Incidental Mutation 'IGL00959:Sult2a6'
ID 27883
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sult2a6
Ensembl Gene ENSMUSG00000070810
Gene Name sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 6
Synonyms Gm6957
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # IGL00959
Quality Score
Status
Chromosome 7
Chromosomal Location 13956328-13988795 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 13988634 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 42 (Y42C)
Ref Sequence ENSEMBL: ENSMUSP00000138842 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076576] [ENSMUST00000184731]
AlphaFold B2RVI8
Predicted Effect probably damaging
Transcript: ENSMUST00000076576
AA Change: Y42C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000075884
Gene: ENSMUSG00000070810
AA Change: Y42C

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 34 278 1.2e-81 PFAM
Pfam:Sulfotransfer_3 35 205 2.2e-11 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000184731
AA Change: Y42C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000138842
Gene: ENSMUSG00000070810
AA Change: Y42C

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 34 116 4.7e-20 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This is one of seven sulfotransferase family 2A genes in a chromosome 7 A1 cluster. [provided by RefSeq, May 2010]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alox12b A T 11: 69,057,069 (GRCm39) H430L probably damaging Het
Aox4 G T 1: 58,278,333 (GRCm39) V443F probably damaging Het
Bmpr2 A T 1: 59,854,474 (GRCm39) I108F possibly damaging Het
Cflar G A 1: 58,768,321 (GRCm39) probably null Het
Chchd3 A G 6: 32,945,188 (GRCm39) V106A probably benign Het
Chl1 G T 6: 103,686,211 (GRCm39) probably null Het
Clvs2 C T 10: 33,404,459 (GRCm39) M252I probably benign Het
Cntnap5a T A 1: 116,112,057 (GRCm39) L449Q probably benign Het
Col6a2 T A 10: 76,450,368 (GRCm39) I188F probably damaging Het
Cyp2c55 A G 19: 39,026,587 (GRCm39) D398G probably benign Het
Dennd1b T C 1: 139,071,626 (GRCm39) probably benign Het
Dop1a T A 9: 86,369,484 (GRCm39) Y106N probably damaging Het
Dpy19l1 A T 9: 24,334,493 (GRCm39) probably null Het
Extl3 C T 14: 65,314,361 (GRCm39) V274I probably benign Het
Fras1 G A 5: 96,929,140 (GRCm39) R3848H probably damaging Het
Gm11437 A C 11: 84,039,448 (GRCm39) probably benign Het
Gss T A 2: 155,423,871 (GRCm39) D2V probably damaging Het
Hnrnpm C A 17: 33,868,876 (GRCm39) R517L probably damaging Het
Ilvbl G A 10: 78,419,739 (GRCm39) D548N probably damaging Het
Jmjd6 A T 11: 116,733,202 (GRCm39) D115E possibly damaging Het
Kidins220 T A 12: 25,101,132 (GRCm39) S1110R possibly damaging Het
Kmt2c T A 5: 25,481,227 (GRCm39) I4784F probably damaging Het
Mrpl52 T C 14: 54,664,494 (GRCm39) V11A possibly damaging Het
Myo3b A G 2: 70,144,636 (GRCm39) Y1036C probably damaging Het
Omp T C 7: 97,794,357 (GRCm39) D90G probably damaging Het
Or6c2b T A 10: 128,947,893 (GRCm39) M134L probably benign Het
Osmr T C 15: 6,854,086 (GRCm39) I541V probably benign Het
Ppp2r1a A T 17: 21,181,840 (GRCm39) probably benign Het
Ptpn13 T A 5: 103,665,437 (GRCm39) probably null Het
Rock2 C A 12: 17,028,056 (GRCm39) N1429K probably benign Het
Saxo4 A T 19: 10,454,887 (GRCm39) probably null Het
Slc25a20 T G 9: 108,559,198 (GRCm39) M188R possibly damaging Het
Slc28a1 T C 7: 80,818,816 (GRCm39) probably benign Het
Tgfb2 A G 1: 186,436,784 (GRCm39) V63A probably benign Het
Ugt2b38 A T 5: 87,559,682 (GRCm39) N403K probably damaging Het
Vmn2r29 A G 7: 7,244,855 (GRCm39) W340R probably benign Het
Wnt5a C T 14: 28,244,866 (GRCm39) T351M probably damaging Het
Other mutations in Sult2a6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01977:Sult2a6 APN 7 13,987,411 (GRCm39) missense probably benign 0.00
IGL02524:Sult2a6 APN 7 13,970,611 (GRCm39) missense possibly damaging 0.80
IGL03209:Sult2a6 APN 7 13,959,897 (GRCm39) missense probably benign 0.36
IGL03379:Sult2a6 APN 7 13,956,511 (GRCm39) missense probably benign 0.01
R1840:Sult2a6 UTSW 7 13,988,754 (GRCm39) missense probably benign 0.03
R1893:Sult2a6 UTSW 7 13,959,814 (GRCm39) missense probably benign 0.00
R2037:Sult2a6 UTSW 7 13,988,634 (GRCm39) missense probably damaging 0.99
R2331:Sult2a6 UTSW 7 13,959,795 (GRCm39) missense possibly damaging 0.94
R3871:Sult2a6 UTSW 7 13,988,701 (GRCm39) missense probably benign 0.16
R3921:Sult2a6 UTSW 7 13,988,668 (GRCm39) missense possibly damaging 0.83
R5599:Sult2a6 UTSW 7 13,988,629 (GRCm39) nonsense probably null
R5761:Sult2a6 UTSW 7 13,984,283 (GRCm39) missense probably damaging 0.97
R6744:Sult2a6 UTSW 7 13,956,470 (GRCm39) missense probably damaging 1.00
R6956:Sult2a6 UTSW 7 13,988,748 (GRCm39) missense possibly damaging 0.50
R7152:Sult2a6 UTSW 7 13,956,445 (GRCm39) missense probably benign 0.36
R7869:Sult2a6 UTSW 7 13,988,737 (GRCm39) missense not run
R7990:Sult2a6 UTSW 7 13,959,795 (GRCm39) missense possibly damaging 0.94
R8347:Sult2a6 UTSW 7 13,959,883 (GRCm39) missense probably benign 0.15
R8369:Sult2a6 UTSW 7 13,987,327 (GRCm39) critical splice donor site probably null
R8391:Sult2a6 UTSW 7 13,956,516 (GRCm39) critical splice acceptor site probably null
R8414:Sult2a6 UTSW 7 13,984,357 (GRCm39) missense probably damaging 1.00
R9317:Sult2a6 UTSW 7 13,970,615 (GRCm39) nonsense probably null
R9654:Sult2a6 UTSW 7 13,956,445 (GRCm39) missense probably benign 0.06
Z1088:Sult2a6 UTSW 7 13,959,819 (GRCm39) missense probably benign
Posted On 2013-04-17