Incidental Mutation 'R3846:Adgrg3'
ID 277373
Institutional Source Beutler Lab
Gene Symbol Adgrg3
Ensembl Gene ENSMUSG00000060470
Gene Name adhesion G protein-coupled receptor G3
Synonyms Pb99, A030001G24Rik, Gpr97
MMRRC Submission 040894-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3846 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 95744320-95771878 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 95767049 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 468 (V468A)
Ref Sequence ENSEMBL: ENSMUSP00000051079 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051259]
AlphaFold Q8R0T6
Predicted Effect probably benign
Transcript: ENSMUST00000051259
AA Change: V468A

PolyPhen 2 Score 0.070 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000051079
Gene: ENSMUSG00000060470
AA Change: V468A

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
GPS 209 256 3.45e-11 SMART
Pfam:7tm_2 260 509 5.1e-33 PFAM
low complexity region 520 531 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211974
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211994
Predicted Effect probably benign
Transcript: ENSMUST00000212570
Meta Mutation Damage Score 0.5934 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency 97% (38/39)
MGI Phenotype PHENOTYPE: Homozygous null mice display normal B and T cell development. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930568D16Rik A G 2: 35,244,570 (GRCm39) Y261H probably damaging Het
Acad10 T A 5: 121,772,749 (GRCm39) I511F probably benign Het
Adgb G A 10: 10,258,465 (GRCm39) probably benign Het
Ano4 A T 10: 88,831,114 (GRCm39) I468N possibly damaging Het
Apool A T X: 111,274,155 (GRCm39) probably benign Het
Arhgap32 T C 9: 32,101,320 (GRCm39) V295A probably benign Het
Ccser2 A G 14: 36,662,245 (GRCm39) V313A probably benign Het
Ctnnd1 T C 2: 84,447,271 (GRCm39) I325V probably benign Het
Cubn T C 2: 13,287,819 (GRCm39) D3420G probably damaging Het
Dnah12 A G 14: 26,431,366 (GRCm39) T395A probably benign Het
Dock2 T G 11: 34,623,198 (GRCm39) H65P possibly damaging Het
Fsip2 A T 2: 82,816,759 (GRCm39) Q4164L possibly damaging Het
Gapvd1 A T 2: 34,619,084 (GRCm39) Y96* probably null Het
Gja3 T A 14: 57,273,161 (GRCm39) K404* probably null Het
Hdac1-ps A G 17: 78,800,401 (GRCm39) K464R possibly damaging Het
Hmcn2 A G 2: 31,320,362 (GRCm39) I3948V possibly damaging Het
Hr C T 14: 70,808,893 (GRCm39) R1090W probably damaging Het
Hrnr A G 3: 93,239,464 (GRCm39) H3234R unknown Het
Ifi207 T A 1: 173,562,869 (GRCm39) E92D probably benign Het
Iqgap2 G A 13: 95,810,186 (GRCm39) probably benign Het
Itgax G T 7: 127,732,939 (GRCm39) V273F probably damaging Het
Lamc3 A G 2: 31,814,604 (GRCm39) M1043V probably benign Het
Lgmn T C 12: 102,370,588 (GRCm39) N114S possibly damaging Het
Mov10l1 A G 15: 88,896,345 (GRCm39) N678D possibly damaging Het
Nlrp9c A G 7: 26,081,701 (GRCm39) probably null Het
Notch4 A G 17: 34,797,071 (GRCm39) T940A probably damaging Het
Nudt15 T A 14: 73,760,911 (GRCm39) Q60L probably benign Het
Or10ag56 T C 2: 87,139,526 (GRCm39) V151A probably benign Het
Or52e7 T C 7: 104,684,896 (GRCm39) C164R probably benign Het
Phip G A 9: 82,758,179 (GRCm39) R1505* probably null Het
Ptger2 T G 14: 45,226,784 (GRCm39) S121R probably damaging Het
Scyl2 A T 10: 89,476,403 (GRCm39) F907L probably damaging Het
Silc1 T A 12: 27,210,301 (GRCm39) noncoding transcript Het
