Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01402:Or4d5'

278371

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or4d5

Ensembl Gene

ENSMUSG00000045812

Gene Name

olfactory receptor family 4 subfamily D member 5

Synonyms

Olfr984, MOR239-6, GA_x6K02T2PVTD-33799484-33798540

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.201) question?

Stock #

IGL01402

Quality Score

Status

Chromosome

Chromosomal Location

40011840-40012784 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 40012558 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 76 (I76T)

Ref Sequence

ENSEMBL: ENSMUSP00000150287 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000056795] [ENSMUST00000213858] [ENSMUST00000214856] [ENSMUST00000217536]

AlphaFold

Q8VFN1

Predicted Effect

probably benign
Transcript: ENSMUST00000056795
AA Change: I76T

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000060787
Gene: ENSMUSG00000045812
AA Change: I76T

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	305	1.3e-42	PFAM
Pfam:7tm_1	41	287	6e-20	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213858
AA Change: I76T

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

Predicted Effect

probably benign
Transcript: ENSMUST00000214856
AA Change: I76T

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

Predicted Effect

probably benign
Transcript: ENSMUST00000217536
AA Change: I76T

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921524L21Rik	T	C	18: 6,638,653 (GRCm39)	S351P	possibly damaging	Het
Abca2	T	C	2: 25,332,015 (GRCm39)	S1376P	probably damaging	Het
Ablim3	A	G	18: 62,004,754 (GRCm39)	Y12H	probably damaging	Het
Akr1b7	A	G	6: 34,398,052 (GRCm39)	R294G	possibly damaging	Het
Aldh3b1	A	C	19: 3,971,205 (GRCm39)	V153G	probably benign	Het
Alk	A	T	17: 72,181,173 (GRCm39)	H1372Q	probably damaging	Het
Ano9	A	C	7: 140,681,955 (GRCm39)	Y731*	probably null	Het
Apol11b	G	A	15: 77,522,219 (GRCm39)	T26M	probably damaging	Het
Asl	T	C	5: 130,048,645 (GRCm39)	E43G	probably damaging	Het
Cd4	G	A	6: 124,856,341 (GRCm39)	T50I	probably benign	Het
Cfap43	T	C	19: 47,784,105 (GRCm39)	D476G	probably benign	Het
Cpa1	A	G	6: 30,645,275 (GRCm39)	H417R	possibly damaging	Het
Cpeb3	T	C	19: 37,065,948 (GRCm39)	D407G	probably benign	Het
Dcaf15	A	T	8: 84,825,026 (GRCm39)	C469S	probably damaging	Het
Dpy19l4	C	A	4: 11,273,006 (GRCm39)		probably null	Het
E4f1	A	T	17: 24,663,208 (GRCm39)	L699Q	probably damaging	Het
Eif4g2	A	G	7: 110,676,234 (GRCm39)	F349S	possibly damaging	Het
Ermap	T	C	4: 119,044,355 (GRCm39)	Y147C	probably damaging	Het
Frk	A	C	10: 34,423,381 (GRCm39)	E153A	probably damaging	Het
Fubp3	G	A	2: 31,494,733 (GRCm39)		probably null	Het
Gdi2	A	G	13: 3,614,611 (GRCm39)	T319A	probably benign	Het
Gjc3	A	G	5: 137,956,120 (GRCm39)	F55S	probably damaging	Het
Gm10762	C	T	2: 128,809,005 (GRCm39)		probably benign	Het
Got1	A	G	19: 43,493,048 (GRCm39)	I291T	possibly damaging	Het
Gpr179	C	A	11: 97,229,012 (GRCm39)	G1048*	probably null	Het
Hectd3	G	T	4: 116,853,262 (GRCm39)	R163L	probably damaging	Het
Hectd4	T	C	5: 121,477,480 (GRCm39)		probably benign	Het
Ifnb1	T	C	4: 88,440,480 (GRCm39)	R178G	probably benign	Het
Ino80	T	A	2: 119,287,199 (GRCm39)	D56V	possibly damaging	Het
Kctd1	T	A	18: 15,102,610 (GRCm39)	Q857L	probably damaging	Het
Kdm5a	T	A	6: 120,367,640 (GRCm39)	L445*	probably null	Het
Lins1	G	A	7: 66,363,676 (GRCm39)	V524I	probably damaging	Het
Lrp1	A	T	10: 127,430,901 (GRCm39)	Y383N	probably damaging	Het
Malrd1	G	A	2: 16,106,768 (GRCm39)		probably null	Het
Mgam	A	C	6: 40,621,879 (GRCm39)	K84Q	probably benign	Het
Mlh3	A	T	12: 85,314,703 (GRCm39)	F494L	probably benign	Het
Mpped1	T	C	15: 83,676,414 (GRCm39)	F60S	possibly damaging	Het
Myo1e	A	G	9: 70,245,048 (GRCm39)	Y382C	probably benign	Het
Ncor1	C	A	11: 62,231,300 (GRCm39)	V836F	probably damaging	Het
Nktr	G	A	9: 121,570,218 (GRCm39)		probably null	Het
Or10al4	A	G	17: 38,037,193 (GRCm39)	T93A	probably benign	Het
Or5k8	G	A	16: 58,644,958 (GRCm39)	T38I	probably damaging	Het
Rnf144a	T	A	12: 26,377,300 (GRCm39)	Y93F	probably benign	Het
Rubcn	G	A	16: 32,647,666 (GRCm39)	T636M	probably damaging	Het
Scn5a	A	C	9: 119,315,536 (GRCm39)	L1724R	probably damaging	Het
Sel1l	A	G	12: 91,808,607 (GRCm39)	S45P	possibly damaging	Het
Serpina3k	A	G	12: 104,306,882 (GRCm39)	D38G	probably benign	Het
Sh3bgr	A	C	16: 96,007,690 (GRCm39)	K18N	probably damaging	Het
Slc28a2	T	G	2: 122,282,538 (GRCm39)	I287M	probably damaging	Het
St8sia6	T	C	2: 13,670,318 (GRCm39)	N214S	probably damaging	Het
Syt11	A	G	3: 88,669,523 (GRCm39)	I123T	probably benign	Het
Tcerg1l	A	T	7: 137,861,568 (GRCm39)	I387N	probably damaging	Het
Tfg	C	A	16: 56,514,856 (GRCm39)		probably benign	Het
Tgm4	A	G	9: 122,880,519 (GRCm39)	K307E	possibly damaging	Het
Tmem177	T	C	1: 119,837,791 (GRCm39)	D296G	probably damaging	Het
Tmem270	C	T	5: 134,930,763 (GRCm39)		probably benign	Het
Tnrc6b	G	T	15: 80,764,745 (GRCm39)	G749V	possibly damaging	Het
Trp63	C	A	16: 25,639,135 (GRCm39)		probably benign	Het
Ugt1a8	T	C	1: 88,015,617 (GRCm39)	L10P	probably benign	Het
Vmn2r107	A	T	17: 20,596,009 (GRCm39)	K854M	probably damaging	Het
Vmn2r45	T	C	7: 8,484,467 (GRCm39)	N446S	probably damaging	Het
Vps13c	A	T	9: 67,820,486 (GRCm39)		probably null	Het
Wdr91	G	A	6: 34,865,998 (GRCm39)	P518L	probably benign	Het
Yap1	G	A	9: 7,934,742 (GRCm39)		probably benign	Het
Zfp282	A	C	6: 47,874,770 (GRCm39)	D325A	probably damaging	Het

