Incidental Mutation 'IGL00902:Vmn2r56'
| ID |
27771 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r56
|
| Ensembl Gene |
ENSMUSG00000090762 |
| Gene Name |
vomeronasal 2, receptor 56 |
| Synonyms |
EG629079 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.066)
|
| Stock # |
IGL00902
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
12427787-12468785 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 12449426 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Glycine
at position 271
(S271G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129566
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000163852]
|
| AlphaFold |
A0A3B2WBA1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163852
AA Change: S271G
PolyPhen 2
Score 0.385 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000129566
Gene: ENSMUSG00000090762
AA Change: S271G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
5 |
397 |
1.9e-55 |
PFAM |
|
Pfam:NCD3G
|
439 |
492 |
6.4e-20 |
PFAM |
|
Pfam:7tm_3
|
523 |
760 |
1.3e-53 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 41 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts7 |
T |
G |
9: 90,070,847 (GRCm39) |
|
probably null |
Het |
| Akap11 |
A |
G |
14: 78,733,278 (GRCm39) |
S1876P |
probably benign |
Het |
| Bltp1 |
G |
A |
3: 37,095,494 (GRCm39) |
G1001D |
probably damaging |
Het |
| Capn10 |
A |
G |
1: 92,870,281 (GRCm39) |
I256V |
probably benign |
Het |
| Catsperg2 |
T |
A |
7: 29,400,568 (GRCm39) |
H262L |
possibly damaging |
Het |
| Col22a1 |
C |
A |
15: 71,836,508 (GRCm39) |
G509V |
probably damaging |
Het |
| Dab2ip |
T |
C |
2: 35,607,124 (GRCm39) |
F523S |
probably damaging |
Het |
| Dbnl |
G |
T |
11: 5,748,105 (GRCm39) |
A313S |
probably benign |
Het |
| Ddo |
T |
C |
10: 40,523,550 (GRCm39) |
V180A |
probably damaging |
Het |
| Enox1 |
A |
G |
14: 77,819,844 (GRCm39) |
M200V |
possibly damaging |
Het |
| Fabp6 |
G |
A |
11: 43,489,543 (GRCm39) |
R33C |
probably damaging |
Het |
| Gm9104 |
T |
C |
17: 45,776,940 (GRCm39) |
|
probably benign |
Het |
| Gspt1 |
C |
T |
16: 11,050,443 (GRCm39) |
V303I |
probably damaging |
Het |
| Igf2r |
C |
T |
17: 12,919,245 (GRCm39) |
C1469Y |
probably damaging |
Het |
| Igflr1 |
T |
C |
7: 30,266,700 (GRCm39) |
S183P |
possibly damaging |
Het |
| Itga6 |
T |
C |
2: 71,679,738 (GRCm39) |
V1001A |
probably benign |
Het |
| Itih1 |
G |
A |
14: 30,654,439 (GRCm39) |
|
probably benign |
Het |
| Itprid2 |
G |
A |
2: 79,490,822 (GRCm39) |
R980Q |
probably damaging |
Het |
| Krt86 |
C |
T |
15: 101,371,741 (GRCm39) |
H104Y |
probably benign |
Het |
| Lrp5 |
T |
C |
19: 3,650,774 (GRCm39) |
N1220S |
probably damaging |
Het |
| Marchf6 |
A |
G |
15: 31,485,124 (GRCm39) |
Y434H |
probably damaging |
Het |
| Mbd1 |
A |
G |
18: 74,408,310 (GRCm39) |
Y211C |
possibly damaging |
Het |
| Mpeg1 |
C |
A |
19: 12,439,133 (GRCm39) |
A197D |
probably damaging |
Het |
| Mroh2b |
T |
A |
15: 4,944,704 (GRCm39) |
L435Q |
probably damaging |
Het |
| Mss51 |
A |
C |
14: 20,536,235 (GRCm39) |
M160R |
probably damaging |
Het |
| Ndufs7 |
T |
G |
10: 80,091,839 (GRCm39) |
Y190* |
probably null |
Het |
| Or6c38 |
T |
A |
10: 128,929,265 (GRCm39) |
I193L |
probably benign |
Het |
| Or9g4b |
T |
C |
2: 85,616,461 (GRCm39) |
M202T |
probably benign |
Het |
| Pcdh17 |
A |
G |
14: 84,684,289 (GRCm39) |
E252G |
probably damaging |
Het |
| Ric1 |
T |
C |
19: 29,544,631 (GRCm39) |
V151A |
probably benign |
Het |
| Sgo2a |
A |
G |
1: 58,055,258 (GRCm39) |
T481A |
probably benign |
Het |
| Slc5a8 |
A |
G |
10: 88,755,323 (GRCm39) |
T477A |
probably benign |
Het |
| Smg5 |
G |
A |
3: 88,260,392 (GRCm39) |
V661I |
probably benign |
Het |
| Snx19 |
A |
T |
9: 30,340,028 (GRCm39) |
I389F |
possibly damaging |
Het |
| Spem1 |
A |
T |
11: 69,712,643 (GRCm39) |
I64N |
probably damaging |
Het |
| Thada |
A |
T |
17: 84,755,404 (GRCm39) |
M262K |
probably damaging |
Het |
