Incidental Mutation 'IGL01786:Otud3'
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ID278908
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Otud3
Ensembl Gene ENSMUSG00000041161
Gene NameOTU domain containing 3
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.211) question?
Stock #IGL01786
Quality Score
Status
Chromosome4
Chromosomal Location138895379-138913945 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 138896897 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 278 (D278G)
Ref Sequence ENSEMBL: ENSMUSP00000095441 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097830]
Predicted Effect probably benign
Transcript: ENSMUST00000097830
AA Change: D278G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000095441
Gene: ENSMUSG00000041161
AA Change: D278G

DomainStartEndE-ValueType
low complexity region 16 40 N/A INTRINSIC
Pfam:OTU 70 185 3.6e-12 PFAM
coiled coil region 340 370 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam9 T A 8: 24,996,839 H20L probably damaging Het
Ano3 T A 2: 110,682,715 Q645L probably damaging Het
Clasp1 T A 1: 118,497,736 L272Q possibly damaging Het
Corin T C 5: 72,339,876 N532S probably damaging Het
Ddx1 A T 12: 13,229,136 D468E probably benign Het
Hk2 A G 6: 82,739,553 S333P probably benign Het
Kctd19 T C 8: 105,390,304 T398A probably benign Het
Klra8 T A 6: 130,119,068 probably null Het
Mcm8 A G 2: 132,827,948 D314G probably benign Het
Mga T A 2: 119,902,912 D80E probably damaging Het
Mylk3 T C 8: 85,359,317 Q36R probably benign Het
Myom2 T C 8: 15,106,330 S726P probably damaging Het
Nuf2 T C 1: 169,510,483 S242G possibly damaging Het
Nup210l T A 3: 90,122,776 Y265* probably null Het
Olfr1445 C T 19: 12,884,277 T132I probably damaging Het
Olfr530 T A 7: 140,373,125 M162L probably benign Het
Papolg A G 11: 23,874,488 V298A probably damaging Het
Phc1 T C 6: 122,319,520 D847G possibly damaging Het
Pkd2l1 A G 19: 44,191,442 F110L probably damaging Het
Plxnd1 T A 6: 115,959,935 T1638S probably damaging Het
Polr3a G A 14: 24,484,120 Q106* probably null Het
Rnf32 T C 5: 29,206,814 probably benign Het
Slc30a9 A G 5: 67,346,238 probably benign Het
Slc44a2 A G 9: 21,352,486 Y650C probably damaging Het
Sv2a A T 3: 96,188,209 Y306F probably benign Het
Tmem50a T C 4: 134,898,447 E153G probably damaging Het
Tor1a A G 2: 30,963,703 probably null Het
Tusc5 G A 11: 76,680,466 V103I probably benign Het
Usp20 A G 2: 31,017,163 E594G probably benign Het
Other mutations in Otud3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01785:Otud3 APN 4 138896897 missense probably benign
IGL02125:Otud3 APN 4 138896714 critical splice donor site probably null
IGL03256:Otud3 APN 4 138909617 missense probably damaging 1.00
R0647:Otud3 UTSW 4 138913637 missense probably damaging 1.00
R1723:Otud3 UTSW 4 138898018 missense probably damaging 0.99
R1744:Otud3 UTSW 4 138895748 missense probably damaging 1.00
R1760:Otud3 UTSW 4 138895781 missense possibly damaging 0.51
R1954:Otud3 UTSW 4 138898032 missense possibly damaging 0.86
R3900:Otud3 UTSW 4 138896885 missense probably benign
R4890:Otud3 UTSW 4 138913749 missense probably damaging 1.00
R5534:Otud3 UTSW 4 138897583 missense probably damaging 1.00
R5769:Otud3 UTSW 4 138898110 missense possibly damaging 0.89
R5948:Otud3 UTSW 4 138897614 missense probably benign 0.00
R6235:Otud3 UTSW 4 138901901 missense probably damaging 1.00
R7121:Otud3 UTSW 4 138896756 missense probably benign 0.01
Posted On2015-04-16