Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01018:Or6p1'

278237

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or6p1

Ensembl Gene

ENSMUSG00000051509

Gene Name

olfactory receptor family 6 subfamily P member 1

Synonyms

MOR103-10, Olfr414, GA_x6K02T2P20D-20749615-20748662

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.096) question?

Stock #

IGL01018

Quality Score

Status

Chromosome

Chromosomal Location

174257996-174258950 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 174258908 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 305 (V305I)

Ref Sequence

ENSEMBL: ENSMUSP00000142051 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000053178] [ENSMUST00000192358]

AlphaFold

E9Q5P8

Predicted Effect

probably benign
Transcript: ENSMUST00000053178
AA Change: V305I

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000052426
Gene: ENSMUSG00000051509
AA Change: V305I

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	2.8e-53	PFAM
Pfam:7tm_1	41	290	8.3e-21	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000192358
AA Change: V305I

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000142051
Gene: ENSMUSG00000051509
AA Change: V305I

Domain	Start	End	E-Value	Type
Pfam:7tm_1	41	290	2.9e-29	PFAM
Pfam:7tm_4	139	283	1.1e-45	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5530400C23Rik	G	T	6: 133,271,460 (GRCm39)	R168I	probably benign	Het
5530400C23Rik	A	T	6: 133,271,461 (GRCm39)	R168S	probably benign	Het
Armt1	T	A	10: 4,400,732 (GRCm39)	S160T	probably benign	Het
Armt1	C	T	10: 4,404,237 (GRCm39)		probably benign	Het
Ccdc170	T	C	10: 4,462,788 (GRCm39)	W35R	probably benign	Het
Ccdc170	T	C	10: 4,464,114 (GRCm39)	V31A	probably benign	Het
Ccdc170	G	T	10: 4,464,155 (GRCm39)	A99S	probably benign	Het
Glp2r	C	A	11: 67,600,470 (GRCm39)	V460F	probably benign	Het
Gm21411	C	T	4: 146,977,067 (GRCm39)	S69N	possibly damaging	Het
Gm21411	T	C	4: 146,977,034 (GRCm39)	Q80R	probably benign	Het
Gm21738	G	A	14: 19,418,856 (GRCm38)	P24L	probably benign	Het
H2-M10.6	C	T	17: 37,123,112 (GRCm39)	A15V	probably benign	Het
H60c	T	C	10: 3,209,766 (GRCm39)	M174V	probably benign	Het
H60c	A	C	10: 3,210,343 (GRCm39)	F69V	probably benign	Het
Ipcef1	G	A	10: 6,840,551 (GRCm39)	A382V	probably benign	Het
Ipcef1	C	T	10: 6,869,968 (GRCm39)	R144Q	probably damaging	Het
Mapk8ip3	T	G	17: 25,118,693 (GRCm39)		probably benign	Het
Mthfd1l	T	C	10: 3,928,708 (GRCm39)	V100A	probably benign	Het
Mthfd1l	T	C	10: 3,957,800 (GRCm39)	V279A	probably benign	Het
Mthfd1l	T	C	10: 3,982,345 (GRCm39)		probably benign	Het
Mtrf1l	A	G	10: 5,764,180 (GRCm39)		probably benign	Het
Myo18b	T	C	5: 112,957,613 (GRCm39)	E1450G	probably damaging	Het
Obscn	C	T	11: 59,018,895 (GRCm39)	V973M	probably damaging	Het
Oprm1	T	C	10: 6,987,170 (GRCm39)		probably benign	Het
Pou5f2	A	G	13: 78,174,057 (GRCm39)		probably benign	Het
Ralgapa2	G	A	2: 146,252,113 (GRCm39)	H891Y	probably benign	Het
Ralgapa2	T	G	2: 146,252,112 (GRCm39)	H806P	probably benign	Het
Rmnd1	A	G	10: 4,377,392 (GRCm39)	W96R	probably benign	Het
Rmnd1	A	T	10: 4,377,290 (GRCm39)	S130T	probably benign	Het
Spata31e2	T	C	1: 26,721,991 (GRCm39)	E1063G	probably damaging	Het
Speer4a3	G	T	5: 26,155,721 (GRCm39)	H208N	probably benign	Het
Trappc12	A	C	12: 28,741,853 (GRCm39)		probably benign	Het
Ulbp3	G	A	10: 3,075,031 (GRCm39)		noncoding transcript	Het
Ulbp3	C	T	10: 3,075,193 (GRCm39)		noncoding transcript	Het
Ulbp3	A	G	10: 3,070,231 (GRCm39)		noncoding transcript	Het
Ulbp3	A	G	10: 3,070,209 (GRCm39)		noncoding transcript	Het
Vip	A	G	10: 5,592,480 (GRCm39)	D40G	probably benign	Het
Vmn2r125	T	C	4: 156,702,907 (GRCm39)		probably benign	Het
Vmn2r125	A	G	4: 156,703,140 (GRCm39)	N173D	probably damaging	Het
Vmn2r125	C	A	4: 156,703,194 (GRCm39)	Q191K	probably benign	Het
Vmn2r125	A	C	4: 156,703,195 (GRCm39)	Q191P	probably benign	Het
Vmn2r125	A	T	4: 156,703,332 (GRCm39)	T237S	probably benign	Het
Vmn2r125	T	A	4: 156,703,521 (GRCm39)	L300M	probably benign	Het
Vmn2r125	C	T	4: 156,703,333 (GRCm39)	T237I	probably benign	Het
Vmn2r129	C	A	4: 156,690,730 (GRCm39)		noncoding transcript	Het
Vmn2r129	A	T	4: 156,690,441 (GRCm39)		noncoding transcript	Het
Vmn2r129	G	A	4: 156,686,900 (GRCm39)		noncoding transcript	Het
Vmn2r129	T	C	4: 156,687,885 (GRCm39)		noncoding transcript	Het
Vmn2r129	T	C	4: 156,686,558 (GRCm39)		noncoding transcript	Het
Vmn2r40	G	A	7: 8,911,175 (GRCm39)	S706F	probably damaging	Het
Zfp14	T	A	7: 29,737,526 (GRCm39)	R486S	probably damaging	Het

