Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01801:Wdr70'

278930

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Wdr70

Ensembl Gene

ENSMUSG00000039828

Gene Name

WD repeat domain 70

Synonyms

4833422F06Rik

Accession Numbers

Essential gene?

Probably essential (E-score: 0.966) question?

Stock #

IGL01801

Quality Score

Status

Chromosome

Chromosomal Location

7902536-8128693 bp(-) (GRCm39)

Type of Mutation

splice site (5 bp from exon)

DNA Base Change (assembly)

C to T at 7916805 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000037340 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000045766]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000045766

SMART Domains

Protein: ENSMUSP00000037340
Gene: ENSMUSG00000039828

Domain	Start	End	E-Value	Type
coiled coil region	51	81	N/A	INTRINSIC
low complexity region	137	167	N/A	INTRINSIC
WD40	174	213	1.61e-3	SMART
WD40	220	260	3.2e0	SMART
WD40	272	315	1.03e0	SMART
WD40	324	363	1.7e-2	SMART
WD40	367	409	1.38e-2	SMART
Blast:WD40	413	460	5e-16	BLAST
WD40	463	502	3.44e0	SMART
low complexity region	570	586	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000226928

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932415M13Rik	C	T	17: 54,031,870 (GRCm39)		noncoding transcript	Het
Acsm4	C	T	7: 119,306,486 (GRCm39)	T308I	possibly damaging	Het
Adamtsl1	A	G	4: 86,117,559 (GRCm39)	N174S	probably benign	Het
Atp1b1	C	T	1: 164,265,918 (GRCm39)	G281D	probably damaging	Het
Cacna1e	T	C	1: 154,347,086 (GRCm39)	N1027S	probably null	Het
Cacnb4	A	T	2: 52,324,723 (GRCm39)	N446K	probably benign	Het
Cfap210	A	T	2: 69,606,623 (GRCm39)		probably benign	Het
Col13a1	T	C	10: 61,679,393 (GRCm39)	D215G	probably damaging	Het
Cyp2d22	T	C	15: 82,257,046 (GRCm39)	T312A	probably benign	Het
Cyp4f40	A	T	17: 32,895,279 (GRCm39)	N467I	probably damaging	Het
Dnaaf10	T	C	11: 17,169,015 (GRCm39)	I62T	probably benign	Het
Ehd4	A	T	2: 119,932,822 (GRCm39)	D201E	probably damaging	Het
Farsb	T	C	1: 78,435,216 (GRCm39)	T444A	probably benign	Het
Gabra6	A	C	11: 42,205,935 (GRCm39)	I307R	probably damaging	Het
Impg2	G	A	16: 56,057,111 (GRCm39)	R287H	probably damaging	Het
Khdrbs1	A	G	4: 129,635,574 (GRCm39)	V127A	probably benign	Het
Lcp1	A	T	14: 75,436,815 (GRCm39)	T54S	probably benign	Het
Mrgpra6	T	C	7: 46,835,572 (GRCm39)	D283G	possibly damaging	Het
Mterf4	T	C	1: 93,232,642 (GRCm39)	R70G	probably benign	Het
Mtmr12	T	C	15: 12,270,045 (GRCm39)	L711P	probably damaging	Het
Or4n4	A	G	14: 50,519,665 (GRCm39)	I15T	probably benign	Het
Pax8	A	G	2: 24,334,576 (GRCm39)		probably null	Het
Prmt9	T	C	8: 78,289,069 (GRCm39)	V257A	probably damaging	Het
Sspo	T	C	6: 48,434,072 (GRCm39)	V959A	probably damaging	Het
Vps54	T	C	11: 21,225,131 (GRCm39)		probably null	Het

