Incidental Mutation 'IGL01142:Tedc1'
ID 278212
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tedc1
Ensembl Gene ENSMUSG00000037466
Gene Name tubulin epsilon and delta complex 1
Synonyms 4930427A07Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL01142
Quality Score
Status
Chromosome 12
Chromosomal Location 113120041-113129668 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 113126808 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 357 (R357*)
Ref Sequence ENSEMBL: ENSMUSP00000035351 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049271] [ENSMUST00000196755] [ENSMUST00000200522]
AlphaFold Q3UK37
Predicted Effect probably null
Transcript: ENSMUST00000049271
AA Change: R357*
SMART Domains Protein: ENSMUSP00000035351
Gene: ENSMUSG00000037466
AA Change: R357*

DomainStartEndE-ValueType
low complexity region 2 21 N/A INTRINSIC
Pfam:DUF4509 41 221 4.8e-65 PFAM
low complexity region 233 245 N/A INTRINSIC
Pfam:DUF4510 258 418 3.1e-73 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000196755
SMART Domains Protein: ENSMUSP00000143431
Gene: ENSMUSG00000037466

DomainStartEndE-ValueType
low complexity region 1 20 N/A INTRINSIC
Pfam:DUF4509 40 138 4.1e-32 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198072
Predicted Effect probably benign
Transcript: ENSMUST00000200522
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Armc3 C T 2: 19,302,709 (GRCm39) probably benign Het
Cacnb3 T A 15: 98,539,883 (GRCm39) L269* probably null Het
Calu T C 6: 29,366,207 (GRCm39) probably null Het
Cep97 A G 16: 55,742,561 (GRCm39) S129P probably damaging Het
Cpt1b T C 15: 89,303,196 (GRCm39) M620V probably benign Het
Dnah7b T C 1: 46,234,538 (GRCm39) probably null Het
Evi5 T C 5: 107,963,477 (GRCm39) K410R probably benign Het
Gad2 T C 2: 22,571,297 (GRCm39) probably benign Het
Helb A T 10: 119,947,049 (GRCm39) V88D probably damaging Het
Hexim2 A G 11: 103,024,960 (GRCm39) E19G probably benign Het
Klhl25 T C 7: 75,516,344 (GRCm39) Y112H probably damaging Het
Lin52 T C 12: 84,503,009 (GRCm39) probably benign Het
Ms4a4c A G 19: 11,403,614 (GRCm39) T157A probably benign Het
Or12e8 T C 2: 87,187,889 (GRCm39) F34L possibly damaging Het
Or7g17 A G 9: 18,768,830 (GRCm39) N303S probably damaging Het
Plxnb1 A G 9: 108,931,765 (GRCm39) T472A probably benign Het
Sez6 T G 11: 77,864,642 (GRCm39) V534G probably damaging Het
Sim1 C A 10: 50,786,767 (GRCm39) T333K probably damaging Het
Tmem115 A G 9: 107,411,844 (GRCm39) N56S possibly damaging Het
Ubac1 T C 2: 25,896,580 (GRCm39) I150V probably damaging Het
Vps13a T C 19: 16,664,479 (GRCm39) K1455E possibly damaging Het
Yrdc T C 4: 124,747,787 (GRCm39) F97L probably damaging Het
Other mutations in Tedc1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01066:Tedc1 APN 12 113,126,770 (GRCm39) missense probably damaging 0.97
IGL01074:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01075:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01077:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01084:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01103:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01108:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01137:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01149:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01150:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01151:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL02646:Tedc1 APN 12 113,120,921 (GRCm39) missense possibly damaging 0.68
IGL02989:Tedc1 APN 12 113,126,941 (GRCm39) missense probably benign 0.09
ANU05:Tedc1 UTSW 12 113,126,808 (GRCm39) nonsense probably null
ANU22:Tedc1 UTSW 12 113,126,808 (GRCm39) nonsense probably null
R1309:Tedc1 UTSW 12 113,125,400 (GRCm39) missense probably benign
R1555:Tedc1 UTSW 12 113,120,117 (GRCm39) unclassified probably benign
R2092:Tedc1 UTSW 12 113,121,340 (GRCm39) missense probably damaging 1.00
R3053:Tedc1 UTSW 12 113,120,087 (GRCm39) unclassified probably benign
R4130:Tedc1 UTSW 12 113,126,828 (GRCm39) missense probably benign 0.01
R5050:Tedc1 UTSW 12 113,120,325 (GRCm39) missense possibly damaging 0.86
R5386:Tedc1 UTSW 12 113,120,302 (GRCm39) missense probably benign 0.03
R6377:Tedc1 UTSW 12 113,124,975 (GRCm39) missense probably damaging 1.00
R6749:Tedc1 UTSW 12 113,121,702 (GRCm39) missense probably damaging 1.00
R6761:Tedc1 UTSW 12 113,125,334 (GRCm39) missense probably damaging 1.00
R8220:Tedc1 UTSW 12 113,120,375 (GRCm39) critical splice donor site probably null
R9240:Tedc1 UTSW 12 113,121,310 (GRCm39) missense probably benign 0.43
Posted On 2015-04-16