Incidental Mutation 'IGL00960:Hnrnpm'
ID 278124
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Hnrnpm
Ensembl Gene ENSMUSG00000059208
Gene Name heterogeneous nuclear ribonucleoprotein M
Synonyms 2610023M21Rik, Hnrpm
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL00960
Quality Score
Status
Chromosome 17
Chromosomal Location 33865207-33904432 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 33868876 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Leucine at position 517 (R517L)
Ref Sequence ENSEMBL: ENSMUSP00000115787 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052079] [ENSMUST00000087582] [ENSMUST00000114385] [ENSMUST00000116619] [ENSMUST00000139302] [ENSMUST00000148178]
AlphaFold Q9D0E1
Predicted Effect probably benign
Transcript: ENSMUST00000052079
SMART Domains Protein: ENSMUSP00000057065
Gene: ENSMUSG00000032739

DomainStartEndE-ValueType
internal_repeat_1 15 151 3.3e-6 PROSPERO
internal_repeat_1 237 378 3.3e-6 PROSPERO
low complexity region 393 404 N/A INTRINSIC
low complexity region 445 453 N/A INTRINSIC
low complexity region 458 471 N/A INTRINSIC
low complexity region 480 486 N/A INTRINSIC
SH3 581 655 1.09e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000087582
AA Change: R517L

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000084864
Gene: ENSMUSG00000059208
AA Change: R517L

DomainStartEndE-ValueType
low complexity region 2 13 N/A INTRINSIC
Pfam:HnRNP_M 40 69 2.7e-20 PFAM
RRM 71 144 2.35e-20 SMART
RRM 165 237 1.66e-20 SMART
low complexity region 257 274 N/A INTRINSIC
low complexity region 307 321 N/A INTRINSIC
low complexity region 350 356 N/A INTRINSIC
Blast:AAA 430 589 2e-50 BLAST
low complexity region 590 603 N/A INTRINSIC
RRM 614 685 1.51e-23 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000114385
AA Change: R556L

PolyPhen 2 Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000110027
Gene: ENSMUSG00000059208
AA Change: R556L

DomainStartEndE-ValueType
low complexity region 2 13 N/A INTRINSIC
Pfam:HnRNP_M 40 69 1.5e-20 PFAM
RRM 71 144 2.35e-20 SMART
low complexity region 164 175 N/A INTRINSIC
low complexity region 176 193 N/A INTRINSIC
RRM 204 276 1.66e-20 SMART
low complexity region 296 313 N/A INTRINSIC
internal_repeat_2 332 432 3.9e-5 PROSPERO
internal_repeat_2 479 581 3.9e-5 PROSPERO
low complexity region 591 602 N/A INTRINSIC
low complexity region 606 616 N/A INTRINSIC
low complexity region 629 642 N/A INTRINSIC
internal_repeat_1 643 676 1.39e-5 PROSPERO
Predicted Effect probably benign
Transcript: ENSMUST00000116619
Predicted Effect probably benign
Transcript: ENSMUST00000130946
SMART Domains Protein: ENSMUSP00000116671
Gene: ENSMUSG00000059208

DomainStartEndE-ValueType
low complexity region 28 42 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000139302
AA Change: R517L

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000115787
Gene: ENSMUSG00000059208
AA Change: R517L

DomainStartEndE-ValueType
low complexity region 2 13 N/A INTRINSIC
Pfam:HnRNP_M 40 69 1.4e-20 PFAM
RRM 71 144 2.35e-20 SMART
RRM 165 237 1.66e-20 SMART
low complexity region 257 274 N/A INTRINSIC
low complexity region 307 321 N/A INTRINSIC
low complexity region 350 356 N/A INTRINSIC
Blast:AAA 430 589 8e-51 BLAST
low complexity region 590 603 N/A INTRINSIC
internal_repeat_1 611 635 5.49e-5 PROSPERO
Predicted Effect probably benign
Transcript: ENSMUST00000148178
AA Change: R556L

PolyPhen 2 Score 0.185 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000120115
Gene: ENSMUSG00000059208
AA Change: R556L

DomainStartEndE-ValueType
low complexity region 2 13 N/A INTRINSIC
Pfam:HnRNP_M 40 69 2.2e-22 PFAM
RRM 71 144 2.35e-20 SMART
low complexity region 164 175 N/A INTRINSIC
low complexity region 176 193 N/A INTRINSIC
RRM 204 276 1.66e-20 SMART
low complexity region 296 313 N/A INTRINSIC
internal_repeat_2 332 432 6.64e-5 PROSPERO
internal_repeat_2 479 581 6.64e-5 PROSPERO
low complexity region 591 602 N/A INTRINSIC
low complexity region 606 616 N/A INTRINSIC
low complexity region 629 642 N/A INTRINSIC
RRM 653 724 1.51e-23 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000166215
Predicted Effect noncoding transcript
Transcript: ENSMUST00000163245
Predicted Effect probably benign
Transcript: ENSMUST00000148258
SMART Domains Protein: ENSMUSP00000123580
Gene: ENSMUSG00000059208