Trpc4 C A 3: 54,225,433 (GRCm39) F843L probably benign Het
Tysnd1 C T 10: 61,531,867 (GRCm39) S173L possibly damaging Het
Vmn2r124 T A 17: 18,293,953 (GRCm39) V680D possibly damaging Het
Vmn2r91 G A 17: 18,327,860 (GRCm39) V485I probably benign Het
Other mutations in Adgrg3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01096:Adgrg3 APN 8 95,766,221 (GRCm39) missense possibly damaging 0.90
IGL01724:Adgrg3 APN 8 95,766,053 (GRCm39) missense probably benign 0.04
IGL02111:Adgrg3 APN 8 95,761,627 (GRCm39) missense probably damaging 0.96
IGL02142:Adgrg3 APN 8 95,766,483 (GRCm39) missense probably damaging 1.00
IGL02577:Adgrg3 APN 8 95,766,555 (GRCm39) missense probably damaging 0.99
IGL02940:Adgrg3 APN 8 95,760,084 (GRCm39) missense possibly damaging 0.48
IGL03395:Adgrg3 APN 8 95,761,701 (GRCm39) missense probably damaging 1.00
R0111:Adgrg3 UTSW 8 95,761,738 (GRCm39) splice site probably benign
R0288:Adgrg3 UTSW 8 95,766,568 (GRCm39) missense possibly damaging 0.92
R0403:Adgrg3 UTSW 8 95,763,550 (GRCm39) missense probably benign 0.07
R1553:Adgrg3 UTSW 8 95,766,896 (GRCm39) missense possibly damaging 0.90
R1667:Adgrg3 UTSW 8 95,760,001 (GRCm39) nonsense probably null
R1686:Adgrg3 UTSW 8 95,759,997 (GRCm39) missense probably benign 0.02
R1872:Adgrg3 UTSW 8 95,760,070 (GRCm39) missense possibly damaging 0.87
R1882:Adgrg3 UTSW 8 95,766,943 (GRCm39) missense probably benign 0.03
R1924:Adgrg3 UTSW 8 95,762,562 (GRCm39) missense probably benign
R1998:Adgrg3 UTSW 8 95,763,296 (GRCm39) missense probably damaging 1.00
R2090:Adgrg3 UTSW 8 95,766,558 (GRCm39) missense possibly damaging 0.54
R2696:Adgrg3 UTSW 8 95,747,702 (GRCm39) missense probably benign 0.01
R4013:Adgrg3 UTSW 8 95,761,727 (GRCm39) splice site probably benign
R4405:Adgrg3 UTSW 8 95,763,536 (GRCm39) missense probably benign 0.15
R4622:Adgrg3 UTSW 8 95,767,153 (GRCm39) missense probably damaging 1.00
R4878:Adgrg3 UTSW 8 95,761,714 (GRCm39) missense possibly damaging 0.86
R5101:Adgrg3 UTSW 8 95,763,563 (GRCm39) missense probably benign 0.00
R5309:Adgrg3 UTSW 8 95,766,492 (GRCm39) missense probably benign 0.00
R5312:Adgrg3 UTSW 8 95,766,492 (GRCm39) missense probably benign 0.00
R5353:Adgrg3 UTSW 8 95,762,556 (GRCm39) missense probably damaging 0.99
R5820:Adgrg3 UTSW 8 95,766,221 (GRCm39) missense possibly damaging 0.90
R6240:Adgrg3 UTSW 8 95,766,544 (GRCm39) missense probably benign 0.23
R6272:Adgrg3 UTSW 8 95,762,889 (GRCm39) missense noncoding transcript
R7110:Adgrg3 UTSW 8 95,761,591 (GRCm39) missense possibly damaging 0.62
R7645:Adgrg3 UTSW 8 95,761,392 (GRCm39) intron probably benign
R8178:Adgrg3 UTSW 8 95,761,675 (GRCm39) missense probably damaging 0.98
R8397:Adgrg3 UTSW 8 95,767,141 (GRCm39) missense probably benign 0.01
R8730:Adgrg3 UTSW 8 95,766,556 (GRCm39) missense probably benign 0.09
R8951:Adgrg3 UTSW 8 95,761,362 (GRCm39) intron probably benign
R9100:Adgrg3 UTSW 8 95,762,891 (GRCm39) intron probably benign
R9523:Adgrg3 UTSW 8 95,766,186 (GRCm39) missense probably benign 0.06
R9583:Adgrg3 UTSW 8 95,760,071 (GRCm39) missense probably benign 0.00
R9589:Adgrg3 UTSW 8 95,760,093 (GRCm39) missense possibly damaging 0.87
X0017:Adgrg3 UTSW 8 95,744,398 (GRCm39) start codon destroyed probably null 0.53
Predicted Primers PCR Primer
(F):5'- AATGGTCAGGGGTTTCCTCC -3'
(R):5'- TGATCTGTAGAACACCCTCCC -3'

Sequencing Primer
(F):5'- AGCGGCTATCCACCTCCTG -3'
(R):5'- CCAATTCCCAGTGCCCCTTAG -3'
Posted On 2015-04-06