Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01084:Tedc1'

278165

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tedc1

Ensembl Gene

ENSMUSG00000037466

Gene Name

tubulin epsilon and delta complex 1

Synonyms

4930427A07Rik

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL01084

Quality Score

Status

Chromosome

Chromosomal Location

113120041-113129668 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to T at 113126808 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Stop codon at position 357 (R357*)

Ref Sequence

ENSEMBL: ENSMUSP00000035351 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049271] [ENSMUST00000196755] [ENSMUST00000200522]

AlphaFold

Q3UK37

Predicted Effect

probably null
Transcript: ENSMUST00000049271
AA Change: R357*

SMART Domains

Protein: ENSMUSP00000035351
Gene: ENSMUSG00000037466
AA Change: R357*

Domain	Start	End	E-Value	Type
low complexity region	2	21	N/A	INTRINSIC
Pfam:DUF4509	41	221	4.8e-65	PFAM
low complexity region	233	245	N/A	INTRINSIC
Pfam:DUF4510	258	418	3.1e-73	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000196755

SMART Domains

Protein: ENSMUSP00000143431
Gene: ENSMUSG00000037466

Domain	Start	End	E-Value	Type
low complexity region	1	20	N/A	INTRINSIC
Pfam:DUF4509	40	138	4.1e-32	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000198072

Predicted Effect

probably benign
Transcript: ENSMUST00000200522

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aagab	C	A	9: 63,546,901 (GRCm39)	Q284K	probably damaging	Het
Adgrd1	A	T	5: 129,216,656 (GRCm39)	N341I	probably benign	Het
Arhgap40	T	C	2: 158,385,138 (GRCm39)	F457S	probably damaging	Het
Cacng5	C	T	11: 107,772,531 (GRCm39)	V106I	probably benign	Het
Catsper1	G	A	19: 5,387,800 (GRCm39)	V360M	probably damaging	Het
Cdc42bpa	T	A	1: 179,969,839 (GRCm39)		probably benign	Het
Cep250	C	T	2: 155,840,313 (GRCm39)	H2424Y	probably benign	Het
Cln3	T	C	7: 126,174,426 (GRCm39)	E304G	probably damaging	Het
Eml2	T	A	7: 18,924,663 (GRCm39)	C177*	probably null	Het
Epha5	G	A	5: 84,218,946 (GRCm39)	R917*	probably null	Het
Gabra2	A	G	5: 71,163,576 (GRCm39)	F244L	probably damaging	Het
Gars1	C	A	6: 55,032,812 (GRCm39)	D261E	probably benign	Het
Gata3os	A	G	2: 9,887,884 (GRCm39)		probably benign	Het
Keg1	A	G	19: 12,691,976 (GRCm39)	K98E	probably damaging	Het
Kif13a	A	G	13: 46,904,110 (GRCm39)		probably benign	Het
Matn1	A	G	4: 130,679,245 (GRCm39)	K300E	probably benign	Het
Mesp1	A	G	7: 79,442,831 (GRCm39)	S149P	probably benign	Het
Mmp10	T	C	9: 7,505,651 (GRCm39)	V305A	possibly damaging	Het
Muc5b	T	C	7: 141,397,186 (GRCm39)		probably benign	Het
Myof	T	C	19: 37,924,884 (GRCm39)	T1181A	probably damaging	Het
Or1r1	A	T	11: 73,875,353 (GRCm39)	L27Q	probably damaging	Het
Or5d35	T	C	2: 87,855,347 (GRCm39)	S94P	probably benign	Het
Or9i16	G	T	19: 13,864,866 (GRCm39)	T236N	probably damaging	Het
Osbpl11	T	C	16: 33,047,221 (GRCm39)		probably benign	Het
Prune2	T	C	19: 17,095,573 (GRCm39)	V359A	probably benign	Het
Ptch1	T	A	13: 63,691,451 (GRCm39)	E267D	probably damaging	Het
Rbl2	A	G	8: 91,848,941 (GRCm39)	E1049G	probably damaging	Het
Ruvbl2	A	T	7: 45,071,947 (GRCm39)		probably null	Het
Sec23b	A	G	2: 144,406,509 (GRCm39)	I101M	possibly damaging	Het
Srms	A	C	2: 180,848,177 (GRCm39)		probably null	Het
Svep1	T	A	4: 58,111,419 (GRCm39)	T1067S	possibly damaging	Het
Tmem127	T	C	2: 127,099,006 (GRCm39)	V180A	probably damaging	Het
Trpm7	A	G	2: 126,687,992 (GRCm39)		probably null	Het
Trpv3	G	A	11: 73,184,826 (GRCm39)		probably null	Het
Tti1	C	T	2: 157,824,379 (GRCm39)	V1025I	probably damaging	Het
Vmn2r80	A	G	10: 79,030,433 (GRCm39)	Y753C	probably damaging	Het
Vps13d	A	G	4: 144,881,525 (GRCm39)	L1350S	probably benign	Het
Zfp287	G	T	11: 62,604,716 (GRCm39)	Y730*	probably null	Het
Zfp583	A	G	7: 6,320,184 (GRCm39)	F276S	probably damaging	Het
Zfp638	T	C	6: 83,921,780 (GRCm39)	Y636H	probably benign	Het

