Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01885:Gm21738'

279000

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm21738

Ensembl Gene

ENSMUSG00000095280

Gene Name

predicted gene, 21738

Synonyms

Accession Numbers

Essential gene?

Probably essential (E-score: 0.905) question?

Stock #

IGL01885

Quality Score

Status

Chromosome

Chromosomal Location

(GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 19416979 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Leucine at position 144 (S144L)

Ref Sequence

ENSEMBL: ENSMUSP00000137127 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000177817]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000177817
AA Change: S144L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000137127
Gene: ENSMUSG00000095280
AA Change: S144L

Domain	Start	End	E-Value	Type
internal_repeat_1	1	19	1.11e-9	PROSPERO
transmembrane domain	20	42	N/A	INTRINSIC
transmembrane domain	77	99	N/A	INTRINSIC
internal_repeat_1	117	135	1.11e-9	PROSPERO
transmembrane domain	152	174	N/A	INTRINSIC
low complexity region	179	195	N/A	INTRINSIC
transmembrane domain	198	220	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aars1	T	C	8: 111,774,575 (GRCm39)	V568A	possibly damaging	Het
Abcb11	T	A	2: 69,117,971 (GRCm39)	Q469L	probably damaging	Het
Ahsg	G	A	16: 22,717,731 (GRCm39)	G264E	probably damaging	Het
Ankar	T	C	1: 72,697,862 (GRCm39)	Y788C	probably damaging	Het
Birc6	T	A	17: 74,911,511 (GRCm39)	F1508I	possibly damaging	Het
Cd6	C	A	19: 10,776,601 (GRCm39)	Q141H	probably benign	Het
Cercam	A	C	2: 29,771,015 (GRCm39)	T471P	probably damaging	Het
Cux1	T	C	5: 136,337,301 (GRCm39)	D729G	possibly damaging	Het
Dglucy	T	A	12: 100,816,540 (GRCm39)	F394Y	probably damaging	Het
E130308A19Rik	A	G	4: 59,720,004 (GRCm39)	N512S	probably benign	Het
Ephb4	T	C	5: 137,356,059 (GRCm39)	C223R	probably damaging	Het
Gcn1	T	A	5: 115,714,174 (GRCm39)		probably null	Het
Gm10718	A	T	9: 3,025,118 (GRCm39)	Y194F	probably benign	Het
Hirip3	T	A	7: 126,463,381 (GRCm39)	S446T	probably benign	Het
Hoxa5	A	T	6: 52,179,647 (GRCm39)	F243I	probably damaging	Het
Iars1	T	C	13: 49,844,975 (GRCm39)	V162A	probably benign	Het
Lama2	G	A	10: 26,981,135 (GRCm39)	R1840*	probably null	Het
Lbp	T	A	2: 158,166,493 (GRCm39)	L349Q	probably damaging	Het
Lrp4	T	C	2: 91,331,452 (GRCm39)	I1604T	probably benign	Het
Mapk10	T	C	5: 103,144,455 (GRCm39)	K121E	probably damaging	Het
Nav3	T	A	10: 109,578,521 (GRCm39)	R1579*	probably null	Het
Obscn	T	C	11: 58,965,794 (GRCm39)	D652G	possibly damaging	Het
Or10x1	A	G	1: 174,196,967 (GRCm39)	I161M	probably damaging	Het
Or5b117	G	A	19: 13,431,449 (GRCm39)	T144I	probably benign	Het
Or7g30	A	G	9: 19,352,760 (GRCm39)	I184V	probably benign	Het
Ostm1	C	T	10: 42,574,147 (GRCm39)	S280L	possibly damaging	Het
Peak1	C	T	9: 56,167,388 (GRCm39)	R180K	probably damaging	Het
Plcz1	T	C	6: 139,947,837 (GRCm39)	Y515C	probably benign	Het
Postn	T	C	3: 54,283,455 (GRCm39)		probably benign	Het
Ptchd4	C	T	17: 42,814,493 (GRCm39)	T798I	probably damaging	Het
Rnf41	A	T	10: 128,271,344 (GRCm39)	N85Y	probably damaging	Het
Shisa7	A	T	7: 4,833,825 (GRCm39)	H323Q	probably damaging	Het
Slco2a1	T	A	9: 102,951,629 (GRCm39)	M386K	probably damaging	Het
St18	G	A	1: 6,914,596 (GRCm39)		probably null	Het
Stra6	T	A	9: 58,048,431 (GRCm39)	L175M	probably damaging	Het
Tmem67	A	G	4: 12,057,389 (GRCm39)	L600P	probably damaging	Het
Try5	G	T	6: 41,288,672 (GRCm39)	N182K	possibly damaging	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het
Xpo7	G	A	14: 70,903,475 (GRCm39)	T1078I	probably benign	Het
Zan	G	A	5: 137,462,386 (GRCm39)	T931I	unknown	Het

