Incidental Mutation 'IGL01791:Gzf1'
ID 278923
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gzf1
Ensembl Gene ENSMUSG00000027439
Gene Name GDNF-inducible zinc finger protein 1
Synonyms Zfp336, 8430437G08Rik
Accession Numbers
Essential gene? Possibly essential (E-score: 0.500) question?
Stock # IGL01791
Quality Score
Status
Chromosome 2
Chromosomal Location 148522943-148534869 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 148525981 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 151 (A151T)
Ref Sequence ENSEMBL: ENSMUSP00000028928 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028928] [ENSMUST00000131292]
AlphaFold Q4VBD9
Predicted Effect probably benign
Transcript: ENSMUST00000028928
AA Change: A151T

PolyPhen 2 Score 0.405 (Sensitivity: 0.89; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000028928
Gene: ENSMUSG00000027439
AA Change: A151T

DomainStartEndE-ValueType
BTB 31 133 2.01e-20 SMART
low complexity region 199 213 N/A INTRINSIC
coiled coil region 287 308 N/A INTRINSIC
ZnF_C2H2 315 337 6.32e-3 SMART
ZnF_C2H2 346 369 1.2e-3 SMART
ZnF_C2H2 375 398 8.34e-3 SMART
ZnF_C2H2 405 427 7.78e-3 SMART
ZnF_C2H2 433 455 1.69e-3 SMART
ZnF_C2H2 461 483 1.43e-1 SMART
ZnF_C2H2 489 511 2.4e-3 SMART
ZnF_C2H2 517 539 1.47e-3 SMART
ZnF_C2H2 545 567 1.38e-3 SMART
ZnF_C2H2 573 595 1.04e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000131292
SMART Domains Protein: ENSMUSP00000121799
Gene: ENSMUSG00000027439

DomainStartEndE-ValueType
BTB 31 133 2.01e-20 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151362
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(5) : Gene trapped(5)

Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap32 A G 9: 32,158,486 (GRCm39) I174V probably damaging Het
Asb15 T A 6: 24,567,211 (GRCm39) C511S probably damaging Het
Atr C T 9: 95,803,834 (GRCm39) A1896V probably benign Het
B3gnt4 C T 5: 123,649,162 (GRCm39) R176C probably damaging Het
Brf1 T C 12: 112,926,095 (GRCm39) D557G probably benign Het
Catsperg2 T A 7: 29,404,090 (GRCm39) probably null Het
Cdip1 A G 16: 4,586,729 (GRCm39) I122T probably damaging Het
Ctrl C T 8: 106,659,199 (GRCm39) E147K probably benign Het
Dennd2c T C 3: 103,073,741 (GRCm39) V829A probably benign Het
Dync1h1 T A 12: 110,625,364 (GRCm39) L3874Q probably damaging Het
Dynlt4 T A 4: 116,985,794 (GRCm39) S206T probably damaging Het
Gm10521 T C 1: 171,723,964 (GRCm39) S92P unknown Het
Gm57858 T C 3: 36,089,416 (GRCm39) probably benign Het
Hddc2 A G 10: 31,202,022 (GRCm39) Y123C probably damaging Het
Hyal4 T C 6: 24,763,894 (GRCm39) probably benign Het
Ighv16-1 T C 12: 114,032,589 (GRCm39) N71S probably benign Het
Ing2 A T 8: 48,122,070 (GRCm39) S159R probably benign Het
Itga1 A T 13: 115,124,197 (GRCm39) N698K probably benign Het
Lemd2 A T 17: 27,409,702 (GRCm39) I483N probably damaging Het
Lyst T C 13: 13,809,887 (GRCm39) L519P probably damaging Het
Mapk10 T C 5: 103,144,514 (GRCm39) N101S probably damaging Het
Nfatc4 A T 14: 56,069,695 (GRCm39) E164V probably null Het
Nfkb2 T G 19: 46,298,278 (GRCm39) probably benign Het
Nox3 A G 17: 3,733,218 (GRCm39) V231A possibly damaging Het
Nup160 G A 2: 90,534,197 (GRCm39) G674D probably damaging Het
Or1l4b A T 2: 37,036,548 (GRCm39) D108V probably damaging Het
Or56b1 C T 7: 104,285,682 (GRCm39) T267I possibly damaging Het
Otoa T G 7: 120,755,072 (GRCm39) V998G probably benign Het
Pcnx3 A T 19: 5,723,295 (GRCm39) M1300K probably benign Het
Pde4b A G 4: 102,448,127 (GRCm39) probably benign Het
Rfc1 T A 5: 65,420,488 (GRCm39) K1104I probably benign Het
Serpina1f G T 12: 103,659,761 (GRCm39) Q174K probably damaging Het
Serping1 T C 2: 84,603,721 (GRCm39) N107D possibly damaging Het
Speer4c2 C A 5: 15,861,884 (GRCm39) probably benign Het
Surf6 A G 2: 26,789,759 (GRCm39) S94P probably benign Het
Tigd4 T A 3: 84,502,052 (GRCm39) I323N probably damaging Het
Vmn2r28 T C 7: 5,491,161 (GRCm39) D362G probably benign Het
Wdfy3 A G 5: 102,085,278 (GRCm39) S739P probably damaging Het
Other mutations in Gzf1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01129:Gzf1 APN 2 148,532,916 (GRCm39) missense probably damaging 0.99
IGL01647:Gzf1 APN 2 148,525,570 (GRCm39) missense probably damaging 1.00
IGL01789:Gzf1 APN 2 148,525,981 (GRCm39) missense probably benign 0.41
IGL01952:Gzf1 APN 2 148,525,981 (GRCm39) missense probably benign 0.41
IGL01954:Gzf1 APN 2 148,525,981 (GRCm39) missense probably benign 0.41
IGL01956:Gzf1 APN 2 148,525,981 (GRCm39) missense probably benign 0.41
IGL03391:Gzf1 APN 2 148,525,603 (GRCm39) missense probably damaging 1.00
I0000:Gzf1 UTSW 2 148,528,540 (GRCm39) unclassified probably benign
P0019:Gzf1 UTSW 2 148,525,900 (GRCm39) missense probably damaging 1.00
R0420:Gzf1 UTSW 2 148,525,753 (GRCm39) missense probably benign 0.30
R0725:Gzf1 UTSW 2 148,526,569 (GRCm39) nonsense probably null
R1131:Gzf1 UTSW 2 148,532,787 (GRCm39) missense probably benign 0.02
R2000:Gzf1 UTSW 2 148,526,531 (GRCm39) missense probably benign 0.16
R2211:Gzf1 UTSW 2 148,526,870 (GRCm39) missense probably damaging 1.00
R2251:Gzf1 UTSW 2 148,525,856 (GRCm39) missense probably damaging 1.00
R2252:Gzf1 UTSW 2 148,525,856 (GRCm39) missense probably damaging 1.00
R2253:Gzf1 UTSW 2 148,525,856 (GRCm39) missense probably damaging 1.00
R4233:Gzf1 UTSW 2 148,528,453 (GRCm39) missense possibly damaging 0.86
R5551:Gzf1 UTSW 2 148,526,248 (GRCm39) missense probably damaging 1.00
R6050:Gzf1 UTSW 2 148,526,158 (GRCm39) missense possibly damaging 0.89
R6891:Gzf1 UTSW 2 148,526,689 (GRCm39) nonsense probably null
R7457:Gzf1 UTSW 2 148,532,002 (GRCm39) missense probably damaging 0.99
R7735:Gzf1 UTSW 2 148,530,083 (GRCm39) missense possibly damaging 0.91
R7839:Gzf1 UTSW 2 148,525,815 (GRCm39) nonsense probably null
R8168:Gzf1 UTSW 2 148,526,686 (GRCm39) missense probably damaging 1.00
R8225:Gzf1 UTSW 2 148,532,764 (GRCm39) missense probably benign 0.02
R8432:Gzf1 UTSW 2 148,532,115 (GRCm39) missense probably benign 0.22
R9081:Gzf1 UTSW 2 148,525,317 (GRCm39) intron probably benign
R9761:Gzf1 UTSW 2 148,530,011 (GRCm39) missense probably damaging 0.99
Posted On 2015-04-16