Incidental Mutation 'IGL00901:Cyp2b9'
ID 27766
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cyp2b9
Ensembl Gene ENSMUSG00000040660
Gene Name cytochrome P450, family 2, subfamily b, polypeptide 9
Synonyms phenobarbitol inducible, type a, Cyp2b
Accession Numbers
Essential gene? Probably non essential (E-score: 0.125) question?
Stock # IGL00901
Quality Score
Status
Chromosome 7
Chromosomal Location 25872836-25910086 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 25897930 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 245 (I245F)
Ref Sequence ENSEMBL: ENSMUSP00000080846 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000082214]
AlphaFold P12790
Predicted Effect probably damaging
Transcript: ENSMUST00000082214
AA Change: I245F

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000080846
Gene: ENSMUSG00000040660
AA Change: I245F

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:p450 31 488 1.7e-146 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot6 A G 12: 84,153,250 (GRCm39) Y164C probably benign Het
Anpep A G 7: 79,489,171 (GRCm39) S334P probably benign Het
Arhgef1 A G 7: 24,612,118 (GRCm39) E129G probably damaging Het
Bmt2 G T 6: 13,628,748 (GRCm39) H312N probably damaging Het
Brme1 A G 8: 84,893,400 (GRCm39) D189G probably damaging Het
Ces2g A G 8: 105,691,761 (GRCm39) Y272C probably benign Het
Cfap69 T A 5: 5,669,162 (GRCm39) probably benign Het
Cftr T C 6: 18,268,429 (GRCm39) probably null Het
Clec2g A G 6: 128,925,655 (GRCm39) probably benign Het
Fbxo6 T A 4: 148,230,600 (GRCm39) I221F probably damaging Het
Fbxw21 A C 9: 108,985,467 (GRCm39) C104G probably benign Het
Flna A G X: 73,273,534 (GRCm39) S101P probably damaging Het
Hnrnpm C A 17: 33,868,876 (GRCm39) R517L probably damaging Het
Ift88 T A 14: 57,681,902 (GRCm39) F229I probably damaging Het
Map2k3 T C 11: 60,832,747 (GRCm39) S31P probably benign Het
Mia2 A G 12: 59,154,815 (GRCm39) D176G probably damaging Het
Or12d2 T G 17: 37,624,598 (GRCm39) K226Q possibly damaging Het
Or12e10 A G 2: 87,640,992 (GRCm39) Y276C probably damaging Het
Or14j6 T A 17: 38,215,148 (GRCm39) V237D probably damaging Het
Pde7b C T 10: 20,494,875 (GRCm39) probably null Het
Polr3b T C 10: 84,467,660 (GRCm39) I80T possibly damaging Het
Prpf4b T A 13: 35,078,465 (GRCm39) Y692N probably damaging Het
Rabl2 T C 15: 89,474,473 (GRCm39) probably benign Het
Rasgrp1 T C 2: 117,115,611 (GRCm39) K659R probably damaging Het
Ryr3 A T 2: 112,716,934 (GRCm39) S774T probably damaging Het
Sema5b C T 16: 35,471,685 (GRCm39) T426M probably damaging Het
Serpinb10 A G 1: 107,468,726 (GRCm39) K123R probably benign Het
Slc33a1 T C 3: 63,871,433 (GRCm39) D60G probably benign Het
Tnks A T 8: 35,305,549 (GRCm39) Y92* probably null Het
Tvp23b T A 11: 62,774,606 (GRCm39) probably benign Het
Wnk1 T A 6: 119,937,669 (GRCm39) Q1218L probably damaging Het
