Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00774:Cts6'

277924

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cts6

Ensembl Gene

ENSMUSG00000021441

Gene Name

cathepsin 6

Synonyms

1600022N02Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00774

Quality Score

Status

Chromosome

Chromosomal Location

61342961-61351206 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 61346153 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000021890 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000021890]

AlphaFold

Q9ET52

Predicted Effect

probably benign
Transcript: ENSMUST00000021890

SMART Domains

Protein: ENSMUSP00000021890
Gene: ENSMUSG00000021441

Domain	Start	End	E-Value	Type
Inhibitor_I29	29	88	3.17e-22	SMART
Pept_C1	115	333	9.61e-111	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamtsl1	G	A	4: 86,306,776 (GRCm39)	A1397T	possibly damaging	Het
Aldob	A	G	4: 49,536,843 (GRCm39)	S349P	probably benign	Het
Cd2	A	T	3: 101,190,345 (GRCm39)		probably null	Het
Cmtm2a	A	G	8: 105,019,562 (GRCm39)	S43P	probably damaging	Het
Cyp4a10	A	T	4: 115,389,735 (GRCm39)	I447F	probably damaging	Het
E2f3	A	T	13: 30,102,687 (GRCm39)	D68E	probably damaging	Het
Ect2	G	A	3: 27,152,592 (GRCm39)	R869W	probably damaging	Het
Eml1	A	G	12: 108,480,774 (GRCm39)		probably null	Het
Fundc1	T	A	X: 17,424,252 (GRCm39)		probably null	Het
Gabrb1	G	T	5: 72,265,789 (GRCm39)		probably null	Het
Lrrk2	T	G	15: 91,686,036 (GRCm39)		probably benign	Het
Map3k2	C	T	18: 32,361,292 (GRCm39)	P584L	probably benign	Het
Mindy2	T	C	9: 70,538,315 (GRCm39)	D340G	probably benign	Het
Nav3	T	C	10: 109,652,124 (GRCm39)	D877G	probably damaging	Het
Nol9	T	C	4: 152,136,472 (GRCm39)	S515P	probably benign	Het
Osgepl1	A	G	1: 53,359,405 (GRCm39)	I305V	probably benign	Het
Pign	A	G	1: 105,525,481 (GRCm39)	V449A	probably benign	Het
Rad54b	G	A	4: 11,593,765 (GRCm39)	R131K	probably benign	Het
Rgl3	A	T	9: 21,899,018 (GRCm39)		probably benign	Het
Scn2a	A	G	2: 65,566,197 (GRCm39)	D1407G	probably damaging	Het
Sf3b3	A	T	8: 111,544,270 (GRCm39)	I790N	probably damaging	Het
Srebf1	C	T	11: 60,095,965 (GRCm39)	R358Q	probably damaging	Het
Tmem18	A	G	12: 30,638,720 (GRCm39)	R133G	unknown	Het
Tnfrsf11b	T	G	15: 54,117,468 (GRCm39)	R262S	probably benign	Het
Tsc1	A	T	2: 28,555,023 (GRCm39)	H171L	probably damaging	Het
Ubr5	T	C	15: 38,006,785 (GRCm39)	T1157A	probably benign	Het
Wdcp	A	G	12: 4,905,303 (GRCm39)	E608G	probably damaging	Het
Zbtb40	T	G	4: 136,721,835 (GRCm39)	H848P	probably damaging	Het

Other mutations in Cts6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00770:Cts6	APN	13	61,346,153 (GRCm39)	splice site	probably benign
IGL02237:Cts6	APN	13	61,345,313 (GRCm39)	missense	probably benign	0.01
IGL03071:Cts6	APN	13	61,350,064 (GRCm39)	missense	probably damaging	0.97
IGL03224:Cts6	APN	13	61,349,547 (GRCm39)	missense	probably damaging	1.00
IGL03282:Cts6	APN	13	61,344,261 (GRCm39)	missense	possibly damaging	0.56
R0086:Cts6	UTSW	13	61,344,271 (GRCm39)	splice site	probably benign
R0201:Cts6	UTSW	13	61,349,313 (GRCm39)	nonsense	probably null
R0238:Cts6	UTSW	13	61,349,633 (GRCm39)	missense	probably damaging	1.00
R0238:Cts6	UTSW	13	61,349,633 (GRCm39)	missense	probably damaging	1.00
R0401:Cts6	UTSW	13	61,346,153 (GRCm39)	splice site	probably benign
R0676:Cts6	UTSW	13	61,345,298 (GRCm39)	splice site	probably benign
R1471:Cts6	UTSW	13	61,344,194 (GRCm39)	missense	probably benign	0.00
R1594:Cts6	UTSW	13	61,346,181 (GRCm39)	missense	probably damaging	1.00
R1864:Cts6	UTSW	13	61,349,393 (GRCm39)	missense	probably benign	0.26
R1865:Cts6	UTSW	13	61,349,393 (GRCm39)	missense	probably benign	0.26
R1902:Cts6	UTSW	13	61,349,329 (GRCm39)	nonsense	probably null
R2097:Cts6	UTSW	13	61,343,259 (GRCm39)	missense	probably damaging	1.00
R2235:Cts6	UTSW	13	61,343,247 (GRCm39)	missense	probably damaging	1.00
R2829:Cts6	UTSW	13	61,349,311 (GRCm39)	missense	probably benign	0.01
R2910:Cts6	UTSW	13	61,344,215 (GRCm39)	missense	probably damaging	1.00
R3757:Cts6	UTSW	13	61,349,972 (GRCm39)	nonsense	probably null
R4460:Cts6	UTSW	13	61,343,272 (GRCm39)	missense	probably benign	0.25
R4553:Cts6	UTSW	13	61,345,407 (GRCm39)	missense	probably damaging	1.00
R4623:Cts6	UTSW	13	61,349,974 (GRCm39)	missense	possibly damaging	0.57
R4793:Cts6	UTSW	13	61,349,626 (GRCm39)	missense	probably benign	0.00
R4809:Cts6	UTSW	13	61,349,995 (GRCm39)	missense	probably damaging	1.00
R4849:Cts6	UTSW	13	61,349,415 (GRCm39)	missense	probably null
R4866:Cts6	UTSW	13	61,350,090 (GRCm39)	critical splice acceptor site	probably null
R5055:Cts6	UTSW	13	61,344,164 (GRCm39)	missense	probably damaging	1.00
R5590:Cts6	UTSW	13	61,349,626 (GRCm39)	missense	probably benign	0.00
R6236:Cts6	UTSW	13	61,344,192 (GRCm39)	nonsense	probably null
R6428:Cts6	UTSW	13	61,344,237 (GRCm39)	missense	probably damaging	0.96
R6501:Cts6	UTSW	13	61,344,149 (GRCm39)	missense	probably damaging	1.00
R6508:Cts6	UTSW	13	61,344,221 (GRCm39)	missense	probably damaging	1.00
R6643:Cts6	UTSW	13	61,349,607 (GRCm39)	missense	probably damaging	0.96
R7397:Cts6	UTSW	13	61,350,014 (GRCm39)	missense	possibly damaging	0.94
R8283:Cts6	UTSW	13	61,349,457 (GRCm39)	missense	probably damaging	0.99
R8329:Cts6	UTSW	13	61,343,282 (GRCm39)	missense	probably damaging	1.00
R9009:Cts6	UTSW	13	61,344,261 (GRCm39)	missense	probably benign	0.04
R9438:Cts6	UTSW	13	61,350,069 (GRCm39)	missense	probably benign	0.01

Posted On

2015-04-16