Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00916:Zp2'

27794

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zp2

Ensembl Gene

ENSMUSG00000030911

Gene Name

zona pellucida glycoprotein 2

Synonyms

Zp-2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.072) question?

Stock #

IGL00916

Quality Score

Status

Chromosome

Chromosomal Location

119725995-119744514 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 119737397 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Tyrosine at position 264 (N264Y)

Ref Sequence

ENSEMBL: ENSMUSP00000147097 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000033207] [ENSMUST00000207726] [ENSMUST00000208874]

AlphaFold

P20239

Predicted Effect

probably damaging
Transcript: ENSMUST00000033207
AA Change: N264Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000033207
Gene: ENSMUSG00000030911
AA Change: N264Y

Domain	Start	End	E-Value	Type
signal peptide	1	34	N/A	INTRINSIC
ZP	364	630	1.06e-86	SMART
low complexity region	655	668	N/A	INTRINSIC
transmembrane domain	684	703	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000207333

Predicted Effect

probably damaging
Transcript: ENSMUST00000207726
AA Change: N264Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208122

Predicted Effect

probably damaging
Transcript: ENSMUST00000208874
AA Change: N264Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: This gene encodes a member of the zona pellucida family of glycoproteins that play an important role in the survival of growing oocytes, successful fertilization and the passage of early embryos through the oviduct. The encoded preproprotein undergoes proteolytic processing to generate the mature polypeptide that is incorporated into the extracellular matrix surrounding mouse oocytes. Mice lacking the encoded protein develop defective zonae pellucidae that disrupt folliculogenesis, fertility and development. [provided by RefSeq, Sep 2016]
PHENOTYPE: Female homozygous mutants exhibit a thin zona pellucida matrix in early ovarian follicles that becomes disassociated in pre-ovulatory follicles. Few oocytes are produced, and any that are fertilized fail to survive to the two-cell stage. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aass	T	A	6: 23,075,851 (GRCm39)	Q762L	probably benign	Het
Aldh1a1	T	C	19: 20,597,361 (GRCm39)	V114A	probably benign	Het
Ano4	T	C	10: 88,833,960 (GRCm39)	I459V	probably benign	Het
Atad5	C	T	11: 80,009,826 (GRCm39)	P1199S	probably damaging	Het
Bmp10	T	C	6: 87,406,142 (GRCm39)	F43S	possibly damaging	Het
Cd96	T	C	16: 45,861,675 (GRCm39)	E505G	probably benign	Het
Eapp	T	C	12: 54,739,593 (GRCm39)	T75A	possibly damaging	Het
Emilin1	T	C	5: 31,071,246 (GRCm39)	Y10H	probably damaging	Het
Ercc6	A	G	14: 32,284,612 (GRCm39)		probably benign	Het
Gucy2e	T	C	11: 69,113,923 (GRCm39)	I1089V	possibly damaging	Het
H6pd	C	A	4: 150,078,925 (GRCm39)		probably null	Het
Igsf10	A	T	3: 59,238,548 (GRCm39)	F544L	probably damaging	Het
Il23r	T	C	6: 67,450,915 (GRCm39)	Y188C	probably damaging	Het
Ilrun	A	G	17: 27,986,893 (GRCm39)	Y278H	probably damaging	Het
Inpp5j	T	C	11: 3,452,389 (GRCm39)	E287G	probably damaging	Het
Lrp6	T	C	6: 134,461,252 (GRCm39)	D735G	probably damaging	Het
Mast2	A	T	4: 116,184,830 (GRCm39)	M240K	possibly damaging	Het
Mreg	T	A	1: 72,203,291 (GRCm39)	T96S	probably benign	Het
Mta2	A	T	19: 8,924,465 (GRCm39)	M220L	probably benign	Het
Mycbp2	A	G	14: 103,528,719 (GRCm39)		probably benign	Het
Naip2	T	A	13: 100,297,939 (GRCm39)	N699I	probably damaging	Het
Ncapg	T	G	5: 45,828,534 (GRCm39)	I95S	probably benign	Het
Ndufa13	A	G	8: 70,347,069 (GRCm39)		probably benign	Het
Nol10	T	A	12: 17,411,130 (GRCm39)		probably benign	Het
Parp8	T	A	13: 117,063,859 (GRCm39)	I85F	probably damaging	Het
Rgs2	T	A	1: 143,877,967 (GRCm39)	I78F	probably damaging	Het
Rpia	C	T	6: 70,752,086 (GRCm39)		probably benign	Het
Sec63	T	C	10: 42,688,453 (GRCm39)	S488P	possibly damaging	Het
Tfcp2	T	G	15: 100,418,559 (GRCm39)	H201P	probably damaging	Het
Tnfaip2	T	G	12: 111,419,983 (GRCm39)	I705R	probably damaging	Het
Ttf1	A	G	2: 28,960,054 (GRCm39)	N554S	probably benign	Het
Ulk1	A	G	5: 110,940,877 (GRCm39)	S351P	probably damaging	Het