Other mutations in Cyp2b9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01133:Cyp2b9 APN 7 25,909,660 (GRCm39) missense probably damaging 1.00
IGL01331:Cyp2b9 APN 7 25,887,140 (GRCm39) missense probably damaging 0.99
IGL02281:Cyp2b9 APN 7 25,900,529 (GRCm39) missense probably damaging 0.99
IGL02502:Cyp2b9 APN 7 25,887,239 (GRCm39) critical splice donor site probably null
IGL02713:Cyp2b9 APN 7 25,872,945 (GRCm39) missense probably benign 0.12
IGL03032:Cyp2b9 APN 7 25,898,025 (GRCm39) splice site probably benign
IGL03307:Cyp2b9 APN 7 25,898,476 (GRCm39) missense probably benign 0.00
R0010:Cyp2b9 UTSW 7 25,886,178 (GRCm39) splice site probably benign
R0025:Cyp2b9 UTSW 7 25,900,238 (GRCm39) missense probably benign 0.09
R0040:Cyp2b9 UTSW 7 25,872,899 (GRCm39) missense possibly damaging 0.68
R0184:Cyp2b9 UTSW 7 25,886,432 (GRCm39) nonsense probably null
R0370:Cyp2b9 UTSW 7 25,909,531 (GRCm39) missense probably damaging 1.00
R1595:Cyp2b9 UTSW 7 25,900,332 (GRCm39) missense possibly damaging 0.72
R1751:Cyp2b9 UTSW 7 25,886,100 (GRCm39) missense probably benign 0.05
R1835:Cyp2b9 UTSW 7 25,900,208 (GRCm39) missense probably benign
R1879:Cyp2b9 UTSW 7 25,897,994 (GRCm39) missense probably damaging 0.99
R2256:Cyp2b9 UTSW 7 25,873,030 (GRCm39) critical splice donor site probably null
R2257:Cyp2b9 UTSW 7 25,873,030 (GRCm39) critical splice donor site probably null
R2418:Cyp2b9 UTSW 7 25,886,132 (GRCm39) missense probably benign 0.00
R3420:Cyp2b9 UTSW 7 25,909,528 (GRCm39) missense probably damaging 1.00
R4088:Cyp2b9 UTSW 7 25,872,881 (GRCm39) missense probably damaging 0.99
R4412:Cyp2b9 UTSW 7 25,897,868 (GRCm39) missense probably damaging 1.00
R4495:Cyp2b9 UTSW 7 25,900,180 (GRCm39) missense probably benign 0.00
R4615:Cyp2b9 UTSW 7 25,900,550 (GRCm39) missense probably damaging 1.00
R5375:Cyp2b9 UTSW 7 25,887,167 (GRCm39) missense probably damaging 1.00
R5426:Cyp2b9 UTSW 7 25,887,080 (GRCm39) missense probably benign
R5862:Cyp2b9 UTSW 7 25,887,232 (GRCm39) missense probably benign 0.01
R6237:Cyp2b9 UTSW 7 25,872,999 (GRCm39) missense probably benign 0.02
R6445:Cyp2b9 UTSW 7 25,886,412 (GRCm39) missense probably benign 0.13
R6992:Cyp2b9 UTSW 7 25,900,564 (GRCm39) missense probably benign 0.00
R7515:Cyp2b9 UTSW 7 25,898,596 (GRCm39) missense probably damaging 1.00
R7654:Cyp2b9 UTSW 7 25,886,367 (GRCm39) missense possibly damaging 0.72
R7816:Cyp2b9 UTSW 7 25,900,517 (GRCm39) missense probably benign 0.01
R7850:Cyp2b9 UTSW 7 25,886,111 (GRCm39) nonsense probably null
R8734:Cyp2b9 UTSW 7 25,898,035 (GRCm39) intron probably benign
R8790:Cyp2b9 UTSW 7 25,898,167 (GRCm39) intron probably benign
R8839:Cyp2b9 UTSW 7 25,900,185 (GRCm39) missense probably damaging 0.96
R9209:Cyp2b9 UTSW 7 25,873,004 (GRCm39) missense possibly damaging 0.52
R9723:Cyp2b9 UTSW 7 25,909,596 (GRCm39) nonsense probably null
R9787:Cyp2b9 UTSW 7 25,900,259 (GRCm39) missense probably benign 0.04
Z1177:Cyp2b9 UTSW 7 25,900,588 (GRCm39) missense probably benign 0.31
Posted On 2013-04-17