Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01786:Trarg1'

278910

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trarg1

Ensembl Gene

ENSMUSG00000046275

Gene Name

trafficking regulator of GLUT4 (SLC2A4) 1

Synonyms

C130069F04Rik, Tusc5, LOST1

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01786

Quality Score

Status

Chromosome

Chromosomal Location

76570699-76589490 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 76571292 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 103 (V103I)

Ref Sequence

ENSEMBL: ENSMUSP00000061634 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000062024]

AlphaFold

Q8C838

Predicted Effect

probably benign
Transcript: ENSMUST00000062024
AA Change: V103I

PolyPhen 2 Score 0.072 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000061634
Gene: ENSMUSG00000046275
AA Change: V103I

Domain	Start	End	E-Value	Type
Pfam:Dispanin	83	165	3.7e-25	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele display abnormal adipocyte glucose uptake and show increased body weight, elevated blood insulin and glucose levels, and insulin resistance when fed a high-fat diet. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam9	T	A	8: 25,486,855 (GRCm39)	H20L	probably damaging	Het
Ano3	T	A	2: 110,513,060 (GRCm39)	Q645L	probably damaging	Het
Clasp1	T	A	1: 118,425,466 (GRCm39)	L272Q	possibly damaging	Het
Corin	T	C	5: 72,497,219 (GRCm39)	N532S	probably damaging	Het
Ddx1	A	T	12: 13,279,137 (GRCm39)	D468E	probably benign	Het
Hk2	A	G	6: 82,716,534 (GRCm39)	S333P	probably benign	Het
Kctd19	T	C	8: 106,116,936 (GRCm39)	T398A	probably benign	Het
Klra8	T	A	6: 130,096,031 (GRCm39)		probably null	Het
Mcm8	A	G	2: 132,669,868 (GRCm39)	D314G	probably benign	Het
Mga	T	A	2: 119,733,393 (GRCm39)	D80E	probably damaging	Het
Mylk3	T	C	8: 86,085,946 (GRCm39)	Q36R	probably benign	Het
Myom2	T	C	8: 15,156,330 (GRCm39)	S726P	probably damaging	Het
Nuf2	T	C	1: 169,338,052 (GRCm39)	S242G	possibly damaging	Het
Nup210l	T	A	3: 90,030,083 (GRCm39)	Y265*	probably null	Het
Or12j3	T	A	7: 139,953,038 (GRCm39)	M162L	probably benign	Het
Or5b12b	C	T	19: 12,861,641 (GRCm39)	T132I	probably damaging	Het
Otud3	T	C	4: 138,624,208 (GRCm39)	D278G	probably benign	Het
Papolg	A	G	11: 23,824,488 (GRCm39)	V298A	probably damaging	Het
Phc1	T	C	6: 122,296,479 (GRCm39)	D847G	possibly damaging	Het
Pkd2l1	A	G	19: 44,179,881 (GRCm39)	F110L	probably damaging	Het
Plxnd1	T	A	6: 115,936,896 (GRCm39)	T1638S	probably damaging	Het
Polr3a	G	A	14: 24,534,188 (GRCm39)	Q106*	probably null	Het
Rnf32	T	C	5: 29,411,812 (GRCm39)		probably benign	Het
Slc30a9	A	G	5: 67,503,581 (GRCm39)		probably benign	Het
Slc44a2	A	G	9: 21,263,782 (GRCm39)	Y650C	probably damaging	Het
Sv2a	A	T	3: 96,095,525 (GRCm39)	Y306F	probably benign	Het
Tmem50a	T	C	4: 134,625,758 (GRCm39)	E153G	probably damaging	Het
Tor1a	A	G	2: 30,853,715 (GRCm39)		probably null	Het
Usp20	A	G	2: 30,907,175 (GRCm39)	E594G	probably benign	Het

Other mutations in Trarg1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01785:Trarg1	APN	11	76,571,292 (GRCm39)	missense	probably benign	0.07
R5184:Trarg1	UTSW	11	76,571,134 (GRCm39)	missense	probably damaging	1.00
R5217:Trarg1	UTSW	11	76,585,102 (GRCm39)	missense	possibly damaging	0.57
R6377:Trarg1	UTSW	11	76,571,355 (GRCm39)	missense	probably damaging	1.00
R6703:Trarg1	UTSW	11	76,584,988 (GRCm39)	critical splice acceptor site	probably null
R7421:Trarg1	UTSW	11	76,585,051 (GRCm39)	missense	unknown
R9463:Trarg1	UTSW	11	76,571,098 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16