Incidental Mutation 'IGL01402:Or5k8'
ID 278354
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5k8
Ensembl Gene ENSMUSG00000060663
Gene Name olfactory receptor family 5 subfamily K member 8
Synonyms GA_x54KRFPKG5P-55026345-55025418, MOR184-10P, MOR184-1, GA_x54KRFPKG5P-54993816-54992890, Olfr175-ps1, Olfr175, Olfr174
Accession Numbers
Essential gene? Probably non essential (E-score: 0.122) question?
Stock # IGL01402
Quality Score
Status
Chromosome 16
Chromosomal Location 58644144-58647124 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 58644958 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 38 (T38I)
Ref Sequence ENSEMBL: ENSMUSP00000150202 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079955] [ENSMUST00000215069]
AlphaFold A0A140T8K4
Predicted Effect probably damaging
Transcript: ENSMUST00000079955
AA Change: T38I

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000078873
Gene: ENSMUSG00000060663
AA Change: T38I

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.3e-52 PFAM
Pfam:7TM_GPCR_Srsx 35 305 6.8e-6 PFAM
Pfam:7tm_1 41 290 2.5e-18 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215069
AA Change: T38I

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Meta Mutation Damage Score 0.4653 question?
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921524L21Rik T C 18: 6,638,653 (GRCm39) S351P possibly damaging Het
Abca2 T C 2: 25,332,015 (GRCm39) S1376P probably damaging Het
Ablim3 A G 18: 62,004,754 (GRCm39) Y12H probably damaging Het
Akr1b7 A G 6: 34,398,052 (GRCm39) R294G possibly damaging Het
Aldh3b1 A C 19: 3,971,205 (GRCm39) V153G probably benign Het
Alk A T 17: 72,181,173 (GRCm39) H1372Q probably damaging Het
Ano9 A C 7: 140,681,955 (GRCm39) Y731* probably null Het
Apol11b G A 15: 77,522,219 (GRCm39) T26M probably damaging Het
Asl T C 5: 130,048,645 (GRCm39) E43G probably damaging Het
Cd4 G A 6: 124,856,341 (GRCm39) T50I probably benign Het
Cfap43 T C 19: 47,784,105 (GRCm39) D476G probably benign Het
Cpa1 A G 6: 30,645,275 (GRCm39) H417R possibly damaging Het
Cpeb3 T C 19: 37,065,948 (GRCm39) D407G probably benign Het
Dcaf15 A T 8: 84,825,026 (GRCm39) C469S probably damaging Het
Dpy19l4 C A 4: 11,273,006 (GRCm39) probably null Het
E4f1 A T 17: 24,663,208 (GRCm39) L699Q probably damaging Het
Eif4g2 A G 7: 110,676,234 (GRCm39) F349S possibly damaging Het
Ermap T C 4: 119,044,355 (GRCm39) Y147C probably damaging Het
Frk A C 10: 34,423,381 (GRCm39) E153A probably damaging Het
Fubp3 G A 2: 31,494,733 (GRCm39) probably null Het
Gdi2 A G 13: 3,614,611 (GRCm39) T319A probably benign Het
Gjc3 A G 5: 137,956,120 (GRCm39) F55S probably damaging Het
Gm10762 C T 2: 128,809,005 (GRCm39) probably benign Het
Got1 A G 19: 43,493,048 (GRCm39) I291T possibly damaging Het
Gpr179 C A 11: 97,229,012 (GRCm39) G1048* probably null Het
Hectd3 G T 4: 116,853,262 (GRCm39) R163L probably damaging Het
Hectd4 T C 5: 121,477,480 (GRCm39) probably benign Het
Ifnb1 T C 4: 88,440,480 (GRCm39) R178G probably benign Het
Ino80 T A 2: 119,287,199 (GRCm39) D56V possibly damaging Het
Kctd1 T A 18: 15,102,610 (GRCm39) Q857L probably damaging Het
Kdm5a T A 6: 120,367,640 (GRCm39) L445* probably null Het
Lins1 G A 7: 66,363,676 (GRCm39) V524I probably damaging Het
Lrp1 A T 10: 127,430,901 (GRCm39) Y383N probably damaging Het
Malrd1 G A 2: 16,106,768 (GRCm39) probably null Het
Mgam A C 6: 40,621,879 (GRCm39) K84Q probably benign Het
Mlh3 A T 12: 85,314,703 (GRCm39) F494L probably benign Het
Mpped1 T C 15: 83,676,414 (GRCm39) F60S possibly damaging Het
Myo1e A G 9: 70,245,048 (GRCm39) Y382C probably benign Het
Ncor1 C A 11: 62,231,300 (GRCm39) V836F probably damaging Het
Nktr G A 9: 121,570,218 (GRCm39) probably null Het
Or10al4 A G 17: 38,037,193 (GRCm39) T93A probably benign Het
Or4d5 A G 9: 40,012,558 (GRCm39) I76T probably benign Het
Rnf144a T A 12: 26,377,300 (GRCm39) Y93F probably benign Het
Rubcn G A 16: 32,647,666 (GRCm39) T636M probably damaging Het
Scn5a A C 9: 119,315,536 (GRCm39) L1724R probably damaging Het
Sel1l A G 12: 91,808,607 (GRCm39) S45P possibly damaging Het
