Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01923:Gm21738'

279124

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm21738

Ensembl Gene

ENSMUSG00000095280

Gene Name

predicted gene, 21738

Synonyms

Accession Numbers

Essential gene?

Probably essential (E-score: 0.883) question?

Stock #

IGL01923

Quality Score

Status

Chromosome

Chromosomal Location

(GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 19416979 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Leucine at position 144 (S144L)

Ref Sequence

ENSEMBL: ENSMUSP00000137127 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000177817]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000177817
AA Change: S144L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000137127
Gene: ENSMUSG00000095280
AA Change: S144L

Domain	Start	End	E-Value	Type
internal_repeat_1	1	19	1.11e-9	PROSPERO
transmembrane domain	20	42	N/A	INTRINSIC
transmembrane domain	77	99	N/A	INTRINSIC
internal_repeat_1	117	135	1.11e-9	PROSPERO
transmembrane domain	152	174	N/A	INTRINSIC
low complexity region	179	195	N/A	INTRINSIC
transmembrane domain	198	220	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrd1	T	A	5: 129,255,143 (GRCm39)	S597T	possibly damaging	Het
Btnl9	T	C	11: 49,071,409 (GRCm39)	D138G	probably benign	Het
Cep135	T	A	5: 76,788,829 (GRCm39)	*1141K	probably null	Het
Ctnnd2	A	T	15: 30,480,974 (GRCm39)	Q74L	probably damaging	Het
Cyp2j13	A	T	4: 95,950,294 (GRCm39)	W236R	probably benign	Het
Dixdc1	A	T	9: 50,606,803 (GRCm39)	I271N	possibly damaging	Het
Dlec1	A	G	9: 118,957,182 (GRCm39)		probably null	Het
Dnah9	C	A	11: 66,016,061 (GRCm39)		probably benign	Het
Dop1a	A	T	9: 86,404,920 (GRCm39)	Y275F	probably damaging	Het
Dysf	T	A	6: 84,187,811 (GRCm39)	*2105R	probably null	Het
Eif4a1	A	T	11: 69,563,129 (GRCm39)	D25E	possibly damaging	Het
Fras1	T	A	5: 96,883,139 (GRCm39)	I2557N	probably damaging	Het
Gm10717	C	T	9: 3,025,616 (GRCm39)	S67L	probably benign	Het
Gm12253	G	T	11: 58,325,727 (GRCm39)		probably null	Het
Hsd17b7	A	G	1: 169,787,035 (GRCm39)	V254A	probably benign	Het
Kif21a	T	A	15: 90,840,633 (GRCm39)	D143V	probably damaging	Het
Lrrc9	T	C	12: 72,557,186 (GRCm39)	V1417A	possibly damaging	Het
Macf1	C	T	4: 123,274,237 (GRCm39)	A4926T	possibly damaging	Het
Mef2a	A	C	7: 66,914,620 (GRCm39)	S91R	probably damaging	Het
Myh7	A	G	14: 55,222,916 (GRCm39)		probably null	Het
Or6c65	T	A	10: 129,603,973 (GRCm39)	F203I	probably benign	Het
Pbx2	A	G	17: 34,813,024 (GRCm39)	D160G	probably damaging	Het
Pcdhb17	T	C	18: 37,619,790 (GRCm39)	F527L	probably benign	Het
Ppm1b	T	C	17: 85,301,489 (GRCm39)	L123P	probably damaging	Het
Ppm1k	T	A	6: 57,499,813 (GRCm39)	K154N	probably benign	Het
Ppp2r1a	T	G	17: 21,185,731 (GRCm39)	*590G	probably null	Het
Raver1	A	T	9: 20,990,536 (GRCm39)	L589Q	probably damaging	Het
Rrbp1	A	G	2: 143,832,081 (GRCm39)	S29P	probably damaging	Het
Senp5	A	G	16: 31,784,634 (GRCm39)	Y673H	probably damaging	Het
Serpina3j	T	A	12: 104,281,473 (GRCm39)		probably benign	Het
Serpinc1	A	G	1: 160,817,116 (GRCm39)	E70G	probably damaging	Het
Sp140l2	A	G	1: 85,231,907 (GRCm39)		probably benign	Het
Stag3	A	G	5: 138,287,492 (GRCm39)	Q139R	probably damaging	Het
Sva	T	A	6: 42,019,104 (GRCm39)	H91Q	probably benign	Het
Tmem263	C	T	10: 84,950,295 (GRCm39)	Q29*	probably null	Het
Tpp1	T	C	7: 105,400,857 (GRCm39)	N57D	probably benign	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het
Vmn2r27	T	A	6: 124,177,484 (GRCm39)	I507L	probably benign	Het
Wdr11	A	T	7: 129,234,046 (GRCm39)		probably null	Het
Zfp236	C	T	18: 82,700,344 (GRCm39)	E42K	probably damaging	Het