Other mutations in Wdr70

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00777:Wdr70	APN	15	8,049,088 (GRCm39)	missense	probably benign	0.07
IGL01121:Wdr70	APN	15	7,902,655 (GRCm39)	missense	possibly damaging	0.53
IGL01508:Wdr70	APN	15	8,108,747 (GRCm39)	missense	probably benign	0.33
IGL01815:Wdr70	APN	15	7,916,805 (GRCm39)	splice site	probably null
IGL01929:Wdr70	APN	15	7,950,115 (GRCm39)	splice site	probably null
IGL02150:Wdr70	APN	15	8,112,030 (GRCm39)	missense	possibly damaging	0.72
IGL02245:Wdr70	APN	15	8,075,965 (GRCm39)	missense	possibly damaging	0.86
IGL02541:Wdr70	APN	15	7,913,783 (GRCm39)	nonsense	probably null
IGL02800:Wdr70	APN	15	8,111,980 (GRCm39)	missense	probably benign	0.25
IGL02829:Wdr70	APN	15	8,006,463 (GRCm39)	missense	possibly damaging	0.92
IGL02831:Wdr70	APN	15	7,913,787 (GRCm39)	missense	possibly damaging	0.86
IGL03169:Wdr70	APN	15	7,913,821 (GRCm39)	missense	possibly damaging	0.73
IGL03405:Wdr70	APN	15	8,065,352 (GRCm39)	missense	possibly damaging	0.73
R0106:Wdr70	UTSW	15	8,049,068 (GRCm39)	critical splice donor site	probably null
R0106:Wdr70	UTSW	15	8,049,068 (GRCm39)	critical splice donor site	probably null
R0462:Wdr70	UTSW	15	8,108,645 (GRCm39)	missense	probably benign	0.00
R0539:Wdr70	UTSW	15	7,915,118 (GRCm39)	missense	possibly damaging	0.96
R1398:Wdr70	UTSW	15	8,065,325 (GRCm39)	missense	probably benign	0.01
R1812:Wdr70	UTSW	15	8,108,663 (GRCm39)	missense	probably benign	0.00
R1863:Wdr70	UTSW	15	7,950,054 (GRCm39)	missense	probably benign	0.25
R1913:Wdr70	UTSW	15	7,913,891 (GRCm39)	missense	possibly damaging	0.72
R2425:Wdr70	UTSW	15	7,916,840 (GRCm39)	nonsense	probably null
R4013:Wdr70	UTSW	15	8,108,698 (GRCm39)	nonsense	probably null
R4015:Wdr70	UTSW	15	8,108,698 (GRCm39)	nonsense	probably null
R4017:Wdr70	UTSW	15	8,108,698 (GRCm39)	nonsense	probably null
R4111:Wdr70	UTSW	15	8,006,472 (GRCm39)	missense	probably benign	0.32
R5241:Wdr70	UTSW	15	8,108,700 (GRCm39)	missense	probably benign
R5277:Wdr70	UTSW	15	8,006,465 (GRCm39)	nonsense	probably null
R5306:Wdr70	UTSW	15	7,953,754 (GRCm39)	missense	probably benign	0.04
R5426:Wdr70	UTSW	15	7,951,586 (GRCm39)	missense	possibly damaging	0.59
R5586:Wdr70	UTSW	15	7,913,769 (GRCm39)	missense	possibly damaging	0.86
R6010:Wdr70	UTSW	15	7,916,900 (GRCm39)	splice site	probably null
R6035:Wdr70	UTSW	15	7,916,830 (GRCm39)	missense	possibly damaging	0.86
R6035:Wdr70	UTSW	15	7,916,830 (GRCm39)	missense	possibly damaging	0.86
R6109:Wdr70	UTSW	15	8,108,638 (GRCm39)	splice site	probably null
R6139:Wdr70	UTSW	15	8,108,735 (GRCm39)	missense	probably benign	0.04
R6400:Wdr70	UTSW	15	8,072,322 (GRCm39)	missense	probably benign	0.32
R6456:Wdr70	UTSW	15	7,915,118 (GRCm39)	missense	possibly damaging	0.96
R6518:Wdr70	UTSW	15	8,108,821 (GRCm39)	missense	unknown
R7036:Wdr70	UTSW	15	7,913,855 (GRCm39)	missense	possibly damaging	0.85
R7056:Wdr70	UTSW	15	7,913,877 (GRCm39)	missense	possibly damaging	0.53
R7341:Wdr70	UTSW	15	7,953,725 (GRCm39)	missense	possibly damaging	0.71
R7484:Wdr70	UTSW	15	7,951,562 (GRCm39)	missense	probably benign	0.23
R7572:Wdr70	UTSW	15	8,065,327 (GRCm39)	missense	possibly damaging	0.85
R7652:Wdr70	UTSW	15	8,108,700 (GRCm39)	missense	probably benign
R7886:Wdr70	UTSW	15	8,108,733 (GRCm39)	missense	probably benign	0.02
R8103:Wdr70	UTSW	15	8,006,612 (GRCm39)	missense	possibly damaging	0.70
R8214:Wdr70	UTSW	15	7,916,851 (GRCm39)	missense	probably benign	0.03
R8252:Wdr70	UTSW	15	8,072,337 (GRCm39)	splice site	probably benign
R8869:Wdr70	UTSW	15	8,123,210 (GRCm39)	missense	probably benign	0.02
R9203:Wdr70	UTSW	15	7,902,684 (GRCm39)	missense	probably benign

Posted On

2015-04-16