Serpina3k A G 12: 104,306,882 (GRCm39) D38G probably benign Het
Sh3bgr A C 16: 96,007,690 (GRCm39) K18N probably damaging Het
Slc28a2 T G 2: 122,282,538 (GRCm39) I287M probably damaging Het
St8sia6 T C 2: 13,670,318 (GRCm39) N214S probably damaging Het
Syt11 A G 3: 88,669,523 (GRCm39) I123T probably benign Het
Tcerg1l A T 7: 137,861,568 (GRCm39) I387N probably damaging Het
Tfg C A 16: 56,514,856 (GRCm39) probably benign Het
Tgm4 A G 9: 122,880,519 (GRCm39) K307E possibly damaging Het
Tmem177 T C 1: 119,837,791 (GRCm39) D296G probably damaging Het
Tmem270 C T 5: 134,930,763 (GRCm39) probably benign Het
Tnrc6b G T 15: 80,764,745 (GRCm39) G749V possibly damaging Het
Trp63 C A 16: 25,639,135 (GRCm39) probably benign Het
Ugt1a8 T C 1: 88,015,617 (GRCm39) L10P probably benign Het
Vmn2r107 A T 17: 20,596,009 (GRCm39) K854M probably damaging Het
Vmn2r45 T C 7: 8,484,467 (GRCm39) N446S probably damaging Het
Vps13c A T 9: 67,820,486 (GRCm39) probably null Het
Wdr91 G A 6: 34,865,998 (GRCm39) P518L probably benign Het
Yap1 G A 9: 7,934,742 (GRCm39) probably benign Het
Zfp282 A C 6: 47,874,770 (GRCm39) D325A probably damaging Het
Other mutations in Or5k8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01404:Or5k8 APN 16 58,644,958 (GRCm39) missense probably damaging 1.00
IGL01867:Or5k8 APN 16 58,644,337 (GRCm39) missense probably damaging 1.00
IGL02073:Or5k8 APN 16 58,644,169 (GRCm39) missense probably benign
IGL02393:Or5k8 APN 16 58,644,409 (GRCm39) missense probably damaging 0.99
IGL02474:Or5k8 APN 16 58,645,019 (GRCm39) missense probably benign
IGL02548:Or5k8 APN 16 58,644,691 (GRCm39) missense probably benign 0.42
IGL02948:Or5k8 APN 16 58,644,451 (GRCm39) missense probably benign 0.00
PIT4504001:Or5k8 UTSW 16 58,644,671 (GRCm39) missense probably benign 0.00
R0553:Or5k8 UTSW 16 58,644,518 (GRCm39) missense probably damaging 0.99
R1191:Or5k8 UTSW 16 58,644,922 (GRCm39) missense probably benign
R1201:Or5k8 UTSW 16 58,644,226 (GRCm39) missense probably damaging 0.98
R1458:Or5k8 UTSW 16 58,645,039 (GRCm39) missense probably null 0.68
R1469:Or5k8 UTSW 16 58,644,973 (GRCm39) missense probably benign
R1469:Or5k8 UTSW 16 58,644,973 (GRCm39) missense probably benign
R1843:Or5k8 UTSW 16 58,644,440 (GRCm39) missense probably damaging 0.99
R2147:Or5k8 UTSW 16 58,644,842 (GRCm39) missense probably damaging 0.99
R2421:Or5k8 UTSW 16 58,644,709 (GRCm39) missense probably damaging 1.00
R4370:Or5k8 UTSW 16 58,644,956 (GRCm39) missense probably benign 0.00
R4621:Or5k8 UTSW 16 58,644,469 (GRCm39) missense possibly damaging 0.94
R4622:Or5k8 UTSW 16 58,644,469 (GRCm39) missense possibly damaging 0.94
R4623:Or5k8 UTSW 16 58,644,469 (GRCm39) missense possibly damaging 0.94
R4711:Or5k8 UTSW 16 58,645,069 (GRCm39) start codon destroyed probably null 0.98
R5323:Or5k8 UTSW 16 58,645,066 (GRCm39) missense probably benign
R5447:Or5k8 UTSW 16 58,644,846 (GRCm39) nonsense probably null
R5457:Or5k8 UTSW 16 58,644,796 (GRCm39) missense probably damaging 0.97
R5546:Or5k8 UTSW 16 58,644,516 (GRCm39) nonsense probably null
R5623:Or5k8 UTSW 16 58,644,706 (GRCm39) missense probably benign 0.02
R5767:Or5k8 UTSW 16 58,644,316 (GRCm39) missense probably benign 0.42
R6270:Or5k8 UTSW 16 58,644,782 (GRCm39) missense probably damaging 1.00
R6449:Or5k8 UTSW 16 58,644,889 (GRCm39) missense probably damaging 1.00
R7356:Or5k8 UTSW 16 58,644,718 (GRCm39) missense probably damaging 0.99
R7521:Or5k8 UTSW 16 58,644,257 (GRCm39) missense probably benign 0.00
R7638:Or5k8 UTSW 16 58,644,958 (GRCm39) missense probably damaging 1.00
R7814:Or5k8 UTSW 16 58,644,365 (GRCm39) missense probably damaging 0.98
R9109:Or5k8 UTSW 16 58,644,677 (GRCm39) missense probably damaging 1.00
R9276:Or5k8 UTSW 16 58,644,734 (GRCm39) missense probably benign 0.09
R9681:Or5k8 UTSW 16 58,644,176 (GRCm39) missense possibly damaging 0.90
X0011:Or5k8 UTSW 16 58,645,026 (GRCm39) missense probably benign
Z1176:Or5k8 UTSW 16 58,644,670 (GRCm39) frame shift probably null
Z1177:Or5k8 UTSW 16 58,645,061 (GRCm39) missense possibly damaging 0.47
Posted On 2015-04-16