Other mutations in Or4d5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00946:Or4d5	APN	9	40,012,450 (GRCm39)	missense	probably benign	0.03
IGL01404:Or4d5	APN	9	40,012,558 (GRCm39)	missense	probably benign	0.00
IGL01445:Or4d5	APN	9	40,012,608 (GRCm39)	missense	probably benign	0.45
IGL01448:Or4d5	APN	9	40,012,378 (GRCm39)	missense	probably damaging	0.97
IGL02598:Or4d5	APN	9	40,011,861 (GRCm39)	missense	probably benign
IGL03106:Or4d5	APN	9	40,012,030 (GRCm39)	missense	probably damaging	1.00
R0616:Or4d5	UTSW	9	40,012,283 (GRCm39)	missense	probably damaging	1.00
R0712:Or4d5	UTSW	9	40,012,726 (GRCm39)	missense	probably benign
R2049:Or4d5	UTSW	9	40,012,415 (GRCm39)	missense	probably benign
R2938:Or4d5	UTSW	9	40,012,039 (GRCm39)	missense	probably benign	0.20
R4609:Or4d5	UTSW	9	40,012,102 (GRCm39)	missense	possibly damaging	0.81
R4907:Or4d5	UTSW	9	40,011,955 (GRCm39)	missense	probably benign	0.02
R5001:Or4d5	UTSW	9	40,012,523 (GRCm39)	missense	probably benign	0.02
R5174:Or4d5	UTSW	9	40,012,043 (GRCm39)	missense	possibly damaging	0.87
R5587:Or4d5	UTSW	9	40,012,540 (GRCm39)	missense	probably damaging	1.00
R5880:Or4d5	UTSW	9	40,012,543 (GRCm39)	missense	possibly damaging	0.95
R5896:Or4d5	UTSW	9	40,012,189 (GRCm39)	missense	probably damaging	0.99
R6611:Or4d5	UTSW	9	40,012,316 (GRCm39)	missense	probably benign	0.03
R6904:Or4d5	UTSW	9	40,012,652 (GRCm39)	missense	probably benign	0.04
R7015:Or4d5	UTSW	9	40,012,751 (GRCm39)	missense	probably benign	0.30
R7870:Or4d5	UTSW	9	40,011,973 (GRCm39)	missense	possibly damaging	0.93
R8191:Or4d5	UTSW	9	40,012,767 (GRCm39)	missense	probably benign	0.13
R8739:Or4d5	UTSW	9	40,012,636 (GRCm39)	missense	probably benign	0.13
R8799:Or4d5	UTSW	9	40,011,985 (GRCm39)	missense	possibly damaging	0.84
R9307:Or4d5	UTSW	9	40,012,451 (GRCm39)	missense	probably benign	0.00
R9315:Or4d5	UTSW	9	40,012,270 (GRCm39)	missense	probably benign	0.02
R9497:Or4d5	UTSW	9	40,011,935 (GRCm39)	missense	probably damaging	1.00
R9554:Or4d5	UTSW	9	40,012,160 (GRCm39)	missense	probably benign
R9568:Or4d5	UTSW	9	40,011,864 (GRCm39)	missense	probably benign	0.01

Posted On

2015-04-16