DomainStartEndE-ValueType
RRM 21 93 1.66e-20 SMART
low complexity region 113 130 N/A INTRINSIC
low complexity region 146 167 N/A INTRINSIC
low complexity region 196 202 N/A INTRINSIC
internal_repeat_1 206 227 9.85e-5 PROSPERO
internal_repeat_1 221 238 9.85e-5 PROSPERO
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc10 C A 17: 46,634,671 (GRCm39) R444L probably damaging Het
Baiap2 T A 11: 119,890,118 (GRCm39) S460T possibly damaging Het
Cckar A G 5: 53,858,634 (GRCm39) Y158H probably damaging Het
Cdk4 A G 10: 126,900,166 (GRCm39) Y21C probably damaging Het
Entpd1 C T 19: 40,699,714 (GRCm39) P42S probably benign Het
Epha8 A T 4: 136,679,150 (GRCm39) probably null Het
Fastkd1 A T 2: 69,524,997 (GRCm39) probably benign Het
Fmnl2 A G 2: 53,013,494 (GRCm39) D951G probably damaging Het
Kcnj5 T A 9: 32,233,719 (GRCm39) T199S probably damaging Het
Med13 T C 11: 86,181,866 (GRCm39) probably benign Het
Mycbp2 G T 14: 103,466,820 (GRCm39) H1314Q possibly damaging Het
Ncapd2 A T 6: 125,150,811 (GRCm39) S795T probably benign Het
Nf1 T C 11: 79,335,947 (GRCm39) S1042P probably damaging Het
Nlgn1 C A 3: 25,966,861 (GRCm39) L197F probably damaging Het
Nsun7 A G 5: 66,446,846 (GRCm39) Y428C probably benign Het
Or10d5j A G 9: 39,867,455 (GRCm39) Y259H probably damaging Het
Parp14 T C 16: 35,661,589 (GRCm39) D1453G probably benign Het
Pcdhb8 A T 18: 37,489,026 (GRCm39) I235F probably benign Het
Pclo T C 5: 14,725,234 (GRCm39) V1364A unknown Het
Polq T C 16: 36,880,874 (GRCm39) S734P probably damaging Het
Sco1 T C 11: 66,954,864 (GRCm39) *290Q probably null Het
Slc22a3 A T 17: 12,644,497 (GRCm39) I496N probably damaging Het
Slc5a8 T G 10: 88,757,627 (GRCm39) I539S probably benign Het
Tecta A G 9: 42,270,376 (GRCm39) F1311L possibly damaging Het
Tex261 A T 6: 83,752,650 (GRCm39) I19N possibly damaging Het
Tfr2 T C 5: 137,569,954 (GRCm39) V120A probably benign Het
Vmn2r71 A T 7: 85,273,582 (GRCm39) S799C probably damaging Het
Zar1 G A 5: 72,734,628 (GRCm39) T197I probably damaging Het
Zfa-ps A G 10: 52,420,043 (GRCm39) noncoding transcript Het
Other mutations in Hnrnpm
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00743:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00869:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00870:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00886:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00898:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00900:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00901:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00905:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00907:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00908:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00911:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00912:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00920:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00921:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00922:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00923:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00924:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00926:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00927:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00928:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00929:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00930:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00931:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00932:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00935:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00938:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00945:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00950:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00952:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00953:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00954:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00955:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00956:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00957:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00958:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL00959:Hnrnpm APN 17 33,868,876 (GRCm39) missense probably damaging 0.99
IGL01301:Hnrnpm APN 17 33,888,142 (GRCm39) critical splice donor site probably null
IGL02152:Hnrnpm APN 17 33,877,386 (GRCm39) missense probably damaging 1.00
IGL02319:Hnrnpm APN 17 33,868,924 (GRCm39) missense probably damaging 0.98
IGL02487:Hnrnpm APN 17 33,867,787 (GRCm39) missense probably damaging 1.00
IGL03099:Hnrnpm APN 17 33,888,146 (GRCm39) missense probably damaging 1.00
ANU18:Hnrnpm UTSW 17 33,888,142 (GRCm39) critical splice donor site probably null
E0370:Hnrnpm UTSW 17 33,877,896 (GRCm39) splice site probably benign
R0153:Hnrnpm UTSW 17 33,865,489 (GRCm39) missense probably damaging 0.99
R0254:Hnrnpm UTSW 17 33,871,242 (GRCm39) splice site probably null
R0606:Hnrnpm UTSW 17 33,877,364 (GRCm39) missense probably damaging 0.97
R0940:Hnrnpm UTSW 17 33,868,976 (GRCm39) missense probably damaging 1.00
R1216:Hnrnpm UTSW 17 33,868,687 (GRCm39) missense probably damaging 0.99
R1392:Hnrnpm UTSW 17 33,877,389 (GRCm39) missense possibly damaging 0.62
R1392:Hnrnpm UTSW 17 33,877,389 (GRCm39) missense possibly damaging 0.62
R1454:Hnrnpm UTSW 17 33,885,462 (GRCm39) splice site probably benign
R2011:Hnrnpm UTSW 17 33,883,598 (GRCm39) missense probably damaging 1.00
R4678:Hnrnpm UTSW 17 33,869,185 (GRCm39) missense possibly damaging 0.54
R4926:Hnrnpm UTSW 17 33,868,775 (GRCm39) missense probably damaging 0.97
R7456:Hnrnpm UTSW 17 33,865,622 (GRCm39) missense possibly damaging 0.95
R8695:Hnrnpm UTSW 17 33,877,884 (GRCm39) missense probably benign 0.00
R9079:Hnrnpm UTSW 17 33,868,775 (GRCm39) missense probably damaging 0.97
R9626:Hnrnpm UTSW 17 33,896,264 (GRCm39) missense probably damaging 1.00
Z1177:Hnrnpm UTSW 17 33,877,375 (GRCm39) missense probably benign 0.00
Z1177:Hnrnpm UTSW 17 33,865,719 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16