Other mutations in Or6p1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01560:Or6p1	APN	1	174,258,467 (GRCm39)	missense	probably benign	0.17
IGL01795:Or6p1	APN	1	174,258,215 (GRCm39)	missense	possibly damaging	0.83
IGL03286:Or6p1	APN	1	174,258,743 (GRCm39)	missense	probably benign	0.01
PIT4131001:Or6p1	UTSW	1	174,258,390 (GRCm39)	missense	probably damaging	1.00
R0219:Or6p1	UTSW	1	174,258,032 (GRCm39)	missense	probably benign	0.00
R0492:Or6p1	UTSW	1	174,258,129 (GRCm39)	missense	possibly damaging	0.95
R1052:Or6p1	UTSW	1	174,258,701 (GRCm39)	nonsense	probably null
R1054:Or6p1	UTSW	1	174,258,419 (GRCm39)	missense	probably benign	0.36
R1473:Or6p1	UTSW	1	174,258,209 (GRCm39)	missense	probably damaging	0.97
R1675:Or6p1	UTSW	1	174,258,663 (GRCm39)	missense	probably benign
R1774:Or6p1	UTSW	1	174,258,905 (GRCm39)	missense	probably benign	0.00
R1861:Or6p1	UTSW	1	174,258,657 (GRCm39)	missense	probably damaging	1.00
R1959:Or6p1	UTSW	1	174,258,471 (GRCm39)	missense	probably damaging	1.00
R1978:Or6p1	UTSW	1	174,258,657 (GRCm39)	missense	probably damaging	1.00
R4043:Or6p1	UTSW	1	174,258,657 (GRCm39)	missense	probably damaging	1.00
R5020:Or6p1	UTSW	1	174,258,237 (GRCm39)	missense	probably damaging	0.98
R5354:Or6p1	UTSW	1	174,258,252 (GRCm39)	missense	probably damaging	0.98
R5873:Or6p1	UTSW	1	174,258,348 (GRCm39)	missense	possibly damaging	0.84
R6053:Or6p1	UTSW	1	174,258,135 (GRCm39)	nonsense	probably null
R8300:Or6p1	UTSW	1	174,258,100 (GRCm39)	nonsense	probably null
R9105:Or6p1	UTSW	1	174,258,861 (GRCm39)	missense	probably damaging	1.00
R9716:Or6p1	UTSW	1	174,258,641 (GRCm39)	missense	probably benign	0.21
Z1176:Or6p1	UTSW	1	174,258,157 (GRCm39)	missense	probably benign	0.39

Posted On

2015-04-16