Other mutations in Gm21738

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Gm21738	APN	14	19,418,885 (GRCm38)	missense	probably benign
IGL01010:Gm21738	APN	14	19,417,361 (GRCm38)	missense	probably benign	0.03
IGL01018:Gm21738	APN	14	19,418,856 (GRCm38)	missense	probably benign	0.39
IGL01865:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01869:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01873:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01877:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01878:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01879:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01880:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01882:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01883:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01884:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01886:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01888:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01891:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01892:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01893:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01894:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01895:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01896:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01898:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01899:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01900:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01901:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01902:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01903:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01904:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01905:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01906:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01908:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01909:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01910:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01911:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01912:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01913:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01914:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01915:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01916:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01917:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01918:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01919:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01922:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01923:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01924:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01925:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01926:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01932:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01940:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01949:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
PIT4131001:Gm21738	UTSW	14	19,417,330 (GRCm38)	missense	probably benign	0.00
PIT4142001:Gm21738	UTSW	14	19,417,330 (GRCm38)	missense	probably benign	0.00
R0831:Gm21738	UTSW	14	19,415,963 (GRCm38)	missense	probably benign
R0831:Gm21738	UTSW	14	19,415,957 (GRCm38)	missense	probably benign	0.01
R0976:Gm21738	UTSW	14	19,415,963 (GRCm38)	missense	probably benign
R1029:Gm21738	UTSW	14	19,415,957 (GRCm38)	missense	probably benign	0.01
R1146:Gm21738	UTSW	14	19,415,963 (GRCm38)	missense	probably benign
R1231:Gm21738	UTSW	14	19,415,963 (GRCm38)	missense	probably benign
R1231:Gm21738	UTSW	14	19,415,957 (GRCm38)	missense	probably benign	0.01
R1402:Gm21738	UTSW	14	19,415,963 (GRCm38)	missense	probably benign
R1402:Gm21738	UTSW	14	19,415,957 (GRCm38)	missense	probably benign	0.01
R1638:Gm21738	UTSW	14	19,418,908 (GRCm38)	missense	probably benign
R1874:Gm21738	UTSW	14	19,418,824 (GRCm38)	missense	possibly damaging	0.64
R4392:Gm21738	UTSW	14	19,417,178 (GRCm38)	missense	probably benign
R4393:Gm21738	UTSW	14	19,417,178 (GRCm38)	missense	probably benign
R5049:Gm21738	UTSW	14	19,415,957 (GRCm38)	missense	probably benign	0.01
R5257:Gm21738	UTSW	14	19,415,942 (GRCm38)	missense	probably benign
R6756:Gm21738	UTSW	14	19,418,824 (GRCm38)	missense	possibly damaging	0.64
R6915:Gm21738	UTSW	14	19,415,933 (GRCm38)	missense	probably benign
V5622:Gm21738	UTSW	14	19,417,180 (GRCm38)	missense	probably damaging	1.00

Posted On

2015-04-16