Incidental Mutation 'IGL01132:Tas2r134'
| ID |
278197 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Tas2r134
|
| Ensembl Gene |
ENSMUSG00000056115 |
| Gene Name |
taste receptor, type 2, member 134 |
| Synonyms |
Tas2r34, T2R134 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.056)
|
| Stock # |
IGL01132
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
2 |
| Chromosomal Location |
51517523-51518419 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 51517671 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Phenylalanine
at position 50
(C50F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000064657
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000070028]
|
| AlphaFold |
Q7TQB0 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000070028
AA Change: C50F
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000064657
Gene: ENSMUSG00000056115
AA Change: C50F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
291 |
1.4e-75 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 27 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110038F14Rik |
G |
A |
15: 76,834,475 (GRCm39) |
V124I |
probably damaging |
Het |
| Adcy6 |
T |
C |
15: 98,495,732 (GRCm39) |
N619S |
probably benign |
Het |
| Adgrf5 |
G |
T |
17: 43,733,400 (GRCm39) |
D75Y |
possibly damaging |
Het |
| Aldh1a7 |
T |
C |
19: 20,704,404 (GRCm39) |
H30R |
possibly damaging |
Het |
| Birc6 |
T |
C |
17: 74,910,055 (GRCm39) |
S1483P |
probably damaging |
Het |
| Cd209e |
T |
C |
8: 3,901,274 (GRCm39) |
T127A |
probably benign |
Het |
| Clmn |
T |
A |
12: 104,740,810 (GRCm39) |
|
probably null |
Het |
| Dcc |
A |
T |
18: 71,815,245 (GRCm39) |
Y376* |
probably null |
Het |
| Dennd2b |
A |
G |
7: 109,169,212 (GRCm39) |
|
probably null |
Het |
| Dscaml1 |
C |
T |
9: 45,663,626 (GRCm39) |
R1950* |
probably null |
Het |
| Eml2 |
A |
T |
7: 18,934,464 (GRCm39) |
S388C |
probably damaging |
Het |
| Ext2 |
C |
T |
2: 93,621,418 (GRCm39) |
M370I |
probably benign |
Het |
| Foxo1 |
C |
T |
3: 52,252,580 (GRCm39) |
R248W |
probably damaging |
Het |
| Gan |
T |
A |
8: 117,923,183 (GRCm39) |
|
probably benign |
Het |
| Klra1 |
A |
T |
6: 130,341,237 (GRCm39) |
C245* |
probably null |
Het |
| Myh10 |
A |
T |
11: 68,659,094 (GRCm39) |
M491L |
possibly damaging |
Het |
| Myrf |
A |
G |
19: 10,200,569 (GRCm39) |
Y343H |
probably damaging |
Het |
| Oplah |
C |
T |
15: 76,185,157 (GRCm39) |
S852N |
probably benign |
Het |
| Or6c75 |
T |
C |
10: 129,337,515 (GRCm39) |
V254A |
probably damaging |
Het |
| Or7e168 |
G |
A |
9: 19,719,950 (GRCm39) |
S112N |
probably damaging |
Het |
| Or8k37 |
A |
T |
2: 86,469,510 (GRCm39) |
C181S |
probably benign |
Het |
| Prag1 |
T |
C |
8: 36,613,511 (GRCm39) |
V1021A |
probably damaging |
Het |
| Rassf4 |
C |
T |
6: 116,636,568 (GRCm39) |
|
probably benign |
Het |
| Sf3b3 |
T |
C |
8: 111,569,413 (GRCm39) |
I102V |
probably benign |
Het |
| Slc27a4 |
T |
C |
2: 29,694,314 (GRCm39) |
I46T |
probably benign |
Het |
| Slc5a12 |
T |
C |
2: 110,428,167 (GRCm39) |
V74A |
probably damaging |
Het |
| Tcte1 |
G |
T |
17: 45,850,788 (GRCm39) |
A355S |
possibly damaging |
Het |
|
| Other mutations in Tas2r134 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00562:Tas2r134
|
APN |
2 |
51,518,100 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL00563:Tas2r134
|
APN |
2 |
51,518,100 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01121:Tas2r134
|
APN |
2 |
51,518,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01122:Tas2r134
|
APN |
2 |
51,517,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01128:Tas2r134
|
APN |
2 |
51,517,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01312:Tas2r134
|
APN |
2 |
51,518,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01419:Tas2r134
|
APN |
2 |
51,517,759 (GRCm39) |
nonsense |
probably null |
|
|
IGL01774:Tas2r134
|
APN |
2 |
51,518,160 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02735:Tas2r134
|
APN |
2 |
51,517,839 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0799:Tas2r134
|
UTSW |
2 |
51,518,385 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1205:Tas2r134
|
UTSW |
2 |
51,517,998 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2267:Tas2r134
|
UTSW |
2 |
51,518,249 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3736:Tas2r134
|
UTSW |
2 |
51,517,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5254:Tas2r134
|
UTSW |
2 |
51,517,559 (GRCm39) |
missense |
probably benign |
0.39 |
|
R5752:Tas2r134
|
UTSW |
2 |
51,517,880 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6162:Tas2r134
|
UTSW |
2 |
51,517,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6940:Tas2r134
|
UTSW |
2 |
51,518,148 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6954:Tas2r134
|
UTSW |
2 |
51,517,782 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6996:Tas2r134
|
UTSW |
2 |
51,517,601 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7206:Tas2r134
|
UTSW |
2 |
51,518,120 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7303:Tas2r134
|
UTSW |
2 |
51,518,145 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7348:Tas2r134
|
UTSW |
2 |
51,518,414 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7479:Tas2r134
|
UTSW |
2 |
51,517,541 (GRCm39) |
missense |
not run |
|
|
R7575:Tas2r134
|
UTSW |
2 |
51,518,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7686:Tas2r134
|
UTSW |
2 |
51,518,255 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R8721:Tas2r134
|
UTSW |
2 |
51,517,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9384:Tas2r134
|
UTSW |
2 |
51,518,034 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9622:Tas2r134
|
UTSW |
2 |
51,518,358 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
| Posted On |
2015-04-16 |
Incidental Mutation