Other mutations in Gm21738

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Gm21738	APN	14	19,418,885 (GRCm38)	missense	probably benign
IGL01010:Gm21738	APN	14	19,417,361 (GRCm38)	missense	probably benign	0.03
IGL01018:Gm21738	APN	14	19,418,856 (GRCm38)	missense	probably benign	0.39
IGL01865:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01869:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01873:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01877:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01878:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01879:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01880:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01882:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01883:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01884:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01885:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01886:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01888:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01891:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01892:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01893:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01894:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01895:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01896:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01898:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01899:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01900:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01901:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01902:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01903:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01904:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01905:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01906:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01908:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01909:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01910:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01911:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01912:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01913:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01914:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01915:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01916:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01917:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01918:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01919:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01922:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01924:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01925:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01926:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01932:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01940:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01949:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
PIT4131001:Gm21738	UTSW	14	19,417,330 (GRCm38)	missense	probably benign	0.00
PIT4142001:Gm21738	UTSW	14	19,417,330 (GRCm38)	missense	probably benign	0.00
R0831:Gm21738	UTSW	14	19,415,963 (GRCm38)	missense	probably benign
R0831:Gm21738	UTSW	14	19,415,957 (GRCm38)	missense	probably benign	0.01
R0976:Gm21738	UTSW	14	19,415,963 (GRCm38)	missense	probably benign
R1029:Gm21738	UTSW	14	19,415,957 (GRCm38)	missense	probably benign	0.01
R1146:Gm21738	UTSW	14	19,415,963 (GRCm38)	missense	probably benign
R1231:Gm21738	UTSW	14	19,415,963 (GRCm38)	missense	probably benign
R1231:Gm21738	UTSW	14	19,415,957 (GRCm38)	missense	probably benign	0.01
R1402:Gm21738	UTSW	14	19,415,963 (GRCm38)	missense	probably benign
R1402:Gm21738	UTSW	14	19,415,957 (GRCm38)	missense	probably benign	0.01
R1638:Gm21738	UTSW	14	19,418,908 (GRCm38)	missense	probably benign
R1874:Gm21738	UTSW	14	19,418,824 (GRCm38)	missense	possibly damaging	0.64
R4392:Gm21738	UTSW	14	19,417,178 (GRCm38)	missense	probably benign
R4393:Gm21738	UTSW	14	19,417,178 (GRCm38)	missense	probably benign
R5049:Gm21738	UTSW	14	19,415,957 (GRCm38)	missense	probably benign	0.01
R5257:Gm21738	UTSW	14	19,415,942 (GRCm38)	missense	probably benign
R6756:Gm21738	UTSW	14	19,418,824 (GRCm38)	missense	possibly damaging	0.64
R6915:Gm21738	UTSW	14	19,415,933 (GRCm38)	missense	probably benign
V5622:Gm21738	UTSW	14	19,417,180 (GRCm38)	missense	probably damaging	1.00

Posted On

2015-04-16