Other mutations in Tedc1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01066:Tedc1	APN	12	113,126,770 (GRCm39)	missense	probably damaging	0.97
IGL01074:Tedc1	APN	12	113,126,808 (GRCm39)	nonsense	probably null
IGL01075:Tedc1	APN	12	113,126,808 (GRCm39)	nonsense	probably null
IGL01077:Tedc1	APN	12	113,126,808 (GRCm39)	nonsense	probably null
IGL01103:Tedc1	APN	12	113,126,808 (GRCm39)	nonsense	probably null
IGL01108:Tedc1	APN	12	113,126,808 (GRCm39)	nonsense	probably null
IGL01137:Tedc1	APN	12	113,126,808 (GRCm39)	nonsense	probably null
IGL01142:Tedc1	APN	12	113,126,808 (GRCm39)	nonsense	probably null
IGL01149:Tedc1	APN	12	113,126,808 (GRCm39)	nonsense	probably null
IGL01150:Tedc1	APN	12	113,126,808 (GRCm39)	nonsense	probably null
IGL01151:Tedc1	APN	12	113,126,808 (GRCm39)	nonsense	probably null
IGL02646:Tedc1	APN	12	113,120,921 (GRCm39)	missense	possibly damaging	0.68
IGL02989:Tedc1	APN	12	113,126,941 (GRCm39)	missense	probably benign	0.09
ANU05:Tedc1	UTSW	12	113,126,808 (GRCm39)	nonsense	probably null
ANU22:Tedc1	UTSW	12	113,126,808 (GRCm39)	nonsense	probably null
R1309:Tedc1	UTSW	12	113,125,400 (GRCm39)	missense	probably benign
R1555:Tedc1	UTSW	12	113,120,117 (GRCm39)	unclassified	probably benign
R2092:Tedc1	UTSW	12	113,121,340 (GRCm39)	missense	probably damaging	1.00
R3053:Tedc1	UTSW	12	113,120,087 (GRCm39)	unclassified	probably benign
R4130:Tedc1	UTSW	12	113,126,828 (GRCm39)	missense	probably benign	0.01
R5050:Tedc1	UTSW	12	113,120,325 (GRCm39)	missense	possibly damaging	0.86
R5386:Tedc1	UTSW	12	113,120,302 (GRCm39)	missense	probably benign	0.03
R6377:Tedc1	UTSW	12	113,124,975 (GRCm39)	missense	probably damaging	1.00
R6749:Tedc1	UTSW	12	113,121,702 (GRCm39)	missense	probably damaging	1.00
R6761:Tedc1	UTSW	12	113,125,334 (GRCm39)	missense	probably damaging	1.00
R8220:Tedc1	UTSW	12	113,120,375 (GRCm39)	critical splice donor site	probably null
R9240:Tedc1	UTSW	12	113,121,310 (GRCm39)	missense	probably benign	0.43

Posted On

2015-04-16