Incidental Mutation 'IGL01785:Otud3'
ID278867
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Otud3
Ensembl Gene ENSMUSG00000041161
Gene NameOTU domain containing 3
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.240) question?
Stock #IGL01785
Quality Score
Status
Chromosome4
Chromosomal Location138895379-138913945 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 138896897 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 278 (D278G)
Ref Sequence ENSEMBL: ENSMUSP00000095441 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097830]
Predicted Effect probably benign
Transcript: ENSMUST00000097830
AA Change: D278G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000095441
Gene: ENSMUSG00000041161
AA Change: D278G

DomainStartEndE-ValueType
low complexity region 16 40 N/A INTRINSIC
Pfam:OTU 70 185 3.6e-12 PFAM
coiled coil region 340 370 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb4 T A 5: 8,915,058 Y309* probably null Het
Abhd18 G A 3: 40,905,904 R42Q probably damaging Het
Ano3 T A 2: 110,682,715 Q645L probably damaging Het
Clasp1 T A 1: 118,497,736 L272Q possibly damaging Het
Clec1b A G 6: 129,403,562 D115G probably damaging Het
Clec2e A T 6: 129,093,401 probably benign Het
Corin T C 5: 72,339,876 N532S probably damaging Het
Csn1s2b A G 5: 87,809,913 K2R possibly damaging Het
Mcm8 A G 2: 132,827,948 D314G probably benign Het
Mga T A 2: 119,902,912 D80E probably damaging Het
Msh4 A G 3: 153,857,507 L744P probably damaging Het
Myof A T 19: 37,980,423 L348* probably null Het
Olfr1348 T C 7: 6,501,900 I109V probably benign Het
Olfr530 T A 7: 140,373,125 M162L probably benign Het
Pdpr C A 8: 111,129,656 H670Q probably damaging Het
Phf21b C A 15: 84,808,061 probably benign Het
Polr3a G A 14: 24,484,120 Q106* probably null Het
Ptprm G T 17: 66,685,623 N1366K probably damaging Het
Slc10a5 G A 3: 10,335,199 P134S probably benign Het
Slc30a9 A G 5: 67,346,238 probably benign Het
Stat6 T A 10: 127,657,227 V576D probably damaging Het
Tmem132d T C 5: 127,984,315 I408V probably benign Het
Tmem50a T C 4: 134,898,447 E153G probably damaging Het
Tmod4 A G 3: 95,125,618 T22A probably benign Het
Tmprss7 C T 16: 45,680,634 G268D probably damaging Het
Tor1a A G 2: 30,963,703 probably null Het
Ttc29 T C 8: 78,282,341 L280P probably damaging Het
Tusc5 G A 11: 76,680,466 V103I probably benign Het
Usp20 A G 2: 31,017,163 E594G probably benign Het
Vmn1r31 A C 6: 58,472,724 M3R possibly damaging Het
Other mutations in Otud3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01786:Otud3 APN 4 138896897 missense probably benign
IGL02125:Otud3 APN 4 138896714 critical splice donor site probably null
IGL03256:Otud3 APN 4 138909617 missense probably damaging 1.00
R0647:Otud3 UTSW 4 138913637 missense probably damaging 1.00
R1723:Otud3 UTSW 4 138898018 missense probably damaging 0.99
R1744:Otud3 UTSW 4 138895748 missense probably damaging 1.00
R1760:Otud3 UTSW 4 138895781 missense possibly damaging 0.51
R1954:Otud3 UTSW 4 138898032 missense possibly damaging 0.86
R3900:Otud3 UTSW 4 138896885 missense probably benign
R4890:Otud3 UTSW 4 138913749 missense probably damaging 1.00
R5534:Otud3 UTSW 4 138897583 missense probably damaging 1.00
R5769:Otud3 UTSW 4 138898110 missense possibly damaging 0.89
R5948:Otud3 UTSW 4 138897614 missense probably benign 0.00
R6235:Otud3 UTSW 4 138901901 missense probably damaging 1.00
Posted On2015-04-16