| Uox |
A |
G |
3: 146,316,161 (GRCm39) |
D32G |
possibly damaging |
Het |
| Usp42 |
A |
T |
5: 143,705,629 (GRCm39) |
|
probably benign |
Het |
| Usp43 |
G |
A |
11: 67,782,245 (GRCm39) |
P391L |
probably benign |
Het |
| Wdr64 |
T |
A |
1: 175,556,391 (GRCm39) |
C213S |
probably damaging |
Het |
| Zfp26 |
A |
T |
9: 20,350,844 (GRCm39) |
S194T |
possibly damaging |
Het |
|
| Other mutations in Vmn2r56 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01060:Vmn2r56
|
APN |
7 |
12,447,016 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01433:Vmn2r56
|
APN |
7 |
12,449,541 (GRCm39) |
missense |
probably benign |
|
|
IGL01859:Vmn2r56
|
APN |
7 |
12,449,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01874:Vmn2r56
|
APN |
7 |
12,449,602 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02208:Vmn2r56
|
APN |
7 |
12,449,408 (GRCm39) |
missense |
probably benign |
0.01 |
|
PIT4445001:Vmn2r56
|
UTSW |
7 |
12,449,153 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0077:Vmn2r56
|
UTSW |
7 |
12,449,332 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0278:Vmn2r56
|
UTSW |
7 |
12,449,644 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0512:Vmn2r56
|
UTSW |
7 |
12,449,350 (GRCm39) |
missense |
probably benign |
|
|
R0658:Vmn2r56
|
UTSW |
7 |
12,444,235 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0789:Vmn2r56
|
UTSW |
7 |
12,466,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1534:Vmn2r56
|
UTSW |
7 |
12,427,954 (GRCm39) |
missense |
probably benign |
|
|
R1731:Vmn2r56
|
UTSW |
7 |
12,466,972 (GRCm39) |
missense |
probably benign |
|
|
R1817:Vmn2r56
|
UTSW |
7 |
12,449,542 (GRCm39) |
missense |
probably benign |
|
|
R2047:Vmn2r56
|
UTSW |
7 |
12,466,918 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2139:Vmn2r56
|
UTSW |
7 |
12,446,890 (GRCm39) |
nonsense |
probably null |
|
|
R2160:Vmn2r56
|
UTSW |
7 |
12,428,146 (GRCm39) |
missense |
probably benign |
0.43 |
|
R2449:Vmn2r56
|
UTSW |
7 |
12,428,082 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R2877:Vmn2r56
|
UTSW |
7 |
12,444,954 (GRCm39) |
missense |
probably benign |
|
|
R2878:Vmn2r56
|
UTSW |
7 |
12,444,954 (GRCm39) |
missense |
probably benign |
|
|
R4910:Vmn2r56
|
UTSW |
7 |
12,449,462 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R5072:Vmn2r56
|
UTSW |
7 |
12,427,983 (GRCm39) |
missense |
probably benign |
0.40 |
|
R5340:Vmn2r56
|
UTSW |
7 |
12,449,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5697:Vmn2r56
|
UTSW |
7 |
12,449,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5798:Vmn2r56
|
UTSW |
7 |
12,446,892 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6166:Vmn2r56
|
UTSW |
7 |
12,427,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6290:Vmn2r56
|
UTSW |
7 |
12,428,809 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6458:Vmn2r56
|
UTSW |
7 |
12,427,984 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6751:Vmn2r56
|
UTSW |
7 |
12,428,719 (GRCm39) |
missense |
probably benign |
|
|
R6978:Vmn2r56
|
UTSW |
7 |
12,449,333 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7090:Vmn2r56
|
UTSW |
7 |
12,449,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7200:Vmn2r56
|
UTSW |
7 |
12,444,259 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7861:Vmn2r56
|
UTSW |
7 |
12,449,351 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8222:Vmn2r56
|
UTSW |
7 |
12,444,960 (GRCm39) |
missense |
probably benign |
|
|
R8282:Vmn2r56
|
UTSW |
7 |
12,449,601 (GRCm39) |
nonsense |
probably null |
|
|
R8786:Vmn2r56
|
UTSW |
7 |
12,449,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8970:Vmn2r56
|
UTSW |
7 |
12,428,632 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9230:Vmn2r56
|
UTSW |
7 |
12,444,237 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
RF002:Vmn2r56
|
UTSW |
7 |
12,428,757 (GRCm39) |
missense |
probably benign |
0.02 |
|
| Posted On |
2013-04-17 |
Incidental Mutation