2 87,139,402 (GRCm39) missense probably benign 0.07
R0525:Or10ag56 UTSW 2 87,139,693 (GRCm39) missense probably benign 0.10
R1703:Or10ag56 UTSW 2 87,139,754 (GRCm39) missense probably benign 0.00
R1750:Or10ag56 UTSW 2 87,139,196 (GRCm39) missense probably benign 0.02
R2005:Or10ag56 UTSW 2 87,139,792 (GRCm39) missense probably benign 0.24
R2090:Or10ag56 UTSW 2 87,139,762 (GRCm39) missense probably benign 0.02
R4011:Or10ag56 UTSW 2 87,139,555 (GRCm39) missense probably benign 0.03
R4077:Or10ag56 UTSW 2 87,139,208 (GRCm39) splice site probably null 0.42
R5132:Or10ag56 UTSW 2 87,139,282 (GRCm39) missense probably damaging 1.00
R5368:Or10ag56 UTSW 2 87,139,126 (GRCm39) splice site probably null
R7355:Or10ag56 UTSW 2 87,139,754 (GRCm39) missense probably benign 0.00
R7405:Or10ag56 UTSW 2 87,139,339 (GRCm39) missense probably benign 0.00
R7437:Or10ag56 UTSW 2 87,139,687 (GRCm39) missense probably benign
R7554:Or10ag56 UTSW 2 87,139,349 (GRCm39) missense probably damaging 1.00
R7609:Or10ag56 UTSW 2 87,139,853 (GRCm39) missense probably benign 0.01
R8156:Or10ag56 UTSW 2 87,139,318 (GRCm39) missense probably damaging 0.97
R8482:Or10ag56 UTSW 2 87,139,726 (GRCm39) missense probably benign 0.07
R8558:Or10ag56 UTSW 2 87,139,583 (GRCm39) missense probably benign 0.11
R9136:Or10ag56 UTSW 2 87,139,219 (GRCm39) missense possibly damaging 0.95
R9229:Or10ag56 UTSW 2 87,139,165 (GRCm39) missense probably benign 0.00
R9326:Or10ag56 UTSW 2 87,139,730 (GRCm39) missense probably benign 0.37
RF010:Or10ag56 UTSW 2 87,139,184 (GRCm39) missense possibly damaging 0.83
Predicted Primers PCR Primer
(F):5'- GCTACTATTCCAAGAATGCTTATGG -3'
(R):5'- CCATCCCTTTGGCTGAAGAC -3'

Sequencing Primer
(F):5'- ACAGAGTGCCTCTTGCT -3'
(R):5'- CCTTTGGCTGAAGACAGTTTC -3'
Posted On 2015-04-06