Other mutations in Zp2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00402:Zp2	APN	7	119,732,623 (GRCm39)	missense	probably benign	0.00
IGL00707:Zp2	APN	7	119,732,636 (GRCm39)	missense	probably benign	0.03
IGL01554:Zp2	APN	7	119,737,548 (GRCm39)	missense	possibly damaging	0.78
IGL01845:Zp2	APN	7	119,737,414 (GRCm39)	missense	probably damaging	1.00
IGL02111:Zp2	APN	7	119,731,641 (GRCm39)	missense	possibly damaging	0.75
IGL02145:Zp2	APN	7	119,739,074 (GRCm39)	critical splice acceptor site	probably null
IGL02155:Zp2	APN	7	119,743,340 (GRCm39)	missense	probably benign	0.00
IGL02178:Zp2	APN	7	119,732,973 (GRCm39)	missense	possibly damaging	0.85
IGL02646:Zp2	APN	7	119,734,564 (GRCm39)	missense	possibly damaging	0.92
IGL03220:Zp2	APN	7	119,736,450 (GRCm39)	missense	possibly damaging	0.90
PIT4687001:Zp2	UTSW	7	119,741,102 (GRCm39)	missense	probably benign	0.00
R0138:Zp2	UTSW	7	119,736,423 (GRCm39)	missense	probably damaging	0.96
R0197:Zp2	UTSW	7	119,742,799 (GRCm39)	splice site	probably benign
R0519:Zp2	UTSW	7	119,737,372 (GRCm39)	missense	probably damaging	1.00
R0573:Zp2	UTSW	7	119,734,693 (GRCm39)	splice site	probably benign
R0879:Zp2	UTSW	7	119,734,757 (GRCm39)	missense	probably damaging	1.00
R0883:Zp2	UTSW	7	119,742,799 (GRCm39)	splice site	probably benign
R1160:Zp2	UTSW	7	119,735,268 (GRCm39)	missense	probably damaging	1.00
R1235:Zp2	UTSW	7	119,737,566 (GRCm39)	missense	possibly damaging	0.57
R1753:Zp2	UTSW	7	119,737,328 (GRCm39)	missense	probably benign
R1883:Zp2	UTSW	7	119,732,624 (GRCm39)	missense	probably benign	0.02
R1995:Zp2	UTSW	7	119,734,388 (GRCm39)	missense	probably damaging	0.97
R2196:Zp2	UTSW	7	119,737,529 (GRCm39)	missense	probably benign
R2850:Zp2	UTSW	7	119,737,529 (GRCm39)	missense	probably benign
R3715:Zp2	UTSW	7	119,741,057 (GRCm39)	missense	possibly damaging	0.95
R3931:Zp2	UTSW	7	119,731,580 (GRCm39)	intron	probably benign
R4082:Zp2	UTSW	7	119,734,475 (GRCm39)	missense	probably benign	0.01
R4731:Zp2	UTSW	7	119,737,343 (GRCm39)	missense	probably damaging	0.96
R4732:Zp2	UTSW	7	119,737,343 (GRCm39)	missense	probably damaging	0.96
R4733:Zp2	UTSW	7	119,737,343 (GRCm39)	missense	probably damaging	0.96
R4754:Zp2	UTSW	7	119,737,541 (GRCm39)	missense	probably benign	0.01
R4863:Zp2	UTSW	7	119,734,995 (GRCm39)	missense	probably damaging	1.00
R5274:Zp2	UTSW	7	119,737,315 (GRCm39)	missense	possibly damaging	0.92
R5392:Zp2	UTSW	7	119,734,987 (GRCm39)	nonsense	probably null
R5877:Zp2	UTSW	7	119,732,562 (GRCm39)	missense	probably null	0.94
R6390:Zp2	UTSW	7	119,740,453 (GRCm39)	missense	probably benign	0.23
R6404:Zp2	UTSW	7	119,734,765 (GRCm39)	missense	possibly damaging	0.73
R6546:Zp2	UTSW	7	119,731,748 (GRCm39)	missense	probably benign	0.00
R6622:Zp2	UTSW	7	119,741,136 (GRCm39)	missense	probably benign
R6622:Zp2	UTSW	7	119,731,748 (GRCm39)	missense	probably benign	0.00
R6707:Zp2	UTSW	7	119,733,145 (GRCm39)	missense	possibly damaging	0.85
R7274:Zp2	UTSW	7	119,731,614 (GRCm39)	makesense	probably null
R7275:Zp2	UTSW	7	119,734,576 (GRCm39)	splice site	probably null
R7541:Zp2	UTSW	7	119,735,279 (GRCm39)	missense	probably damaging	1.00
R7585:Zp2	UTSW	7	119,733,167 (GRCm39)	missense	probably damaging	1.00
R7709:Zp2	UTSW	7	119,734,998 (GRCm39)	missense	probably damaging	1.00
R7742:Zp2	UTSW	7	119,731,731 (GRCm39)	missense	unknown
R7767:Zp2	UTSW	7	119,736,392 (GRCm39)	missense	probably benign	0.01
R7771:Zp2	UTSW	7	119,742,865 (GRCm39)	missense	probably damaging	0.96
R8391:Zp2	UTSW	7	119,726,179 (GRCm39)	missense	probably benign	0.00
R8872:Zp2	UTSW	7	119,733,025 (GRCm39)	missense	probably benign	0.14
R8880:Zp2	UTSW	7	119,742,835 (GRCm39)	missense	possibly damaging	0.80
R9673:Zp2	UTSW	7	119,733,238 (GRCm39)	missense	probably damaging	1.00
X0017:Zp2	UTSW	7	119,732,608 (GRCm39)	missense	probably damaging	1.00
X0023:Zp2	UTSW	7	119,732,590 (GRCm39)	missense	probably damaging	1.00
Z1176:Zp2	UTSW	7	119,734,402 (GRCm39)	missense	not run
Z1177:Zp2	UTSW	7	119,734,432 (GRCm39)	missense	probably damaging	1.00
Z1177:Zp2	UTSW	7	119,734,402 (GRCm39)	missense	not run

Posted On

2013-04-17