Incidental Mutation 'IGL00903:Gvin1'
ID27773
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gvin1
Ensembl Gene ENSMUSG00000045868
Gene NameGTPase, very large interferon inducible 1
Synonyms9130002C22Rik, VLIG, 9830104F22Rik, Iigs1, VLIG-1
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL00903
Quality Score
Status
Chromosome7
Chromosomal Location106156556-106215326 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 106158170 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Glycine at position 2364 (E2364G)
Ref Sequence ENSEMBL: ENSMUSP00000138950 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000006667] [ENSMUST00000183409]
Predicted Effect probably benign
Transcript: ENSMUST00000006667
AA Change: E2364G

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000006667
Gene: ENSMUSG00000045868
AA Change: E2364G

DomainStartEndE-ValueType
low complexity region 104 116 N/A INTRINSIC
low complexity region 122 135 N/A INTRINSIC
Blast:PGAM 860 1554 7e-61 BLAST
coiled coil region 1625 1655 N/A INTRINSIC
low complexity region 1769 1781 N/A INTRINSIC
coiled coil region 1851 1877 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000183409
AA Change: E2364G

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000138950
Gene: ENSMUSG00000045868
AA Change: E2364G

DomainStartEndE-ValueType
low complexity region 104 116 N/A INTRINSIC
low complexity region 122 135 N/A INTRINSIC
Blast:PGAM 860 1554 7e-61 BLAST
coiled coil region 1625 1655 N/A INTRINSIC
low complexity region 1769 1781 N/A INTRINSIC
coiled coil region 1851 1877 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1500012F01Rik G T 2: 167,065,486 probably benign Het
Arsk A G 13: 76,098,368 probably null Het
As3mt A G 19: 46,712,234 I159V probably benign Het
Ctsll3 C A 13: 60,800,261 V201L probably benign Het
Dapk1 T C 13: 60,761,397 Y1275H probably damaging Het
Erap1 G A 13: 74,673,707 R727H probably benign Het
Fam173b T C 15: 31,606,115 V73A possibly damaging Het
Fcrl6 T A 1: 172,599,107 T91S probably benign Het
Hacd3 T C 9: 65,004,253 probably benign Het
Hcls1 T A 16: 36,956,021 probably null Het
Igf2r C T 17: 12,683,867 R2432H possibly damaging Het
Kif27 C A 13: 58,344,672 V218F possibly damaging Het
Klhl20 T C 1: 161,090,506 Y70C probably benign Het
Krt86 C T 15: 101,473,860 H104Y probably benign Het
Lcn12 G T 2: 25,493,320 N15K possibly damaging Het
Mrgpra1 T C 7: 47,335,578 M118V probably benign Het
Nacad G T 11: 6,600,632 T853K probably damaging Het
Nos3 A T 5: 24,369,862 Q293L probably damaging Het
Prkca C T 11: 107,983,974 V381M probably damaging Het
Ptcd3 A G 6: 71,907,844 F37S possibly damaging Het
Ptgs2 A G 1: 150,104,424 Y371C probably damaging Het
Pygl T C 12: 70,207,742 Y143C probably damaging Het
Samhd1 A G 2: 157,107,423 probably benign Het
Scube1 T A 15: 83,703,501 H89L probably damaging Het
Tmem59l G A 8: 70,485,665 probably benign Het
Vmn2r108 A G 17: 20,462,512 V810A probably damaging Het
Vmn2r61 T G 7: 42,300,511 F785C probably damaging Het
Other mutations in Gvin1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4860:Gvin1 UTSW 7 106163436 missense possibly damaging 0.95
R4860:Gvin1 UTSW 7 106163436 missense possibly damaging 0.95
R5648:Gvin1 UTSW 7 106163399 missense possibly damaging 0.92
R5806:Gvin1 UTSW 7 106158206 missense probably benign
Posted On2013-04-17